Wee1-like protein kinase: Difference between revisions
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{{see also|Wee1}} | {{see also|Wee1}} | ||
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'''WEE1 homolog (''S. pombe'')''', also known as '''WEE1''', is a [[protein]] which in humans is encoded by the ''WEE1'' [[gene]].<ref name="pmid1840647">{{cite journal |vauthors=Igarashi M, Nagata A, Jinno S, Suto K, Okayama H | title = Wee1(+)-like gene in human cells | journal = Nature | volume = 353 | issue = 6339 | pages = 80–3 |date=September 1991 | pmid = 1840647 | doi = 10.1038/353080a0 | url = }}</ref> | '''WEE1 homolog (''S. pombe'')''', also known as '''WEE1''', is a [[protein]] which in humans is encoded by the ''WEE1'' [[gene]].<ref name="pmid1840647">{{cite journal |vauthors=Igarashi M, Nagata A, Jinno S, Suto K, Okayama H | title = Wee1(+)-like gene in human cells | journal = Nature | volume = 353 | issue = 6339 | pages = 80–3 |date=September 1991 | pmid = 1840647 | doi = 10.1038/353080a0 | url = | bibcode =1991Natur.353...80I }}</ref> | ||
== Function == | == Function == | ||
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| citations = | | citations = | ||
*{{cite journal |vauthors=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }} | *{{cite journal |vauthors=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }} | ||
*{{cite journal |vauthors=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }} | *{{cite journal |vauthors=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 |bibcode=2004NYASA1024..153K }} | ||
*{{cite journal |vauthors=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 | pmc=554975 }} | *{{cite journal |vauthors=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 | pmc=554975 }} | ||
*{{cite journal |vauthors=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }} | *{{cite journal |vauthors=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }} | ||
*{{cite journal |vauthors=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi= }} | *{{cite journal |vauthors=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi= }} | ||
*{{cite journal |vauthors=Li L, Li HS, Pauza CD, etal |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923–34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }} | *{{cite journal |vauthors=Li L, Li HS, Pauza CD, etal |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923–34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }} | ||
*{{cite journal |vauthors=Igarashi M, Nagata A, Jinno S, etal |title=Wee1(+)-like gene in human cells. |journal=Nature |volume=353 |issue= 6339 |pages= 80–3 |year= 1991 |pmid= 1840647 |doi= 10.1038/353080a0 }} | *{{cite journal |vauthors=Igarashi M, Nagata A, Jinno S, etal |title=Wee1(+)-like gene in human cells. |journal=Nature |volume=353 |issue= 6339 |pages= 80–3 |year= 1991 |pmid= 1840647 |doi= 10.1038/353080a0 |bibcode=1991Natur.353...80I }} | ||
*{{cite journal |vauthors=Baldin V, Ducommun B |title=Subcellular localisation of human wee1 kinase is regulated during the cell cycle. |journal=J. Cell Sci. |volume=108 |issue= 6|pages= 2425–32 |year= 1995 |pmid= 7673359 |doi= }} | *{{cite journal |vauthors=Baldin V, Ducommun B |title=Subcellular localisation of human wee1 kinase is regulated during the cell cycle. |journal=J. Cell Sci. |volume=108 |issue= 6|pages= 2425–32 |year= 1995 |pmid= 7673359 |doi= }} | ||
*{{cite journal |vauthors=Watanabe N, Broome M, Hunter T |title=Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. |journal=EMBO J. |volume=14 |issue= 9 |pages= 1878–91 |year= 1995 |pmid= 7743995 |doi= | pmc=398287 }} | *{{cite journal |vauthors=Watanabe N, Broome M, Hunter T |title=Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. |journal=EMBO J. |volume=14 |issue= 9 |pages= 1878–91 |year= 1995 |pmid= 7743995 |doi= | pmc=398287 }} | ||
| Line 35: | Line 35: | ||
*{{cite journal |vauthors=Taviaux SA, Demaille JG |title=Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization. |journal=Genomics |volume=15 |issue= 1 |pages= 194–6 |year= 1993 |pmid= 8432534 |doi= 10.1006/geno.1993.1032 }} | *{{cite journal |vauthors=Taviaux SA, Demaille JG |title=Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization. |journal=Genomics |volume=15 |issue= 1 |pages= 194–6 |year= 1993 |pmid= 8432534 |doi= 10.1006/geno.1993.1032 }} | ||
*{{cite journal |vauthors=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=10.1074/jbc.272.35.22300 }} | *{{cite journal |vauthors=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=10.1074/jbc.272.35.22300 }} | ||
