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{{Use dmy dates|date=April 2016}}
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{{Infobox_gene}}
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'''MAP/microtubule affinity-regulating kinase 3''' is an [[enzyme]] that in humans is encoded by the ''MARK3'' [[gene]].<ref name="pmid9533022">{{cite journal | vauthors = Ono T, Kawabe T, Sonta S, Okamoto T | title = Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 79 | issue = 1–2 | pages = 101–2 | date = April 1998 | pmid = 9533022 | pmc = | doi = 10.1159/000134692 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4140| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_MARK3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ul7.
| PDB = {{PDB2|1ul7}}
| Name = MAP/microtubule affinity-regulating kinase 3
| HGNCid = 6897
| Symbol = MARK3
| AltSymbols =; CTAK1; KP78; PAR1A
| OMIM = 602678
| ECnumber = 
| Homologene = 55653
| MGIid = 1341865
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4140
    | Hs_Ensembl = ENSG00000075413
    | Hs_RefseqProtein = NP_002367
    | Hs_RefseqmRNA = NM_002376
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 102921524
    | Hs_GenLoc_end = 103039917
    | Hs_Uniprot = P27448
    | Mm_EntrezGene = 17169
    | Mm_Ensembl = ENSMUSG00000007411
    | Mm_RefseqmRNA = XM_992051
    | Mm_RefseqProtein = XP_997145
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 112022344
    | Mm_GenLoc_end = 112104031
    | Mm_Uniprot = Q91Y96
  }}
}}
'''MAP/microtubule affinity-regulating kinase 3''', also known as '''MARK3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4140| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MARK3 has been shown to [[Protein–protein interaction|interact]] with [[Stratifin]].<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein–protein interaction network | journal = [[Nature (journal)|Nature]] | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid15778465>{{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | date = June 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
It has been linked to a form of genetic blindness, believed to be a genetic recessive  disease that progressively destroys the eyes.<ref>https://www.unige.ch/communication/communiques/2018/cdp180723/</ref>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Tassan JP, Le Goff X | title = An overview of the KIN1/PAR-1/MARK kinase family. | journal = Biol. Cell | volume = 96 | issue = 3 | pages = 193–9 | year = 2004 | pmid = 15182702 | doi = 10.1016/j.biolcel.2003.10.009 }}
| citations =
* {{cite journal | vauthors = Meller N, Liu YC, Collins TL, Bonnefoy-Bérard N, Baier G, Isakov N, Altman A | title = Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function. | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5782–91 | year = 1996 | pmid = 8816492 | pmc = 231579 | doi =  }}
*{{cite journal | author=Tassan JP, Le Goff X |title=An overview of the KIN1/PAR-1/MARK kinase family. |journal=Biol. Cell |volume=96 |issue= 3 |pages= 193-9 |year= 2004 |pmid= 15182702 |doi= 10.1016/j.biolcel.2003.10.009 }}
* {{cite journal | vauthors = Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ, Wu Z, Stephenson MT, Piwnica-Worms H | title = C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. | journal = Cell Growth Differ. | volume = 9 | issue = 3 | pages = 197–208 | year = 1998 | pmid = 9543386 | doi =  }}
*{{cite journal | author=Meller N, Liu YC, Collins TL, ''et al.'' |title=Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5782-91 |year= 1996 |pmid= 8816492 |doi=  }}
* {{cite journal | vauthors = Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT | title = PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. | journal = Nat. Cell Biol. | volume = 3 | issue = 7 | pages = 628–36 | year = 2001 | pmid = 11433294 | doi = 10.1038/35083016 }}
*{{cite journal | author=Ono T, Kawabe T, Sonta S, Okamoto T |title=Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 101-2 |year= 1998 |pmid= 9533022 |doi=  }}
* {{cite journal | vauthors = Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D | title = Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. | journal = Oncogene | volume = 22 | issue = 30 | pages = 4752–6 | year = 2003 | pmid = 12879020 | doi = 10.1038/sj.onc.1206669 }}
*{{cite journal | author=Peng CY, Graves PR, Ogg S, ''et al.'' |title=C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. |journal=Cell Growth Differ. |volume=9 |issue= 3 |pages= 197-208 |year= 1998 |pmid= 9543386 |doi= }}
* {{cite journal | vauthors = Müller J, Ritt DA, Copeland TD, Morrison DK | title = Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. | journal = EMBO J. | volume = 22 | issue = 17 | pages = 4431–42 | year = 2003 | pmid = 12941695 | pmc = 202368 | doi = 10.1093/emboj/cdg426 }}
*{{cite journal | author=Sun TQ, Lu B, Feng JJ, ''et al.'' |title=PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. |journal=Nat. Cell Biol. |volume=3 |issue= 7 |pages= 628-36 |year= 2001 |pmid= 11433294 |doi= 10.1038/35083016 }}
