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{{Infobox_gene}}
{{PBB_Controls
'''Ribosomal protein S6 kinase, 90kDa, polypeptide 3''', also known as '''RPS6KA3''', is an [[enzyme]] that in humans is encoded by the ''RPS6KA3''  [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6197| accessdate = }}</ref><ref name="pmid8141249">{{cite journal | vauthors = Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M | title = Human rsk isoforms: cloning and characterization of tissue-specific expression | journal = The American Journal of Physiology | volume = 266 | issue = 2 Pt 1 | pages = C351–9 | date = February 1994 | pmid = 8141249 | doi = 10.1152/ajpcell.1994.266.2.C351| url = http://ajpcell.physiology.org/cgi/content/abstract/266/2/C351 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ribosomal protein S6 kinase, 90kDa, polypeptide 3
| HGNCid = 10432
| Symbol = RPS6KA3
| AltSymbols =; RSK; CLS; HU-3; ISPK-1; MAPKAPK1B; MRX19; RSK2; S6K-alpha3; p90-RSK2; pp90RSK2
| OMIM = 300075
| ECnumber = 
| Homologene = 37940
| MGIid = 104557
| GeneAtlas_image1 = PBB_GE_RPS6KA3_203843_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6197
    | Hs_Ensembl = ENSG00000177189
    | Hs_RefseqProtein = NP_004577
    | Hs_RefseqmRNA = NM_004586
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 20077950
    | Hs_GenLoc_end = 20194671
    | Hs_Uniprot = P51812
    | Mm_EntrezGene = 110651
    | Mm_Ensembl = ENSMUSG00000031309
    | Mm_RefseqmRNA = NM_148945
    | Mm_RefseqProtein = NP_683747
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 154600225
    | Mm_GenLoc_end = 154707590
    | Mm_Uniprot = P18654
  }}
}}
'''Ribosomal protein S6 kinase, 90kDa, polypeptide 3''', also known as '''RPS6KA3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6197| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the RSK ([[ribosomal S6 kinase]]) family of [[serine/threonine-specific protein kinase|serine/threonine kinase]]s. This kinase contains 2 non-identical kinase catalytic domains and [[phosphorylation|phosphorylates]] various substrates, including members of the [[mitogen-activated protein kinase|mitogen-activated kinase]] (MAPK) [[MAPK/ERK pathway|signalling pathway]]. The activity of this protein has been implicated in controlling cell growth and differentiation.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).<ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6197| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Omary MB, Baxter GT, Chou CF, ''et al.'' |title=PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18. |journal=J. Cell Biol. |volume=117 |issue= 3 |pages= 583-93 |year= 1992 |pmid= 1374067 |doi=  }}
*{{cite journal  | author=Ku NO, Omary MB |title=Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. |journal=J. Cell Biol. |volume=127 |issue= 1 |pages= 161-71 |year= 1994 |pmid= 7523419 |doi=  }}
*{{cite journal  | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi=  }}
*{{cite journal  | author=Zhao Y, Bjørbaek C, Weremowicz S, ''et al.'' |title=RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. |journal=Mol. Cell. Biol. |volume=15 |issue= 8 |pages= 4353-63 |year= 1995 |pmid= 7623830 |doi=  }}
*{{cite journal  | author=Bjørbaek C, Vik TA, Echwald SM, ''et al.'' |title=Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients. |journal=Diabetes |volume=44 |issue= 1 |pages= 90-7 |year= 1995 |pmid= 7813820 |doi=  }}
*{{cite journal  | author=Donnelly AJ, Choo KH, Kozman HM, ''et al.'' |title=Regional localisation of a non-specific X-linked mental retardation gene (MRX19) to Xp22. |journal=Am. J. Med. Genet. |volume=51 |issue= 4 |pages= 581-5 |year= 1994 |pmid= 7943043 |doi= 10.1002/ajmg.1320510457 }}
*{{cite journal  | author=Moller DE, Xia CH, Tang W, ''et al.'' |title=Human rsk isoforms: cloning and characterization of tissue-specific expression. |journal=Am. J. Physiol. |volume=266 |issue= 2 Pt 1 |pages= C351-9 |year= 1994 |pmid= 8141249 |doi=  }}
*{{cite journal  | author=Xing J, Ginty DD, Greenberg ME |title=Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. |journal=Science |volume=273 |issue= 5277 |pages= 959-63 |year= 1996 |pmid= 8688081 |doi=  }}
*{{cite journal  | author=Trivier E, De Cesare D, Jacquot S, ''et al.'' |title=Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. |journal=Nature |volume=384 |issue= 6609 |pages= 567-70 |year= 1997 |pmid= 8955270 |doi= 10.1038/384567a0 }}
*{{cite journal  | author=Paudel HK |title=Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28328-34 |year= 1997 |pmid= 9353289 |doi=  }}
*{{cite journal  | author=Joel PB, Smith J, Sturgill TW, ''et al.'' |title=pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. |journal=Mol. Cell. Biol. |volume=18 |issue= 4 |pages= 1978-84 |year= 1998 |pmid= 9528769 |doi=  }}
*{{cite journal  | author=Zheng-Fischhöfer Q, Biernat J, Mandelkow EM, ''et al.'' |title=Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation. |journal=Eur. J. Biochem. |volume=252 |issue= 3 |pages= 542-52 |year= 1998 |pmid= 9546672 |doi=  }}
*{{cite journal  | author=Deak M, Clifton AD, Lucocq LM, Alessi DR |title=Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. |journal=EMBO J. |volume=17 |issue= 15 |pages= 4426-41 |year= 1998 |pmid= 9687510 |doi= 10.1093/emboj/17.15.4426 }}
*{{cite journal  | author=Du K, Montminy M |title=CREB is a regulatory target for the protein kinase Akt/PKB. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32377-9 |year= 1999 |pmid= 9829964 |doi=  }}
*{{cite journal  | author=Hanger DP, Betts JC, Loviny TL, ''et al.'' |title=New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. |journal=J. Neurochem. |volume=71 |issue= 6 |pages= 2465-76 |year= 1998 |pmid= 9832145 |doi=  }}
*{{cite journal  | author=Jacquot S, Merienne K, De Cesare D, ''et al.'' |title=Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations. |journal=Am. J. Hum. Genet. |volume=63 |issue= 6 |pages= 1631-40 |year= 1999 |pmid= 9837815 |doi=  }}
*{{cite journal  | author=Jacquot S, Merienne K, Pannetier S, ''et al.'' |title=Germline mosaicism in Coffin-Lowry syndrome. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 6 |pages= 578-82 |year= 1999 |pmid= 9887375 |doi= 10.1038/sj.ejhg.5200230 }}
*{{cite journal  | author=Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW |title=Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2893-8 |year= 1999 |pmid= 9915826 |doi=  }}
*{{cite journal  | author=Abidi F, Jacquot S, Lassiter C, ''et al.'' |title=Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome (CLS). |journal=Eur. J. Hum. Genet. |volume=7 |issue= 1 |pages= 20-6 |year= 1999 |pmid= 10094187 |doi= 10.1038/sj.ejhg.5200231 }}
*{{cite journal  | author=Merienne K, Jacquot S, Pannetier S, ''et al.'' |title=A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation. |journal=Nat. Genet. |volume=22 |issue= 1 |pages= 13-4 |year= 1999 |pmid= 10319851 |doi= 10.1038/8719 }}
}}
{{refend}}


