Vision loss: Difference between revisions

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'''For patient information, click [[Vision loss (patient information)|here]]'''
'''For patient information, click [[Vision loss (patient information)|here]]'''
{{SI}}
{{SI}}
{{CMG}}
{{CMG}} {{AE}} {{JC}} {{AE}} {{LRO}}
 
{{SK}} Visual loss
{{SK}} Visual loss
==Overview==
==Overview==
'''Vision loss'''  is the absence of [[Visual perception|vision]] where it existed before, which can happen either [[Acute (medical)|acutely]] (i.e. abruptly) or [[chronic (medicine)|chronically]] (i.e. over a long period of time). The effects of visual loss can, before the acquisition of alternative adaptations and skills, be devastating; especially when a person's vision disappears over a short period of time.
'''Vision loss'''  is the absence of [[Visual perception|vision]] where it existed before, which can happen either [[Acute (medical)|acutely]] (i.e. abruptly) or [[chronic (medicine)|chronically]] (i.e. over a long period of time). It may be caused by media opacities, [[retina]]l disease, [[optic nerve]] disease, [[#visual pathway disorder|visual pathway disorder]]s, or [[#Functional disorder|functional disorder]]s, or it may be due to an abnormality in the central nervous system.


==Classification==
==Classification==
*Vision Loss may be:
In order to gain insight into the pathophysiology of vision loss which will in turn guide treatment decisions, the signs and symptoms should be characterized:
:*unilateral
*Unilateral
:*bilateral
*Bilateral
:*transient
*Transient
:*persistant
*Persistant
:*sudden
*Sudden
:*gradual
*Gradual
:*painless
*Painless
:*painful<br>
*Painful<br>
Loss of vision in one eye can quickly lead to loss in the other eye, thus rendering the patient blind. <br>
 
Vision loss can be reversed, however it must be treated promptly. It can be an indication of a more serious underlying condition.
==Pathophysiology==
==Pathophysiology==
===Media opacity===
===Media Opacity===
Opacities of the clear refractive media of the [[eye]] such as the [[cornea]], anterior chamber, [[lens (anatomy)|lens]], and [[vitreous humor]] may cause acute visual loss as manifested by blurry vision or reduced [[visual acuity]].
Opacities of the clear refractive media of the [[eye]] such as the [[cornea]], anterior chamber, [[lens (anatomy)|lens]], and [[vitreous humor]] may cause acute visual loss as manifested by blurry vision or reduced [[visual acuity]].
While [[pupillary reflex]]es may be affected, these conditions generally do not cause a relative afferent pupillary defect.
While [[pupillary reflex]]es may be affected, these conditions generally do not cause a relative afferent pupillary defect.


Causes of media opacity include corneal edema, [[hyphema]], [[cataract]] and vitreous hemorrhage.
Causes of media opacity include corneal edema, [[hyphema]], [[cataract]] and vitreous hemorrhage.
===Retinal disease===
 
===Retinal Disease===
Retinal diseases may cause sudden visual loss.
Retinal diseases may cause sudden visual loss.
Because the retina is being affected, there is usually a concomitant relative afferent pupillary defect.
Because the retina is being affected, there is usually a concomitant relative afferent pupillary defect.
Conditions that affect or destroy the retina include [[retinal detachment]]; [[macula]]r disease (''e.g.'', [[macular degeneration]]); and retinal vascular occlusions, the most important of which is central retinal artery occlusion.
Conditions that affect or destroy the retina include [[retinal detachment]]; [[macula]]r disease (''e.g.'', [[macular degeneration]]); and retinal vascular occlusions, the most important of which is central retinal artery occlusion.
===Optic nerve disease===
 
===Optic Nerve Disease===
Diseases which affect the optic nerve may cause acute visual loss.
Diseases which affect the optic nerve may cause acute visual loss.
[[Sign (medicine)|Sign]]s include an abnormal pupillary reflex, with an afferent pupillary defect when the optic nerve disease is unilateral.
[[Sign (medicine)|Sign]]s include an abnormal pupillary reflex, with an afferent pupillary defect when the optic nerve disease is unilateral.


The [[optic nerve]] can be affected by many diseases including [[optic neuritis]], [[retrobulbar neuritis]], [[papillitis]], [[papilledema]], [[glaucoma]], [[ischemic optic neuropathy]], and [[giant cell arteritis]].
The [[optic nerve]] can be affected by many diseases including [[optic neuritis]], [[retrobulbar neuritis]], [[papillitis]], [[papilledema]], [[glaucoma]], [[ischemic optic neuropathy]], and [[giant cell arteritis]].
===Hypoxia===
===Hypoxia===
The eye is very sensitive to restriction of its supply of oxygen.  A dimming of vision (a [[brownout (medical)|brownout]] or [[brownout (medical)|greyout]]) accompanied by loss of peripheral perception may result from low blood pressure, [[Shock (medical)|shock]], [[g-LOC]] (an aviation related problem) or simply standing up suddenly, especially if sick or otherwise infirm.  Vision usually returns readily once the conditions restricting blood flow are lifted.  
The eye is very sensitive to restriction of its supply of oxygen.  A dimming of vision (a [[brownout (medical)|brownout]] or [[brownout (medical)|greyout]]) accompanied by loss of peripheral perception may result from low blood pressure, [[Shock (medical)|shock]], [[g-LOC]] (an aviation related problem) or simply standing up suddenly, especially if sick or otherwise infirm.  Vision usually returns readily once the conditions restricting blood flow are lifted.  


===Visual pathway disorder===
===Visual Pathway Disorder===
Visual pathway disorders are any problems that may impede the [[visual pathway]].
Visual pathway disorders are any problems that may impede the [[visual pathway]].
Rarely, acute visual loss is caused by [[homonymous hemianopia]] and, more rarely, [[cortical blindness]].
Rarely, acute visual loss is caused by [[homonymous hemianopia]] and, more rarely, [[cortical blindness]].


===Functional disorder===
===Functional Disorder===
The term '''functional disorder''' is now used where hysterical and [[malingering]] were historically used.
The term functional disorder is now used where hysterical and [[malingering]] were historically used.
This shift recognizes the inherent inability of the physician to identify the subjective experience of a patient (and thus whether that patient can truly see or not).
This shift recognizes the inherent inability of the physician to identify the subjective experience of a patient (and thus whether that patient can truly see or not).
===Acute visual loss===
''Acute visual loss'' may be dramatic in presentation, and is almost always alarming to the person experiencing the loss.
It may be caused by media opacities, [[retina]]l disease, [[optic nerve]] disease, [[#visual pathway disorder|visual pathway disorder]]s, or [[#Functional disorder|functional disorder]]s, or it may be in fact an acute discovery of chronic visual loss.


==Causes==  
==Causes==  
'''<u>Transient vision loss (<24 hours)</u>'''
===Transient Vision Loss (<24 hours)===
*Amaurosis fugax
*Amaurosis fugax
:*Vision loss is unilateral and lasts only minutes
:*Vision loss is unilateral and lasts only minutes
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*Ocular ischemic syndrome ([[Cartoid Occlusive Disease]])
*Ocular ischemic syndrome ([[Cartoid Occlusive Disease]])
*[[Papilledema]]
*[[Papilledema]]
:*raised intracranial pressure
:*Raised intracranial pressure
:*malignant hypertension
:*Malignant hypertension
*Retinal detachment
*Retinal detachment
*Sudden change in blood pressure
*Sudden change in blood pressure
:*orthostatic hypotension
:*Orthostatic hypotension
*Transient acute increase in thraocular pressure
*Transient acute increase in thraocular pressure
:*Acute Angle Closure [[Glaucoma]]
:*Acute Angle Closure [[Glaucoma]]
:*retro-or peribulbar hemorrhage
:*Retro-or peribulbar hemorrhage
*Vertebrobasilar artery insufficiency
*Vertebrobasilar artery insufficiency
:*Vision loss is bilateral and lasts minutes
:*Vision loss is bilateral and lasts minutes
*Vitreous hemorrhage
*Vitreous hemorrhage
*Vitreous detachment
*Vitreous detachment
'''<u>Vision loss > 24 hours:sudden, painless</u>'''
===Vision Loss > 24 hours:Sudden, Painless===
*Exposure(Welder's flash)
*Exposure(Welder's flash)
:*prolonged exposure to intense light/sunlight
:*prolonged exposure to intense light/sunlight
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:*To prevent permanent loss, rule out giant cell/temporal arteritis  
:*To prevent permanent loss, rule out giant cell/temporal arteritis  
*Other retinal or central nervous system disease
*Other retinal or central nervous system disease
:*occipital lobe CVA causing cortical blindness
:*Occipital lobe CVA causing cortical blindness
*[[Optic Neuritis]]
*[[Optic Neuritis]]
*Retinal artery/vein occlusion
*Retinal artery/vein occlusion
*Retinal detachment
*Retinal detachment
*Vitreous or aqueous hemmorrhage (hyphema)
*Vitreous or aqueous hemmorrhage (hyphema)
'''<u>Vision loss >24 hours:gradual, painless</u>'''
===Vision Loss >24 hours:Gradual, Painless===
*[[Cataracts]]
*[[Cataracts]]
*[[Cerebral Neoplasm]]
*[[Cerebral Neoplasm]]
*Chronic retinopathy
*Chronic retinopathy
:*age related macular degeneration
:*Age related macular degeneration
:*[[Diabetic Retinopathy]]
:*[[Diabetic Retinopathy]]
*Chronic corneal disease
*Chronic corneal disease
:*corneal dystrophy
:*Corneal dystrophy
*Corneal Ulcer
*Corneal Ulcer
*Open angle [[Glaucoma]]
*Open angle [[Glaucoma]]
*Optic neuropathy/atrophy
*Optic neuropathy/atrophy
:*compressive lesion
:*Compressive lesion
:*toxic-metabolic cause
:*Toxic-metabolic cause
:*radiation
:*Radiation
*Pseudotumor cerebri
*Pseudotumor cerebri
*Refractive error
*Refractive error
*Retitnitis pigmentosa
*Retitnitis pigmentosa
'''<u>Vision loss >24 hours:Painful</u>'''
===Vision Loss >24 hours:Painful===
*Acute Angle Closure [[Glaucoma]]
*Acute Angle Closure [[Glaucoma]]
*Corneal hydrops  
*Corneal hydrops  
:*keratoconus
:*Keratoconus
*Corneal abrasion/ulcer
*Corneal abrasion/ulcer
*Herepes simplex/zoster
*Herepes simplex/zoster
*Ocular onchocerciasis
*Ocular onchocerciasis
:*"river blindness"
:*"River blindness"
:*''Onchocera volvulus'' worm
:*''Onchocera volvulus'' worm
*Optic neuritis
*Optic neuritis
*Orbital apex/superior orbital fissure/cavernous sinus syndrome
*Orbital apex/superior orbital fissure/cavernous sinus syndrome
*[[Uveitis]
*[[Uveitis]]
 