* {{cite journal | vauthors = Trinczek B, Brajenovic M, Ebneth A, Drewes G | title = MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. | journal = J. Biol. Chem. | volume = 279 | issue = 7 | pages = 5915–23 | year = 2004 | pmid = 14594945 | doi = 10.1074/jbc.M304528200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I | title = Proteomic identification of brain proteins that interact with dynein light chain LC8. | journal = Proteomics | volume = 4 | issue = 2 | pages = 339–46 | year = 2004 | pmid = 14760703 | doi = 10.1002/pmic.200300528 }}
*{{cite journal | author=Spicer J, Rayter S, Young N, ''et al.'' |title=Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. |journal=Oncogene |volume=22 |issue= 30 |pages= 4752-6 |year= 2003 |pmid= 12879020 |doi= 10.1038/sj.onc.1206669 }}
* {{cite journal | vauthors = Bachmann M, Hennemann H, Xing PX, Hoffmann I, Möröy T | title = The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. | journal = J. Biol. Chem. | volume = 279 | issue = 46 | pages = 48319–28 | year = 2005 | pmid = 15319445 | doi = 10.1074/jbc.M404440200 }}
*{{cite journal | author=Müller J, Ritt DA, Copeland TD, Morrison DK |title=Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. |journal=EMBO J. |volume=22 |issue= 17 |pages= 4431-42 |year= 2003 |pmid= 12941695 |doi= 10.1093/emboj/cdg426 }}
* {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | year = 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Trinczek B, Brajenovic M, Ebneth A, Drewes G |title=MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5915-23 |year= 2004 |pmid= 14594945 |doi= 10.1074/jbc.M304528200 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein–protein interaction network: a resource for annotating the proteome. | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | year = 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Navarro-Lérida I, Martínez Moreno M, Roncal F, ''et al.'' |title=Proteomic identification of brain proteins that interact with dynein light chain LC8. |journal=Proteomics |volume=4 |issue= 2 |pages= 339-46 |year= 2004 |pmid= 14760703 |doi= 10.1002/pmic.200300528 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein–protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Bachmann M, Hennemann H, Xing PX, ''et al.'' |title=The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. |journal=J. Biol. Chem. |volume=279 |issue= 46 |pages= 48319-28 |year= 2005 |pmid= 15319445 |doi= 10.1074/jbc.M404440200 }}
* {{cite journal | vauthors = Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR | title = Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. | journal = J. Cell Sci. | volume = 119 | issue = Pt 19 | pages = 4059–70 | year = 2007 | pmid = 16968750 | doi = 10.1242/jcs.03097 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R | title = New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. | journal = Mol. Cell. Biol. | volume = 26 | issue = 19 | pages = 7086–102 | year = 2006 | pmid = 16980613 | pmc = 1592903 | doi = 10.1128/MCB.00231-06 | url = http://orbi.ulg.ac.be/bitstream/2268/32348/1/Dequiedt%20et%20al%202006.pdf }}
*{{cite journal  | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
* {{cite journal | vauthors = Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H | title = Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. | journal = Mol. Cell. Proteomics | volume = 6 | issue = 3 | pages = 537–47 | year = 2007 | pmid = 17192257 | doi = 10.1074/mcp.T600062-MCP200 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein–protein interactions by mass spectrometry. | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Göransson O, Deak M, Wullschleger S, ''et al.'' |title=Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. |journal=J. Cell. Sci. |volume=119 |issue= Pt 19 |pages= 4059-70 |year= 2007 |pmid= 16968750 |doi= 10.1242/jcs.03097 }}
*{{cite journal | author=Dequiedt F, Martin M, Von Blume J, ''et al.'' |title=New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. |journal=Mol. Cell. Biol. |volume=26 |issue= 19 |pages= 7086-102 |year= 2006 |pmid= 16980613 |doi= 10.1128/MCB.00231-06 }}
*{{cite journal  | author=Wissing J, Jänsch L, Nimtz M, ''et al.'' |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537-47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:27, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.[1][2]

Interactions

MARK3 has been shown to interact with Stratifin.[3][4]

It has been linked to a form of genetic blindness, believed to be a genetic recessive disease that progressively destroys the eyes.[5]

References

  1. ↑ Ono T, Kawabe T, Sonta S, Okamoto T (April 1998). "Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 101–2. doi:10.1159/000134692. PMID 9533022.
  2. ↑ "Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3".
  3. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  4. ↑ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  5. ↑ https://www.unige.ch/communication/communiques/2018/cdp180723/

Further reading


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