Quinapril drug interactions
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2], Amr Marawan, M.D. [3]
For patient information about Quinapril, click here.
Quinapril
Quinapril and Hydrochlorothiazide tablet
Overview
Quinapril tablet is an angiontensin converting enzyme inhibitor drug that is FDA approved for the treatment of hypertension, heart failure, left ventricular dysfunction after myocardial infarction, diabetic nephropathy. Adverse reactions include hypotension, rash, hyperkalemia, disorder of taste, cough. hypotension, rash, hyperkalemia, disorder of taste, cough.
Category
Antihypertensive Agents, Angiotensin Converting Enzyme Inhibitors. Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4]; Associate Editor(s)-in-Chief: Amr Marawan, M.D. [5]
Drug Interactions
Concomitant diuretic therapy
As with other ACE inhibitors, patients on diuretics, especially those on recently instituted diuretic therapy, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with ACCUPRIL. The possibility of hypotensive effects with ACCUPRIL may be minimized by either discontinuing the diuretic or cautiously increasing salt intake prior to initiation of treatment with ACCUPRIL. If it is not possible to discontinue the diuretic, the starting dose of quinapril should be reduced.
Agents increasing serum potassium
Quinapril can attenuate potassium loss caused by thiazide diuretics and increase serum potassium when used alone. If concomitant therapy of ACCUPRIL with potassium-sparing diuretics (eg, spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes is indicated, they should be used with caution along with appropriate monitoring of serum potassium.
Tetracycline and other drugs that interact with magnesium
Simultaneous administration of tetracycline with ACCUPRIL reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in ACCUPRIL tablets. This interaction should be considered if coprescribing ACCUPRIL and tetracycline or other drugs that interact with magnesium.
Lithium
Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coadministered with caution and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, it may increase the risk of lithium toxicity.
Gold
Nitritoid reactions (symptoms include facial flushing, nausea, [[[vomiting]], and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy.
Non-steroidal anti-inflammatory agents including selective cyclooxygenase-2 inhibitors (COX-2 inhibitors)
In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including quinapril, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving quinapril and NSAID therapy.
The antihypertensive effect of ACE inhibitors, including quinapril may be attenuated by NSAIDs.
Agents that inhibit mTOR
Patients taking concomitant mTOR inhibitor (e.g. temsirolimus) therapy may be at increased risk for angioedema.
Other agents
Drug interaction studies of ACCUPRIL with other agents showed:
Multiple dose therapy with propranolol or cimetidine has no effect on the pharmacokinetics of single doses of ACCUPRIL. The anticoagulant effect of a single dose of warfarin (measured by prothrombin time) was not significantly changed by quinapril coadministration twice-daily. ACCUPRIL treatment did not affect the pharmacokinetics of digoxin. No pharmacokinetic interaction was observed when single doses of ACCUPRIL and hydrochlorothiazide were administered concomitantly. Co-administration of multiple 10 mg doses of atorvastatin with 80 mg of ACCUPRIL resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.
Dual Blockade of the Renin-Angiotensin System (RAS)
Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Closely monitor blood pressure, renal function and electrolytes in patients on ACCUPRIL and other agents that affect the RAS.
Do not co-administer aliskiren with ACCUPRIL in patients with diabetes. Avoid concomitant use of aliskiren with ACCUPRIL in patients with renal impairment (GFR <60 mL/min/1.73 m2).
Carcinogenesis, Mutagenesis, Impairment of Fertility
Quinapril hydrochloride was not carcinogenic in mice or rats when given in doses up to 75 or 100 mg/kg/day (50 to 60 times the maximum human daily dose, respectively, on an mg/kg basis and 3.8 to 10 times the maximum human daily dose when based on an mg/m2 basis) for 104 weeks. Female rats given the highest dose level had an increased incidence of mesenteric lymph node hemangiomas and skin/subcutaneous lipomas. Neither quinapril nor quinaprilat were mutagenic in the Ames bacterial assay with or without metabolic activation. Quinapril was also negative in the following genetic toxicology studies: in vitro mammalian cell point mutation, sister chromatid exchange in cultured mammalian cells, micronucleus test with mice, in vitro chromosome aberration with V79 cultured lung cells, and in an in vivo cytogenetic study with rat bone marrow. There were no adverse effects on fertility or reproduction in rats at doses up to 100 mg/kg/day (60 and 10 times the maximum daily human dose when based on mg/kg and mg/m2, respectively). [1]
List of drug interactions
Concomitant diuretic therapy
Agents increasing serum potassium
Tetracycline/other drugs that interact with Mg
Lithium
Propranolol or cimetidine
Digoxin
Hydrochlorothiazide
Atorvastatin
Complete list of drug interactions
Concomitant diuretic therapy
As with other ACE inhibitors, patients on diuretics, especially those on recently instituted diuretic therapy, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with Quinapril hydrochloride. The possibility of hypotensive effects with Quinapril hydrochloride may be minimized by either discontinuing the diuretic or cautiously increasing salt intake prior to initiation of treatment with Quinapril hydrochloride. If it is not possible to discontinue the diuretic, the starting dose of Quinapril should be reduced. Return to top
Agents increasing serum potassium
Quinapril can attenuate potassium loss caused by thiazide diuretics and increase serum potassium when used alone. If concomitant therapy of Quinapril hydrochloride with potassium-sparing diuretics (eg, spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes is indicated, they should be used with caution along with appropriate monitoring of serum potassium. Return to top