 
===Life-Threatening Causes===
 
===Common Causes===
 
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Al amyloidosis]],  [[Arachnoiditis]],  [[Arteriovenous malformation]],  [[Atherosclerosis]],  [[Basilar artery insufficiency syndrome]],  [[Basilar artery migraine ]],  [[Cardiomyopathy]],  [[Carotid atherosclerosis]],  [[Carotid-cavernous fistula]],  [[Central retinal artery occlusion]],  [[Central retinal vein occlusion]],  [[Central serous chorioretinopathy]],  [[Cerebrovascular accident]],  [[Charge syndrome]],  [[Giant cell arteritis]],  [[Hurler syndrome]],  [[Hypertension of pregnancy]],  [[Ischemic optic neuropathy]],  [[Malignant hypertension]],  [[Microvascular diabetes complications]],  [[Microvascular disease]],  [[Ocular ischemic syndrome]],  [[Retinal artery occlusion]],  [[Retinal vein occlusion ]],  [[Stroke]],  [[Takayasu arteritis]],  [[Temporal arteritis]],  [[Transient ischaemic attack]],  [[Vascular diseases]],  [[Vascular retinopathies]],  [[Vasculitis ]],  [[Vertebral artery dissection]]
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|bgcolor="Beige"| [[Aminosalicylic acid]],  [[Capreomycin sulfate]],  [[Herbal agent overdose ]],  [[Irinotecan hydrochloride]],  [[Mayapple poisoning ]],  [[Monosodium methanarsenate ]],  [[O'higgins disease ]],  [[Radium chloride]],  [[Strontium chloride]],  [[Valganciclovir hydrochloride]]
|-
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| [[Oligodontia]]
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| [[Albinism]],  [[Alezzandrini syndrome ]],  [[Behcet's disease]],  [[Cross syndrome]],  [[Ectodermal dysplasia ]],  [[Keratitis]],  [[Keratomalacia]],  [[Mucous membrane pemphigoid]],  [[Oculocutaneous albinism]],  [[Pachydermoperiostosis]],  [[Panuveitis ]],  [[Pigmentary retinopathy ]],  [[Rufous oculocutaneous albinism ]],  [[Shingles]]
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Amitriptyline]],  [[Carbachol]],  [[Carbamazepine]],  [[Celecoxib]],  [[Cesium]],  [[Chalazion]],  [[Chlorpheniramine]],  [[Cinnarizine]],  [[Clomifene]],  [[Coenzyme q - cytochrome c reductase]],  [[Deferoxamine]],  [[Desipramine]],  [[Diphenhydramine]],  [[Dothiepin]],  [[Hydroxyzine]],  [[Ivabradine]],  [[Lithium]],  [[Mefloquine]],  [[Methanol]],  [[Monosodium methanarsenate ]],  [[Monosodium methyl arsenate]],  [[Morpholine ]],  [[Nortriptyline]],  [[Phenylbutazone]],  [[Physostigmine]],  [[Pipecolic acidemia]],  [[Prochlorperazine]],  [[Pterygium]],  [[Quinidine]],  [[Rofecoxib]],  [[Sclerostin]],  [[Septum pellucidum]],  [[Temozolomide]],  [[Thalidomide]],  [[Verteporfin]],  [[Vigabatrin]]
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| [[Albinism]],  [[Ceroid lipofuscinosis]],  [[Citrullinemia ]],  [[Empty sella syndrome ]],  [[Graves ophthalmopathy]],  [[Infantile refsum disease]],  [[Kallmann syndrome]],  [[Linear iga bullous dermatosis]],  [[Mucopolysaccharidosis]],  [[Mucosa-associated lymphoid tissue]],  [[Multiple endocrine neoplasia type 1 ]],  [[Nelson syndrome]],  [[Niemann-pick disease]],  [[Nyssen-van bogaert syndrome ]],  [[Pellagra-like syndrome]],  [[Pituitary adenoma]],  [[Thyroid eye disease ]]
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| [[Foreign body]]
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Diabetic ketoacidosis]],  [[Herpetic keratitis ]],  [[Hurler syndrome]],  [[Mucormycosis ]],  [[Sandhoff disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| [[13q deletion syndrome]],  [[3 alpha methylglutaconicaciduria]],  [[Alström syndrome]],  [[Amaurosis congenita of leber ]],  [[Amelogenesis imperfecta]],  [[Ampola syndrome ]],  [[Bardet-biedl syndrome]],  [[Blue cone monochromatism ]],  [[Cassia stocco dos santos syndrome]],  [[Cenani lenz syndactylism]],  [[Charcot-marie-tooth syndrome]],  [[Chromosome 11, deletion 11p ]],  [[Chromosome 13, partial monosomy 13q ]],  [[Chromosome 13q deletion syndrome ]],  [[Chromosome 13q deletion ]],  [[Chromosome 14q, partial deletion ]],  [[Chromosome 17, deletion 17q23 q24 ]],  [[Chromosome 2p deletion syndrome ]],  [[Classic childhood ald ]],  [[Cohen syndrome]],  [[Congenital disorder of glycosylation type 1g ]],  [[Cross syndrome]],  [[Deletion 11p ]],  [[Deletion 13q ]],  [[Didmoad syndrome]],  [[Ehlers-danlos syndrome ]],  [[Emanuel syndrome ]],  [[Familial amyloid polyneuropathy]],  [[Familial infantile metachromatic leukodystrophy]],  [[Franceschetti-klein syndrome ]],  [[Francois dyscephalic syndrome ]],  [[Goldberg–shprintzen syndrome]],  [[Gronblad-strandberg-touraine syndrome]],  [[Gustavson syndrome ]],  [[Hallervorden-spatz syndrome ]],  [[Hand-schuller-christian syndrome]],  [[Hereditary diseases]],  [[Herns syndrome ]],  [[Imidazole syndrome]],  [[Incontinentia pigmenti]],  [[Infant cytomegalic virus ]],  [[Juvenile retinoschisis ]],  [[Kearns–sayre syndrome]],  [[Krause-kivlin syndrome]],  [[Lawrence-moon syndrome]],  [[Leber's congenital amaurosis]],  [[Lobstein disease]],  [[Mercaptolactace-cysteine disulfiduria]],  [[Neuroaxonal dystrophy]],  [[Noble-bass-sherman syndrome ]],  [[Norrie syndrome ]],  [[Oguchi disease ]],  [[Osteochondrodysplatic dwarfism]],  [[Partial monosomy 13q]],  [[Plum syndrome ]],  [[Polychondritis ]],  [[Pseudoxanthoma elasticum]],  [[Purtscher's retinopathy]],  [[Pyle disease ]],  [[Rieger syndrome ]],  [[Roberts syndrome]],  [[Roy-maroteaux-kremp syndrome ]],  [[Schindler disease]],  [[Sialidosis]],  [[Simell-takki syndrome]],  [[Singh-chhaparwal-dhanda syndrome]],  [[Small syndrome ]],  [[Smith martin dodd syndrome]],  [[Spherophakia-brachymorphia syndrome]],  [[Stargardt disease]],  [[Stevens-johnson syndrome]],  [[Stickler syndrome]],  [[Syndactyly]],  [[Tapetal-like reflex ]],  [[Tay-sachs disease]],  [[Treacher collins syndrome]],  [[Usher syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| [[Aspartoacylase deficiency]],  [[Avitaminosis]],  [[Brain aneurysm]],  [[Canavan leukodystrophy ]],  [[Catastrophic antiphospholipid syndrome]],  [[Cree leukoencephalopathy ]],  [[Diabetes insipidus]],  [[Ebola ]],  [[Familial infantile metachromatic leukodystrophy]],  [[Galactokinase deficiency]],  [[Homonymous hemianopia]],  [[Hypoglycaemia]],  [[Intraocular hemorrhage]],  [[Krabbe leukodystrophy]],  [[Langerhans cell histiocytosis]],  [[Leukodystrophy]],  [[Lymphoma]],  [[Metachromatic leukodystrophy]],  [[Neurodegeneration with brain iron accumulation]],  [[Ornithine translocase deficiency]],  [[Posterior leucoencephalopathy syndrome]],  [[Progressive multifocal leukoencephalopathy]],  [[Sickle cell anemia]],  [[Subacute sclerosing leukoencephalitis ]],  [[Transthyretin amyloidosis ]],  [[Vitamin a deficiency]]
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| [[Acanthamoeba]],  [[Achromatopsia]],  [[Acromegaloid]],  [[Acute disseminated encephalomyelitis]],  [[Acute retinal necrosis]],  [[Alveolar hydatid disease]],  [[Blepharitis]],  [[Congenital cytomegalovirus infection]],  [[Congenital rubella syndrome]],  [[Congenital toxoplasmosis]],  [[Creutzfeldt jakob disease]],  [[Cytomegalovirus retinitis ]],  [[Cytomegalovirus ]],  [[Ebola ]],  [[Euphorbiaceae]],  [[Feline spongiform encephalopathy ]],  [[Fundus albipunctatus]],  [[Giant cell arteritis]],  [[Helminth infections ]],  [[Herpes simplex]],  [[Hiv]],  [[Infant cytomegalic virus ]],  [[Inflammatory processes]],  [[Mucormycosis ]],  [[Multifocal choroiditis]],  [[Mycosis fungoides]],  [[Ocular herpes ]],  [[Ocular histoplasmosis syndrome ]],  [[Panuveitis ]],  [[Papillitis]],  [[Presumed ocular histoplasmosis syndrome]],  [[Rhabditida]],  [[Rhinocerebral mucormycosis ]],  [[Rhinocerebral zygomycosis ]],  [[Rhino-orbito-cerebral phycomycosis ]],  [[Rift valley fever]],  [[Secernentea]],  [[Shingles]],  [[Syphilis]],  [[Toxoplasmosis]],  [[Uveitis]]
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| [[Cardiomyopathy]],  [[Cartilaginous]],  [[Ciliary muscle spasm]],  [[Cycloplegia]],  [[Dysosteosclerosis ]],  [[Episodic ataxia]],  [[Neuropathic ataxia ]],  [[Osteoporosis ]],  [[Posterior column ataxia ]],  [[Rhabdomyosarcoma]],  [[Spastic tetraplegic ]],  [[Spinocerebellar ataxia]]
