Sandbox:Zahir: Difference between revisions

Latest revision as of 19:12, 7 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD [2]

Vaginal/Vulvar mass differential diagnosis

	Symptoms							Physical exam		Lab Findings			Imaging			Histopathology
Diseases	Clinical manifestations									Para-clinical findings							Gold standard
	Abnormal vaginal bleeding	Abnormal vaginal dyscharge	Pelvic pain	Itching or burning of the vulva	Other Genitourinary/ Gastrointestinal symptoms	B symptoms	Abdominal pain	Gynecological examinations	Abdominal mass	HPV	Pap smear	STI Panel	Ultrasound	MRI	CT Scan	Histopathology
Cervical cancer^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]	Postmenopausal Intermenstrual Postcoital Bleeding after pelvic exam	+	+	+	Burning during urination Difficulty urinating Pain during sex	+	+	Cervical mass on exam	+	±	Negative Atypical cells	±Chlamydia	Large cervical cancer Angiogenesis on Doppler sonography Bladder involvement Lymph node involvement	T2-weighted MRI : Ovoid, heterogeneous tumor distending the cervical canal with stromal involvement.	PET/CT scan: Detect tumor size Lymph node involvement, Metastases to bladder or rectum	CIN1: mild dysplasia CIN2: moderate dysplasia CIN3: high degree of dysplasia/metastases	Colposcopy/biopsy
Cervical polyp^[9]^[10]^[11]	Postcoital Intermenstrual Postmenopausal Bleeding after exam	+	−	−	−	−	−	Mass on exam	−	−	−	−	Hyper/hypoechogenic masses with or without cysts Filling the endocervical or vaginal canal	May reveal presence of tumor	CT contrast may show presence of a well defined mass	Epithelial cells with no nuclear atypia/mitoses	Hysteroscopy /Biopsy
Cervical leiomyoma^[12]^[13]^[14]^[15]^[16]^[17]^[18]^[19]	Heavy/prolonged menstrual bleeding Intermenstrual bleeding	+	+	−	Urinary retention Constipation Infertility Bowel obstruction Increase in pregnancy/labor complications	−	+	Large,irregular pelvic mass	±	−	−	−	Well circumscribed hyperechoic mass	T2-weighted MRI: Hypointense masses Homogeneous enhancement Red degeneration	N/A	Spindle shaped smooth muscle cells Mature adipocytes Extracellular matrix consist of collagen,fibronectin.	Clinical diagnosis/ and Ultrasound
Cervical lymphoma^[20]^[21]^[22]	Postmenopausal bleeding	−	+	−	Difficulty urinating Post-coital pain	+	+	Large uterine/cervix mass Irregularity	+	−	−	−	Well-defined, solid, concentric, hypoechoic mass	MRI: Intramyometrial infiltrative nodules	Diffuse heterogeneous uterine/cervical mass & hypoechoic enlarged iliac lymph nodes	Small tumor cells with large nuclei High mitoses and proliferation	Biopsy diffuse large B-Cell lymphoma (DLBCL) most frequent type.
Cervical sarcoma^[23]^[24]^[25]^[26]	Intermentrual Postmenopausal	±	+	−	Post-coital pain Fullness in pelvis	±	+	Cervical mass Lump protruding from vagina/vulva	+	−	−	−	Endometrial mass with heterogeneous echogenicity	MRI: Endometrial polypoid mass Hypointense hypervascular solid components	N/A	Mitotic index Cellular atypia Coagulative necrosis	Biopsy
Cervical erosion(Ectropion)^[27]^[28]^[29]^[30]^[31]	Light bleeding after pelvic exam Spotting	+	+	±	Post-coital pain Painful cramps Pain after sex	−	+	−	−	−	−	-	N/A	N/A	N/A	Squamous metaplasia Vascular ectasia Lymphocytic infiltration	Colposcopy and biopsy
Cervicitis^[32]^[33]^[34]^[35]	Intermenstrual bleeding Postcoital Bleeding after pelvic exam	+	+	Itching	Pain during urination Pain during sex Painful menstruation	May have fever only	+/-	Red,inflammed swollen cervix Inflammation/irritation of vulva/vagina	−	−	−	Chlamydia Gonorrhea Herpes simplex Trichomonas vaginalis	To detect complications like PID	N/A	N/A	N/A	Nucleic acid amplification tests (NAATs)
IUD use^[36]^[37]^[38]	Heavy bleeding	±	+	Itching	Painful menstruation	−	+/-	Strings of IUD device Signs of inflammation Discharge Bleeding	−	−	−	±	To detect IUD location and pregnancy	N/A	N/A	N/A	Physical exam and ultrasound
Pelvic inflammatory diseases^[39]^[40]	Postcoital bleeding Intermenstrual bleeding	+	+	Itching/burning	Pain during sex Painful menstruation Burning sensation during urination Pain during bowel movement	Fever	±Abdominal pain Pelvic pain	Vaginal/vulvar tender lesion depending on microbial cause	−	−	−	Chlamydia Gonorrhea	Enlarged fallopian tubes Abscess Hyperemia Ectopic pregnancy/ovarian cyst/abscess	Thickened fluid filled fallopian tubes	N/A	May show endometritis	CDC diagnostic criteria of PID
