RPS6KA4: Difference between revisions

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{{Infobox_gene}}
'''Ribosomal protein S6 kinase alpha-4''' is an [[enzyme]] that in humans is encoded by the ''RPS6KA4'' [[gene]].<ref name="pmid9792677">{{cite journal |vauthors=Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W | title = RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK) | journal = J Biol Chem | volume = 273 | issue = 45 | pages = 29661–29671 |date=Dec 1998 | pmid = 9792677 | pmc =  | doi =10.1074/jbc.273.45.29661  }}</ref><ref name="pmid9687510">{{cite journal |vauthors=Deak M, Clifton AD, Lucocq LM, Alessi DR | title = Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB | journal = EMBO J | volume = 17 | issue = 15 | pages = 4426–4441 |date=Sep 1998 | pmid = 9687510 | pmc = 1170775 | doi = 10.1093/emboj/17.15.4426 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8986| accessdate = }}</ref>
== Function ==
This gene encodes a member of the RSK ([[ribosomal S6 kinase]]) family of [[serine/threonine kinase]]s. This kinase contains 2 non-identical kinase catalytic domains and [[phosphorylates]] various substrates, including [[CREB1]] and [[c-Fos]]. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez"/>
== Interactions ==
RPS6KA4 has been shown to [[Protein-protein interaction|interact]] with [[MAPK14]].<ref name="pmid9792677"/>
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  |vauthors=Xing J, Ginty DD, Greenberg ME |title=Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase |journal=Science |volume=273 |issue= 5277 |pages= 959–963 |year= 1996 |pmid= 8688081 |doi=10.1126/science.273.5277.959  }}
*{{cite journal  |vauthors=Du K, Montminy M |title=CREB is a regulatory target for the protein kinase Akt/PKB |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32377–32379 |year= 1999 |pmid= 9829964 |doi=10.1074/jbc.273.49.32377  }}
*{{cite journal  |vauthors=Tomás-Zuber M, Mary JL, Lesslauer W |title=Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23549–23558 |year= 2000 |pmid= 10806207 |doi= 10.1074/jbc.M002586200 }}
*{{cite journal  | author=Tomás-Zuber M |title=C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB) |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5892–5899 |year= 2001 |pmid= 11035004 |doi= 10.1074/jbc.M005822200  |name-list-format=vanc| author2=Mary JL  | author3=Lamour F  | display-authors=3  | last4=Bur  | first4=D  | last5=Lesslauer  | first5=W }}
*{{cite journal  | author=Gudi T |title=NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation |journal=Oncogene |volume=19 |issue= 54 |pages= 6324–6333 |year= 2001 |pmid= 11175347 |doi= 10.1038/sj.onc.1204007  |name-list-format=vanc| author2=Casteel DE  | author3=Vinson C  | display-authors=3  | last4=Boss  | first4=Gerry R  | last5=Pilz  | first5=Renate B }}
*{{cite journal  | author=Prymakowska-Bosak M |title=Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5169–5178 |year= 2001 |pmid= 11438671 |doi= 10.1128/MCB.21.15.5169-5178.2001  | pmc=87241  |name-list-format=vanc| author2=Misteli T  | author3=Herrera JE  | display-authors=3  | last4=Shirakawa  | first4=H.  | last5=Birger  | first5=Y.  | last6=Garfield  | first6=S.  | last7=Bustin  | first7=M. }}
*{{cite journal  | author=Wiggin GR |title=MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2871–2881 |year= 2002 |pmid= 11909979 |doi=10.1128/MCB.22.8.2871-2881.2002  | pmc=133730  |name-list-format=vanc| author2=Soloaga A  | author3=Foster JM  | display-authors=3  | last4=Murray-Tait  | first4=V.  | last5=Cohen  | first5=P.  | last6=Arthur  | first6=J. S. C.  }}
*{{cite journal  | author=Soloaga A |title=MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 |journal=EMBO J. |volume=22 |issue= 11 |pages= 2788–2797 |year= 2003 |pmid= 12773393 |doi= 10.1093/emboj/cdg273  | pmc=156769  |name-list-format=vanc| author2=Thomson S  | author3=Wiggin GR  | display-authors=3  | last4=Rampersaud  | first4=N  | last5=Dyson  | first5=MH  | last6=Hazzalin  | first6=CA  | last7=Mahadevan  | first7=LC  | last8=Arthur  | first8=JS }}
*{{cite journal  | author=Wissing J |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry |journal=Mol. Cell. Proteomics |volume=6 |issue= 3 |pages= 537–547 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200  |name-list-format=vanc| author2=Jänsch L  | author3=Nimtz M  | display-authors=3  | last4=Dieterich  | first4=G.  | last5=Hornberger  | first5=R.  | last6=Keri  | first6=G.  | last7=Wehland  | first7=J.  | last8=Daub  | first8=H. }}
*{{cite journal  | author=Gesser B |title=Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect |journal=J. Invest. Dermatol. |volume=127 |issue= 9 |pages= 2129–2137 |year= 2007 |pmid= 17495961 |doi= 10.1038/sj.jid.5700859  |name-list-format=vanc| author2=Johansen C  | author3=Rasmussen MK  | display-authors=3  | last4=Funding  | first4=Anne T  | last5=Otkjaer  | first5=Kristian  | last6=Kjellerup  | first6=Rasmus B  | last7=Kragballe  | first7=Knud  | last8=Iversen  | first8=Lars }}