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| [[Acute disseminated encephalomyelitis]],  [[Alpers' disease]],  [[Amaurosis fugax]],  [[Anencephaly ]],  [[Arachnoiditis]],  [[Basilar artery migraine ]],  [[Batten disease]],  [[Bessman-baldwin syndrome ]],  [[Bilateral occipital lobe infarct]],  [[Bilateral optic neuritis]],  [[Bilateral papilloedema]],  [[Bonnet-dechaume-blanc syndrome]],  [[Brain aneurysm]],  [[Brain tumors]],  [[Cerebral palsy]],  [[Ceroid lipofuscinosis]],  [[Charcot-marie-tooth syndrome]],  [[Cluster headache]],  [[Concussion]],  [[Conversion disorder]],  [[Craniodiaphyseal dysplasia ]],  [[Craniometaphyseal dysplasia]],  [[Craniosynostosis ]],  [[Craniotelencephalic dysplasia ]],  [[Creutzfeldt jakob disease]],  [[Devic disease ]],  [[Empty sella syndrome ]],  [[Encephalocele anterior ]],  [[Encephalocele frontal ]],  [[Encephalocele]],  [[Endophthalmitis]],  [[Episodic ataxia]],  [[Esthesioneuroblastoma ]],  [[Fahr's syndrome]],  [[Familial amyloid polyneuropathy]],  [[Feline spongiform encephalopathy ]],  [[Flynn-aird syndrome ]],  [[Ghose-sachdev-kumar syndrome ]],  [[Heidenhain syndrome ]],  [[Hydranencephaly ]],  [[Hydrocephalus ]],  [[Increased intracranial pressure]],  [[Infantile neuroaxonal dystrophy]],  [[Ischemic optic neuropathy]],  [[Jensen syndrome ]],  [[Lethal congenital contracture syndrome]],  [[Lowe oculocerebrorenal syndrome ]],  [[Microcephaly ]],  [[Midline craniofacial anomalies ]],  [[Migraine]],  [[Minamata disease]],  [[Mitochondrial disease ]],  [[Morning glory disc anomaly]],  [[Multiple lentigines syndrome]],  [[Multiple sclerosis ]],  [[Neuroaxonal dystrophy]],  [[Neurodegeneration with brain iron accumulation]],  [[Neurodegenerative syndrome]],  [[Neurofibromatosis]],  [[Neuromyelitis optica]],  [[Neuropathic ataxia ]],  [[Neuropathy ]],  [[Niemann-pick disease]],  [[Night blindness]],  [[Oculocerebrorenal syndrome]],  [[Olivopontocerebellar atrophy ]],  [[Ophthalmoplegia]],  [[Optic nerve compression]],  [[Optic nerve disorder]],  [[Optic neuritis]],  [[Optic pathway glioma ]],  [[Opticoacoustic nerve atrophy dementia ]],  [[Pantothenate kinase-associated neurodegeneration ]],  [[Papilledema]],  [[Papilloedema]],  [[Paraneoplastic cerebellar degeneration]],  [[Peripheral type neurofibromatosis ]],  [[Photopsia]],  [[Posterior column ataxia ]],  [[Progressive supranuclear palsy]],  [[Pseudotumor cerebri]],  [[Retinal migraine ]],  [[Rhinocerebral mucormycosis ]],  [[Rhinocerebral zygomycosis ]],  [[Rhino-orbito-cerebral phycomycosis ]],  [[Rift valley fever]],  [[Senior-loken syndrome ]],  [[Spastic tetraplegic ]],  [[Spinocerebellar ataxia]],  [[Subacute myelo-optic neuropathy]],  [[Subacute sclerosing panencephalitis]],  [[Sudanophilic cerebral sclerosis]],  [[Tay-sachs disease]],  [[Temporal arteritis]],  [[Tolosa-hunt syndrome]],  [[Treacher collins syndrome]],  [[Vertebral artery dissection]],  [[Visual hallucinations]]
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| [[Avitaminosis]],  [[Blue diaper syndrome]],  [[Diabetes insipidus]],  [[Diabetic eye disease ]],  [[Diabetic ketoacidosis]],  [[Diabetic retinopathy ]],  [[Gangliosidosis ]],  [[Hypoglycaemia]],  [[Imidazole syndrome]],  [[Microvascular diabetes complications]],  [[Mucolipidosis]],  [[Nutritional deficiencies]],  [[Osteoporosis ]],  [[Pyruvate decarboxylase deficiency ]],  [[Pyruvate decarboxylase]],  [[Schindler disease]],  [[Sclerosteosis ]],  [[Senter syndrome ]],  [[Sialidosis]],  [[Vitamin a deficiency]],
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| [[Hypertension of pregnancy]],  [[Pre-eclampsia]]
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| [[Brain tumors]],  [[Car syndrome ]],  [[Eye cancer]],  [[Eye melanoma ]],  [[Glioblastoma ]],  [[Intraocular melanoma]],  [[Langerhans cell histiocytosis]],  [[Lymphoma]],  [[Melanoma of the choroid ]],  [[Multiple endocrine neoplasia type 1 ]],  [[Nasopharyngeal carcinoma]],  [[Nasopharynx cancer ]],  [[Occipital lobe tumours]],  [[Ocular oncology]],  [[Orbit tumour ]],  [[Orbital lymphangioma ]],  [[Orbital mass]],  [[Paraneoplastic cerebellar degeneration]],  [[Phacolytic glaucoma ]],  [[Pituitary adenoma]],  [[Pseudotumor cerebri]],  [[Retinoblastoma ]],  [[Rhabdomyosarcoma]],  [[Trachoma ]],  [[Uveal melanoma]]
|-
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"| [[Acute posterior multifocal placoid pigment epitheliopathy]],  [[Acute retinal necrosis]],  [[Age-related macular degeneration]],  [[Amaurosis fugax]],  [[Amblyopia]],  [[Angioid streaks ]],  [[Aniridia ]],  [[Anisometropia ]],  [[Anophthalmia]],  [[Anophthalmos]],  [[Anterior segment mesenchymal dysgenesis]],  [[Arteriovenous malformation]],  [[Asthenopia ]],  [[Autoimmune uveitis ]],  [[Axenfeld-rieger syndrome]],  [[Basement membrane corneal dystrophy]],  [[Benign essential blepharospasm]],  [[Bessman-baldwin syndrome ]],  [[Best vitelliform macular dystrophy]],  [[Best's disease]],  [[Bilateral occipital lobe infarct]],  [[Bilateral optic neuritis]],  [[Blepharitis]],  [[Blind spot]],  [[Blindness]],  [[Bothnia retina dystrophy]],  [[Calcification of basal ganglia ]],  [[Carotid-cavernous fistula]],  [[Cataract]],  [[Central retinal artery occlusion]],  [[Central retinal vein occlusion]],  [[Central serous chorioretinopathy]],  [[Chandler's syndrome]],  [[Chorioretinitis ]],  [[Choroideremia ]],  [[Choroiditis ]],  [[Cloudy cornea (patient information)]],  [[Cogan-reese syndrome ]],  [[Cogan's syndrome ]],  [[Coloboma]],  [[Color blindness]],  [[Cone dystrophy ]],  [[Cone rod dystrophy ]],  [[Congenital x-linked retinoschisis ]],  [[Conversion disorder]],  [[Cornea plana 1]],  [[Corneal dystrophy]],  [[Corneal foreign body]],  [[Corneal hypesthesia ]],  [[Corneal opacity]],  [[Corneal ulcer ]],  [[Cortical blindness]],  [[Cortical hyperostosis]],  [[Craniodiaphyseal dysplasia ]],  [[Cycloplegia]],  [[Cystoid macular dystrophy]],  [[Cytomegalovirus retinitis ]],  [[Dermatoosteolysis]],  [[Devic disease ]],  [[Diabetic eye disease ]],  [[Diabetic retinopathy ]],  [[Dry eye]],  [[Eales disease]],  [[Endophthalmitis]],  [[Enhanced s-cone syndrome ]],  [[Essential iris atrophy]],  [[Eye cancer]],  [[Eye injury]],  [[Eye melanoma ]],  [[Fuchs atrophia gyrata chorioideae et retinae ]],  [[Fuchs' dystrophy]],  [[Glaucoma]],  [[Hemianopia ]],  [[Hyperopia]],  [[Hyperornithinemia ]],  [[Hyphema]],  [[Infantile cortical hyperostosis]],  [[Intraocular hemorrhage]],  [[Intraocular melanoma]],  [[Intraocular pressure]],  [[Iridocorneal endothelial syndrome]],  [[Iridocyclitis]],  [[Iridogoniodysgenesis]],  [[Lattice corneal dystrophy ]],  [[Leber's congenital amaurosis]],  [[Leber's optic atrophy]],  [[Lens pathology]],  [[Lowe oculocerebrorenal syndrome ]],  [[Macular degeneration]],  [[Macular dystrophy]],  [[Macular edema]],  [[Macular hole]],  [[Maculopathy]],  [[Malignant hypertension]],  [[Marsden syndrome ]],  [[Marshall syndrome]],  [[Melanoma of the choroid ]],  [[Metamorphopsia]],  [[Metaphyseal dysplasia]],  [[Microphthalmia]],  [[Microphthalmos]],  [[Morning glory disc anomaly]],  [[Multifocal choroiditis]],  [[Neuromyelitis optica]],  [[Night blindness]],  [[Nutritional amblyopia]],  [[Obal syndrome]],  [[Occipital lobe tumours]],  [[Ocular cicatricial pemphigoid ]],  [[Ocular herpes ]],  [[Ocular histoplasmosis syndrome ]],  [[Ocular ischemic syndrome]],  [[Ocular oncology]],  [[Ocular trauma]],  [[Oculocerebrorenal syndrome]],  [[Oculocutaneous albinism]],  [[Oguchi disease ]],  [[Oligodontia]],  [[Olivopontocerebellar atrophy ]],  [[Open-angle glaucoma]],  [[Ophthalmia neonatorum]],  [[Ophthalmoplegia]],  [[Optic atrophy]],  [[Optic nerve compression]],  [[Optic nerve disorder]],  [[Optic neuritis]],  [[Optic pathway glioma ]],  [[Opticoacoustic nerve atrophy dementia ]],  [[Orbit tumour ]],  [[Orbital lymphangioma ]],  [[Orbital mass]],  [[Osteochondrodysplatic dwarfism]],  [[Papillitis]],  [[Periorbital cellulitis]],  [[Photopsia]],  [[Pigmentary retinopathy ]],  [[Posterior vitreous detachment ]],  [[Presbyopia ]],  [[Presumed ocular histoplasmosis syndrome]],  [[Progressive multifocal leukoencephalopathy]],  [[Protanopia ]],  [[Purtscher's retinopathy]],  [[Raised intraocular pressure]],  [[Ramos-arroyo syndrome ]],  [[Reese-ellsworth syndrome ]],  [[Refractive error]],  [[Refsum disease ]],  [[Retinal artery occlusion]],  [[Retinal cone dystrophy ]],  [[Retinal degeneration ]],  [[Retinal detachment]],  [[Retinal dysplasia]],  [[Retinal migraine ]],  [[Retinal tear ]],  [[Retinal vein occlusion ]],  [[Retinitis pigmentosa]],  [[Retinitis punctata albescens ]],  [[Retinoblastoma ]],  [[Retinopathy]],  [[Retinoschisis ]],  [[Retrolental fibroplasia]],  [[Rollet syndrome ]],  [[Rufous oculocutaneous albinism ]],  [[Scleritis]],  [[Senile macular degeneration]],  [[Senile retinoschisis]],  [[Senior-loken syndrome ]],  [[Septo-optic dysplasia]],  [[Simell-takki syndrome]],  [[Singh-chhaparwal-dhanda syndrome]],  [[Small syndrome ]],  [[Smith martin dodd syndrome]],  [[Spherophakia-brachymorphia syndrome]],  [[Stargardt disease]],  [[Stevens-johnson syndrome]],  [[Stickler syndrome]],  [[Subacute combined degeneration of the cord]],  [[Subacute myelo-optic neuropathy]],  [[Subacute sclerosing leukoencephalitis ]],  [[Subacute sclerosing panencephalitis]],  [[Superior orbital fissure]],  [[Thyroid eye disease ]],  [[Usher syndrome]],  [[Uveal diseases]],  [[Uveal melanoma]],  [[Uveitis]],  [[Vascular diseases]],  [[Vascular retinopathies]],  [[Vasculitis ]],  [[Vasterbotten dystrophy ]],  [[Verloes van maldergem marneffe syndrome ]],  [[Vision impairment ]],  [[Visual hallucinations]]
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| [[Hysteria]],  [[Mental retardation ]],  [[Psychogenic]],  [[Shaken baby syndrome]],
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| [[Alveolar hydatid disease]],  [[Sarcoidosis]]
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| [[Alport syndrome]],  [[Hypophosphatemia]],  [[Renal tubulopathy ]]
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| [[Al amyloidosis]],  [[Behcet's disease]],  [[Besnier-boeck-schaumann disease ]],  [[Inflammatory processes]],  [[Leprosy]],  [[Mucous membrane pemphigoid]],  [[Sarcoidosis]]
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| [[Herpes simplex]],  [[Hiv]],  [[Syphilis]]
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| [[Concussion]],  [[Eye injury]],  [[Head injury ]],  [[Ocular trauma]],  [[Retinal tear ]],  [[Superior orbital fissure]]
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| [[Hypophosphatemia]]
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
|-
|}
 
