MAP2K5: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Dual specificity mitogen-activated protein kinase kinase 5''' is an [[enzyme]] that in humans is encoded by the ''MAP2K5'' [[gene]].<ref name="pmid7759517">{{cite journal | vauthors = Zhou G, Bao ZQ, Dixon JE | title = Components of a new human protein kinase signal transduction pathway | journal = The Journal of Biological Chemistry | volume = 270 | issue = 21 | pages = 12665–9 | date = May 1995 | pmid = 7759517 | pmc = | doi = 10.1074/jbc.270.21.12665 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5607| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MAP2K5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wi0.
| PDB = {{PDB2|1wi0}}, {{PDB2|2npt}}, {{PDB2|2o2v}}
| Name = Mitogen-activated protein kinase kinase 5
| HGNCid = 6845
| Symbol = MAP2K5
| AltSymbols =; HsT17454; MAPKK5; MEK5; PRKMK5
| OMIM = 602520
| ECnumber = 
| Homologene = 68937
| MGIid = 1346345
| GeneAtlas_image1 = PBB_GE_MAP2K5_204756_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAP2K5_210482_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_MAP2K5_211370_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005819 |text = spindle}}
| Process = {{GNF_GO|id=GO:0000165 |text = MAPKKK cascade}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007507 |text = heart development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5607
    | Hs_Ensembl = ENSG00000137764
    | Hs_RefseqProtein = NP_002748
    | Hs_RefseqmRNA = NM_002757
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 65622075
    | Hs_GenLoc_end = 65886503
    | Hs_Uniprot = Q13163
    | Mm_EntrezGene = 23938
    | Mm_Ensembl = ENSMUSG00000058444
    | Mm_RefseqmRNA = XM_981477
    | Mm_RefseqProtein = XP_986571
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 62961776
    | Mm_GenLoc_end = 63175858
    | Mm_Uniprot = Q3TM51
  }}
}}
'''Mitogen-activated protein kinase kinase 5''', also known as '''MAP2K5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5607| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5607| accessdate = }}</ref>
}}


==References==
==Upstream==
{{reflist|2}}
 
==Further reading==
This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs).
 
==Downstream==
 
This kinase specifically interacts with and activates MAPK7/ERK5.
 