Tetracycline/other drugs that interact with Mg
Simultaneous administration of tetracycline with Quinapril hydrochloride reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in Quinapril tablets. This interaction should be considered if coprescribing Quinapril hydrochloride and tetracycline or other drugs that interact with magnesium. Return to top
Lithium
Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coadministered with caution and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, it may increase the risk of lithium toxicity. Return to top
Propranolol or cimetidine
Multiple dose therapy with propranolol or cimetidine has no effect on the pharmacokinetics of single doses of Quinapril hydrochloride. Return to top
Warfarin
The anticoagulant effect of a single dose of warfarin (measured by prothrombin time) was not significantly changed by Quinapril coadministration twice-daily. Return to top
Digoxin
Quinapril hydrochloride treatment did not affect the pharmacokinetics of digoxin. Return to top
Hydrochlorothiazide
No pharmacokinetic interaction was observed when single doses of Quinapril hydrochloride and hydrochlorothiazide were administered concomitantly. Return to top
Atorvastatin
Co-administration of multiple 10 mg doses of atorvastatin with 80 mg of Quinapril hydrochloride resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin. Return to top
Complete list of drug interactions
Major Interactions
Moderate Interactions
- 40 Winks
- A-Hydrocort
- A-Methapred
- Abilify
- Abilify Discmelt
- acetazolamide
- acetazolamide extended release
- acetocot
- acetohexamide
- Acetylsalicylic Acid
- ACTH
- ACTH Gel
- ACTH-40 HP
- ACTH-80
- Acthar
- Acthar Gel
- H.P.
- Acthrel
- Actiq
- Actonel
- Actron
- Acuprin 81
- Adapin
- Adbeon
- Adgan
- Adlone-40
- Adlone-80
- Adoxa
- Adoxa CK
- Adoxa TT
- Adrenocot
- Adrenocot L.A.
- Advil
- Advil Childrens
- Advil Junior Strength
- Advil Liquigel
- Advil Migraine
- Advil Pediatric
- Aflaxen
- Agenerase
- AK-Fluor
- Ala-Tet
- aldesleukin
- alendronate
- alendronate weekly
- Aler-Dryl
- Aler-Tab
- Aleve
- Aleve Caplet
- Aleve Easy Open Arthritis
- Aleve Gelcap
- Alfenta
- alfentanil
- alfuzosin
- alfuzosin extended release
- All Day Allergy
- Allegra
- Allegra ODT
- Allens Junior Cough
- Allergia-C
- Allermax
- Alodox
- Alophen
- alprazolam
- alprazolam extended release
- Altaryl
- Amaryl
- Ambien
- Ambien CR
- amifostine
- Amigesic
- Aminosyn II 3.5%-Dextrose 25% Electrolytes Ca
- Aminosyn II 4.25%-Dextrose 20% Electrolyte Ca
- Aminosyn II 4.25%-Dextrose 25% Electrolyte Ca
- Aminosyn II with Electrolytes
- Aminosyn II with Electrolytes Sulfite-Free
- Aminosyn with Electrolytes
- Aminosyn with Electrolytes Sulfite-Free
- amitriptyline
- amoxapine
- amprenavir
- Anaflex
- Anafranil
- Anaprox
- Anaprox-DS
- Anergan 50
- Angioscein
- Ansaid
- Antiflex
- Antinaus 50
- Apidra
- Apidra OptiClik Cartridge
- APO-Go
- APO-Go Pen
- Apokyn
- apomorphine
- Aptivus
- Aqua-Ban
- Aqua-Ban with Pamabrom
- Aquachloral Supprettes
- Aquacot
- Aquatensen
- Aquazide H
- Aralen Hydrochloride
- Aralen Phosphate
- Arava
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- aripiprazole
- Aristocort
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- Aristocort Forte
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- Aspergum Cherry
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- aspirin
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- Aspirtab
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- aurothioglucose
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- azithromycin
- Azithromycin 3 Day Dose Pack
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- azithromycin extended release
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- baclofen
- Banaril
- Bandi S15
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- Bayer Aspirin with Calcium
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- Beldin
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- Benadryl
- Benadryl Allergy
- Benadryl Child Dye Free
- Benadryl Childrens Allergy Fastmelt
- Benadryl DF
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- Benahist-10
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- bendroflumethiazide
- Benoject-50
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- Beta-Phos/AC
- betamethasone
- betamethasone acet-betamethasone na phosphate
- betamethasone sodium phosphate
- Betaseron
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- Bisco-Lax
- Bisolax
- Bondronat
- Boniva
- Boots Cough Syrup 3 Months Plus
- Brodspec
- bromfenac
- Bubbli-Pred
- Budeprion SR
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- budesonide
- Buffered Aspirin
- Bufferin
- Bufferin Arthritis Strength
- Bufferin Extra Strength
- Buffex
- bumetanide
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- buprenorphine
- bupropion
- bupropion 24 hour extended release
- bupropion extended release
- Busodium
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- busPIRone
- butabarbital
- Butisol Sodium
- Bydramine
- cabergoline
- Calm-Aid
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- Cardoxin
- Cardura
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- Carduran
- carisoprodol
- Carozide
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- Cascor
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- Ceclor
- Ceclor CD
- Ceclor Pulvules
- cefaclor
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- cefpodoxime
- Ceftin
- cefuroxime
- Celebrex
- celecoxib
- Celestone
- Celestone Phosphate
- Celestone Soluspan
- Celexa
- Cell-U-Jec
- CellCept
- Cena K
- cetirizine
- Chem-Sol
- Childrens Ibuprofen Berry
- chloral hydrate
- chlordiazepoxide
- chloroquine
- chloroquine hydrochloride
- chloroquine phosphate
- chlorothiazide
- chlorproMAZINE
- chlorproMAZINE extended release
- chlorproPAMIDE
- chlorthalidone
- choline salicylate
- Cipro
- Cipro Cystitis Pack
- Cipro I.V.
