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{{for|the airport in Alaska with ICAO code PASK|Selawik Airport}}
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'''PAS domain-containing serine/threonine-protein kinase''' is an [[enzyme]] that in humans is encoded by the ''PASK'' [[gene]].<ref name="pmid11688972">{{cite journal |vauthors=Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH | title = Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors | journal = Biochem Biophys Res Commun | volume = 288 | issue = 4 | pages = 757–64 |date=Nov 2001 | pmid = 11688972 | pmc =  | doi = 10.1006/bbrc.2001.5840 | url =http://www.zora.uzh.ch/1428/1/Hofer_a2001MaV.pdf }}</ref><ref name="pmid11459942">{{cite journal |vauthors=Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL | title = PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 16 | pages = 8991–6 |date=Aug 2001 | pmid = 11459942 | pmc = 55361 | doi = 10.1073/pnas.161284798 }}</ref><ref name="pmid15148392">{{cite journal |vauthors=da Silva Xavier G, Rutter J, Rutter GA | title = Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose | journal = Proc Natl Acad Sci U S A | volume = 101 | issue = 22 | pages = 8319–24 |date=Jun 2004 | pmid = 15148392 | pmc = 420392 | doi = 10.1073/pnas.0307737101 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PASK PAS domain containing serine/threonine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23178| accessdate = }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_PASK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ll8.
| PDB = {{PDB2|1ll8}}
| Name = PAS domain containing serine/threonine kinase
| HGNCid = 17270
| Symbol = PASK
| AltSymbols =; DKFZP434O051; DKFZp686P2031; KIAA0135; PASKIN; STK37
| OMIM = 607505
| ECnumber =
| Homologene = 9038
| MGIid = 2155936
  | GeneAtlas_image1 = PBB_GE_PASK_213534_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PASK_216945_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =  
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23178
    | Hs_Ensembl = ENSG00000115687
    | Hs_RefseqProtein = NP_055963
    | Hs_RefseqmRNA = NM_015148
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 241694385
    | Hs_GenLoc_end = 241738067
    | Hs_Uniprot = Q96RG2
    | Mm_EntrezGene = 269224
    | Mm_Ensembl = ENSMUSG00000026274
    | Mm_RefseqmRNA = NM_080850
    | Mm_RefseqProtein = NP_543126
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 95139851
    | Mm_GenLoc_end = 95173158
    | Mm_Uniprot = Q8CEE6
  }}
}}
'''PAS domain containing serine/threonine kinase''', also known as '''PASK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PASK PAS domain containing serine/threonine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23178| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PASK PAS domain containing serine/threonine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23178| accessdate = }}</ref>
| summary_text = PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal | author=Nagase T, Seki N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167-74, 199-210 |year= 1996 |pmid= 8590280 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Seki N, Tanaka A, etal |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=10.1093/dnares/2.4.167 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal | author=Ceulemans H, Van Eynde A, Pérez-Callejón E, ''et al.'' |title=Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1. |journal=Eur. J. Biochem. |volume=262 |issue= 1 |pages= 36-42 |year= 1999 |pmid= 10231361 |doi=  }}
*{{cite journal   |vauthors=Ceulemans H, Van Eynde A, Pérez-Callejón E, etal |title=Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1 |journal=Eur. J. Biochem. |volume=262 |issue= 1 |pages= 36–42 |year= 1999 |pmid= 10231361 |doi=10.1046/j.1432-1327.1999.00344.x  }}
*{{cite journal  | author=Rutter J, Michnoff CH, Harper SM, ''et al.'' |title=PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 8991-6 |year= 2001 |pmid= 11459942 |doi= 10.1073/pnas.161284798 }}
*{{cite journal  |vauthors=Amezcua CA, Harper SM, Rutter J, Gardner KH |title=Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation |journal=Structure |volume=10 |issue= 10 |pages= 1349–61 |year= 2003 |pmid= 12377121 |doi=10.1016/S0969-2126(02)00857-2 }}
*{{cite journal  | author=Hofer T, Spielmann P, Stengel P, ''et al.'' |title=Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 757-64 |year= 2001 |pmid= 11688972 |doi= 10.1006/bbrc.2001.5840 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Amezcua CA, Harper SM, Rutter J, Gardner KH |title=Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation. |journal=Structure |volume=10 |issue= 10 |pages= 1349-61 |year= 2003 |pmid= 12377121 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=da Silva Xavier G, Rutter J, Rutter GA |title=Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 22 |pages= 8319-24 |year= 2004 |pmid= 15148392 |doi= 10.1073/pnas.0307737101 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Eckhardt K, Troger J, Reissmann J, etal |title=Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1 |journal=Cell. Physiol. Biochem. |volume=20 |issue= 1–4 |pages= 227–40 |year= 2007 |pmid= 17595531 |doi= 10.1159/000104169 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Kikani CK, Antonysamy SA, Bonanno JB, etal |title=Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation |journal=J. Biol. Chem. |volume=285 |issue= 52 |pages=41034–43 |year= 2010 |pmid= 20943661 |doi= 10.1074/jbc.M110.157594 |pmc=3003402}}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Eckhardt K, Troger J, Reissmann J, ''et al.'' |title=Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1. |journal=Cell. Physiol. Biochem. |volume=20 |issue= 1-4 |pages= 227-40 |year= 2007 |pmid= 17595531 |doi= 10.1159/000104169 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:EC 2.7.11]]
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Latest revision as of 01:32, 22 December 2018

For the airport in Alaska with ICAO code PASK, see Selawik Airport.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
View/Edit Human

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.[1][2][3][4]

PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM][4]

References

  1. ↑ Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH (Nov 2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors" (PDF). Biochem Biophys Res Commun. 288 (4): 757–64. doi:10.1006/bbrc.2001.5840. PMID 11688972.
  2. ↑ Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL (Aug 2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase". Proc Natl Acad Sci U S A. 98 (16): 8991–6. doi:10.1073/pnas.161284798. PMC 55361. PMID 11459942.
  3. ↑ da Silva Xavier G, Rutter J, Rutter GA (Jun 2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose". Proc Natl Acad Sci U S A. 101 (22): 8319–24. doi:10.1073/pnas.0307737101. PMC 420392. PMID 15148392.
  4. ↑ 4.0 4.1 "Entrez Gene: PASK PAS domain containing serine/threonine kinase".

Further reading



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