CDK9

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Cyclin-dependent kinase 9 (CDC2-related kinase)
Identifiers
Symbols CDK9 ; C-2k; CDC2L4; PITALRE; TAK
External IDs Template:OMIM5 Template:MGI HomoloGene55566
RNA expression pattern
PBB GE CDK9 203198 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

CDK9 or cyclin-dependent kinase 9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [1] CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle. [2]

References

  1. "Entrez Gene: CDK9 cyclin-dependent kinase 9 (CDC2-related kinase)".<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. MacLachlan TK, Sang N, De Luca A, Puri PL, Levrero M, Giordano A.; et al. (1998). "Binding of CDK9 to TRAF2". J. Cell. Biochem. 71 (4): 467–78. PMID 9827693.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

Further reading

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  • Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. PMID 9570510.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. PMID 9651670.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Romano G, Kasten M, De Falco G; et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. PMID 10536359.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. PMID 11547919.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Huigen MC, Kamp W, Nottet HS (2004). "Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection". Eur. J. Clin. Invest. 34 (1): 57–66. PMID 14984439.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Rice AP, Herrmann CH (2004). "Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages". Curr. HIV Res. 1 (4): 395–404. PMID 15049426.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Minghetti L, Visentin S, Patrizio M; et al. (2004). "Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions". Neurochem. Res. 29 (5): 965–78. PMID 15139295.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Liou LY, Herrmann CH, Rice AP (2005). "HIV-1 infection and regulation of Tat function in macrophages". Int. J. Biochem. Cell Biol. 36 (9): 1767–75. doi:10.1016/j.biocel.2004.02.018. PMID 15183343.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Pugliese A, Vidotto V, Beltramo T; et al. (2005). "A review of HIV-1 Tat protein biological effects". Cell Biochem. Funct. 23 (4): 223–7. doi:10.1002/cbf.1147. PMID 15473004.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Bannwarth S, Gatignol A (2005). "HIV-1 TAR RNA: the target of molecular interactions between the virus and its host". Curr. HIV Res. 3 (1): 61–71. PMID 15638724.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Gibellini D, Vitone F, Schiavone P, Re MC (2005). "HIV-1 tat protein and cell proliferation and survival: a brief review". New Microbiol. 28 (2): 95–109. PMID 16035254.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Peruzzi F (2006). "The multiple functions of HIV-1 Tat: proliferation versus apoptosis". Front. Biosci. 11: 708–17. PMID 16146763.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

External links

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