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{{Infobox_gene}}
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'''Angiopoietin-2''' is a [[protein]] that in humans is encoded by the ''ANGPT2'' [[gene]].<ref name="pmid9545648">{{cite journal | vauthors = Cheung AH, Stewart RJ, Marsden PA | title = Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23 | journal = Genomics | volume = 48 | issue = 3 | pages = 389–91 | date = March 1998 | pmid = 9545648 | pmc =  | doi = 10.1006/geno.1997.5207 }}</ref>
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ANGPT2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z3s.
| PDB = {{PDB2|1z3s}}, {{PDB2|1z3u}}, {{PDB2|2gy7}}
| Name = Angiopoietin 2
| HGNCid = 485
| Symbol = ANGPT2
| AltSymbols =; AGPT2; ANG2
| OMIM = 601922
| ECnumber = 
| Homologene = 22401
| MGIid = 1202890
| GeneAtlas_image1 = PBB_GE_ANGPT2_211148_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ANGPT2_205572_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 285
    | Hs_Ensembl = ENSG00000091879
    | Hs_RefseqProtein = NP_001138
    | Hs_RefseqmRNA = NM_001147
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 6344580
    | Hs_GenLoc_end = 6408338
    | Hs_Uniprot = O15123
    | Mm_EntrezGene = 11601
    | Mm_Ensembl = ENSMUSG00000031465
    | Mm_RefseqmRNA = NM_007426
    | Mm_RefseqProtein = NP_031452
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 18691314
    | Mm_GenLoc_end = 18741528
    | Mm_Uniprot = O35608
  }}
}}
'''Angiopoietin 2''', also known as '''ANGPT2''', is a human [[gene]].


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1<ref>{{cite web | title = Entrez Gene: ANGPT2 angiopoietin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=285| accessdate = }}</ref>
| summary_text =  
}}
}} 
==See also==
-->
 
Naturally occurring antagonist for both [[ANGPT1]] and [[TIE2]]; expressed only at the sites of vascular remodeling; similar to angiopoietin-1<ref>{{cite web | title = Entrez Gene: ANGPT2 angiopoietin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=285| accessdate = }}</ref>
 
== Function ==
* See [[Angiopoietin#Clinical_relevance]]
 
== Interactions ==
 
ANGPT2 has been shown to [[Protein-protein interaction|interact]] with [[TEK tyrosine kinase]].<ref name=pmid12427764>{{cite journal | vauthors = Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, Augustin HG | title = Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats | journal = The Journal of Biological Chemistry | volume = 278 | issue = 3 | pages = 1721–7 | date = January 2003 | pmid = 12427764 | doi = 10.1074/jbc.M208550200 }}</ref><ref name=pmid9723709>{{cite journal | vauthors = Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T | title = Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells | journal = International Immunology | volume = 10 | issue = 8 | pages = 1217–27 | date = August 1998 | pmid = 9723709 | doi = 10.1093/intimm/10.8.1217 }}</ref><ref name=pmid9204896>{{cite journal | vauthors = Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD | title = Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis | journal = Science | volume = 277 | issue = 5322 | pages = 55–60 | date = July 1997 | pmid = 9204896 | doi = 10.1126/science.277.5322.55 }}</ref>
 