*{{cite journal |vauthors=Zhou BB, Li H, Yuan J, Kirschner MW |title=Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6785–90 |year= 1998 |pmid= 9618490 |doi=10.1073/pnas.95.12.6785 | pmc=22635 }} | *{{cite journal |vauthors=Zhou BB, Li H, Yuan J, Kirschner MW |title=Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6785–90 |year= 1998 |pmid= 9618490 |doi=10.1073/pnas.95.12.6785 | pmc=22635 |bibcode=1998PNAS...95.6785Z }} | ||
*{{cite journal |vauthors=Taylor WR, DePrimo SE, Agarwal A, etal |title=Mechanisms of G2 arrest in response to overexpression of p53. |journal=Mol. Biol. Cell |volume=10 |issue= 11 |pages= 3607–22 |year= 1999 |pmid= 10564259 |doi= 10.1091/mbc.10.11.3607| pmc=25646 }} | *{{cite journal |vauthors=Taylor WR, DePrimo SE, Agarwal A, etal |title=Mechanisms of G2 arrest in response to overexpression of p53. |journal=Mol. Biol. Cell |volume=10 |issue= 11 |pages= 3607–22 |year= 1999 |pmid= 10564259 |doi= 10.1091/mbc.10.11.3607| pmc=25646 }} | ||
*{{cite journal |vauthors=Wang Y, Jacobs C, Hook KE, etal |title=Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population. |journal=Cell Growth Differ. |volume=11 |issue= 4 |pages= 211–9 |year= 2000 |pmid= 10775038 |doi= }} | *{{cite journal |vauthors=Wang Y, Jacobs C, Hook KE, etal |title=Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population. |journal=Cell Growth Differ. |volume=11 |issue= 4 |pages= 211–9 |year= 2000 |pmid= 10775038 |doi= }} | ||
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WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.[1]
Function
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.[2]
Interactions
Wee1-like protein kinase has been shown to interact with YWHAB[3] and PIN1.[4]
References
- ↑ Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID 1840647.
- ↑ "Entrez Gene: WEE1 WEE1 homolog (S. pombe)".
- ↑ Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. UNITED STATES. 11 (4): 211–9. ISSN 1044-9523. PMID 10775038.
- ↑ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.
External links
- WEE1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Further reading
- Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
- Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. Bibcode:2004NYASA1024..153K. doi:10.1196/annals.1321.013. PMID 15265780.
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
- Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
- Igarashi M, Nagata A, Jinno S, et al. (1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID 1840647.
- Baldin V, Ducommun B (1995). "Subcellular localisation of human wee1 kinase is regulated during the cell cycle". J. Cell Sci. 108 (6): 2425–32. PMID 7673359.
- Watanabe N, Broome M, Hunter T (1995). "Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle". EMBO J. 14 (9): 1878–91. PMC 398287. PMID 7743995.
- McGowan CH, Russell P (1995). "Cell cycle regulation of human WEE1". EMBO J. 14 (10): 2166–75. PMC 398322. PMID 7774574.
- Kharbanda S, Yuan ZM, Taneja N, et al. (1994). "p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.". Oncogene. 9 (10): 3005–11. PMID 8084605.
- Heald R, McLoughlin M, McKeon F (1993). "Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase". Cell. 74 (3): 463–74. doi:10.1016/0092-8674(93)80048-J. PMID 8348613.
- McGowan CH, Russell P (1993). "Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15". EMBO J. 12 (1): 75–85. PMC 413177. PMID 8428596.
- Taviaux SA, Demaille JG (1993). "Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization". Genomics. 15 (1): 194–6. doi:10.1006/geno.1993.1032. PMID 8432534.
- Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J. Biol. Chem. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
- Zhou BB, Li H, Yuan J, Kirschner MW (1998). "Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6785–90. Bibcode:1998PNAS...95.6785Z. doi:10.1073/pnas.95.12.6785. PMC 22635. PMID 9618490.
- Taylor WR, DePrimo SE, Agarwal A, et al. (1999). "Mechanisms of G2 arrest in response to overexpression of p53". Mol. Biol. Cell. 10 (11): 3607–22. doi:10.1091/mbc.10.11.3607. PMC 25646. PMID 10564259.
- Wang Y, Jacobs C, Hook KE, et al. (2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. 11 (4): 211–9. PMID 10775038.
- Cichutek A, Brueckmann T, Seipel B, et al. (2001). "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)". Cytogenet. Cell Genet. 93 (3–4): 277–83. doi:10.1159/000056998. PMID 11528126.
- Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
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