== Interactions ==
 
MAP2K5 has been shown to [[Protein-protein interaction|interact]] with [[MAPK7]],<ref name=pmid7759517 /> [[MAP3K2]],<ref name=pmid11073940>{{cite journal | vauthors = Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL | title = MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway | journal = The Journal of Biological Chemistry | volume = 276 | issue = 7 | pages = 5093–100 | date = Feb 2001 | pmid = 11073940 | doi = 10.1074/jbc.M003719200 }}</ref> [[Protein kinase Mζ]]<ref name=pmid11158308>{{cite journal | vauthors = Diaz-Meco MT, Moscat J | title = MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling | journal = Molecular and Cellular Biology | volume = 21 | issue = 4 | pages = 1218–27 | date = Feb 2001 | pmid = 11158308 | pmc = 99575 | doi = 10.1128/MCB.21.4.1218-1227.2001 }}</ref> and [[MAP3K3]].<ref name=pmid11073940/><ref name=pmid14743216>{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = Feb 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = English JM, Vanderbilt CA, Xu S, Marcus S, Cobb MH | title = Isolation of MEK5 and differential expression of alternatively spliced forms | journal = The Journal of Biological Chemistry | volume = 270 | issue = 48 | pages = 28897–902 | date = Dec 1995 | pmid = 7499418 | doi = 10.1074/jbc.270.48.28897 }}
| citations =
* {{cite journal | vauthors = Kato Y, Kravchenko VV, Tapping RI, Han J, Ulevitch RJ, Lee JD | title = BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C | journal = The EMBO Journal | volume = 16 | issue = 23 | pages = 7054–66 | date = Dec 1997 | pmid = 9384584 | pmc = 1170308 | doi = 10.1093/emboj/16.23.7054 }}
*{{cite journal | author=English JM, Vanderbilt CA, Xu S, ''et al.'' |title=Isolation of MEK5 and differential expression of alternatively spliced forms. |journal=J. Biol. Chem. |volume=270 |issue= 48 |pages= 28897-902 |year= 1996 |pmid= 7499418 |doi= }}
* {{cite journal | vauthors = Kato Y, Tapping RI, Huang S, Watson MH, Ulevitch RJ, Lee JD | title = Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor | journal = Nature | volume = 395 | issue = 6703 | pages = 713–6 | date = Oct 1998 | pmid = 9790194 | doi = 10.1038/27234 }}
*{{cite journal  | author=Zhou G, Bao ZQ, Dixon JE |title=Components of a new human protein kinase signal transduction pathway. |journal=J. Biol. Chem. |volume=270 |issue= 21 |pages= 12665-9 |year= 1995 |pmid= 7759517 |doi=  }}
* {{cite journal | vauthors = English JM, Pearson G, Hockenberry T, Shivakumar L, White MA, Cobb MH | title = Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control | journal = The Journal of Biological Chemistry | volume = 274 | issue = 44 | pages = 31588–92 | date = Oct 1999 | pmid = 10531364 | doi = 10.1074/jbc.274.44.31588 }}
*{{cite journal | author=Kato Y, Kravchenko VV, Tapping RI, ''et al.'' |title=BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. |journal=EMBO J. |volume=16 |issue= 23 |pages= 7054-66 |year= 1998 |pmid= 9384584 |doi= 10.1093/emboj/16.23.7054 }}
* {{cite journal | vauthors = Chao TH, Hayashi M, Tapping RI, Kato Y, Lee JD | title = MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36035–8 | date = Dec 1999 | pmid = 10593883 | doi = 10.1074/jbc.274.51.36035 }}
*{{cite journal | author=Kato Y, Tapping RI, Huang S, ''et al.'' |title=Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. |journal=Nature |volume=395 |issue= 6703 |pages= 713-6 |year= 1998 |pmid= 9790194 |doi= 10.1038/27234 }}
* {{cite journal | vauthors = Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL | title = MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway | journal = The Journal of Biological Chemistry | volume = 276 | issue = 7 | pages = 5093–100 | date = Feb 2001 | pmid = 11073940 | doi = 10.1074/jbc.M003719200 }}
*{{cite journal | author=English JM, Pearson G, Hockenberry T, ''et al.'' |title=Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control. |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31588-92 |year= 1999 |pmid= 10531364 |doi= }}
* {{cite journal | vauthors = Diaz-Meco MT, Moscat J | title = MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling | journal = Molecular and Cellular Biology | volume = 21 | issue = 4 | pages = 1218–27 | date = Feb 2001 | pmid = 11158308 | pmc = 99575 | doi = 10.1128/MCB.21.4.1218-1227.2001 }}
*{{cite journal | author=Chao TH, Hayashi M, Tapping RI, ''et al.'' |title=MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36035-8 |year= 2000 |pmid= 10593883 |doi= }}
* {{cite journal | vauthors = Nicol RL, Frey N, Pearson G, Cobb M, Richardson J, Olson EN | title = Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy | journal = The EMBO Journal | volume = 20 | issue = 11 | pages = 2757–67 | date = Jun 2001 | pmid = 11387209 | pmc = 125475 | doi = 10.1093/emboj/20.11.2757 }}
*{{cite journal | author=Sun W, Kesavan K, Schaefer BC, ''et al.'' |title=MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5093-100 |year= 2001 |pmid= 11073940 |doi= 10.1074/jbc.M003719200 }}
* {{cite journal | vauthors = Dinev D, Jordan BW, Neufeld B, Lee JD, Lindemann D, Rapp UR, Ludwig S | title = Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells | journal = EMBO Reports | volume = 2 | issue = 9 | pages = 829–34 | date = Sep 2001 | pmid = 11520859 | pmc = 1084032 | doi = 10.1093/embo-reports/kve177 }}
*{{cite journal | author=Diaz-Meco MT, Moscat J |title=MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1218-27 |year= 2001 |pmid= 11158308 |doi= 10.1128/MCB.21.4.1218-1227.2001 }}