===Causes in Alphabetical Order===
{{columns-list|
*[[13q deletion syndrome]]
*[[2-hydroxyglutaricaciduria]]
*[[3 alpha methylglutaconicaciduria]]
*[[3-methylglutaconic aciduria]]
*[[Acanthamoeba]]
*[[Achromatopsia]]
*[[Acromegaloid]]
*[[Acute disseminated encephalomyelitis]]
*[[Acute posterior multifocal placoid pigment epitheliopathy]]
*[[Acute retinal necrosis]]
*[[Age-related macular degeneration]]
*[[Al amyloidosis]]
*[[Albinism]]
*[[Alezzandrini syndrome ]]
*[[Alpers' disease]]
*[[Alport syndrome]]
*[[Alström syndrome]]
*[[Alveolar hydatid disease]]
*[[Amaurosis congenita of leber ]]
*[[Amaurosis fugax]]
*[[Amblyopia]]
*[[Amelogenesis imperfecta]]
*[[Amitriptyline]]
*[[Ampola syndrome ]]
*[[Anencephaly ]]
*[[Angioid streaks ]]
*[[Aniridia ]]
*[[Anisometropia ]]
*[[Anophthalmia]]
*[[Anophthalmos]]
*[[Anterior segment mesenchymal dysgenesis]]
*[[Arachnoiditis]]
*[[Arteriovenous malformation]]
*[[Aspartoacylase deficiency]]
*[[Asthenopia ]]
*[[Atherosclerosis]]
*[[Autoimmune uveitis ]]
*[[Avitaminosis]]
*[[Axenfeld-rieger syndrome]]
*[[Bardet-biedl syndrome]]
*[[Basement membrane corneal dystrophy]]
*[[Basilar artery insufficiency syndrome]]
*[[Basilar artery migraine ]]
*[[Batten disease]]
*[[Behcet's disease]]
*[[Benign essential blepharospasm]]
*[[Besnier-boeck-schaumann disease ]]
*[[Bessman-baldwin syndrome ]]
*[[Best vitelliform macular dystrophy]]
*[[Best's disease]]
*[[Bilateral occipital lobe infarct]]
*[[Bilateral optic neuritis]]
*[[Bilateral papilloedema]]
*[[Blepharitis]]
*[[Blind spot]]
*[[Blindness]]
*[[Blue cone monochromatism ]]
*[[Blue diaper syndrome]]
*[[Blue-ringed octopus poisoning]]
*[[Bonnet-dechaume-blanc syndrome]]
*[[Bothnia retina dystrophy]]
*[[Brain aneurysm]]
*[[Brain tumors]]
*[[Calcification of basal ganglia ]]
*[[Canavan leukodystrophy ]]
*[[Car syndrome ]]
*[[Carbachol]]
*[[Carbamazepine]]
*[[Cardiomyopathy]]
*[[Carotid atherosclerosis]]
*[[Carotid-cavernous fistula]]
*[[Cartilaginous]]
*[[Cassia stocco dos santos syndrome]]
*[[Cataract]]
*[[Catastrophic antiphospholipid syndrome]]
*[[Celecoxib]]
*[[Cenani lenz syndactylism]]
*[[Central retinal artery occlusion]]
*[[Central retinal vein occlusion]]
*[[Central serous chorioretinopathy]]
*[[Cerebral palsy]]
*[[Cerebrovascular accident]]
*[[Ceroid lipofuscinosis]]
*[[Cesium]]
*[[Chalazion]]
*[[Chandler's syndrome]]
*[[Charcot-marie-tooth syndrome]]
*[[Charge syndrome]]
*[[Chemical adverse reaction]]
*[[Chemical burn ]]
*[[Chlorpheniramine]]
*[[Chorioretinitis ]]
*[[Choroideremia ]]
*[[Choroiditis ]]
*[[Chromosome 11, deletion 11p ]]
*[[Chromosome 13, partial monosomy 13q ]]
*[[Chromosome 13q deletion syndrome ]]
*[[Chromosome 13q deletion ]]
*[[Chromosome 14q, partial deletion ]]
*[[Chromosome 17, deletion 17q23 q24 ]]
*[[Chromosome 2p deletion syndrome ]]
*[[Ciliary muscle spasm]]
*[[Cinnarizine]]
*[[Citrullinemia ]]
*[[Classic childhood ald ]]
*[[Clomifene]]
*[[Cloudy cornea (patient information)]]
*[[Cluster headache]]
*[[Cobra poisoning ]]
*[[Coenzyme q - cytochrome c reductase]]
*[[Cogan-reese syndrome ]]
*[[Cogan's syndrome ]]
*[[Cohen syndrome]]
*[[Coloboma]]
*[[Color blindness]]
*[[Concussion]]
*[[Cone dystrophy ]]
*[[Cone rod dystrophy ]]
*[[Congenital cytomegalovirus infection]]
*[[Congenital disorder of glycosylation type 1g ]]
*[[Congenital rubella syndrome]]
*[[Congenital toxoplasmosis]]
*[[Congenital x-linked retinoschisis ]]
*[[Conversion disorder]]
*[[Cornea plana 1]]
*[[Corneal dystrophy]]
*[[Corneal foreign body]]
*[[Corneal hypesthesia ]]
*[[Corneal opacity]]
*[[Corneal ulcer ]]
*[[Cortical blindness]]
*[[Cortical hyperostosis]]
*[[Craniodiaphyseal dysplasia ]]
*[[Craniometaphyseal dysplasia]]
*[[Craniosynostosis ]]
*[[Craniotelencephalic dysplasia ]]
*[[Cree leukoencephalopathy ]]
*[[Creutzfeldt jakob disease]]
*[[Cross syndrome]]
*[[Cycloplegia]]
*[[Cystoid macular dystrophy]]
*[[Cytomegalovirus retinitis ]]
*[[Cytomegalovirus ]]
*[[Daphne poisoning ]]
*[[Deferoxamine]]
*[[Deletion 11p ]]
*[[Deletion 13q ]]
*[[Dermatoosteolysis]]
*[[Desferrioxamine toxicity ]]
*[[Desipramine]]
*[[Devic disease ]]
*[[Diabetes insipidus]]
*[[Diabetic eye disease ]]
*[[Diabetic ketoacidosis]]
*[[Diabetic retinopathy ]]
*[[Didmoad syndrome]]
*[[Diphenhydramine]]
*[[Dothiepin]]
*[[Drugs]]
*[[Dry eye]]
*[[Dysosteosclerosis ]]
*[[Eales disease]]
*[[Ebola ]]
*[[Ectodermal dysplasia ]]
*[[Ehlers-danlos syndrome ]]
*[[Emanuel syndrome ]]
*[[Empty sella syndrome ]]
*[[Encephalocele]]
*[[Encephalocele anterior ]]
*[[Encephalocele frontal ]]
*[[Endophthalmitis]]
*[[Enhanced s-cone syndrome ]]
*[[Episodic ataxia]]
*[[Essential iris atrophy]]
*[[Esthesioneuroblastoma ]]
*[[Euphorbiaceae]]
*[[Eye cancer]]
*[[Eye injury]]
*[[Eye melanoma ]]
*[[Fahr's syndrome]]
*[[Familial amyloid polyneuropathy]]
*[[Familial infantile metachromatic leukodystrophy]]
*[[Feline spongiform encephalopathy ]]
*[[Fetal methylmercury syndrome ]]
*[[Flynn-aird syndrome ]]
*[[Foreign body]]
*[[Franceschetti-klein syndrome ]]
*[[Francois dyscephalic syndrome ]]
*[[Fuchs atrophia gyrata chorioideae et retinae ]]
*[[Fuchs' dystrophy]]
*[[Fundus albipunctatus]]
*[[Galactokinase deficiency]]
*[[Gangliosidosis ]]
*[[Ghose-sachdev-kumar syndrome ]]
*[[Giant cell arteritis]]
*[[Glaucoma]]
*[[Glioblastoma ]]
*[[Goldberg–shprintzen syndrome]]
*[[Graves ophthalmopathy]]
*[[Gronblad-strandberg-touraine syndrome]]
*[[Gustavson syndrome ]]
*[[Hallervorden-spatz syndrome ]]
*[[Hand-schuller-christian syndrome]]
*[[Head injury ]]
*[[Heidenhain syndrome ]]
*[[Helminth infections ]]
*[[Hemianopia ]]
*[[Hereditary diseases]]
*[[Herns syndrome ]]
*[[Herpes]]
*[[Herpes simplex]]
*[[Herpetic keratitis ]]
*[[Hiv]]
*[[Homonymous hemianopia]]
*[[Hurler syndrome]]
*[[Hydranencephaly ]]
*[[Hydrocephalus ]]
*[[Hydroxyzine]]
*[[Hyperopia]]
*[[Hyperornithinemia ]]
*[[Hypertension of pregnancy]]
*[[Hyphema]]
*[[Hypoglycaemia]]
*[[Hypophosphatemia]]
*[[Hysteria]]
*[[Imidazole syndrome]]
*[[Incontinentia pigmenti]]
*[[Increased intracranial pressure]]
*[[Infant cytomegalic virus ]]
*[[Infantile cortical hyperostosis]]
*[[Infantile neuroaxonal dystrophy]]
*[[Infantile refsum disease]]
*[[Inflammatory processes]]
*[[Intraocular hemorrhage]]
*[[Intraocular melanoma]]
*[[Intraocular pressure]]
*[[Iridocorneal endothelial syndrome]]
*[[Iridocyclitis]]
*[[Iridogoniodysgenesis]]
*[[Ischemic optic neuropathy]]
*[[Ivabradine]]
*[[Jensen syndrome ]]
*[[Juvenile retinoschisis ]]
*[[Kallmann syndrome]]
*[[Kearns–sayre syndrome]]
*[[Keratitis]]
*[[Keratomalacia]]
*[[Krabbe leukodystrophy]]
*[[Krause-kivlin syndrome]]
*[[Langerhans cell histiocytosis]]
*[[Lattice corneal dystrophy ]]
*[[Lawrence-moon syndrome]]
*[[Leber's congenital amaurosis]]
*[[Leber's optic atrophy]]
*[[Leg absence ]]
*[[Lens pathology]]
*[[Leprosy]]
*[[Lethal congenital contracture syndrome]]
*[[Leukodystrophy]]
*[[Linear iga bullous dermatosis]]
*[[Lithium]]
