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{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.<ref name="entrez" /> | | summary_text = [[Protein kinase A|Cyclic AMP-dependent protein kinase]] (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is [[Intron|intronless]] and is thought to be a [[retrotransposon]] derived from the gene for the alpha form of the PKA catalytic subunit.<ref name="entrez" /> | ||
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*{{cite journal | author=Foss KB |title=Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13 |journal=Cytogenet. Cell Genet. |volume=60 |issue= 1 |pages= 22–5 |year= 1992 |pmid= 1339328 |doi=10.1159/000133286 |name-list-format=vanc| author2=Simard J | author3=Bérubé D | display-authors=3 | last4=Beebe | first4=S.J. | last5=Sandberg | first5=M. | last6=Grzeschik | first6=K.-H. | last7=GagnÉ | first7=R. | last8=Hansson | first8=V. | last9=Jahnsen | first9=T. }} | *{{cite journal | author=Foss KB |title=Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13 |journal=Cytogenet. Cell Genet. |volume=60 |issue= 1 |pages= 22–5 |year= 1992 |pmid= 1339328 |doi=10.1159/000133286 |name-list-format=vanc| author2=Simard J | author3=Bérubé D | display-authors=3 | last4=Beebe | first4=S.J. | last5=Sandberg | first5=M. | last6=Grzeschik | first6=K.-H. | last7=GagnÉ | first7=R. | last8=Hansson | first8=V. | last9=Jahnsen | first9=T. }} | ||
*{{cite journal | author=Hofmann B |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi= |name-list-format=vanc| author2=Nishanian P | author3=Baldwin RL | display-authors=3 | last4=Insixiengmay | first4=P | last5=Nel | first5=A | last6=Fahey | first6=JL }} | *{{cite journal | author=Hofmann B |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi= |name-list-format=vanc| author2=Nishanian P | author3=Baldwin RL | display-authors=3 | last4=Insixiengmay | first4=P | last5=Nel | first5=A | last6=Fahey | first6=JL }} | ||
*{{cite journal | author=Hofmann B |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=10.1073/pnas.90.14.6676 | pmc=46995 |name-list-format=vanc| author2=Nishanian P | author3=Nguyen T | display-authors=3 | last4=Insixiengmay | first4=P | last5=Fahey | first5=JL }} | *{{cite journal | author=Hofmann B |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=10.1073/pnas.90.14.6676 | pmc=46995 |name-list-format=vanc| author2=Nishanian P | author3=Nguyen T | display-authors=3 | last4=Insixiengmay | first4=P | last5=Fahey | first5=JL |bibcode=1993PNAS...90.6676H}} | ||
*{{cite journal | author=Hofmann B |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=10.1097/00002030-199407000-00025 |name-list-format=vanc| author2=Nishanian P | author3=Fan J | display-authors=3 | last4=Nguyen | first4=T. | last5=Fahey | first5=J. L. }} | *{{cite journal | author=Hofmann B |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=10.1097/00002030-199407000-00025 |name-list-format=vanc| author2=Nishanian P | author3=Fan J | display-authors=3 | last4=Nguyen | first4=T. | last5=Fahey | first5=J. L. }} | ||
*{{cite journal | author=Swingler S |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372–7 |year= 1997 |pmid= 9151826 |doi= | pmc=191654 |name-list-format=vanc| author2=Gallay P | author3=Camaur D | display-authors=3 | last4=Song | first4=J | last5=Abo | first5=A | last6=Trono | first6=D }} | *{{cite journal | author=Swingler S |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372–7 |year= 1997 |pmid= 9151826 |doi= | pmc=191654 |name-list-format=vanc| author2=Gallay P | author3=Camaur D | display-authors=3 | last4=Song | first4=J | last5=Abo | first5=A | last6=Trono | first6=D }} | ||
| Line 28: | Line 28: | ||
*{{cite journal | author=Mayne M |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease |journal=Neuroimmunomodulation |volume=5 |issue= 3–4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=10.1159/000026336 |name-list-format=vanc| author2=Bratanich AC | author3=Chen P | display-authors=3 | last4=Rana | first4=Farazana | last5=Nath | first5=Avindra | last6=Power | first6=Christopher }} | *{{cite journal | author=Mayne M |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease |journal=Neuroimmunomodulation |volume=5 |issue= 3–4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=10.1159/000026336 |name-list-format=vanc| author2=Bratanich AC | author3=Chen P | display-authors=3 | last4=Rana | first4=Farazana | last5=Nath | first5=Avindra | last6=Power | first6=Christopher }} | ||
*{{cite journal | author=Bodnar RJ |title=Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta) |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47080–7 |year= 2003 |pmid= 12361948 |doi= 10.1074/jbc.M208329200 |name-list-format=vanc| author2=Xi X | author3=Li Z | display-authors=3 | last4=Berndt | first4=MC | last5=Du | first5=X }} | *{{cite journal | author=Bodnar RJ |title=Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta) |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47080–7 |year= 2003 |pmid= 12361948 |doi= 10.1074/jbc.M208329200 |name-list-format=vanc| author2=Xi X | author3=Li Z | display-authors=3 | last4=Berndt | first4=MC | last5=Du | first5=X }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}} | ||