Endometriosis^[41]^[42]^[43]^[44]^[45]^[46]	Heavy mentrual bleeding	±	Pelvic pain Back pain	−	Painful menstruation Burning/painful urination Painful bowel movement Pain during or after sex Infertility	−	+	Tender uterosacral nodularity Immobile uterus Cervical motion tenderness Retroverted uterus	+	−	−	−	Unilocular/multilocular cysts contating thin/thick septations Increased vascularity showing increased doppler flow	Hyperintensity on T1 weighted images Hypointensity on T2 weighted images	Catamenial pneumothorax, hemothorax & lung nodules	Presence of endometrial tissue outside the uterus	Visual inspection by laparoscopy
Adenomyosis^[47]^[48]^[49]^[50]^[51]	Abnormal uterine bleeding	−	+	−	Painful menstruation	−	+/-	Polypoid mass protruding into the endocervical canal.	+/-	−	−	−	Transvaginal US shows poorly marginated hypoechoic & heterogenous areas within myometrium Myometrial cysts Globular/enlarged uterus with asymmetry	MRI: Thickened junctional zone	Uterine enlargement Thickened inner myometrium Myometrial cysts	Presence of ectopic endometrial glands into the myometrium.	Histology findings post hysterectomy
Cervical ectopic pregnancy^[52]^[53]	Amenorrhea Bleeding after pelvic exam	−	−	−	Pelvic pain	−	+	Soft and disporportionally enlarged uterus.		−		−	Empty uterus Thickened endometrium	T2-weighted MRI: Hypointense large mass T1-weighted MRI: Partially hyperintense mass	N/A	Necrotic hemorrhagic mass with chorionic villus	Hysterectomy and biopsy
DES exposure (Clear cell adenocarcinoma)^[54]^[55]^[56]	Postcoital bleeding Postmenopausal bleeding	+	+/-	+/-	Abdominal pain Blood in feces	+/-	+	Normal looking cervix Cervical exophytic lesions Barrel shaped cervix	-	−	−	−	To determine uterine extent	To detect metastases	Irregular dense mass occupying inferior lip of cervix and posterior fornix	Tumor cells with abundant clear cytoplasm and round nuclei Nucleus show hyperchromasia, moderate pleomorphism & prominent nucleoli	Biopsy
Paget's disease of vulva to cervix^[57]^[58]^[59]	Bleeding from lesion Oozing	±	−	Itching/burning Pain in vulva	−	−	−	Scaly eczematoid lesion in vulva. Erythematous plaques with white scaling. Inguinal lymphadenopathy in case of metastases.	−	−	−	−	N/A	MRI: Hyperintense on diffusion weighted images	May show bilateral enlarged inguinal lymph nodes	Thickened vulvar skin "Cake-icing effect", pathognomonic for vulvavulvar paget's disease Intraepidermal adenocarcinoma which involves epidermis	Biopsy of lesion
Vaginal cancer^[60]^[61]^[62]^[63]	Postcoital bleeding	+	+	+/-	Tenesmus Dysuria Urinary frequency Constipation Pelvic pain	+/-	+	Vaginal lump Inguinal lymphadenopathy	In case of metastases to internal organs	−	−	−	Ultrasound: Hydronephrosis in case of pelvic metastases Multiple liver metastases	MRI: Isointense on T1-weighted images Soft-tissue mass with intermediate-to-high signal intensity on T2-weighted images	Provide information about size shape and location of tumor Detects metastases Detects lymph node involvement	Biopsy findings: Squamous cell carcinoma of vagina	Biopsy
Nabothian cyst^[64]^[65]^[66]^[67]	Postcoital bleeding	+	−	−	Pain during sex	−	-	Cystic mass on exam	−	−	−	−	An echoic well defined cystic masses	Intermediate or slightly high signal intensity on T1-weighted High signal intensity on T2-weighted images	Small cysts not visible on CT Large cysts seen as focal low attenuation region	Multiple benign cystic masses, usually few millimeters in diameter	Histological exam if large cystic masses
Rectal cancer^[68]^[69]^[70]^[71]^[72]	-	-	+	-	Constipation/diarrhea Absent bowel sounds Rectal mass/bleeding Abdominal tenderness	Weight loss +	LLQ +	NL	+	-	-	+/-	Endoscopic/transrectal US detects tumor extent	Determine tumor stage	Determine tumor stage	Sheets or cords of malignant cells Cellular atypia & pleomorphism High mitotic rate Necrotic debris in glandular lumina	Colonoscopy with biopsy
Submucous uterine leiomyoma^[73]^[74]^[75]	Menorrhagia	-	+	-	Constipation Urinary frequency/incontinence Hydronephrosis	-	+	Enlarged, irregular, firm, nontender uterus	+	-	-	-	Trans vaginal US: well defined hypoechoic Saline US: for submucous fibroids/polypoi	Provides information on no: of fibroids, size, vascularization, relationship with endometrial cavity & serosal surface	Not required	Not required	Physical examination with Ultrasound