*[[Lobstein disease]]
*[[Lord ]]
*[[Lowe oculocerebrorenal syndrome ]]
*[[Lymphoma]]
*[[Macular degeneration]]
*[[Macular dystrophy]]
*[[Macular edema]]
*[[Macular hole]]
*[[Maculopathy]]
*[[Malignant hypertension]]
*[[Marsden syndrome ]]
*[[Marshall syndrome]]
*[[Mefloquine]]
*[[Melanoma of the choroid ]]
*[[Mental retardation ]]
*[[Mercaptolactace-cysteine disulfiduria]]
*[[Mercury poisoning]]
*[[Metachromatic leukodystrophy]]
*[[Metamorphopsia]]
*[[Metaphyseal dysplasia]]
*[[Methanol]]
*[[Microcephaly ]]
*[[Microphthalmia]]
*[[Microphthalmos]]
*[[Microvascular diabetes complications]]
*[[Microvascular disease]]
*[[Midline craniofacial anomalies ]]
*[[Migraine]]
*[[Minamata disease]]
*[[Mitochondrial disease ]]
*[[Monosodium methanarsenate ]]
*[[Monosodium methyl arsenate]]
*[[Morning glory disc anomaly]]
*[[Morpholine ]]
*[[Mucolipidosis]]
*[[Mucopolysaccharidosis]]
*[[Mucormycosis ]]
*[[Mucosa-associated lymphoid tissue]]
*[[Mucous membrane pemphigoid]]
*[[Multifocal choroiditis]]
*[[Multiple endocrine neoplasia type 1 ]]
*[[Multiple lentigines syndrome]]
*[[Multiple sclerosis ]]
*[[Mycosis fungoides]]
*[[Nalidixic acid]]
*[[Nasopharyngeal carcinoma]]
*[[Nasopharyngeal carcinoma ]]
*[[Nasopharynx cancer ]]
*[[Nelson syndrome]]
*[[Neuroaxonal dystrophy]]
*[[Neurodegeneration with brain iron accumulation]]
*[[Neurodegenerative syndrome]]
*[[Neurofibromatosis]]
*[[Neuromyelitis optica]]
*[[Neuropathic ataxia ]]
*[[Neuropathy ]]
*[[Niemann-pick disease]]
*[[Night blindness]]
*[[Noble-bass-sherman syndrome ]]
*[[Norrie syndrome ]]
*[[Nortriptyline]]
*[[Nutritional amblyopia]]
*[[Nutritional deficiencies]]
*[[Nyssen-van bogaert syndrome ]]
*[[Obal syndrome]]
*[[Occipital lobe tumours]]
*[[Ocular cicatricial pemphigoid ]]
*[[Ocular herpes ]]
*[[Ocular histoplasmosis syndrome ]]
*[[Ocular ischemic syndrome]]
*[[Ocular oncology]]
*[[Ocular trauma]]
*[[Oculocerebrorenal syndrome]]
*[[Oculocutaneous albinism]]
*[[Oguchi disease ]]
*[[Oligodontia]]
*[[Olivopontocerebellar atrophy ]]
*[[Open-angle glaucoma]]
*[[Ophthalmia neonatorum]]
*[[Ophthalmoplegia]]
*[[Optic atrophy]]
*[[Optic nerve compression]]
*[[Optic nerve disorder]]
*[[Optic neuritis]]
*[[Optic pathway glioma ]]
*[[Opticoacoustic nerve atrophy dementia ]]
*[[Orbit tumour ]]
*[[Orbital lymphangioma ]]
*[[Orbital mass]]
*[[Ornithine translocase deficiency]]
*[[Osteochondrodysplatic dwarfism]]
*[[Osteoporosis ]]
*[[Pachydermoperiostosis]]
*[[Pantothenate kinase-associated neurodegeneration ]]
*[[Panuveitis ]]
*[[Papilledema]]
*[[Papillitis]]
*[[Papilloedema]]
*[[Papilloedema ]]
*[[Paraneoplastic cerebellar degeneration]]
*[[Partial monosomy 13q]]
*[[Pellagra-like syndrome]]
*[[Pepper spray ]]
*[[Periorbital cellulitis]]
*[[Peripheral type neurofibromatosis ]]
*[[Phacolytic glaucoma ]]
*[[Phenylbutazone]]
*[[Phenytoin toxicity ]]
*[[Phosgene oxime]]
*[[Photopsia]]
*[[Physostigmine]]
*[[Pigmentary retinopathy ]]
*[[Pipecolic acidemia]]
*[[Pituitary adenoma]]
*[[Plant poisoning ]]
*[[Plum syndrome ]]
*[[Polychondritis ]]
*[[Posterior column ataxia ]]
*[[Posterior leucoencephalopathy syndrome]]
*[[Posterior vitreous detachment ]]
*[[Pre-eclampsia]]
*[[Pregnancy toxemia ]]
*[[Presbyopia ]]
*[[Presumed ocular histoplasmosis syndrome]]
*[[Prochlorperazine]]
*[[Progressive multifocal leukoencephalopathy]]
*[[Progressive supranuclear palsy]]
*[[Protanopia ]]
*[[Pseudotumor cerebri]]
*[[Pseudoxanthoma elasticum]]
*[[Psychogenic]]
*[[Pterygium]]
*[[Purtscher's retinopathy]]
*[[Pyle disease ]]
*[[Pyruvate decarboxylase]]
*[[Pyruvate decarboxylase deficiency ]]
*[[Quinidine]]
*[[Raised intraocular pressure]]
*[[Ramos-arroyo syndrome ]]
*[[Reese-ellsworth syndrome ]]
*[[Refractive error]]
*[[Refsum disease ]]
*[[Renal tubulopathy ]]
*[[Retinal artery occlusion]]
*[[Retinal cone dystrophy ]]
*[[Retinal degeneration ]]
*[[Retinal detachment]]
*[[Retinal dysplasia]]
*[[Retinal migraine ]]
*[[Retinal tear ]]
*[[Retinal vein occlusion ]]
*[[Retinitis pigmentosa]]
*[[Retinitis punctata albescens ]]
*[[Retinoblastoma ]]
*[[Retinopathy]]
*[[Retinoschisis ]]
*[[Retrolental fibroplasia]]
*[[Rhabditida]]
*[[Rhabdomyosarcoma]]
*[[Rhinocerebral mucormycosis ]]
*[[Rhinocerebral zygomycosis ]]
*[[Rhino-orbito-cerebral phycomycosis ]]
*[[Rieger syndrome ]]
*[[Rift valley fever]]
*[[Roberts syndrome]]
*[[Rofecoxib]]
*[[Rollet syndrome ]]
*[[Roy-maroteaux-kremp syndrome ]]
*[[Rufous oculocutaneous albinism ]]
*[[Sandhoff disease]]
*[[Sarcoidosis]]
*[[Schindler disease]]
*[[Scleritis]]
*[[Sclerosteosis ]]
*[[Sclerostin]]
*[[Secernentea]]
*[[Senile macular degeneration]]
*[[Senile retinoschisis]]
*[[Senior-loken syndrome ]]
*[[Senter syndrome ]]
*[[Septo-optic dysplasia]]
*[[Septum pellucidum]]
*[[Shaken baby syndrome]]
*[[Shingles]]
*[[Sialidosis]]
*[[Sickle cell anemia]]
*[[Simell-takki syndrome]]
*[[Singh-chhaparwal-dhanda syndrome]]
*[[Small syndrome ]]
*[[Smith martin dodd syndrome]]
*[[Spastic tetraplegic ]]
*[[Spherophakia-brachymorphia syndrome]]
*[[Spinocerebellar ataxia]]
*[[Stargardt disease]]
*[[Stevens-johnson syndrome]]
*[[Stickler syndrome]]
*[[Striped blister beetle poisoning ]]
*[[Stroke]]
*[[Subacute combined degeneration of the cord]]
*[[Subacute myelo-optic neuropathy]]
*[[Subacute sclerosing leukoencephalitis ]]
*[[Subacute sclerosing panencephalitis]]
*[[Sudanophilic cerebral sclerosis]]
*[[Superior orbital fissure]]
*[[Syndactyly]]
*[[Syphilis]]
*[[Takayasu arteritis]]
*[[Tapetal-like reflex ]]
*[[Tay-sachs disease]]
*[[Temozolomide]]
*[[Temporal arteritis]]
*[[Thalidomide]]
*[[Thallium poisoning]]
*[[Thanos syndrome ]]
*[[Thyroid eye disease ]]
*[[Tolosa-hunt syndrome]]
*[[Toxins]]
*[[Toxoplasmosis]]
*[[Trachoma ]]
*[[Transient ischaemic attack]]
*[[Transthyretin amyloidosis ]]
*[[Treacher collins syndrome]]
*[[Usher syndrome]]
*[[Uveal diseases]]
*[[Uveal melanoma]]
*[[Uveitis]]
*[[Vascular diseases]]
*[[Vascular retinopathies]]
*[[Vasculitis ]]
*[[Vasterbotten dystrophy ]]
*[[Verloes van maldergem marneffe syndrome ]]
*[[Vertebral artery dissection]]
*[[Verteporfin]]
*[[Vigabatrin]]
*[[Vision impairment ]]
*[[Visual hallucinations]]
*[[Vitamin a deficiency]]
*[[Vitelliform macular dystrophy]]
*[[Vitreous detachment ]]
*[[Vitreous floaters]]
*[[Vitreous hemorrhage]]
*[[Von hippel-lindau disease]]
*[[Wagener syndrome ]]
*[[Wagner-stickler syndrome]]
*[[Wagr syndrome]]
*[[Wegener's granulomatosis]]
*[[Wegener's granulomatosis ]]
*[[Weill-marchesani syndrome]]
*[[Wells jankovic syndrome]]
*[[Wildervanck syndrome]]
*[[Wilms tumor]]
*[[Winchester syndrome]]
*[[Wolf-hirschhorn syndrome]]
*[[Wolfram syndrome]]
*[[Woods black norbury syndrome]]
*[[Wrinkly skin syndrome]]
*[[Wyburn-mason syndrome ]]
*[[Xanthomatosis cerebrotendinous]]
*[[X-linked congenital stationary night blindness]]
*[[X-linked intellectual disability]]
*[[Ziconotide]]
*[[Zunich neuroectodermal syndrome]]
*[[Zygomycosis]]
}}
 