}}
{{refend}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Category:EC 2.7.11]]
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Ribosomal protein S6 kinase, 90kDa, polypeptide 4
| HGNCid = 10433
| Symbol = RPS6KA4
| AltSymbols =; MSK2; RSK-B
| OMIM = 603606
| ECnumber = 
| Homologene = 69288
| MGIid = 1930076
| GeneAtlas_image1 = PBB_GE_RPS6KA4_204632_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004711 |text = ribosomal protein S6 kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0048273 |text = mitogen-activated protein kinase p38 binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8986
    | Hs_Ensembl = ENSG00000162302
    | Hs_RefseqProtein = NP_001006945
    | Hs_RefseqmRNA = NM_001006944
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 63883201
    | Hs_GenLoc_end = 63896263
    | Hs_Uniprot = O75676
    | Mm_EntrezGene = 56613
    | Mm_Ensembl = ENSMUSG00000024952
    | Mm_RefseqmRNA = NM_019924
    | Mm_RefseqProtein = NP_064308
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 6896129
    | Mm_GenLoc_end = 6907671
    | Mm_Uniprot = Q3U3M8
  }}
}}
'''Ribosomal protein S6 kinase, 90kDa, polypeptide 4''', also known as '''RPS6KA4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8986| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8986| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Xing J, Ginty DD, Greenberg ME |title=Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. |journal=Science |volume=273 |issue= 5277 |pages= 959-63 |year= 1996 |pmid= 8688081 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Deak M, Clifton AD, Lucocq LM, Alessi DR |title=Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. |journal=EMBO J. |volume=17 |issue= 15 |pages= 4426-41 |year= 1998 |pmid= 9687510 |doi= 10.1093/emboj/17.15.4426 }}
*{{cite journal  | author=Pierrat B, Correia JS, Mary JL, ''et al.'' |title=RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29661-71 |year= 1998 |pmid= 9792677 |doi=  }}
*{{cite journal  | author=Du K, Montminy M |title=CREB is a regulatory target for the protein kinase Akt/PKB. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32377-9 |year= 1999 |pmid= 9829964 |doi=  }}
*{{cite journal  | author=Zhu S, Gerhard DS |title=A transcript map of an 800-kb region on human chromosome 11q13, part of the candidate region for SCA5 and BBS1. |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 674-80 |year= 1999 |pmid= 9921902 |doi=  }}
*{{cite journal  | author=Tomás-Zuber M, Mary JL, Lesslauer W |title=Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23549-58 |year= 2000 |pmid= 10806207 |doi= 10.1074/jbc.M002586200 }}
*{{cite journal  | author=Tomás-Zuber M, Mary JL, Lamour F, ''et al.'' |title=C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5892-9 |year= 2001 |pmid= 11035004 |doi= 10.1074/jbc.M005822200 }}
*{{cite journal  | author=Gudi T, Casteel DE, Vinson C, ''et al.'' |title=NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation. |journal=Oncogene |volume=19 |issue= 54 |pages= 6324-33 |year= 2001 |pmid= 11175347 |doi= 10.1038/sj.onc.1204007 }}
*{{cite journal  | author=Prymakowska-Bosak M, Misteli T, Herrera JE, ''et al.'' |title=Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin. |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5169-78 |year= 2001 |pmid= 11438671 |doi= 10.1128/MCB.21.15.5169-5178.2001 }}
*{{cite journal  | author=Wiggin GR, Soloaga A, Foster JM, ''et al.'' |title=MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2871-81 |year= 2002 |pmid= 11909979 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Soloaga A, Thomson S, Wiggin GR, ''et al.'' |title=MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. |journal=EMBO J. |volume=22 |issue= 11 |pages= 2788-97 |year= 2003 |pmid= 12773393 |doi= 10.1093/emboj/cdg273 }}
*{{cite journal  | author=Wissing J, Jänsch L, Nimtz M, ''et al.'' |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537-47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
*{{cite journal  | author=Gesser B, Johansen C, Rasmussen MK, ''et al.'' |title=Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect. |journal=J. Invest. Dermatol. |volume=127 |issue= 9 |pages= 2129-37 |year= 2007 |pmid= 17495961 |doi= 10.1038/sj.jid.5700859 }}
}}
{{refend}}


{{protein-stub}}
{{gene-11-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:28, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.[1][2][3]

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[3]

Interactions

RPS6KA4 has been shown to interact with MAPK14.[1]

References

  1. ↑ 1.0 1.1 Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem. 273 (45): 29661–29671. doi:10.1074/jbc.273.45.29661. PMID 9792677.
  2. ↑ Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
  3. ↑ 3.0 3.1 "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4".

Further reading


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