- Cipro XR
- ciprofloxacin
- ciprofloxacin extended release
- citalopram
- Clexane
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- Clinacort
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- Clinimix E Sulfite Free
- Clinoril
- clofarabine
- Clolar
- clomipramine
- clonazepam
- Clopine
- clorazepate
- clorazepate extended release
- clozapine
- Clozapine Synthon
- Clozaril
- codeine
- codeine phosphate
- codeine sulfate
- Colace Glycerin Suppositories
- Colax
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- Compazine
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- Compoz Nighttime Sleep Aid
- Compro
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- Cortef
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- cosyntropin
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- cycloSPORINE
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- Dalmane
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- Daypro
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- Decadron-LA
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- Declomycin
- delavirdine
- Deltasone
- Demadex
- Demadex I.V.
- demeclocycline
- Demerol HCl
- Denzapine
- Dep Medalone 80
- Depen
- Depmedalone
- Depo-Medrol
- Depo-Predate (obsolete)
- Depoject-80
- Deponit
- Depopred
- Desyrel
- Desyrel Dividose
- Dexacen-4
- Dexacort Phosphate in Respihaler
- Dexacort-LA
- Dexacorten
- dexamethasone
- dexamethasone acetate
- Dexamethasone Intensol
- dexamethasone sodium phosphate
- Dexasone
- Dexasone LA
- Dexone
- Dexone LA
- Dexpak Jr. Taperpak
- Dexpak Taperpak
- Dextrose 10% and Electrolyte No. 48
- Di-Phen
- DiaBeta
- Diabinese
- Diamox
- Diamox Sequels
- Diaqua
- Diaqua-2
- Diastat
- Diastat AcuDial
- Diastat Pediatric
- diazepam
- dichlorphenamide
- diclofenac
- diclofenac potassium
- diclofenac sodium
- diclofenac sodium extended release
- Didronel
- Didronel I.V.
- diflunisal
- Digipepsin
- Digitek
- digoxin
- digoxin capsule
- dihydrocodeine
- Dilantin
- Dilantin Infatabs
- Dilantin Kapseals
- Dilantin-125
- Dilatrate-SR
- Dilaudid
- Dilaudid-5
- Dilaudid-HP
- Diovan
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- Diphen
- Diphen AF
- Diphen Cough
- Diphenadryl
- Diphendryl
- Diphenhist
- diphenhydramine
- diphenhydramine citrate
- diphenhydramine tannate
- Diphenmax
- Diphenydramine Quick Melt
- Diphenyl
- Diphenylin
- Disalcid
- Diskets
- Diucardin
- Diurese
- Diuril
- Diuril Sodium
- Dizac
- Doans Pills
- Doans Pills Extra Strength
- Dolobid
- Dolophine
- Doloral
- Doloral Sirop
- Donnazyme
- Dopar
- Doral
- Doryx
- Dostinex
- Doxadura
- doxazosin
- doxazosin extended release
- doxepin
- doxepin topical
- Doxidan Tablet
- Doxy Lemmon
- Doxy-Caps
- Doxy-D
- doxycycline
- doxycycline hyclate
- doxycycline monohydrate
- DPH
- drospirenone
- Dulcogen
- Dulcolax Laxative
- DurAct
- Duragesic
- Duragesic-100
- Duragesic-12
- Duragesic-25
- Duragesic-50
- Duragesic-75
- Duralone
- Duramorph PF
- Dymelor
- Dynacin
- Dytan
- Dytuss
- Easprin
- EC-Naprosyn
- echinacea
- Ecotrin
- Ecotrin Adult Low Strength
- Ecotrin Maximum Strength
- Ed K+10
- Edecrin
- Edecrin Sodium
- Effervescent Potassium
- Effexor
- Effexor XR
- Elavil
- Eltroxin
- Empirin
- Emtet-500
- Endep
- Endocodone
- Enduron
- enoxaparin
- Entaprin
- Entercote
- Entocort
- Entocort EC
- eplerenone
- epoprostenol
- Equanil
- escitalopram
- Esidrix
- Eskalith
- Eskalith-CR
- ETH-Oxydose
- ethacrynic acid
- Ethyol
- etidronate
- etodolac
- etodolac extended release
- Euthyrox
- Eutroxsig
- Evac-U-Gen
- Evotrox
- Ex-lax Ultra
- Exna
- Extra Strength Bayer
- EXUBERA
- EXUBERA Combination Pack 12
- EXUBERA Combination Pack 15
- EXUBERA Kit
- Ezide
- Fasprin
- FazaClo
- Fe 50
- Fe-Tinic 150
- Feen-A-Mint
- Feldene
- Femiron
- fenoldopam
- fenoprofen
- fentanyl
- Fentora
- Feosol
- Feosol Iron
- Feostat
- Fer-Gen-Sol
- Fer-in-Sol
- Feratab
- Ferate
- Fergon
- Fero-Gradumet Filmtab
- FeroSul
- Ferra T.D. Caps
- Ferra-TD
- Ferralet
- Ferrets
- Ferrex-150
- Ferrimin 150
- Ferro-Bob
- Ferro-Time
- Ferrocite
- Ferrospace
- ferrous fumarate
- ferrous gluconate
- ferrous gluconate extended release
- ferrous sulfate
- ferrous sulfate extended release
- Ferus Pic-150
- fexofenadine
- FK506
- Fleet Babylax
- Fleet Bisacodyl
- Fleet Glycerin Suppositories Adult
- Fleet Glycerin Suppositories Pediatric
- Flexoject
- Flexon
- Flo-Pred
- Flolan
- Florinef Acetate
- Floxin
- Floxin I.V.