==Diagnosis==
==Diagnosis==
===History and Symptoms===  
===History and Symptoms===  
'''History'''<br>
'''History'''<br>
include:<br>
include:<br>
*age
*Age
*onset:
*Onset:
*rate of loss
*Rate of loss
*any specific trauma
*Any specific trauma
*headaches
*Headaches
*medication
*Medication
*specific medical history  
*Specific medical history  
*alcohol, drug and/or tabacco use
*Alcohol, drug and/or tabacco use


===Physical Examination===  
===Physical Examination===  
Line 126: Line 773:
====Eyes====
====Eyes====
The examination should focus on:
The examination should focus on:
*acuity
*Acuity
*blood pressure
*Blood pressure
*color vision
*Color vision
*cranial exam
*Cranial exam
*cranial nerve innervation
*cranial nerve innervation
*fundus
*Fundus
*intraocular pressure
*Intraocular pressure
*ocular media opacity
*Ocular media opacity
*optic disc exam
*Optic disc exam


===Laboratory Findings===  
===Laboratory Findings===  
*ESR
*ESR
*fasting blood glucose
*Fasting blood glucose
*HgBa1c
*HgBa1c
*PPD  
*PPD  
Line 144: Line 791:
*FTR-ABS
*FTR-ABS
*ACE level
*ACE level
*vitamin B12
*Vitamin B12
*folate
*Folate


=== MRI and CT ===  
=== MRI and CT ===  
*CT/MRI of head and chest
*CT/MRI of head and chest
==Evaluation of Monocular Transient Visual Loss==
<span style="font-size: 85%;">
'''Abbreviations''':
'''TVL''', transient visual loss.
</span>
{{Family tree/start}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | | | | A01 | | | | | | | |A01=<div style="text-align: center; padding: 15px;"><BIG>'''Monocular TVL'''</BIG></div>}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | | | | |!| | | | | | | | |}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | | | | A02 | | | | | | | |A02=<div style="padding: 15px; font-weight: bold;"><BIG>Does Monocular TVL Occur Only in Certain Positions of Gaze (Gaze-Evoked TVL)?</BIG></div>}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | | | | |!| | | | | | | | |}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | |,|-|-|^|-|-|.| | | | | |}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | A03 | | | | A04 | | | | |A03=<div style="text-align: center; padding: 15px; font-weight: bold;"><BIG>YES</BIG></div>|A04=<div style="text-align: center; padding: 15px; font-weight: bold;"><BIG>NO</BIG></div>}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | |!| | | | | |!| | | | | |}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | A05 | | | | |!| | | | | |A05=<div style="text-align: center; padding: 15px; font-weight: bold;"><BIG>Orbital MRI</BIG></div>}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | |!| | | | | |!| | | | | |}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | |,|-|-|^|-|-|.| | |!| | | | | |}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | A06 | | | | A07 | |!| | |A06=<div style="text-align: center; padding: 15px; font-weight: bold;"><BIG>Structural lesion of orbit</BIG></div>|A07=<div style="text-align: center; padding: 15px; font-weight: bold;"><BIG>No structural lesion of orbit</BIG></div>}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | | | | |!| | |!| | | | | |}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | | | | A08 |-|'| | | |A08=<div style="text-align: center; padding: 15px; font-weight: bold;"><BIG>Duration of TVL?</BIG></div>}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | | | | |!| | | | | |}}
{{Family tree|boxstyle=text-align: left; font-size: 80%; padding: 0px;  | | | | | | | | A09 | |A09=<table style="width: 100%; border: 2px solid #A8A8A8;" align="center">
<caption> <small><i>Causes of Transient Visual Loss Based on the Duration</i><ref name="isbn978-1588901361">{{cite book | author = | authorlink = | editor = | others = | title = Clinical Pathways in Neuro-ophthalmology: An Evidence-based Approach | edition = | language = | publisher = | location = | year = | origyear = | pages = | quote = | isbn = 978-1588901361 | oclc = | doi = | url = | accessdate = }}</ref></small>
</caption>
<tr>
<td align="center" style="background: #C2DFFF; font-size: 75%; padding: 5px; width: 33%;"> <b>TVL lasts seconds</b>
</td>
<td align="center" style="background: #B0B0B0; font-size: 75%; padding: 5px; width: 33%;"> <b>TVL lasts minutes</b>
</td>
<td align="center" style="background: #FFB5DA; font-size: 75%; padding: 5px; width: 33%;"> <b>TVL lasts hours</b>
</td></tr>
<tr>
<td style="font-size: 90%; padding: 0 5px; background: #E0EFFF;" valign="top">
<ul>
<li> Papilledema
</li>
<li> Optic neuropathy
</li>
<li> Congenital disc anomaly
</li>
<li> Thromboembolism (rare)
</li>
</ul>
</td>
<td style="font-size: 90%; padding: 0 5px; background: #DCDCDC;" valign="top">
<ul>
<li> Migraine
</li>
<li> Giant cell arteritis
</li>
<li> Thromboembolism
</li>
<li> Hypercoagulable state
</li>
<li> Antiphospholipid antibody syndrome
</li>
<li> Spontaneous hyphema
</li>
<li> Intermittent angle closure glaucoma
</li>
<li> Morning glory syndrome
</li>
<li> Peripapillary staphyloma
</li>
<li> Carotid artery dissection
</li>
<li> Venous stasis retinopathy
</li>
<li> Post-scleral buckle
</li>
</ul>
</td>
<td style="font-size: 90%; padding: 0 5px; background: #FEDAEC;" valign="top">
<ul>
<li> Spontaneous hyphema
</li>
<li> Thromboembolism
</li>
<li> Carotid stenosis
</li>
<li> Migraine
</li>
</ul>
</td></tr></table>}}
{{Family tree/end}}


== Treatment ==
== Treatment ==
===Medical Therapy===  
===Medical Therapy===  
*Systemic Steroids can be prescribed for the following:
*Systemic Steroids can be prescribed for the following:
Line 161: Line 893:
:*Asprin
:*Asprin
*Cavernous sinus thrombosis
*Cavernous sinus thrombosis
:*antibiotics
:*Antibiotics
:*anticoagulation
:*Anticoagulation
*Corneal hydrops
*Corneal hydrops
:*cycloplegic,hypertonic NaCl ointment
:*Cycloplegic,hypertonic NaCl ointment


===Surgery===  
===Surgery===  
===Corneal Hydrops===
===Corneal Hydrops===
Corneal transplant
Corneal transplant
===Retinal Detachment===
===Retinal Detachment===
Surgical repair
Surgical repair
===Cataracts===
===Cataracts===
Surgical removal
Surgical removal
 
===Temporal Arteritis===
===Temporal arteritis===
Temporal biopsy and steroids.
Temporal biopsy
 
==References ==
{{reflist|2}}


==Related Chapters==
==Related Chapters==
Line 189: Line 914:
*[[Visual acuity]]
*[[Visual acuity]]
*[[Visual impairment]]
*[[Visual impairment]]
 
==References ==
{{WH}}
{{reflist|2}}
{{WS}}


[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Symptoms]]
[[Category:Signs and symptoms]]
[[Category:Signs and symptoms]]
[[Category:Blindness]]
[[Category:Blindness]]
[[Category:Ophthalmology]]
[[Category:Ophthalmology]]
{{WH}}
{{WS}}

Latest revision as of 23:19, 10 January 2020

For patient information, click here

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Jyostna Chouturi, M.B.B.S [2] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.

Synonyms and keywords: Visual loss

Overview

Vision loss is the absence of vision where it existed before, which can happen either acutely (i.e. abruptly) or chronically (i.e. over a long period of time). It may be caused by media opacities, retinal disease, optic nerve disease, visual pathway disorders, or functional disorders, or it may be due to an abnormality in the central nervous system.

Classification

In order to gain insight into the pathophysiology of vision loss which will in turn guide treatment decisions, the signs and symptoms should be characterized:

  • Unilateral
  • Bilateral
  • Transient
  • Persistant
  • Sudden
  • Gradual
  • Painless
  • Painful

Pathophysiology

Media Opacity

Opacities of the clear refractive media of the eye such as the cornea, anterior chamber, lens, and vitreous humor may cause acute visual loss as manifested by blurry vision or reduced visual acuity. While pupillary reflexes may be affected, these conditions generally do not cause a relative afferent pupillary defect.

Causes of media opacity include corneal edema, hyphema, cataract and vitreous hemorrhage.

Retinal Disease

Retinal diseases may cause sudden visual loss. Because the retina is being affected, there is usually a concomitant relative afferent pupillary defect. Conditions that affect or destroy the retina include retinal detachment; macular disease (e.g., macular degeneration); and retinal vascular occlusions, the most important of which is central retinal artery occlusion.

Optic Nerve Disease

Diseases which affect the optic nerve may cause acute visual loss. Signs include an abnormal pupillary reflex, with an afferent pupillary defect when the optic nerve disease is unilateral.

The optic nerve can be affected by many diseases including optic neuritis, retrobulbar neuritis, papillitis, papilledema, glaucoma, ischemic optic neuropathy, and giant cell arteritis.

Hypoxia

The eye is very sensitive to restriction of its supply of oxygen. A dimming of vision (a brownout or greyout) accompanied by loss of peripheral perception may result from low blood pressure, shock, g-LOC (an aviation related problem) or simply standing up suddenly, especially if sick or otherwise infirm. Vision usually returns readily once the conditions restricting blood flow are lifted.

Visual Pathway Disorder

Visual pathway disorders are any problems that may impede the visual pathway. Rarely, acute visual loss is caused by homonymous hemianopia and, more rarely, cortical blindness.

Functional Disorder

The term functional disorder is now used where hysterical and malingering were historically used. This shift recognizes the inherent inability of the physician to identify the subjective experience of a patient (and thus whether that patient can truly see or not).