== See also ==
* [[Angiopoietin]]
* [[Angiopoietin]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== External links ==
* {{UCSC gene info|ANGPT2}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD | title = Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis | journal = Science | volume = 277 | issue = 5322 | pages = 55–60 | date = July 1997 | pmid = 9204896 | doi = 10.1126/science.277.5322.55 }}
| citations =
* {{cite journal | vauthors = Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T | title = Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells | journal = International Immunology | volume = 10 | issue = 8 | pages = 1217–27 | date = August 1998 | pmid = 9723709 | doi = 10.1093/intimm/10.8.1217 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
* {{cite journal | vauthors = Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR | title = Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma | journal = The Journal of Clinical Investigation | volume = 103 | issue = 3 | pages = 341–5 | date = February 1999 | pmid = 9927494 | pmc = 407900 | doi = 10.1172/JCI4891 }}
*{{cite journal  | author=Maisonpierre PC, Suri C, Jones PF, ''et al.'' |title=Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. |journal=Science |volume=277 |issue= 5322 |pages= 55-60 |year= 1997 |pmid= 9204896 |doi= }}
* {{cite journal | vauthors = Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD | title = Angiopoietins 3 and 4: diverging gene counterparts in mice and humans | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 5 | pages = 1904–9 | date = March 1999 | pmid = 10051567 | pmc = 26709 | doi = 10.1073/pnas.96.5.1904 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
* {{cite journal | vauthors = Grosios K, Leek JP, Markham AF, Yancopoulos GD, Jones PF | title = Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 1-2 | pages = 118–20 | year = 1999 | pmid = 10343124 | doi = 10.1159/000015235 }}
*{{cite journal  | author=Cheung AH, Stewart RJ, Marsden PA |title=Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23. |journal=Genomics |volume=48 |issue= 3 |pages= 389-91 |year= 1998 |pmid= 9545648 |doi= 10.1006/geno.1997.5207 }}
* {{cite journal | vauthors = Procopio WN, Pelavin PI, Lee WM, Yeilding NM | title = Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity | journal = The Journal of Biological Chemistry | volume = 274 | issue = 42 | pages = 30196–201 | date = October 1999 | pmid = 10514510 | doi = 10.1074/jbc.274.42.30196 }}
*{{cite journal | author=Sato A, Iwama A, Takakura N, ''et al.'' |title=Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. |journal=Int. Immunol. |volume=10 |issue= 8 |pages= 1217-27 |year= 1998 |pmid= 9723709 |doi= }}
* {{cite journal | vauthors = Kim I, Kim JH, Ryu YS, Jung SH, Nah JJ, Koh GY | title = Characterization and expression of a novel alternatively spliced human angiopoietin-2 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18550–6 | date = June 2000 | pmid = 10766762 | doi = 10.1074/jbc.M910084199 }}
*{{cite journal | author=Tanaka S, Mori M, Sakamoto Y, ''et al.'' |title=Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. |journal=J. Clin. Invest. |volume=103 |issue= 3 |pages= 341-5 |year= 1999 |pmid= 9927494 |doi= }}
* {{cite journal | vauthors = Mezquita J, Mezquita P, Montserrat P, Mezquita B, Francone V, Vilagrasa X, Mezquita C | title = Genomic structure and alternative splicing of chicken angiopoietin-2 | journal = Biochemical and Biophysical Research Communications | volume = 275 | issue = 2 | pages = 643–51 | date = August 2000 | pmid = 10964717 | doi = 10.1006/bbrc.2000.3345 }}
*{{cite journal | author=Valenzuela DM, Griffiths JA, Rojas J, ''et al.'' |title=Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1904-9 |year= 1999 |pmid= 10051567 |doi= }}
* {{cite journal | vauthors = Xu Y, Yu Q | title = Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region | journal = The Journal of Biological Chemistry | volume = 276 | issue = 37 | pages = 34990–8 | date = September 2001 | pmid = 11447223 | doi = 10.1074/jbc.M103661200 }}
*{{cite journal | author=Grosios K, Leek JP, Markham AF, ''et al.'' |title=Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 118-20 |year= 1999 |pmid= 10343124 |doi= }}
* {{cite journal | vauthors = Acker T, Beck H, Plate KH | title = Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization | journal = Mechanisms of Development | volume = 108 | issue = 1-2 | pages = 45–57 | date = October 2001 | pmid = 11578860 | doi = 10.1016/S0925-4773(01)00471-3 }}
*{{cite journal | author=Procopio WN, Pelavin PI, Lee WM, Yeilding NM |title=Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30196-201 |year= 1999 |pmid= 10514510 |doi= }}
* {{cite journal | vauthors = Ward EG, Grosios K, Markham AF, Jones PF | title = Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2 | journal = Cytogenetics and Cell Genetics | volume = 94 | issue = 3-4 | pages = 147–54 | year = 2002 | pmid = 11856872 | doi = 10.1159/000048807 }}
*{{cite journal | author=Kim I, Kim JH, Ryu YS, ''et al.'' |title=Characterization and expression of a novel alternatively spliced human angiopoietin-2. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18550-6 |year= 2000 |pmid= 10766762 |doi= 10.1074/jbc.M910084199 }}
* {{cite journal | vauthors = Huang YQ, Li JJ, Hu L, Lee M, Karpatkin S | title = Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells | journal = Blood | volume = 99 | issue = 5 | pages = 1646–50 | date = March 2002 | pmid = 11861279 | doi = 10.1182/blood.V99.5.1646 }}
*{{cite journal | author=Mezquita J, Mezquita P, Montserrat P, ''et al.'' |title=Genomic structure and alternative splicing of chicken angiopoietin-2. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 2 |pages= 643-51 |year= 2000 |pmid= 10964717 |doi= 10.1006/bbrc.2000.3345 }}
* {{cite journal | vauthors = Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K | title = Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer | journal = Oncology | volume = 62 | issue = 4 | pages = 340–8 | year = 2002 | pmid = 12138242 | doi = 10.1159/000065066 }}
*{{cite journal | author=Xu Y, Yu Q |title=Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34990-8 |year= 2001 |pmid= 11447223 |doi= 10.1074/jbc.M103661200 }}
* {{cite journal | vauthors = Lin S, Shyu KG, Lee CC, Wang BW, Chang CC, Liu YC, Huang FY, Chang H | title = Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 3 | pages = 710–5 | date = August 2002 | pmid = 12176040 | doi = 10.1016/S0006-291X(02)00924-5 }}
*{{cite journal | author=Acker T, Beck H, Plate KH |title=Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization. |journal=Mech. Dev. |volume=108 |issue= 1-2 |pages= 45-57 |year= 2002 |pmid= 11578860 |doi= }}
* {{cite journal | vauthors = Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB | title = Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2 | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 87 | issue = 9 | pages = 4213–24 | date = September 2002 | pmid = 12213874 | doi = 10.1210/jc.2002-020195 }}
*{{cite journal | author=Ward EG, Grosios K, Markham AF, Jones PF |title=Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2. |journal=Cytogenet. Cell Genet. |volume=94 |issue= 3-4 |pages= 147-54 |year= 2002 |pmid= 11856872 |doi= }}
* {{cite journal | vauthors = Paradis V, Bièche I, Dargère D, Laurendeau I, Nectoux J, Degott C, Belghiti J, Vidaud M, Bedossa P | title = A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia | journal = Gastroenterology | volume = 124 | issue = 3 | pages = 651–9 | date = March 2003 | pmid = 12612904 | doi = 10.1053/gast.2003.50104 }}
*{{cite journal | author=Huang YQ, Li JJ, Hu L, ''et al.'' |title=Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells. |journal=Blood |volume=99 |issue= 5 |pages= 1646-50 |year= 2002 |pmid= 11861279 |doi= }}
*{{cite journal | author=Hata K, Udagawa J, Fujiwaki R, ''et al.'' |title=Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer. |journal=Oncology |volume=62 |issue= 4 |pages= 340-8 |year= 2002 |pmid= 12138242 |doi= }}
*{{cite journal | author=Lin S, Shyu KG, Lee CC, ''et al.'' |title=Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 710-5 |year= 2002 |pmid= 12176040 |doi= }}
*{{cite journal | author=Geva E, Ginzinger DG, Zaloudek CJ, ''et al.'' |title=Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 9 |pages= 4213-24 |year= 2002 |pmid= 12213874 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Paradis V, Bièche I, Dargère D, ''et al.'' |title=A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia. |journal=Gastroenterology |volume=124 |issue= 3 |pages= 651-9 |year= 2003 |pmid= 12612904 |doi= 10.1053/gast.2003.50104 }}
}}
{{refend}}
{{refend}}
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Revision as of 00:42, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.[1]


Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1[2]

Function

Interactions

ANGPT2 has been shown to interact with TEK tyrosine kinase.[3][4][5]

See also

References

  1. ↑ Cheung AH, Stewart RJ, Marsden PA (March 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics. 48 (3): 389–91. doi:10.1006/geno.1997.5207. PMID 9545648.
  2. ↑ "Entrez Gene: ANGPT2 angiopoietin 2".
  3. ↑ Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, Augustin HG (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". The Journal of Biological Chemistry. 278 (3): 1721–7. doi:10.1074/jbc.M208550200. PMID 12427764.
  4. ↑ Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". International Immunology. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.
  5. ↑ Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science.277.5322.55. PMID 9204896.

External links

Further reading

  • Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science.277.5322.55. PMID 9204896.
  • Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". International Immunology. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.
  • Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR (February 1999). "Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma". The Journal of Clinical Investigation. 103 (3): 341–5. doi:10.1172/JCI4891. PMC 407900. PMID 9927494.
  • Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (March 1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 1904–9. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.
  • Grosios K, Leek JP, Markham AF, Yancopoulos GD, Jones PF (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping". Cytogenetics and Cell Genetics. 84 (1–2): 118–20. doi:10.1159/000015235. PMID 10343124.
  • Procopio WN, Pelavin PI, Lee WM, Yeilding NM (October 1999). "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity". The Journal of Biological Chemistry. 274 (42): 30196–201. doi:10.1074/jbc.274.42.30196. PMID 10514510.
  • Kim I, Kim JH, Ryu YS, Jung SH, Nah JJ, Koh GY (June 2000). "Characterization and expression of a novel alternatively spliced human angiopoietin-2". The Journal of Biological Chemistry. 275 (24): 18550–6. doi:10.1074/jbc.M910084199. PMID 10766762.
  • Mezquita J, Mezquita P, Montserrat P, Mezquita B, Francone V, Vilagrasa X, Mezquita C (August 2000). "Genomic structure and alternative splicing of chicken angiopoietin-2". Biochemical and Biophysical Research Communications. 275 (2): 643–51. doi:10.1006/bbrc.2000.3345. PMID 10964717.
  • Xu Y, Yu Q (September 2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region". The Journal of Biological Chemistry. 276 (37): 34990–8. doi:10.1074/jbc.M103661200. PMID 11447223.
  • Acker T, Beck H, Plate KH (October 2001). "Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization". Mechanisms of Development. 108 (1–2): 45–57. doi:10.1016/S0925-4773(01)00471-3. PMID 11578860.
  • Ward EG, Grosios K, Markham AF, Jones PF (2002). "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenetics and Cell Genetics. 94 (3–4): 147–54. doi:10.1159/000048807. PMID 11856872.
  • Huang YQ, Li JJ, Hu L, Lee M, Karpatkin S (March 2002). "Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells". Blood. 99 (5): 1646–50. doi:10.1182/blood.V99.5.1646. PMID 11861279.
  • Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer". Oncology. 62 (4): 340–8. doi:10.1159/000065066. PMID 12138242.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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