- fludrocortisone
- fluorescein
- Fluorescite
- fluoxetine
- fluoxetine extended release
- fluphenazine
- fluphenazine decanoate
- fluphenazine enanthate
- fluphenazine hydrochloride
- flurazepam
- flurbiprofen
- fluvoxamine
- fluvoxamine extended release
- Folex PFS
- Fortamet
- Fosamax
- Fosrenol
- Fragmin
- Freamine III with Electrolytes
- Fumasorb
- Funduscein
- furosemide
- gatifloxacin
- Gen Lax
- Genacote
- Genahist
- Gengraf
- Gennin-FC
- Genpril
- Genprin
- Gentlax Tablet
- Gentle Laxative
- Geodon
- Gilseal Homecare Glycerol BP
- Glauctabs
- glimepiride
- glipiZIDE
- glipiZIDE extended release
- GlipiZIDE XL
- Glu-K
- Glucophage
- Glucophage XR
- Glucotrol
- Glucotrol XL
- Glumetza
- glyburide
- glyburide micronized
- Glycerin
- Glycerin Suppositories Maximum Strength
- Glycerol
- Glycerol Adult
- Glycerol Infant
- Glycerol Pediatric
- Glynase PresTab
- gold sodium thiomalate
- Halfprin
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- HCTZ
- Hemocyte
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- Hep-Pak
- Hep-Pak CVC
- heparin
- Heparin Lock Flush
- Hexadrol
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- Hi-Vegi-Lip
- Humalog
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- Humalog KwikPen
- Humalog Pen
- Humulin L
- Humulin N
- Humulin N Pen
- Humulin R
- Humulin R (Concentrated)
- Humulin U
- Hydeltra-T.B.A.
- Hydeltrasol
- Hydramine
- Hydramine Compound
- Hydramine Cough Syrup
- Hydro Par
- hydrochlorothiazide
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone cypionate
- hydrocortisone hemisuccinate
- hydrocortisone sodium phosphate
- Hydrocortisone Sodium Succinate
- Hydrocortone
- Hydrocortone Phosphate
- hydrodiuril
- hydroflumethiazide
- Hydromorph Contin
- hydromorphone
- hydromorphone extended release
- Hydrostat IR
- hydroxychloroquine
- hydroxyzine
- hydroxyzine hydrochloride
- hydroxyzine pamoate
- Hygroton
- Hyrexin
- Hytinic
- Hytrin
- Hyzine
- ibandronate
- Ibu
- IBU-200
- Ibu-4
- Ibu-6
- Ibu-8
- Ibu-Tab
- ibuprofen
- Ibuprofen PMR
- Ichthammol Glycerin
- Iletin II Lente Pork
- Iletin II NPH Pork
- Iletin II Regular Pork
- Iletin Lente
- Iletin NPH
- Iletin Regular
- iloprost
- Imdur
- imipramine
- imipramine pamoate
- indapamide
- Indocin
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- indomethacin
- indomethacin extended release
- Infumorph
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- insulin
- insulin analog
- insulin aspart
- insulin aspart protamine
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation
- rapid acting
- insulin isophane
- Insulin Lente Pork
- insulin lispro
- insulin lispro protamine
- Insulin Purified NPH Pork
- Insulin Purified Regular Pork
- insulin regular
- insulin zinc
- insulin zinc extended
- insulin lente
- insulin NPH
- insulin ultralente
- interferon alfa-2a
- interferon beta-1a
- interferon beta-1b
- Invega
- Ionosol B and 5% Dextrose
- Ionosol MB and 5% Dextrose
- Ionosol T and 5% Dextrose
- Ionsys
- Ircon
- iron polysaccharide
- ISDN
- ISMO
- Isochron
- Isolyte E
- Isolyte H and 5 % Dextrose
- Isolyte M and 5% Dextrose
- Isolyte P and 5% Dextrose
- Isolyte R and 5% Dextrose
- Isordil
- Isordil Tembids
- Isordil Titradose
- isosorbide dinitrate
- isosorbide dinitrate extended release
- isosorbide mononitrate
- isosorbide mononitrate extended release
- itraconazole
- K + Potassium
- K+Care ET
- K-10
- K-8
- K-Dur 10
- K-Dur 20
- K-Effervescent
- K-Lor
- K-Norm
- K-Phos Original
- K-Sol
- K-Tab
- K-vescent
- K-Vescent (obsolete)