Causes

Transient Vision Loss (<24 hours)

  • Amaurosis fugax
  • Vision loss is unilateral and lasts only minutes
  • Vision loss lasts 10-60 minutes
  • Raised intracranial pressure
  • Malignant hypertension
  • Retinal detachment
  • Sudden change in blood pressure
  • Orthostatic hypotension
  • Transient acute increase in thraocular pressure
  • Acute Angle Closure Glaucoma
  • Retro-or peribulbar hemorrhage
  • Vertebrobasilar artery insufficiency
  • Vision loss is bilateral and lasts minutes
  • Vitreous hemorrhage
  • Vitreous detachment

Vision Loss > 24 hours:Sudden, Painless

  • Exposure(Welder's flash)
  • prolonged exposure to intense light/sunlight
  • Ischemic optic neuropathy
  • To prevent permanent loss, rule out giant cell/temporal arteritis
  • Other retinal or central nervous system disease
  • Occipital lobe CVA causing cortical blindness
  • Optic Neuritis
  • Retinal artery/vein occlusion
  • Retinal detachment
  • Vitreous or aqueous hemmorrhage (hyphema)

Vision Loss >24 hours:Gradual, Painless

  • Chronic corneal disease
  • Corneal dystrophy
  • Corneal Ulcer
  • Open angle Glaucoma
  • Optic neuropathy/atrophy
  • Compressive lesion
  • Toxic-metabolic cause
  • Radiation
  • Pseudotumor cerebri
  • Refractive error
  • Retitnitis pigmentosa

Vision Loss >24 hours:Painful

  • Acute Angle Closure Glaucoma
  • Corneal hydrops
  • Keratoconus
  • Corneal abrasion/ulcer
  • Herepes simplex/zoster
  • Ocular onchocerciasis
  • "River blindness"
  • Onchocera volvulus worm
  • Optic neuritis
  • Orbital apex/superior orbital fissure/cavernous sinus syndrome
  • Uveitis


Life-Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular Al amyloidosis, Arachnoiditis, Arteriovenous malformation, Atherosclerosis, Basilar artery insufficiency syndrome, Basilar artery migraine , Cardiomyopathy, Carotid atherosclerosis, Carotid-cavernous fistula, Central retinal artery occlusion, Central retinal vein occlusion, Central serous chorioretinopathy, Cerebrovascular accident, Charge syndrome, Giant cell arteritis, Hurler syndrome, Hypertension of pregnancy, Ischemic optic neuropathy, Malignant hypertension, Microvascular diabetes complications, Microvascular disease, Ocular ischemic syndrome, Retinal artery occlusion, Retinal vein occlusion , Stroke, Takayasu arteritis, Temporal arteritis, Transient ischaemic attack, Vascular diseases, Vascular retinopathies, Vasculitis , Vertebral artery dissection
Chemical/Poisoning Aminosalicylic acid, Capreomycin sulfate, Herbal agent overdose , Irinotecan hydrochloride, Mayapple poisoning , Monosodium methanarsenate , O'higgins disease , Radium chloride, Strontium chloride, Valganciclovir hydrochloride
Dental Oligodontia
Dermatologic Albinism, Alezzandrini syndrome , Behcet's disease, Cross syndrome, Ectodermal dysplasia , Keratitis, Keratomalacia, Mucous membrane pemphigoid, Oculocutaneous albinism, Pachydermoperiostosis, Panuveitis , Pigmentary retinopathy , Rufous oculocutaneous albinism , Shingles
Drug Side Effect Amitriptyline, Carbachol, Carbamazepine, Celecoxib, Cesium, Chalazion, Chlorpheniramine, Cinnarizine, Clomifene, Coenzyme q - cytochrome c reductase, Deferoxamine, Desipramine, Diphenhydramine, Dothiepin, Hydroxyzine, Ivabradine, Lithium, Mefloquine, Methanol, Monosodium methanarsenate , Monosodium methyl arsenate, Morpholine , Nortriptyline, Phenylbutazone, Physostigmine, Pipecolic acidemia, Prochlorperazine, Pterygium, Quinidine, Rofecoxib, Sclerostin, Septum pellucidum, Temozolomide, Thalidomide, Verteporfin, Vigabatrin
Ear Nose Throat No underlying causes
Endocrine Albinism, Ceroid lipofuscinosis, Citrullinemia , Empty sella syndrome , Graves ophthalmopathy, Infantile refsum disease, Kallmann syndrome, Linear iga bullous dermatosis, Mucopolysaccharidosis, Mucosa-associated lymphoid tissue, Multiple endocrine neoplasia type 1 , Nelson syndrome, Niemann-pick disease, Nyssen-van bogaert syndrome , Pellagra-like syndrome, Pituitary adenoma, Thyroid eye disease 
Environmental Foreign body
Gastroenterologic Diabetic ketoacidosis, Herpetic keratitis , Hurler syndrome, Mucormycosis , Sandhoff disease
Genetic 13q deletion syndrome, 3 alpha methylglutaconicaciduria, Alström syndrome, Amaurosis congenita of leber , Amelogenesis imperfecta, Ampola syndrome , Bardet-biedl syndrome, Blue cone monochromatism , Cassia stocco dos santos syndrome, Cenani lenz syndactylism, Charcot-marie-tooth syndrome, Chromosome 11, deletion 11p , Chromosome 13, partial monosomy 13q , Chromosome 13q deletion syndrome , Chromosome 13q deletion , Chromosome 14q, partial deletion , Chromosome 17, deletion 17q23 q24 , Chromosome 2p deletion syndrome , Classic childhood ald , Cohen syndrome, Congenital disorder of glycosylation type 1g , Cross syndrome, Deletion 11p , Deletion 13q , Didmoad syndrome, Ehlers-danlos syndrome , Emanuel syndrome , Familial amyloid polyneuropathy, Familial infantile metachromatic leukodystrophy, Franceschetti-klein syndrome , Francois dyscephalic syndrome , Goldberg–shprintzen syndrome, Gronblad-strandberg-touraine syndrome, Gustavson syndrome , Hallervorden-spatz syndrome , Hand-schuller-christian syndrome, Hereditary diseases, Herns syndrome , Imidazole syndrome, Incontinentia pigmenti, Infant cytomegalic virus , Juvenile retinoschisis , Kearns–sayre syndrome, Krause-kivlin syndrome, Lawrence-moon syndrome, Leber's congenital amaurosis, Lobstein disease, Mercaptolactace-cysteine disulfiduria, Neuroaxonal dystrophy, Noble-bass-sherman syndrome , Norrie syndrome , Oguchi disease , Osteochondrodysplatic dwarfism, Partial monosomy 13q, Plum syndrome , Polychondritis , Pseudoxanthoma elasticum, Purtscher's retinopathy, Pyle disease , Rieger syndrome , Roberts syndrome, Roy-maroteaux-kremp syndrome , Schindler disease, Sialidosis, Simell-takki syndrome, Singh-chhaparwal-dhanda syndrome, Small syndrome , Smith martin dodd syndrome, Spherophakia-brachymorphia syndrome, Stargardt disease, Stevens-johnson syndrome, Stickler syndrome, Syndactyly, Tapetal-like reflex , Tay-sachs disease, Treacher collins syndrome, Usher syndrome
Hematologic Aspartoacylase deficiency, Avitaminosis, Brain aneurysm, Canavan leukodystrophy , Catastrophic antiphospholipid syndrome, Cree leukoencephalopathy , Diabetes insipidus, Ebola , Familial infantile metachromatic leukodystrophy, Galactokinase deficiency, Homonymous hemianopia, Hypoglycaemia, Intraocular hemorrhage, Krabbe leukodystrophy, Langerhans cell histiocytosis, Leukodystrophy, Lymphoma, Metachromatic leukodystrophy, Neurodegeneration with brain iron accumulation, Ornithine translocase deficiency, Posterior leucoencephalopathy syndrome, Progressive multifocal leukoencephalopathy, Sickle cell anemia, Subacute sclerosing leukoencephalitis , Transthyretin amyloidosis , Vitamin a deficiency
Iatrogenic No underlying causes
Infectious Disease Acanthamoeba, Achromatopsia, Acromegaloid, Acute disseminated encephalomyelitis, Acute retinal necrosis, Alveolar hydatid disease, Blepharitis, Congenital cytomegalovirus infection, Congenital rubella syndrome, Congenital toxoplasmosis, Creutzfeldt jakob disease, Cytomegalovirus retinitis , Cytomegalovirus , Ebola , Euphorbiaceae, Feline spongiform encephalopathy , Fundus albipunctatus, Giant cell arteritis, Helminth infections , Herpes simplex, Hiv, Infant cytomegalic virus , Inflammatory processes, Mucormycosis , Multifocal choroiditis, Mycosis fungoides, Ocular herpes , Ocular histoplasmosis syndrome , Panuveitis , Papillitis, Presumed ocular histoplasmosis syndrome, Rhabditida, Rhinocerebral mucormycosis , Rhinocerebral zygomycosis , Rhino-orbito-cerebral phycomycosis , Rift valley fever, Secernentea, Shingles, Syphilis, Toxoplasmosis, Uveitis
Musculoskeletal/Orthopedic Cardiomyopathy, Cartilaginous, Ciliary muscle spasm, Cycloplegia, Dysosteosclerosis , Episodic ataxia, Neuropathic ataxia , Osteoporosis , Posterior column ataxia , Rhabdomyosarcoma, Spastic tetraplegic , Spinocerebellar ataxia
Neurologic Acute disseminated encephalomyelitis, Alpers' disease, Amaurosis fugax, Anencephaly , Arachnoiditis, Basilar artery migraine , Batten disease, Bessman-baldwin syndrome , Bilateral occipital lobe infarct, Bilateral optic neuritis, Bilateral papilloedema, Bonnet-dechaume-blanc syndrome, Brain aneurysm, Brain tumors, Cerebral palsy, Ceroid lipofuscinosis, Charcot-marie-tooth syndrome, Cluster headache, Concussion, Conversion disorder, Craniodiaphyseal dysplasia , Craniometaphyseal dysplasia, Craniosynostosis , Craniotelencephalic dysplasia , Creutzfeldt jakob disease, Devic disease , Empty sella syndrome , Encephalocele anterior , Encephalocele frontal , Encephalocele, Endophthalmitis, Episodic ataxia, Esthesioneuroblastoma , Fahr's syndrome, Familial amyloid polyneuropathy, Feline spongiform encephalopathy , Flynn-aird syndrome , Ghose-sachdev-kumar syndrome , Heidenhain syndrome , Hydranencephaly , Hydrocephalus , Increased intracranial pressure, Infantile neuroaxonal dystrophy, Ischemic optic neuropathy, Jensen syndrome , Lethal congenital contracture syndrome, Lowe oculocerebrorenal syndrome , Microcephaly , Midline craniofacial anomalies , Migraine, Minamata disease, Mitochondrial disease , Morning glory disc anomaly, Multiple lentigines syndrome, Multiple sclerosis , Neuroaxonal dystrophy, Neurodegeneration with brain iron accumulation, Neurodegenerative syndrome, Neurofibromatosis, Neuromyelitis optica, Neuropathic ataxia , Neuropathy , Niemann-pick disease, Night blindness, Oculocerebrorenal syndrome, Olivopontocerebellar atrophy , Ophthalmoplegia, Optic nerve compression, Optic nerve disorder, Optic neuritis, Optic pathway glioma , Opticoacoustic nerve atrophy dementia , Pantothenate kinase-associated neurodegeneration , Papilledema, Papilloedema, Paraneoplastic cerebellar degeneration, Peripheral type neurofibromatosis , Photopsia, Posterior column ataxia , Progressive supranuclear palsy, Pseudotumor cerebri, Retinal migraine , Rhinocerebral mucormycosis , Rhinocerebral zygomycosis , Rhino-orbito-cerebral phycomycosis , Rift valley fever, Senior-loken syndrome , Spastic tetraplegic , Spinocerebellar ataxia, Subacute myelo-optic neuropathy, Subacute sclerosing panencephalitis, Sudanophilic cerebral sclerosis, Tay-sachs disease, Temporal arteritis, Tolosa-hunt syndrome, Treacher collins syndrome, Vertebral artery dissection, Visual hallucinations
Nutritional/Metabolic Avitaminosis, Blue diaper syndrome, Diabetes insipidus, Diabetic eye disease , Diabetic ketoacidosis, Diabetic retinopathy , Gangliosidosis , Hypoglycaemia, Imidazole syndrome, Microvascular diabetes complications, Mucolipidosis, Nutritional deficiencies, Osteoporosis , Pyruvate decarboxylase deficiency , Pyruvate decarboxylase, Schindler disease, Sclerosteosis , Senter syndrome , Sialidosis, Vitamin a deficiency,
Obstetric/Gynecologic Hypertension of pregnancy, Pre-eclampsia
Oncologic Brain tumors, Car syndrome , Eye cancer, Eye melanoma , Glioblastoma , Intraocular melanoma, Langerhans cell histiocytosis, Lymphoma, Melanoma of the choroid , Multiple endocrine neoplasia type 1 , Nasopharyngeal carcinoma, Nasopharynx cancer , Occipital lobe tumours, Ocular oncology, Orbit tumour , Orbital lymphangioma , Orbital mass, Paraneoplastic cerebellar degeneration, Phacolytic glaucoma , Pituitary adenoma, Pseudotumor cerebri, Retinoblastoma , Rhabdomyosarcoma, Trachoma , Uveal melanoma
Ophthalmologic Acute posterior multifocal placoid pigment epitheliopathy, Acute retinal necrosis, Age-related macular degeneration, Amaurosis fugax, Amblyopia, Angioid streaks , Aniridia , Anisometropia , Anophthalmia, Anophthalmos, Anterior segment mesenchymal dysgenesis, Arteriovenous malformation, Asthenopia , Autoimmune uveitis , Axenfeld-rieger syndrome, Basement membrane corneal dystrophy, Benign essential blepharospasm, Bessman-baldwin syndrome , Best vitelliform macular dystrophy, Best's disease, Bilateral occipital lobe infarct, Bilateral optic neuritis, Blepharitis, Blind spot, Blindness, Bothnia retina dystrophy, Calcification of basal ganglia , Carotid-cavernous fistula, Cataract, Central retinal artery occlusion, Central retinal vein occlusion, Central serous chorioretinopathy, Chandler's syndrome, Chorioretinitis , Choroideremia , Choroiditis , Cloudy cornea (patient information), Cogan-reese syndrome , Cogan's syndrome , Coloboma, Color blindness, Cone dystrophy , Cone rod dystrophy , Congenital x-linked retinoschisis , Conversion disorder, Cornea plana 1, Corneal dystrophy, Corneal foreign body, Corneal hypesthesia , Corneal opacity, Corneal ulcer , Cortical blindness, Cortical hyperostosis, Craniodiaphyseal dysplasia , Cycloplegia, Cystoid macular dystrophy, Cytomegalovirus retinitis , Dermatoosteolysis, Devic disease , Diabetic eye disease , Diabetic retinopathy , Dry eye, Eales disease, Endophthalmitis, Enhanced s-cone syndrome , Essential iris atrophy, Eye cancer, Eye injury, Eye melanoma , Fuchs atrophia gyrata chorioideae et retinae , Fuchs' dystrophy, Glaucoma, Hemianopia , Hyperopia, Hyperornithinemia , Hyphema, Infantile cortical hyperostosis, Intraocular hemorrhage, Intraocular melanoma, Intraocular pressure, Iridocorneal endothelial syndrome, Iridocyclitis, Iridogoniodysgenesis, Lattice corneal dystrophy , Leber's congenital amaurosis, Leber's optic atrophy, Lens pathology, Lowe oculocerebrorenal syndrome , Macular degeneration, Macular dystrophy, Macular edema, Macular hole, Maculopathy, Malignant hypertension, Marsden syndrome , Marshall syndrome, Melanoma of the choroid , Metamorphopsia, Metaphyseal dysplasia, Microphthalmia, Microphthalmos, Morning glory disc anomaly, Multifocal choroiditis, Neuromyelitis optica, Night blindness, Nutritional amblyopia, Obal syndrome, Occipital lobe tumours, Ocular cicatricial pemphigoid , Ocular herpes , Ocular histoplasmosis syndrome , Ocular ischemic syndrome, Ocular oncology, Ocular trauma, Oculocerebrorenal syndrome, Oculocutaneous albinism, Oguchi disease , Oligodontia, Olivopontocerebellar atrophy , Open-angle glaucoma, Ophthalmia neonatorum, Ophthalmoplegia, Optic atrophy, Optic nerve compression, Optic nerve disorder, Optic neuritis, Optic pathway glioma , Opticoacoustic nerve atrophy dementia , Orbit tumour , Orbital lymphangioma , Orbital mass, Osteochondrodysplatic dwarfism, Papillitis, Periorbital cellulitis, Photopsia, Pigmentary retinopathy , Posterior vitreous detachment , Presbyopia , Presumed ocular histoplasmosis syndrome, Progressive multifocal leukoencephalopathy, Protanopia , Purtscher's retinopathy, Raised intraocular pressure, Ramos-arroyo syndrome , Reese-ellsworth syndrome , Refractive error, Refsum disease , Retinal artery occlusion, Retinal cone dystrophy , Retinal degeneration , Retinal detachment, Retinal dysplasia, Retinal migraine , Retinal tear , Retinal vein occlusion , Retinitis pigmentosa, Retinitis punctata albescens , Retinoblastoma , Retinopathy, Retinoschisis , Retrolental fibroplasia, Rollet syndrome , Rufous oculocutaneous albinism , Scleritis, Senile macular degeneration, Senile retinoschisis, Senior-loken syndrome , Septo-optic dysplasia, Simell-takki syndrome, Singh-chhaparwal-dhanda syndrome, Small syndrome , Smith martin dodd syndrome, Spherophakia-brachymorphia syndrome, Stargardt disease, Stevens-johnson syndrome, Stickler syndrome, Subacute combined degeneration of the cord, Subacute myelo-optic neuropathy, Subacute sclerosing leukoencephalitis , Subacute sclerosing panencephalitis, Superior orbital fissure, Thyroid eye disease , Usher syndrome, Uveal diseases, Uveal melanoma, Uveitis, Vascular diseases, Vascular retinopathies, Vasculitis , Vasterbotten dystrophy , Verloes van maldergem marneffe syndrome , Vision impairment , Visual hallucinations
Overdose/Toxicity No underlying causes
Psychiatric Hysteria, Mental retardation , Psychogenic, Shaken baby syndrome,
Pulmonary Alveolar hydatid disease, Sarcoidosis
Renal/Electrolyte Alport syndrome, Hypophosphatemia, Renal tubulopathy
Rheumatology/Immunology/Allergy Al amyloidosis, Behcet's disease, Besnier-boeck-schaumann disease , Inflammatory processes, Leprosy, Mucous membrane pemphigoid, Sarcoidosis
Sexual Herpes simplex, Hiv, Syphilis
Trauma Concussion, Eye injury, Head injury , Ocular trauma, Retinal tear , Superior orbital fissure
Urologic Hypophosphatemia
Miscellaneous No underlying causes