{{protein-stub}}
Mutations in this gene have been associated with [[Coffin–Lowry syndrome]] (CLS).<ref name="pmid11896450">{{cite journal | vauthors = Jacquot S, Zeniou M, Touraine R, Hanauer A | title = X-linked Coffin-Lowry syndrome (CLS, MIM 303600, RPS6KA3 gene, protein product known under various names: pp90(rsk2), RSK2, ISPK, MAPKAP1) | journal = European Journal of Human Genetics | volume = 10 | issue = 1 | pages = 2–5 | date = January 2002 | pmid = 11896450 | doi = 10.1038/sj.ejhg.5200738 }}</ref>
{{WikiDoc Sources}}
 
== Interactions ==
 
RPS6KA3 has been shown to [[Protein-protein interaction|interact]] with [[CREB-binding protein]],<ref name=pmid11564891>{{cite journal | vauthors = Merienne K, Pannetier S, Harel-Bellan A, Sassone-Corsi P | title = Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities | journal = Molecular and Cellular Biology | volume = 21 | issue = 20 | pages = 7089–96 | date = October 2001 | pmid = 11564891 | pmc = 99884 | doi = 10.1128/MCB.21.20.7089-7096.2001 }}</ref> [[MAPK1]]<ref name=pmid8939914>{{cite journal | vauthors = Zhao Y, Bjorbaek C, Moller DE | title = Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases | journal = The Journal of Biological Chemistry | volume = 271 | issue = 47 | pages = 29773–9 | date = November 1996 | pmid = 8939914 | doi = 10.1074/jbc.271.47.29773 }}</ref><ref name=pmid9915826>{{cite journal | vauthors = Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW | title = Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo | journal = The Journal of Biological Chemistry | volume = 274 | issue = 5 | pages = 2893–8 | date = January 1999 | pmid = 9915826 | doi = 10.1074/jbc.274.5.2893 }}</ref> and [[PEA15]].<ref name=pmid12796492>{{cite journal | vauthors = Vaidyanathan H, Ramos JW | title = RSK2 activity is regulated by its interaction with PEA-15 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 34 | pages = 32367–72 | date = August 2003 | pmid = 12796492 | doi = 10.1074/jbc.M303988200 }}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Omary MB, Baxter GT, Chou CF, Riopel CL, Lin WY, Strulovici B | title = PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18 | journal = The Journal of Cell Biology | volume = 117 | issue = 3 | pages = 583–93 | date = May 1992 | pmid = 1374067 | pmc = 2289443 | doi = 10.1083/jcb.117.3.583 }}
* {{cite journal | vauthors = Ku NO, Omary MB | title = Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization | journal = The Journal of Cell Biology | volume = 127 | issue = 1 | pages = 161–71 | date = October 1994 | pmid = 7523419 | pmc = 2120194 | doi = 10.1083/jcb.127.1.161 }}
* {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | date = September 1995 | pmid = 7566098 | doi = <!-- none available --> | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format = PDF }}
* {{cite journal | vauthors = Zhao Y, Bjørbaek C, Weremowicz S, Morton CC, Moller DE | title = RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation | journal = Molecular and Cellular Biology | volume = 15 | issue = 8 | pages = 4353–63 | date = August 1995 | pmid = 7623830 | pmc = 230675 | doi =  }}
* {{cite journal | vauthors = Bjørbaek C, Vik TA, Echwald SM, Yang PY, Vestergaard H, Wang JP, Webb GC, Richmond K, Hansen T, Erikson RL | title = Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients | journal = Diabetes | volume = 44 | issue = 1 | pages = 90–7 | date = January 1995 | pmid = 7813820 | doi = 10.2337/diabetes.44.1.90 }}
* {{cite journal | vauthors = Donnelly AJ, Choo KH, Kozman HM, Gedeon AK, Danks DM, Mulley JC | title = Regional localisation of a non-specific X-linked mental retardation gene (MRX19) to Xp22 | journal = American Journal of Medical Genetics | volume = 51 | issue = 4 | pages = 581–5 | date = July 1994 | pmid = 7943043 | doi = 10.1002/ajmg.1320510457 }}
* {{cite journal | vauthors = Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M | title = Human rsk isoforms: cloning and characterization of tissue-specific expression | journal = The American Journal of Physiology | volume = 266 | issue = 2 Pt 1 | pages = C351–9 | date = February 1994 | pmid = 8141249 | doi =  }}