- K-Vescent (Potassium Chloride)
- Kadian
- Kaochlor
- Kaochlor S-F
- Kaon
- Kaon-CI
- Kaon-CL 10
- Kaon-CL 20%
- Kato
- Kay Ciel
- Kayexalate
- KCl
- KCl-20
- Kefurox
- Ken-Jec 40
- Kenaject-40
- Kenalog-10
- Kenalog-40
- ketoconazole
- ketoprofen
- ketoprofen extended release
- ketorolac
- Key-Pred
- Key-Pred SP
- Kionex
- Klonopin
- Klonopin Wafer
- Klor-Con
- Klor-Con 10
- Klor-Con 8
- Klor-Con M10
- Klor-Con M15
- Klor-Con M20
- Klor-Con/25
- Klotrix
- L THYROXINE ROCHE
- l-thyroxine
- Lanoxicaps
- Lanoxin
- lanthanum carbonate
- Lantus
- Lantus OptiClik Cartridge
- Lantus Solostar Pen
- Largon
- Larodopa
- Lasix
- Laxative Gentle Suppositories
- Leader Naproxen Sodium
- leflunomide
- Lente insulin
- Levaquin
- Levaquin Leva-Pak
- Levemir
- Levemir FlexPen
- Levemir InnoLet
- Levemir PenFill
- Levo-T
- levocetirizine
- levodopa
- levofloxacin
- Levoprome
- Levotabs
- Levotec
- Levothroid
- LEVOTHYROX
- levothyroxine
- Levoxyl
- LEVRIX
- Lexapro
- Librium
- Lioresal
- Lioresal Intrathecal
- Liquid Pred
- Litecoat Aspirin
- lithium
- lithium carbonate
- lithium carbonate extended release
- lithium citrate
- Lithobid
- Lithonate
- Lithotabs
- Lo-Aqua
- Lodine
- Lodine XL
- Loqua
- lorazepam
- Lovenox
- Lovenox HP
- Low Dose ASA
- Lozol
- Ludiomil
- Luminal
- Luvox
- Luvox CR
- LVP solution with potassium
- Lydia E. Pinkham
- M-Eslon
- M-Oxy
- M-Prednisolone
- M. O. S.
- Magan
- Magic Bullet
- magnesium salicylate
- mannitol
- maprotiline
- maraviroc
- Marthritic
- MB-TAB
- meclofenamate
- Meclomen
- Med-Jec-40
- Medicort
- Medidex
- Medidex LA
- Medipred
- Medralone
- Medralone 40
- Medralone 80
- Medrol
- Medrol Dosepak
- mefenamic acid
- Mellaril
- Mellaril-S
- meloxicam
- Menadol
- meperidine
- meprobamate
- mesoridazine
- Metahydrin
- metformin
- metformin extended release
- Methacort 40
- Methacort 80
- methadone
- Methadose
- methazolamide
- methdilazine
- methocarbamol
- methotrexate
- Methotrexate Sodium
- Preservative Free
- methotrimeprazine
- methyclothiazide
- Methylcotol
- Methylcotolone
- Methylpred DP
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone dose pack
- methylprednisolone sodium succinate
- Meticorten
- metolazone
- Micro-K
- Micro-K 10
- Micronase
- Microzide
- Midol Extended Relief
- Midol IB
- Midol Maximum Strength Cramp Formula
- Millipred
- Miltown
- Minipress
- Minitabs
- Minitran
- Minocin
- Minocin PAC
- minocycline
- minocycline extended release
- Mio-Rel
- mirtazapine
- misoprostol
- Mitran
- Mobic
- Mobidin
- Modane
- Mol-Iron
- Mono-Gesic
- Monodox
- Monoket
- morphine
- morphine 24 hour extended release
- morphine extended release
- Morphine IR
- Morphine LP Epidural
- morphine preservative-free
- Morphine Rapi-Ject
- Morphitec
- Motrin
- Motrin Childrens
- Motrin IB
- Motrin Infant Drops
- Motrin Junior Strength
- Motrin Migraine Pain
- moxifloxacin
- MS
- MS Contin
- MS/S
- MSIR
- MST
- mycophenolate mofetil
- mycophenolic acid
- Myfortic
- MyKidz Iron 10
- Mykrox
- Myochrysine
- Myolin
- Myrac
- MZM
- nabumetone
- nalbuphine
- Nalfon
- nalidixic acid
- naltrexone
- Naprelan '375'
- Naprelan '500'
- Naprosyn
- naproxen
- naproxen sodium
- Naproxen Sodium DS
- naproxen sodium extended release
- Naqua
- nateglinide
- Natrecor
- Naturetin-10
- Naturetin-5
- nefazodone
- Neggram
- NeoProfen
- Neoral
- Nephro-Fer
- Neptazane
- Nervine
- nesiritide
- Neutra-Phos-K
- Niferex
- Niferex Elixir
- Niferex-150(obsolete)
- Nightime Sleepaid
- Niravam
- Nitrek
- Nitro TD Patch-A
- Nitro-Bid
- Nitro-Bid IV