Uterine cancer^[76]^[77]^[78]^[79]	Menometorrhagia Intermenstrual bleeding Postcoital bleeding	+	+	-	Polyuria Dysuria	Fatigue Weight loss	+	Enlarged uterus Lymphadenopathy Mesenteric nodules (metastases)	+	-	-	-	Thickened endometrial lining >4cm	Endometrial thickening Lymph node involvement Pelvic metastases	Not required	Endometrial malignant cells Low grade type 1 High grade type 2	Histologic diagnosis
Vaginal lymphoma^[80]^[81]^[82]	+	+	+	+	Abdominal/pelvic pain	-	+	Palpable mass between rectum & vagina	+/-	-	-	-	Diffuse mass in external cervical orifice & invading the vagina	Diffuse mass in external cervical orifice & invading the vagina	Not required	CD20 & CD79a positive	Immunohistochemistry & biopsy
Vaginal polyp^[83]^[84]^[85]^[86]	Postmenopausal bleeding	+	+	+	Dyspareunia Postcoidal bleeding Dysuria Constipation	-	+	Mass protruding from vagina	+/-	-	-	-	To exclude uterine hyperplasia/carcinoma	To determine the extent	N/A	Benign tissue/premalignant cells	Excisional biopsy
Vaginal adenosis^[87]^[88]	Intermenstrual bleeding Postmenopausal bleeding	+/-	+/-	+/-	-	-	-	Palpable cysts,nodularity or ulcers	-	-	-	-	N/A	N/A	N/A	Columnar cells in the ectocervix	Biopsy with histopathological examination

Differentiating [Disease name] from other Diseases

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].

OR

As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].

Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

	Symptoms				Physical examination				Diagnosis
Diseases	Clinical manifestations								Diagnosis							Gold standard	Additional findings	Others
	Symptoms				Physical examination				Lab Findings			Imaging
	Abdominal pain	Bowel habits	Blood in stool	Weight loss	General appearance	Abdominal exam	Rectal exam	Genitourinary exam	CBC	Tumor markers	Stool test	Colonoscopy	Barium enema	Ultrasound	CT scan
Rectal carcinoma^[89]^[90]^[91]^[92]^[93]	LLQ	Constipation/diarrhea	+	+	lethargy pallor confusion emaciation	tenderness hepatomegaly ascites absent bowel sounds	rectal mass rectal bleeding	NL	Anemia	↑ CEA ↑ CA19-9	FOBT+	mass/polyp	Apple core apearance	Endoscopic/trnasrectal US detects tumor extent	Determine tumor stage	colonoscopy with biopsy	DRE & proctoscopy detects tumor localization & extension	↓ Serum iron ↓ Vit: B12 & folate
Rectal polyp^[94]^[95]^[96]	+	Mucous diarrhea	+	+	NL	NL	rectal mass/polyp	NL	NL/anemia	NL	FOBT+	Polyp	N/A	Polyp	N/A	colonoscopy with biopsy	hypoproteinemia hypoalbuminemia	N/A
Anal cancer^[97]^[98]^[99]^[100]	+/-	constipation/diarrhea	+	+/-	NL	NL	lump/mass at anal opening	NL	NL/anemia	N/A	FOBT+	N/A	N/A	Determines anal cancer depth into sphincter	Hypoattenuated necrotic mass on contrast CT	Biopsy	PET/CT detects localization of small anal tumors <2cm	Sentinal lymph node biopsy detects lymph node metastases
Hemorrhoids^[101]^[102]^[103]^[104]	+/-	fecal incontinence/mucous discharge	+	-	NL/weakness,irritability	NL	palpable perianal lump Bleeding PR	NL	iron deficiency anemia	N/A	blood on stool outer surface	Done if colorectal cancer suspected	N/A	N/A	N/A	DRE + anoscopy	anoscopy shows bulging purplish hue veins or dark, pink, glistening mass	None
Rectal prolapse^[105]^[106]^[107]^[108]	Abdominal discomfort	constipation/diarrhea	+/-	-	NL	NL	Intermittent rectum protrusion seen	NL	NL/anemia	N/A	Mucous/blood in stool	May be used for screening	N/A	Reveals asymmetry & any sphincter defect	N/A	History & physical examination	DRE shows patulous anus, attenuated sphincter tone & mass	Anal manometry to assess sphincter function
Foreign body^[109]^[110]^[111]^[112]	Anorectal pain and abdominal pain	Constipation	+	-	Anxious Fever Tachycardia Hypotension	Palpable foreign body Absent bowel sounds Signs of peritonitis	Bleeding per rectum Laceration Mucosal tear Sphincter disruption	NL	Leucocytosis Metabolic acidosis	NL	FOBT+	Foreign body	Contraindicated	Foreign body	Foreign body	Plain radiographs show presence of foreign body	NL	NL
Diseases	Abdominal pain	Bowel habits	Blood in stool	Weight loss	General appearance	Abdominal exam	Rectal exam	Genitourinary exam	CBC	Tumor markers	Stool test	Colonoscopy	Barium enema	Ultrasound	CT scan	Gold standard	Additional findings	Others