* {{cite journal | vauthors = Xing J, Ginty DD, Greenberg ME | title = Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase | journal = Science | volume = 273 | issue = 5277 | pages = 959–63 | date = August 1996 | pmid = 8688081 | doi = 10.1126/science.273.5277.959 }}
* {{cite journal | vauthors = Trivier E, De Cesare D, Jacquot S, Pannetier S, Zackai E, Young I, Mandel JL, Sassone-Corsi P, Hanauer A | title = Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome | journal = Nature | volume = 384 | issue = 6609 | pages = 567–70 | date = December 1996 | pmid = 8955270 | doi = 10.1038/384567a0 }}
* {{cite journal | vauthors = Paudel HK | title = Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro | journal = The Journal of Biological Chemistry | volume = 272 | issue = 45 | pages = 28328–34 | date = November 1997 | pmid = 9353289 | doi = 10.1074/jbc.272.45.28328 }}
* {{cite journal | vauthors = Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA | title = pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167 | journal = Molecular and Cellular Biology | volume = 18 | issue = 4 | pages = 1978–84 | date = April 1998 | pmid = 9528769 | pmc = 121427 | doi = 10.1128/mcb.18.4.1978 }}
* {{cite journal | vauthors = Zheng-Fischhöfer Q, Biernat J, Mandelkow EM, Illenberger S, Godemann R, Mandelkow E | title = Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation | journal = European Journal of Biochemistry | volume = 252 | issue = 3 | pages = 542–52 | date = March 1998 | pmid = 9546672 | doi = 10.1046/j.1432-1327.1998.2520542.x }}
* {{cite journal | vauthors = Deak M, Clifton AD, Lucocq LM, Alessi DR | title = Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB | journal = The EMBO Journal | volume = 17 | issue = 15 | pages = 4426–41 | date = August 1998 | pmid = 9687510 | pmc = 1170775 | doi = 10.1093/emboj/17.15.4426 }}
* {{cite journal | vauthors = Du K, Montminy M | title = CREB is a regulatory target for the protein kinase Akt/PKB | journal = The Journal of Biological Chemistry | volume = 273 | issue = 49 | pages = 32377–9 | date = December 1998 | pmid = 9829964 | doi = 10.1074/jbc.273.49.32377 }}
* {{cite journal | vauthors = Hanger DP, Betts JC, Loviny TL, Blackstock WP, Anderton BH | title = New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry | journal = Journal of Neurochemistry | volume = 71 | issue = 6 | pages = 2465–76 | date = December 1998 | pmid = 9832145 | doi = 10.1046/j.1471-4159.1998.71062465.x }}
* {{cite journal | vauthors = Jacquot S, Merienne K, De Cesare D, Pannetier S, Mandel JL, Sassone-Corsi P, Hanauer A | title = Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations | journal = American Journal of Human Genetics | volume = 63 | issue = 6 | pages = 1631–40 | date = December 1998 | pmid = 9837815 | pmc = 1377634 | doi = 10.1086/302153 }}
* {{cite journal | vauthors = Jacquot S, Merienne K, Pannetier S, Blumenfeld S, Schinzel A, Hanauer A | title = Germline mosaicism in Coffin-Lowry syndrome | journal = European Journal of Human Genetics | volume = 6 | issue = 6 | pages = 578–82 | year = 1999 | pmid = 9887375 | doi = 10.1038/sj.ejhg.5200230 }}
* {{cite journal | vauthors = Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW | title = Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo | journal = The Journal of Biological Chemistry | volume = 274 | issue = 5 | pages = 2893–8 | date = January 1999 | pmid = 9915826 | doi = 10.1074/jbc.274.5.2893 }}
* {{cite journal | vauthors = Abidi F, Jacquot S, Lassiter C, Trivier E, Hanauer A, Schwartz CE | title = Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome (CLS) | journal = European Journal of Human Genetics | volume = 7 | issue = 1 | pages = 20–6 | date = January 1999 | pmid = 10094187 | doi = 10.1038/sj.ejhg.5200231 }}
* {{cite journal | vauthors = Merienne K, Jacquot S, Pannetier S, Zeniou M, Bankier A, Gecz J, Mandel JL, Mulley J, Sassone-Corsi P, Hanauer A | title = A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation | journal = Nature Genetics | volume = 22 | issue = 1 | pages = 13–4 | date = May 1999 | pmid = 10319851 | doi = 10.1038/8719 }}
{{Refend}}
 