- Nitro-Dur
- Nitro-Par
- Nitro-Time
- Nitrocot
- Nitrodisc
- Nitrogard
- nitroglycerin
- Nitroglyn E-R
- Nitrol
- Nitrol Appli-Kit
- Nitrolingual
- Nitrong
- Nitroquick
- Nitrostat
- Nizoral
- Norflex
- Norflex Injectable
- norfloxacin
- Normosol-M and 5% Dextrose
- Noroxin
- nortriptyline
- Norwich Aspirin
- Novolin L
- Novolin N
- Novolin N Innolet
- Novolin N PenFill
- Novolin R
- Novolin R Innolet
- Novolin R PenFill
- NovoLog
- NovoLog FlexPen
- NovoLog PenFill
- NPH insulin
- NTG
- Nu-Iron
- Nu-Iron 150
- Nu-Med
- Nubain
- Nuprin
- Nuprin Backache Caplet
- Nytol Caplet
- ofloxacin
- olanzapine
- OMS
- opium
- Opium Deodorized
- Oracea
- Oramorph SR
- Orapred
- Orapred ODT
- Orasone
- Oraxyl
- Oretic
- Orfro
- Orinase
- Ormazine
- Oroxine
- orphenadrine
- orphenadrine extended release
- Orphenate
- Orudis
- Orudis KT
- Oruvail
- Osmitrol
- Osmoglyn
- oxaprozin
- oxazepam
- oxycodone
- oxycodone extended release
- OxyContin
- Oxyfast
- OxyIR
- oxytetracycline
- paliperidone
- Palladone
- Palladone SR
- pamabrom
- Pamelor
- pancreatin
- Pancreatin 4X
- Panmycin
- Paral
- paraldehyde
- Pardryl
- Paregoric
- parenteral nutrition solution w/electrolytes
- paroxetine
- paroxetine extended release
- paroxetine mesylate
- Paxil
- Paxil CR
- PC-10
- Pedia-Lax Liquid
- Pediacare Fever
- Pediapred
- penicillamine
- Pentazine
- pentazocine
- Perchloracap
- Percolone
- pergolide
- Periostat
- Permax
- Permitil
- perphenazine
- Pexeva
- Phenadoz
- Phenazine 50
- Phenergan
- Phenergan Fortis
- phenobarbital
- Phenoject-50
- phenyl salicylate
- phenylbutazone
- Phenytek
- phenytoin
- phenytoin extended release
- Phenytoin Sodium
- Prompt
- piroxicam
- Plaquenil Sulfate
- Plasma-Lyte 56
- Plasma-Lyte and 5% Dextrose
- Poly Iron
- Polysaccharide Iron
- polythiazide
- Ponstel
- potassium acetate
- potassium acid phosphate
- potassium bicarbonate
- potassium chloride
- potassium chloride extended release
- potassium citrate
- potassium gluconate
- potassium guaiacolsulfonate
- potassium perchlorate
- potassium phosphate
- PP-Cap
- Prandin
- prazosin
- Pred-Ject-50
- Predacort 50
- Predacorten
- Predaject-50
- Predalone 50
- Predate-50
- Predcor
- Predicort RP
- Predicort-50
- Prednicen-M
- Prednicot
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisolone tebutate
- prednisone
- Prelone
- Pri-Cortin 50
- Primethasone
- Primsol
- Pro-Med
- Procalamine
- prochlorperazine
- prochlorperazine extended release
- Procot
- Prograf
- proguanil
- Proleukin
- Prolixin
- Prolixin Decanoate
- Prolixin Enanthate
- Proloprim
- Promacot
- promazine
- promethazine
- Promethegan
- propiomazine
- propoxyphene
- propoxyphene hydrochloride
- propoxyphene napsylate
- Proquin XR
- Prorex
- prostacyclin
- protamine zinc insulin
- Prozac
- Prozac Weekly
- Prudoxin
- Pulmicort Flexhaler
- Pulmicort Nebuamp
- Pulmicort Respules
- Pulmicort Turbuhaler
- Q-Dryl
- Q-Dryl A/F
- Q-Profen
- quazepam
- Quenalin
- quetiapine
- quetiapine extended release
- Quineprox
- Raniclor
- Rapamune
- Rapiflux
- Ravin
- Rebif
- regular insulin
- Relafen
- ReliOn/Novolin N
- ReliOn/Novolin R
- Remeron
- Remeron SolTab
- Remodulin
- Renese
- repaglinide
- Rescriptor
- Rescudose
- Resectisol
- Restoril
- ReVia
- Rexolate
- Reyataz
- Rezine
- Rheumatrex Dose Pack
- Rifadin
- Rifadin IV
- rifampin
- Rimactane
- Riomet
- risedronate
- Risperdal
- Risperdal Consta
- Risperdal M-Tab
- risperidone
- RMS
- Robaxin
- Robaxin-750
- Robitet 500
- rofecoxib
- Roferon-A
- rosuvastatin
- Roxanol
- Roxanol 100
- Roxanol-T
