Quinapril drug interactions

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

List of drug interactions

Concomitant diuretic therapy

Agents increasing serum potassium

Tetracycline/other drugs that interact with Mg

Lithium

Propranolol or cimetidine

Digoxin

Hydrochlorothiazide

Atorvastatin

Complete list of drug interactions

Concomitant diuretic therapy

As with other ACE inhibitors, patients on diuretics, especially those on recently instituted diuretic therapy, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with Quinapril hydrochloride. The possibility of hypotensive effects with Quinapril hydrochloride may be minimized by either discontinuing the diuretic or cautiously increasing salt intake prior to initiation of treatment with Quinapril hydrochloride. If it is not possible to discontinue the diuretic, the starting dose of Quinapril should be reduced. Return to top

Agents increasing serum potassium

Quinapril can attenuate potassium loss caused by thiazide diuretics and increase serum potassium when used alone. If concomitant therapy of Quinapril hydrochloride with potassium-sparing diuretics (eg, spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes is indicated, they should be used with caution along with appropriate monitoring of serum potassium. Return to top

Tetracycline/other drugs that interact with Mg

Simultaneous administration of tetracycline with Quinapril hydrochloride reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in Quinapril tablets. This interaction should be considered if coprescribing Quinapril hydrochloride and tetracycline or other drugs that interact with magnesium. Return to top

Lithium

Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coadministered with caution and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, it may increase the risk of lithium toxicity. Return to top

Propranolol or cimetidine

Multiple dose therapy with propranolol or cimetidine has no effect on the pharmacokinetics of single doses of Quinapril hydrochloride. Return to top

Warfarin

The anticoagulant effect of a single dose of warfarin (measured by prothrombin time) was not significantly changed by Quinapril coadministration twice-daily. Return to top

Digoxin

Quinapril hydrochloride treatment did not affect the pharmacokinetics of digoxin. Return to top

Hydrochlorothiazide

No pharmacokinetic interaction was observed when single doses of Quinapril hydrochloride and hydrochlorothiazide were administered concomitantly. Return to top

Atorvastatin

Co-administration of multiple 10 mg doses of atorvastatin with 80 mg of Quinapril hydrochloride resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin. Return to top

Complete list of drug interactions

Major Interactions

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Moderate Interactions

Minor Interactions

Adapted from the FDA Package Insert.