Prostatitis^[113]^[114]^[115]^[116]	LLQ/groin pain	NL	N/A	-	NL	NL	NL	Tender/enlarged prostate	leukocytosis	NL/↑ PSA	N/A	N/A	N/A	Focal hypoechoic regoin in peripheral prostate Fluid collection suggests abscess	Edematous/enlarged prostate	N/A	prostate biopsy & thermograms may also be done	↑ CRP
Fecal impaction^[117]^[118]^[119]^[120]	+	constipation	-	+/-	agitation confusion Worsening psychosis	abdominal distension with tympany Diffuse abdominal tenderness with palpable malleable tubular structure indicating stool filled rectosigmoid	DRE shows fecal impaction	NL	Mild leukocytosis	N/A	N/A	N/A	Used in softening of stool & stimulation of evacuation	N/A	Presence of fecal matter in colon	DRE to detect fecal impaction	dehydration hyponatremia Hypokalemic metabolic alkalosis	Abdominal radiograph to detect fecal loading
Anal stenosis^[121]^[122]^[123]	+	constipation	+	+/-	NL	NL	Visual inspection shows stenosis	NL	NL	N/A	NL	Contraindicated	N/A	N/A	N/A	Visual inspection with DRE	Incomplete evacuation	None
Hypertrophied anal papillae^[124]^[125]^[126]^[127]	-	NL	+/-	-	NL	NL	Firm & palpable papillae on digital examination	NL	NL	N/A	Mixed with blood	N/A	Smooth polyp located inside anal verge	N/A	N/A	Visual inspection with digital examination	Associated with anal fissure & anal skin tag	None
Endometriosis^[128]^[129]^[130]	+/- Dull pelvic pain	Constipation Diarrhea Dyschezia Bowel cramping	-	-	Fatigue	Mild tenderness	Nodules in posterior fornix Adnexal masses Immobility Lateral placement of the cervix or uterus	Tenderness on vaginal exam	Anemia	-	-	N/A	N/A	Lesions can be detected on usg	Not required	N/A	N/A	N/A
Uterine malignancy^[131]^[132]^[133]	-	NL	-	+	Pallor Fatigue	NL	Pelvic mass	Vaginal bleeding Enlarged uterus Fixed uterus	Anemia	Hcg	-	N/A	N/A	Increased thickness of uterine wall >4mm	N/A	Endometrial biopsy	N/A	N/A
Diseases	Abdominal pain	Bowel habits	Blood in stool	Weight loss	General appearance	Abdominal exam	Rectal exam	Genitourinary exam	CBC	Tumor markers	Stool test	Colonoscopy	Barium enema	Ultrasound	CT scan	Gold standard	Additional findings	Others
Cervical malignancy^[134]	-	Normal	-	+	Pallor Fatigue	NL	Pelvic mass	Cervical growth Bleeding Cervical stenosis Fixed uterus	Anemia	N/A	FOBT -	N/A	N/A	Cervical thickening	Detects metastasis	Cone biopsy	N/A	N/A
Pelvic abscess^[135]^[136]	+	Nil	-	+/-	Fever Tachycardia	Guarding Generalized tenderness	Fluctuating mass	Vaginal discharge in females	leucocytosis	-	FOBT -	N/A	N/A	Location and consistency of abscess	Location and consistency of abscess	N/A	N/A	N/A
Pelvic sarcoma^[137]^[138]^[139]	+	NL/constipation	+/-	+/-	NL/cachetic with fever	presence of mass	NL	N/A	Lleukocytosis	↑LDH ↑AFP ↑b-hCG	NL	N/A	N/A	N/A	Well circusmscribed, multinodular/infiltrating mass of soft tissue attenuation	CT/MRI/Biopsy	PET with FDG used for staging	None

References

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↑ Angela D. Levy, Maria A. Manning, Waddah B. Al-Refaie & Markku M. Miettinen (2017). "Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 1-Common Sarcomas: From the Radiologic Pathology Archives". Radiographics : a review publication of the Radiological Society of North America, Inc. 37 (2): 462–483. doi:10.1148/rg.2017160157. PMID 28287938. Unknown parameter |month= ignored (help)

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@@ Line 85: / Line 85: @@
 * [[Colposcopy]]/[[biopsy]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Cervical polyp]]<ref name="pmid151660702">{{cite journal |vauthors=Mitchell H |title=Vaginal discharge--causes, diagnosis, and treatment |journal=BMJ |volume=328 |issue=7451 |pages=1306–8 |date=May 2004 |pmid=15166070 |pmc=420177 |doi=10.1136/bmj.328.7451.1306 |url=}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Cervical polyp]]<ref name="pmid151660702">{{cite journal |vauthors=Mitchell H |title=Vaginal discharge--causes, diagnosis, and treatment |journal=BMJ |volume=328 |issue=7451 |pages=1306–8 |date=May 2004 |pmid=15166070 |pmc=420177 |doi=10.1136/bmj.328.7451.1306 |url=}}</ref><ref>{{Cite journal
+ | author = [[Irene Pecorella]], [[Marco Monti]], [[Maria Luisa Framarino Dei Malatesta]] & [[Gaia Ciardi]]
+ | title = Polyp of the uterine cervix with heterologous fatty tissue
+ | journal = [[Indian journal of pathology & microbiology]]
+ | volume = 61
+ | issue = 4
+ | pages = 593–595
+ | year = 2018
+ | month = October-December
+ | doi = 10.4103/IJPM.IJPM_105_17
+ | pmid = 30303160