- Roxicodone
- Roxicodone Intensol
- Rufen
- Rum-K
- Sal-Tropine
- Saleto-200
- Saleto-400
- Saleto-600
- Saleto-800
- Salflex
- salicylamide
- salsalate
- Salsitab
- Saluron
- Sandimmune
- Sani-Supp
- Sarafem
- Scot-Tussin Allergy Relief Formula
- secobarbital
- Seconal Sodium
- Selestoject
- Selfemra
- Selzentry
- Senokot Direct Relief
- Serax
- Serentil
- Seroquel
- Seroquel XR
- sertraline
- Serzone
- Siladryl
- Siladryl DAS
- Siladyl SA
- Silphen Cough
- Simply Sleep
- Simron
- Sinequan
- sirolimus
- Skelex
- Skelid
- Sleep Tab II
- Sleep Tabs
- Sleep-ettes
- Sleep-Eze-3
- Sleepinal
- Sloprin
- Slow Fe
- Slow Release Iron
- Slow-K
- sodium polystyrene sulfonate
- sodium salicylate
- sodium thiosalicylate
- Solfoton
- Solganal
- Solodyn
- Solu-Cortef
- Solu-Medrol
- Solurex
- Solurex LA
- Soma
- Sominex
- Sominex Maximum Strength Caplet
- Somnicaps
- Somnote
- Sonata
- Sorbitrate
- Sparine
- Spectrobid
- Sporanox
- St. Joseph Aspirin
- St. Joseph Aspirin Adult Chewable
- St. Joseph Aspirin Adult EC
- Stanback Analgesic
- Starlix
- Statex
- Stelazine
- Sterapred
- Sterapred DS
- Sublimaze
- Subutex
- sucralfate
- sulindac
- Sumycin
- Surmontil
- Synthroid
- Syprine
- TAC 3
- Tacaryl
- tacrolimus
- Talwin Lactate
- Temaril
- temazepam
- temsirolimus
- Ten-K
- Tequin
- Tequin Teqpaq
- terazosin
- Terramycin
- Tetracap
- Tetracon
- tetracycline
- Thalitone
- Theraflu Thin Strips Multi Symptom
- Therapy Bayer
- thiethylperazine
- thioguanine
- thioridazine
- Thorazine
- tiludronate
- tinzaparin
- tipranavir
- Tirosint
- Tixylix Baby
- TMP
- Tofranil
- Tofranil-PM
- Tol-Tab
- tolazamide
- tolbutamide
- Tolectin
- Tolectin 600
- Tolectin DS
- Tolinase
- tolmetin
- Toradol
- Toradol IM
- Toradol IV/IM
- Torecan
- Torisel
- torsemide
- Total Allergy
- Tramacort-D
- Tranxene SD
- Tranxene T-Tab
- Travasol with Electrolytes
- Travasol with Electrolytes Dual Chamber
- Travert 10% and Electrolyte No.2
- Travert 5% and Electrolyte No.2
- trazodone
- treprostinil
- Trexall
- Tri-Buffered Aspirin
- Triam-A
- Triam-Forte
- triamcinolone
- triamcinolone acetonide
- triamcinolone diacetate
- triamcinolone hexacetonide
- Triamcot
- Triaminic Thin Strips Cough & Runny Nose
- Triamonide 40
- trichlormethiazide
- Tridil
- trientine
- trifluoperazine
- triflupromazine
- Trilafon
- Trilog
- Trilone
- trimeprazine
- trimethoprim
- trimipramine
- Trimpex
- Tristoject
- Trux-adryl
- Tusal
- Tusstat
- Twilite
- Twin-K
- U-Tri-Lone
- Ultralente insulin
- Uni-Tann
- Unisom Sleepgels Maximum Strength
- Unithroid
- Uprima
- Urocit-K
- Uroxatral
- V-Gan-25
- V-Gan-50
- valdecoxib
- Valium
- Valrelease
- valsartan
- Valu-Dryl
- Vanadom
- Vanatrip
- Vantin
- Vectrin
- Velosulin BR
- venlafaxine
- venlafaxine extended release
- Ventavis
- Veracolate
- Vibra-Tabs
- Vibramycin
- Vibramycin Calcium
- Vibramycin Hyclate
- Vibramycin Monohydrate
- Vioxx
- Vistacon
- Vistacot
- Vistaject-50
- Vistaril
- Vistaril IM
- Vistazine
- Vistazine 50
- Vivitrol
- Voltaren
- Voltaren-XR
- Wellbutrin
- Wellbutrin SR
- Wellbutrin XL
- Xanax
- Xanax XR
- Xyzal
- XYZALL
- Yieronia
- YSP Aspirin
- Z-Pak
- zaleplon
- Zaponex
- Zaroxolyn
- Zero-Order Release
- Zetran
- Zinacef
- ziprasidone
- Zithromax
- Zithromax IV
- Zithromax TRI-PAK
- Zithromax Z-Pak
- Zmax
- Zoloft
- zolpidem
- zolpidem extended release
- Zonalon
- Zorprin
- Zyban
- Zyban Advantage Pack
- Zyprexa
- Zyprexa Zydis
- Zyrtec
- Zyrtec Hives
Minor Interactions
- Acid Relief
- Adalat
- Adalat CC
- Afeditab CR
- Alka-Mints
- Alkets