*{{cite journal | author=Cartier C |title=Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35211–9 |year= 2003 |pmid= 12842892 |doi= 10.1074/jbc.M301257200 |name-list-format=vanc| author2=Hemonnot B | author3=Gay B | display-authors=3 | last4=Bardy | first4=M | last5=Sanchiz | first5=C | last6=Devaux | first6=C | last7=Briant | first7=L }} | *{{cite journal | author=Cartier C |title=Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35211–9 |year= 2003 |pmid= 12842892 |doi= 10.1074/jbc.M301257200 |name-list-format=vanc| author2=Hemonnot B | author3=Gay B | display-authors=3 | last4=Bardy | first4=M | last5=Sanchiz | first5=C | last6=Devaux | first6=C | last7=Briant | first7=L }} | ||
*{{cite journal | author=Masci AM |title=HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling |journal=J. Leukoc. Biol. |volume=74 |issue= 6 |pages= 1117–24 |year= 2004 |pmid= 12972513 |doi= 10.1189/jlb.0503239 |name-list-format=vanc| author2=Galgani M | author3=Cassano S | display-authors=3 | last4=De Simone | first4=S | last5=Gallo | first5=A | last6=De Rosa | first6=V | last7=Zappacosta | first7=S | last8=Racioppi | first8=L }} | *{{cite journal | author=Masci AM |title=HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling |journal=J. Leukoc. Biol. |volume=74 |issue= 6 |pages= 1117–24 |year= 2004 |pmid= 12972513 |doi= 10.1189/jlb.0503239 |name-list-format=vanc| author2=Galgani M | author3=Cassano S | display-authors=3 | last4=De Simone | first4=S | last5=Gallo | first5=A | last6=De Rosa | first6=V | last7=Zappacosta | first7=S | last8=Racioppi | first8=L }} | ||
Revision as of 07:42, 30 June 2018
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| External IDs | GeneCards: [1] | ||||||
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| Location (UCSC) | n/a | n/a | |||||
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cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.[1][2][3]
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.[3]
Interactions
PRKACG has been shown to interact with Ryanodine receptor 2.[4]
References
- ↑ Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T (June 1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase". Mol Endocrinol. 4 (3): 465–75. doi:10.1210/mend-4-3-465. PMID 2342480.
- ↑ Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K (August 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics. 49 (2): 290–7. doi:10.1006/geno.1998.5240. PMID 9598317.
- ↑ 3.0 3.1 "Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma".
- ↑ Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. UNITED STATES. 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164.
Further reading
- Foss KB, Simard J, Bérubé D, et al. (1992). "Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13". Cytogenet. Cell Genet. 60 (1): 22–5. doi:10.1159/000133286. PMID 1339328.
- Hofmann B, Nishanian P, Baldwin RL, et al. (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. 145 (11): 3699–705. PMID 1978848.
- Hofmann B, Nishanian P, Nguyen T, et al. (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. Bibcode:1993PNAS...90.6676H. doi:10.1073/pnas.90.14.6676. PMC 46995. PMID 7688126.
- Hofmann B, Nishanian P, Fan J, et al. (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016–7. doi:10.1097/00002030-199407000-00025. PMID 7946090.
- Swingler S, Gallay P, Camaur D, et al. (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix". J. Virol. 71 (6): 4372–7. PMC 191654. PMID 9151826.
- Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
- Liapi C, Takahashi N, Raynaud F, et al. (1998). "Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts". J. Invest. Dermatol. 110 (4): 332–7. doi:10.1046/j.1523-1747.1998.00149.x. PMID 9540970.
- Zidovetzki R, Wang JL, Chen P, et al. (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Res. Hum. Retroviruses. 14 (10): 825–33. doi:10.1089/aid.1998.14.825. PMID 9671211.
- Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685.
- Bodnar RJ, Xi X, Li Z, et al. (2003). "Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta)". J. Biol. Chem. 277 (49): 47080–7. doi:10.1074/jbc.M208329200. PMID 12361948.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cartier C, Hemonnot B, Gay B, et al. (2003). "Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein". J. Biol. Chem. 278 (37): 35211–9. doi:10.1074/jbc.M301257200. PMID 12842892.
- Masci AM, Galgani M, Cassano S, et al. (2004). "HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling". J. Leukoc. Biol. 74 (6): 1117–24. doi:10.1189/jlb.0503239. PMID 12972513.
- Zhang W, Morris GZ, Beebe SJ (2004). "Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells". Protein Expr. Purif. 35 (1): 156–69. doi:10.1016/j.pep.2004.01.006. PMID 15039079.
- Stevanin G, Hahn V, Lohmann E, et al. (2004). "Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14". Arch. Neurol. 61 (8): 1242–8. doi:10.1001/archneur.61.8.1242. PMID 15313841.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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