+}}</ref><ref>{{Cite journal
+ | author = [[Seema Anushka Tirlapur]], [[Adewale Adeyemo]], [[Neil O'Gorman]] & [[Dan Selo-Ojeme]]
+ | title = Clinico-pathological study of cervical polyps
+ | journal = [[Archives of gynecology and obstetrics]]
+ | volume = 282
+ | issue = 5
+ | pages = 535–538
+ | year = 2010
+ | month = November
+ | doi = 10.1007/s00404-010-1364-x
+ | pmid = 20091045
+}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Postcoital
+* [[Coitus|Postcoital]]
-* Intermenstrual
+* [[Abnormal uterine bleeding|Intermenstrual]]
-* Postmenopausal
+* [[Postmenopausal]]
-* Bleeding after exam
+* [[Bleeding]] after exam
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" | −
@@ Line 98: / Line 120: @@
 | style="background: #F5F5F5; padding: 5px;" | −
 | style="background: #F5F5F5; padding: 5px;" |
-* Mass on exam
+* [[Mass]] on exam
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
@@ Line 104: / Line 126: @@
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Hyper/hypoechogenic masses with or without cysts
+* Hyper/hypoechogenic [[Mass|masses]] with or without [[Cyst|cysts]]
+* Filling the [[Endocervix|endocervical]] or [[Vagina|vaginal canal]]
-* Filling the endocervical or vaginal canal
+| style="background: #F5F5F5; padding: 5px;" |May reveal presence of [[tumor]]
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |[[Computed tomography|CT contrast]] may show presence of a well defined [[mass]]
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-* Epithelial cells with no nuclear atypia/mitoses
-| style="background: #F5F5F5; padding: 5px;" |
-* Hysteroscopy /Biopsy
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Epithelial cells]] with no [[nuclear]] [[atypia]]/[[Mitosis|mitoses]]
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Hysteroscopy]] /[[Biopsy]]
 |-
 | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Leiomyoma|Cervical leiomyoma]]<ref name="pmid27887011">{{cite journal |vauthors=Al-Habib A, Elgamal EA, Aldhahri S, Alokaili R, AlShamrani R, Abobotain A, AlRaddadi K, Alkhalidi H |title=Large primary leiomyoma causing progressive cervical deformity |journal=J Surg Case Rep |volume=2016 |issue=11 |pages= |date=November 2016 |pmid=27887011 |pmc=5159177 |doi=10.1093/jscr/rjw190 |url=}}</ref><ref name="pmid27190823">{{cite journal |vauthors=Adaikkalam J |title=Lipoleiomyoma of Cervix |journal=J Clin Diagn Res |volume=10 |issue=4 |pages=EJ01–2 |date=April 2016 |pmid=27190823 |doi=10.7860/JCDR/2016/16505.7531 |url=}}</ref><ref name="HouserCarrasco1979">{{cite journal|last1=Houser|first1=L. Murray|last2=Carrasco|first2=C. H.|last3=Sheehan|first3=C. R.|title=Lipomatous tumour of the uterus: radiographic and ultrasonic appearance|journal=The British Journal of Radiology|volume=52|issue=624|year=1979|pages=992–993|issn=0007-1285|doi=10.1259/0007-1285-52-624-992}}</ref><ref name="KeriakosMaher2013">{{cite journal|last1=Keriakos|first1=Remon|last2=Maher|first2=Mark|title=Management of Cervical Fibroid during the Reproductive Period|journal=Case Reports in Obstetrics and Gynecology|volume=2013|year=2013|pages=1–3|issn=2090-6684|doi=10.1155/2013/984030}}</ref><ref name="pmid10775744">{{cite journal |vauthors=Coronado GD, Marshall LM, Schwartz SM |title=Complications in pregnancy, labor, and delivery with uterine leiomyomas: a population-based study |journal=Obstet Gynecol |volume=95 |issue=5 |pages=764–9 |date=May 2000 |pmid=10775744 |doi= |url=}}</ref><ref name="Kamra2013">{{cite journal|last1=Kamra|first1=Hemlata T|title=Myxoid Leiomyoma of Cervix|journal=JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH|year=2013|issn=2249782X|doi=10.7860/JCDR/2013/6171.3805}}</ref><ref name="El-agwany2015">{{cite journal|last1=El-agwany|first1=Ahmed Samy|title=Lipoleiomyoma of the uterine cervix: An unusual variant of uterine leiomyoma|journal=The Egyptian Journal of Radiology and Nuclear Medicine|volume=46|issue=1|year=2015|pages=211–213|issn=0378603X|doi=10.1016/j.ejrnm.2014.10.001}}</ref><ref name="pmid14960521">{{cite journal |vauthors=Chaparala RP, Fawole AS, Ambrose NS, Chapman AH |title=Large bowel obstruction due to a benign uterine leiomyoma |journal=Gut |volume=53 |issue=3 |pages=386, 430 |date=March 2004 |pmid=14960521 |pmc=1773948 |doi= |url=}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Heavy/prolonged menstrual bleeding