== External links ==
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cls  GeneReviews/NCBI/NIH/UW entry on Coffin–Lowry syndrome]
 
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
 
 
[[Category:EC 2.7.11]]

Latest revision as of 22:40, 5 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.[1][2]

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.[1]

Clinical significance

Mutations in this gene have been associated with Coffin–Lowry syndrome (CLS).[3]

Interactions

RPS6KA3 has been shown to interact with CREB-binding protein,[4] MAPK1[5][6] and PEA15.[7]

References

  1. ↑ 1.0 1.1 "Entrez Gene: RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3".
  2. ↑ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (February 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". The American Journal of Physiology. 266 (2 Pt 1): C351–9. doi:10.1152/ajpcell.1994.266.2.C351. PMID 8141249.
  3. ↑ Jacquot S, Zeniou M, Touraine R, Hanauer A (January 2002). "X-linked Coffin-Lowry syndrome (CLS, MIM 303600, RPS6KA3 gene, protein product known under various names: pp90(rsk2), RSK2, ISPK, MAPKAP1)". European Journal of Human Genetics. 10 (1): 2–5. doi:10.1038/sj.ejhg.5200738. PMID 11896450.
  4. ↑ Merienne K, Pannetier S, Harel-Bellan A, Sassone-Corsi P (October 2001). "Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities". Molecular and Cellular Biology. 21 (20): 7089–96. doi:10.1128/MCB.21.20.7089-7096.2001. PMC 99884. PMID 11564891.
  5. ↑ Zhao Y, Bjorbaek C, Moller DE (November 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". The Journal of Biological Chemistry. 271 (47): 29773–9. doi:10.1074/jbc.271.47.29773. PMID 8939914.
  6. ↑ Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (January 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo". The Journal of Biological Chemistry. 274 (5): 2893–8. doi:10.1074/jbc.274.5.2893. PMID 9915826.
  7. ↑ Vaidyanathan H, Ramos JW (August 2003). "RSK2 activity is regulated by its interaction with PEA-15". The Journal of Biological Chemistry. 278 (34): 32367–72. doi:10.1074/jbc.M303988200. PMID 12796492.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=RPS6KA3&oldid=1534432"