Causes in Alphabetical Order

Diagnosis

History and Symptoms

History
include:

  • Age
  • Onset:
  • Rate of loss
  • Any specific trauma
  • Headaches
  • Medication
  • Specific medical history
  • Alcohol, drug and/or tabacco use

Physical Examination

Eyes

The examination should focus on:

  • Acuity
  • Blood pressure
  • Color vision
  • Cranial exam
  • cranial nerve innervation
  • Fundus
  • Intraocular pressure
  • Ocular media opacity
  • Optic disc exam

Laboratory Findings

  • ESR
  • Fasting blood glucose
  • HgBa1c
  • PPD
  • RPR
  • FTR-ABS
  • ACE level
  • Vitamin B12
  • Folate

MRI and CT

  • CT/MRI of head and chest

Evaluation of Monocular Transient Visual Loss

Abbreviations: TVL, transient visual loss.

 
 
 
 
 
 
 
Monocular TVL
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Does Monocular TVL Occur Only in Certain Positions of Gaze (Gaze-Evoked TVL)?
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
YES
 
 
 
NO
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Orbital MRI
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Structural lesion of orbit
 
 
 
No structural lesion of orbit
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Duration of TVL?
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Causes of Transient Visual Loss Based on the Duration[1]
TVL lasts seconds TVL lasts minutes TVL lasts hours
  • Papilledema
  • Optic neuropathy
  • Congenital disc anomaly
  • Thromboembolism (rare)
  • Migraine
  • Giant cell arteritis
  • Thromboembolism
  • Hypercoagulable state
  • Antiphospholipid antibody syndrome
  • Spontaneous hyphema
  • Intermittent angle closure glaucoma
  • Morning glory syndrome
  • Peripapillary staphyloma
  • Carotid artery dissection
  • Venous stasis retinopathy
  • Post-scleral buckle
  • Spontaneous hyphema
  • Thromboembolism
  • Carotid stenosis
  • Migraine
 

Treatment

Medical Therapy

  • Systemic Steroids can be prescribed for the following:
  • Temporal arteritis
  • Optic neuritis
  • Pituitary apoplexy
  • Herpes zoster
  • Nonarteritic ischemic optic neuropathy patients
  • Asprin
  • Cavernous sinus thrombosis
  • Antibiotics
  • Anticoagulation
  • Corneal hydrops
  • Cycloplegic,hypertonic NaCl ointment

Surgery

Corneal Hydrops

Corneal transplant

Retinal Detachment

Surgical repair

Cataracts

Surgical removal

Temporal Arteritis

Temporal biopsy and steroids.

Related Chapters

References

  1. Clinical Pathways in Neuro-ophthalmology: An Evidence-based Approach. ISBN 978-1588901361.


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