+* Heavy/prolonged [[menstrual bleeding]]
-* Intermenstrual bleeding
+* [[Abnormal uterine bleeding|Intermenstrual bleeding]]
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Urinary retention
+* [[Urinary retention]]
-* Constipation
+* [[Constipation]]
-* Infertility
+* [[Infertility]]
-* Bowel obstruction
+* [[Bowel obstruction]]
-* Increase in pregnancy/labor complications
+* Increase in [[pregnancy]]/[[Childbirth|labor]] complications
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Large,irregular pelvic mass
+* Large,irregular [[Pelvic masses|pelvic mass]]
 | style="background: #F5F5F5; padding: 5px;" |±
 *
@@ Line 141: / Line 158: @@
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Well circumscribed hyperechoic mass
+* Well circumscribed hyperechoic [[mass]]
-| style="background: #F5F5F5; padding: 5px;" |'''T2-weighted MRI''':
+| style="background: #F5F5F5; padding: 5px;" |'''T2-weighted [[Magnetic resonance imaging|MRI]]''':
-* Hypointense masses
+* Hypointense [[Mass|masses]]
 * Homogeneous
 enhancement
 * Red degeneration
+| style="background: #F5F5F5; padding: 5px;" |N/A
 | style="background: #F5F5F5; padding: 5px;" |
+* Spindle shaped [[smooth muscle cells]]
+* Mature [[Adipocyte|adipocytes]]
+* [[Extracellular matrix]] consist of [[collagen]],[[fibronectin]].
 | style="background: #F5F5F5; padding: 5px;" |
-* Spindle shaped smooth muscle cells
+* [[Clinical]] [[diagnosis]]/ and
-* Mature adipocytes
-* Extracellular matrix consist of collagen,fibronectin.
-| style="background: #F5F5F5; padding: 5px;" |
-* Clinical diagnosis/ and
-* Ultrasound
+* [[Ultrasound]]
 |-
 | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Lymphoma|Cervical lymphoma]]<ref name="pmid10422676">{{cite journal |vauthors=Grace A, O'Connell N, Byrne P, Prendiville W, O'Donnell R, Royston D, Walsh CB, Leader M, Kay E |title=Malignant lymphoma of the cervix. An unusual presentation and a rare disease |journal=Eur. J. Gynaecol. Oncol. |volume=20 |issue=1 |pages=26–8 |date=1999 |pmid=10422676 |doi= |url=}}</ref><ref name="KanaanParente2012">{{cite journal|last1=Kanaan|first1=Daniel|last2=Parente|first2=Daniella Braz|last3=Constantino|first3=Carolina Pesce Lamas|last4=Souza|first4=Rodrigo Canellas de|title=Linfoma de colo de útero: achados na ressonância magnética|journal=Radiologia Brasileira|volume=45|issue=3|year=2012|pages=167–169|issn=0100-3984|doi=10.1590/S0100-39842012000300009}}</ref><ref name="pmid17065003">{{cite journal |vauthors=Frey NV, Svoboda J, Andreadis C, Tsai DE, Schuster SJ, Elstrom R, Rubin SC, Nasta SD |title=Primary lymphomas of the cervix and uterus: the University of Pennsylvania's experience and a review of the literature |journal=Leuk. Lymphoma |volume=47 |issue=9 |pages=1894–901 |date=September 2006 |pmid=17065003 |doi=10.1080/10428190600687653 |url=}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Postmenopausal bleeding
+* [[Postmenopausal bleeding]]
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Difficulty urinating
+* [[Dysuria|Difficulty urinating]]
-* Post-coital pain
+* [[Coitus|Post-coital]] [[pain]]
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Larrge uterine/cervix mass
+* Large [[Uterus|uterine]]/[[cervix]] [[mass]]
 * Irregularity
@@ Line 178: / Line 195: @@
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Well-defined, solid, concentric, hypoechoic mass
+* Well-defined, solid, concentric, hypoechoic [[mass]]
-| style="background: #F5F5F5; padding: 5px;" |'''MRI:'''
+| style="background: #F5F5F5; padding: 5px;" |'''[[Magnetic resonance imaging|MRI:]]'''
-* Intramyometrial infiltrative nodules
+* [[Myometrium|Intramyometrial]] infiltrative nodules
-| style="background: #F5F5F5; padding: 5px;" |Diffuse heterogeneous uterine cervical mass & hypoechoic enlarged iliac lymph nodes
+| style="background: #F5F5F5; padding: 5px;" |Diffuse heterogeneous [[Uterus|uterine]]/[[Cervix|cervical]] [[mass]] & hypoechoic enlarged [[iliac lymph nodes]]
 | style="background: #F5F5F5; padding: 5px;" |
-* Small tumor cells with large nuclei
+* Small [[Tumor cell|tumor cells]] with large [[nuclei]]
-* High mitoses and proliferation
+* High [[Mitosis|mitoses]] and [[proliferation]]
 | style="background: #F5F5F5; padding: 5px;" |
-* Biopsy
+* [[Biopsy]]
-* diffuse large B-Cell lymphoma (DLBCL) most frequent type.