- Alkums
- Aloh-Gel
- Alphagan
- Alphagan P
- Alternagel
- Alu-Cap
- Alu-Tab
- aluminum carbonate
- aluminum hydroxide
- Amilac
- Amitone
- amlodipine
- Amphojel
- Analgesic Balm with Capsaicin
- apraclonidine ophthalmic
- Aranesp
- Aranesp Albumin Free
- Aranesp SureClick
- Atapryl
- Axsain
- Azilect
- Basaljel
- Benemid
- brimonidine ophthalmic
- Cal Oys
- Cal-Gest
- Calan
- Calan SR
- Calcarb
- Calci Mix
- Calci-Chew
- Calcitab
- calcium carbonate
- Calcium Concentrate
- Calcium Liquid Softgel
- Calcium Oyster
- Calcium Oyster Shell
- Caltrate
- Caltro
- capsaicin topical
- Capsicum Oleoresin
- Capsin
- Capzasin Back and Body
- Capzasin-HP
- Capzasin-HP Arthritis Formula
- Capzasin-P
- Carbex
- Cardene
- Cardene IV
- Cardene SR
- Cardizem
- Cardizem CD
- Cardizem LA
- Cardizem Monovial
- Cardizem SR
- Cartia XT
- Castiva Warming
- Chooz
- Cialis
- Citra pH
- Citrate-Phos-Dex
- Concentrated Phillips Milk of Magnesia
- Covera-HS
- darbepoetin alfa
- ddI
- Dewees Carminative
- Dialume
- Dicarbosil
- didanosine
- didanosine delayed release capsule
- dihydroxyaluminum sodium carbonate
- Dilacor XR
- Diltia XT
- diltiazem
- diltiazem 24 hour extended release
- diltiazem extended release
- Diltiazem Hydrochloride CD
- Diltiazem Hydrochloride SR
- Diltiazem Hydrochloride XR
- Diltiazem Hydrochloride XT
- Dolorac
- Dr.s Cream
- Dynacirc
- Dynacirc CR
- Eldepryl
- Emsam
- EPO
- epoetin alfa
- Epogen
- Equilet
- erythropoietin
- recombinant
- Ex-Lax Milk of Magnesia
- Extra Strength Mylanta Calci Tabs
- felodipine
- felodipine extended release
- furazolidone
- Furoxone
- Icar Prenatal Chewable Calcium
- Icy Hot PM
- Icy Hot with Capsaicin
- Iopidine
- isocarboxazid
- Isoptin
- Isoptin I.V.
- Isoptin SR
- isradipine
- isradipine extended release
- Jumex
- linezolid
- Losospan
- Lowsium
- Maalox Antacid Barrier
- Maalox Childrens'
- Maalox Quick Dissolve
- Maalox Quick Dissolve Extra Strength
- Maalox Quick Dissolve Maximum Strength
- Maalox Regular Strength
- Mag-200
- Mag-Carb
- Mag-Ox 400
- magaldrate
- MagGel
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- magnesium trisilicate
- Maoson
- Marplan
- Matulane
- Menthac Arthritis Cream with Capsaicin
- Mg hydroxide
- Mg oxide
- mibefradil
- Milk of Magnesia
- Mylanta Child
- Nardil
- Nephro Calci
- Neut
- nicardipine
- nicardipine extended release
- nifediac cc
- nifedical xl
- nifedipine
- nifedipine extended release
- nisoldipine
- Norvasc
- Os-Cal
- Os-Cal 500
- Oysco 500
- Oyst Cal
- Oyst Cal 500
- Oyster
- Oyster Cal
- Oyster Cal 500
- Oyster Calcium
- Oyster Shell
- oyster shell calcium
- Oyster Shell Calcium 500
- Parnate
- Pepto Children's
- phenelzine
- Phillips Milk of Magnesia
- Phillips' Cramp-free
- Plendil
- Posicor
- probenecid
- procarbazine
- Procardia
- Procardia XL
- Procrit
- rasagiline
- Ri-Mag
- Riopan
- Rolaids Sodium Free
- Rolaids Soft Chew
- Ron Acid
- RT Capsin
- Salonpas Gel-Patch
- Salonpas Pain Patch with Capsaicin
- selegiline
- Selgene
- Sloan's Liniment
- sodium bicarbonate
- sodium citrate
- Sular
- Super Calcium
- Surpass
- Surpass Extra Strength
- tadalafil
- Taztia XT
- Tiazac
- Titralac
- tranylcypromine
- Tricitrasol
- Trixaicin
- Trixaicin HP
- Tums
- Tums 500
- Tums E-X
- Tums Extra Strength
- Tums Ultra
- Ultra Mylanta Calci Tabs
- Uro-Mag
- verapamil
- verapamil 24 hour extended release
- verapamil extended release
- Verelan
- Verelan PM
- Videx
- Videx EC
- Zelapar
- Zostrix
- Zostrix Sports
- Zostrix-HP
- Zyvox
Adapted from the FDA Package Insert.