* {{cite journal | vauthors = Weldon CB, Scandurro AB, Rolfe KW, Clayton JL, Elliott S, Butler NN, Melnik LI, Alam J, McLachlan JA, Jaffe BM, Beckman BS, Burow ME | title = Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray | journal = Surgery | volume = 132 | issue = 2 | pages = 293–301 | date = Aug 2002 | pmid = 12219026 | doi = 10.1067/msy.2002.125389 }}
*{{cite journal | author=Nicol RL, Frey N, Pearson G, ''et al.'' |title=Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. |journal=EMBO J. |volume=20 |issue= 11 |pages= 2757-67 |year= 2001 |pmid= 11387209 |doi= 10.1093/emboj/20.11.2757 }}
* {{cite journal | vauthors = Mehta PB, Jenkins BL, McCarthy L, Thilak L, Robson CN, Neal DE, Leung HY | title = MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion | journal = Oncogene | volume = 22 | issue = 9 | pages = 1381–9 | date = Mar 2003 | pmid = 12618764 | doi = 10.1038/sj.onc.1206154 }}
*{{cite journal | author=Dinev D, Jordan BW, Neufeld B, ''et al.'' |title=Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells. |journal=EMBO Rep. |volume=2 |issue= 9 |pages= 829-34 |year= 2001 |pmid= 11520859 |doi= 10.1093/embo-reports/kve177 }}
* {{cite journal | vauthors = Mody N, Campbell DG, Morrice N, Peggie M, Cohen P | title = An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro | journal = The Biochemical Journal | volume = 372 | issue = Pt 2 | pages = 567–75 | date = Jun 2003 | pmid = 12628002 | pmc = 1223423 | doi = 10.1042/BJ20030193 }}
*{{cite journal | author=Weldon CB, Scandurro AB, Rolfe KW, ''et al.'' |title=Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray. |journal=Surgery |volume=132 |issue= 2 |pages= 293-301 |year= 2002 |pmid= 12219026 |doi=  }}
* {{cite journal | vauthors = Huang J, Tu Z, Lee FS | title = Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity | journal = Biochemical and Biophysical Research Communications | volume = 303 | issue = 2 | pages = 532–40 | date = Apr 2003 | pmid = 12659851 | doi = 10.1016/S0006-291X(03)00387-5 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lamark T, Perander M, Outzen H, Kristiansen K, Øvervatn A, Michaelsen E, Bjørkøy G, Johansen T | title = Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins | journal = The Journal of Biological Chemistry | volume = 278 | issue = 36 | pages = 34568–81 | date = Sep 2003 | pmid = 12813044 | doi = 10.1074/jbc.M303221200 }}
*{{cite journal | author=Mehta PB, Jenkins BL, McCarthy L, ''et al.'' |title=MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. |journal=Oncogene |volume=22 |issue= 9 |pages= 1381-9 |year= 2003 |pmid= 12618764 |doi= 10.1038/sj.onc.1206154 }}
* {{cite journal | vauthors = Cameron SJ, Abe J, Malik S, Che W, Yang J | title = Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 1506–12 | date = Jan 2004 | pmid = 14583600 | doi = 10.1074/jbc.M308755200 }}
*{{cite journal | author=Mody N, Campbell DG, Morrice N, ''et al.'' |title=An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro. |journal=Biochem. J. |volume=372 |issue= Pt 2 |pages= 567-75 |year= 2003 |pmid= 12628002 |doi= 10.1042/BJ20030193 }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = Feb 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal | author=Huang J, Tu Z, Lee FS |title=Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 2 |pages= 532-40 |year= 2003 |pmid= 12659851 |doi= }}
* {{cite journal | vauthors = Raviv Z, Kalie E, Seger R | title = MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation | journal = Journal of Cell Science | volume = 117 | issue = Pt 9 | pages = 1773–84 | date = Apr 2004 | pmid = 15075238 | doi = 10.1242/jcs.01040 }}
*{{cite journal | author=Lamark T, Perander M, Outzen H, ''et al.'' |title=Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34568-81 |year= 2003 |pmid= 12813044 |doi= 10.1074/jbc.M303221200 }}
*{{cite journal | author=Cameron SJ, Abe J, Malik S, ''et al.'' |title=Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1506-12 |year= 2004 |pmid= 14583600 |doi= 10.1074/jbc.M308755200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Raviv Z, Kalie E, Seger R |title=MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. |journal=J. Cell. Sci. |volume=117 |issue= Pt 9 |pages= 1773-84 |year= 2004 |pmid= 15075238 |doi= 10.1242/jcs.01040 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:05, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.[1][2]

Function

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.[2]

Upstream

This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs).

Downstream

This kinase specifically interacts with and activates MAPK7/ERK5.

Interactions

MAP2K5 has been shown to interact with MAPK7,[1] MAP3K2,[3] Protein kinase Mζ[4] and MAP3K3.[3][5]

References

  1. ↑ 1.0 1.1 Zhou G, Bao ZQ, Dixon JE (May 1995). "Components of a new human protein kinase signal transduction pathway". The Journal of Biological Chemistry. 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517.
  2. ↑ 2.0 2.1 "Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5".
  3. ↑ 3.0 3.1 Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL (Feb 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". The Journal of Biological Chemistry. 276 (7): 5093–100. doi:10.1074/jbc.M003719200. PMID 11073940.
  4. ↑ Diaz-Meco MT, Moscat J (Feb 2001). "MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling". Molecular and Cellular Biology. 21 (4): 1218–27. doi:10.1128/MCB.21.4.1218-1227.2001. PMC 99575. PMID 11158308.
  5. ↑ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.

Further reading

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