The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.[1] ACVR1C is a type I receptor for the TGFB family of signaling molecules.[1]
ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADsSMAD2 or SMAD3.[2]
Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.[1]
References
↑ 1.01.11.2Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O (2001). "cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)". Cytogenet. Cell Genet. 95 (3–4): 157–62. doi:10.1159/000059339. PMID12063393.
↑Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS (July 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol. 62 (1): 65–74. doi:10.1124/mol.62.1.65. PMID12065756.
Watanabe R, Shen ZP, Tsuda K, Yamada Y (2008). "Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells". Biochem. Biophys. Res. Commun. 377 (3): 867–72. doi:10.1016/j.bbrc.2008.10.074. PMID18951876.
Roberts HJ, Hu S, Qiu Q, et al. (2003). "Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta". Biol. Reprod. 68 (5): 1719–26. doi:10.1095/biolreprod.102.013045. PMID12606401.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID15815621.
Xu G, Zhong Y, Munir S, et al. (2004). "Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7". J. Clin. Endocrinol. Metab. 89 (11): 5523–34. doi:10.1210/jc.2004-0893. PMID15531507.
Kim BC, van Gelder H, Kim TA, et al. (2004). "Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells". J. Biol. Chem. 279 (27): 28458–65. doi:10.1074/jbc.M313277200. PMID15107418.
Munir S, Xu G, Wu Y, et al. (2004). "Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells". J. Biol. Chem. 279 (30): 31277–86. doi:10.1074/jbc.M400641200. PMID15150278.
Xu G, Zhou H, Wang Q, et al. (2006). "Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines". Mol. Cancer Res. 4 (4): 235–46. doi:10.1158/1541-7786.MCR-05-0174. PMID16603637.
Tsuchida K, Nakatani M, Yamakawa N, et al. (2004). "Activin isoforms signal through type I receptor serine/threonine kinase ALK7". Mol. Cell. Endocrinol. 220 (1–2): 59–65. doi:10.1016/j.mce.2004.03.009. PMID15196700.