+* [[Diffuse large B cell lymphoma|diffuse large B-Cell lymphoma (DLBCL)]] most frequent type.
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Sarcoma|Cervical sarcoma]]<ref name="pmid16051326">{{cite journal |vauthors=Wright JD, Rosenblum K, Huettner PC, Mutch DG, Rader JS, Powell MA, Gibb RK |title=Cervical sarcomas: an analysis of incidence and outcome |journal=Gynecol. Oncol. |volume=99 |issue=2 |pages=348–51 |date=November 2005 |pmid=16051326 |doi=10.1016/j.ygyno.2005.06.021 |url=}}</ref><ref name="pmid26587944">{{cite journal |vauthors=Miccò M, Sala E, Lakhman Y, Hricak H, Vargas HA |title=Imaging Features of Uncommon Gynecologic Cancers |journal=AJR Am J Roentgenol |volume=205 |issue=6 |pages=1346–59 |date=December 2015 |pmid=26587944 |pmc=5502476 |doi=10.2214/AJR.14.12695 |url=}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Sarcoma|Cervical sarcoma]]<ref name="pmid16051326">{{cite journal |vauthors=Wright JD, Rosenblum K, Huettner PC, Mutch DG, Rader JS, Powell MA, Gibb RK |title=Cervical sarcomas: an analysis of incidence and outcome |journal=Gynecol. Oncol. |volume=99 |issue=2 |pages=348–51 |date=November 2005 |pmid=16051326 |doi=10.1016/j.ygyno.2005.06.021 |url=}}</ref><ref name="KhoslaGupta2012">{{cite journal|last1=Khosla|first1=Divya|last2=Gupta|first2=Ruchi|last3=Srinivasan|first3=Radhika|last4=Patel|first4=Firuza D.|last5=Rajwanshi|first5=Arvind|title=Sarcomas of Uterine Cervix|journal=International Journal of Gynecological Cancer|volume=22|issue=6|year=2012|pages=1026–1030|issn=1048-891X|doi=10.1097/IGC.0b013e31825a97f6}}</ref><ref name="pmid26587944">{{cite journal |vauthors=Miccò M, Sala E, Lakhman Y, Hricak H, Vargas HA |title=Imaging Features of Uncommon Gynecologic Cancers |journal=AJR Am J Roentgenol |volume=205 |issue=6 |pages=1346–59 |date=December 2015 |pmid=26587944 |pmc=5502476 |doi=10.2214/AJR.14.12695 |url=}}</ref><ref>{{cite journal|doi=10.1097/IGC.0b013e31825a97f6.}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Intermentrual
+* [[Abnormal uterine bleeding|Intermentrual]]
-* Postmenopausal
+* [[Postmenopausal]]
 | style="background: #F5F5F5; padding: 5px;" |±
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Post-coital pain
+* [[Coitus|Post-coital]] [[pain]]
-* Fullness in pelvic
+* Fullness in [[pelvis]]
 | style="background: #F5F5F5; padding: 5px;" | ±
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Cervical mass
+* [[Cervix|Cervical]] [[mass]]
-* Lump protruding  from vagina/vulva
+* [[Lump]] protruding  from [[vagina]]/[[vulva]]
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |−
@@ Line 209: / Line 226: @@
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Endometrial mass with heterogeneous echogenicity
+* [[Endometrium|Endometrial]] [[mass]] with heterogeneous echogenicity
-| style="background: #F5F5F5; padding: 5px;" |'''MRI:'''
+| style="background: #F5F5F5; padding: 5px;" |'''[[Magnetic resonance imaging|MRI]]:'''
-* Endometrial polypoid mass
+* [[Endometrium|Endometrial]] polypoid [[mass]]
 * Hypointense hypervascular solid components
 | style="background: #F5F5F5; padding: 5px;" |N/A
 | style="background: #F5F5F5; padding: 5px;" |
-* Mitotic index
+* [[Mitotic index]]
-* Cellular atypia
+* [[Cell (biology)|Cellular]] [[atypia]]
-* Coagulative necrosis
+* [[Coagulative necrosis]]
 | style="background: #F5F5F5; padding: 5px;" |
-* Biopsy
+* [[Biopsy]]
 |-
 | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Cervical erosion|Cervical erosion(Ectropion)]]<ref name="pmid28460993">{{cite journal |vauthors=Mitchell L, King M, Brillhart H, Goldstein A |title=Cervical Ectropion May Be a Cause of Desquamative Inflammatory Vaginitis |journal=Sex Med |volume=5 |issue=3 |pages=e212–e214 |date=September 2017 |pmid=28460993 |pmc=5562466 |doi=10.1016/j.esxm.2017.03.001 |url=}}</ref><ref name="pmid15166070">{{cite journal |vauthors=Mitchell H |title=Vaginal discharge--causes, diagnosis, and treatment |journal=BMJ |volume=328 |issue=7451 |pages=1306–8 |date=May 2004 |pmid=15166070 |pmc=420177 |doi=10.1136/bmj.328.7451.1306 |url=}}</ref><ref name="SharmaOjha2013">{{cite journal|last1=Sharma|first1=Abhishek|last2=Ojha|first2=Ranapratap|last3=Sengupta|first3=Parama|last4=Chattopadhyay|first4=Sarbani|last5=Mondal|first5=Soumit|title=Cervical intramural pregnancy: Report of a rare case|journal=Nigerian Medical Journal|volume=54|issue=4|year=2013|pages=271|issn=0300-1652|doi=10.4103/0300-1652.119670}}</ref><ref>{{cite journal|doi=10.12865/CHSJ.42.02.11}}</ref><ref name="pmid212702912">{{cite journal |vauthors=Casey PM, Long ME, Marnach ML |title=Abnormal cervical appearance: what to do, when to worry? |journal=Mayo Clin. Proc. |volume=86 |issue=2 |pages=147–50; quiz 151 |date=February 2011 |pmid=21270291 |pmc=3031439 |doi=10.4065/mcp.2010.0512 |url=}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Light bleeding after pelvic exam
+* Light [[bleeding]] after [[Pelvic examination|pelvic exam]]
 * Spotting
 | style="background: #F5F5F5; padding: 5px;" | +
@@ Line 229: / Line 246: @@
 | style="background: #F5F5F5; padding: 5px;" |±
 | style="background: #F5F5F5; padding: 5px;" |
-* Post-coital pain
+* [[Coitus|Post-coital]] [[pain]]
-* Painful cramps
+* Painful [[Cramp|cramps]]
-* Pain after sex
+* [[Dyspareunia|Pain after sex]]
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" | +
@@ Line 238: / Line 255: @@
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
 | style="background: #F5F5F5; padding: 5px;" |N/A
 | style="background: #F5F5F5; padding: 5px;" |N/A
 | style="background: #F5F5F5; padding: 5px;" |N/A
 | style="background: #F5F5F5; padding: 5px;" |
-* Squamous metaplasia
+* [[Squamous metaplasia]]
-* Vascular ectasia
+* [[Ectasia|Vascular ectasia]]
-* Lymphocytic infiltration
+* [[Lymphocytic]] [[Infiltration (medical)|infiltration]]
 | style="background: #F5F5F5; padding: 5px;" |
 * [[Colposcopy]] and [[biopsy]]
@@ Line 251: / Line 268: @@
 | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Cervicitis]]<ref name="pmid27243142">{{cite journal |vauthors=Mattson SK, Polk JP, Nyirjesy P |title=Chronic Cervicitis: Presenting Features and Response to Therapy |journal=J Low Genit Tract Dis |volume=20 |issue=3 |pages=e30–3 |date=July 2016 |pmid=27243142 |doi=10.1097/LGT.0000000000000225 |url=}}</ref><ref name="pmid2660084">{{cite journal |vauthors=Rosenfeld WD, Clark J |title=Vulvovaginitis and cervicitis |journal=Pediatr. Clin. North Am. |volume=36 |issue=3 |pages=489–511 |date=June 1989 |pmid=2660084 |doi= |url=}}</ref><ref name="pmid27681919">{{cite journal |vauthors=Meyer T |title=Diagnostic Procedures to Detect Chlamydia trachomatis Infections |journal=Microorganisms |volume=4 |issue=3 |pages= |date=August 2016 |pmid=27681919 |doi=10.3390/microorganisms4030025 |url=}}</ref><ref name="WoodsBailey2011">{{cite journal|last1=Woods|first1=Jennifer L.|last2=Bailey|first2=Sarabeth L.|last3=Hensel|first3=Devon J.|last4=Scurlock|first4=Amy M.|title=Cervicitis in Adolescents: Do Clinicians Understand Diagnosis and Treatment?|journal=Journal of Pediatric and Adolescent Gynecology|volume=24|issue=6|year=2011|pages=359–364|issn=10833188|doi=10.1016/j.jpag.2011.06.006}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Intermenstrual bleeding
+* [[Abnormal uterine bleeding|Intermenstrual bleeding]]
-* Postcoital
+* [[Coitus|Postcoital]]
-* Bleeding after pelvic exam
+* [[Bleeding]] after [[Pelvic examination|pelvic exam]]
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Itching
+* [[Itching]]
 | style="background: #F5F5F5; padding: 5px;" |
-* Pain during urination
+* [[Dysuria|Pain during urination]]
-* Pain during sex
+* [[Dyspareunia|Pain during sex]]
-* Painful menstruation
+* [[Dysmenorrhea|Painful menstruation]]
 | style="background: #F5F5F5; padding: 5px;" |
-* May have fever only
+* May have [[fever]] only
+| style="background: #F5F5F5; padding: 5px;" | +/-
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+* Red,[[Inflammation|inflammed]] swollen [[cervix]]
-* Red,inflammed swollen cervix
+* [[Inflammation]]/[[irritation]] of [[vulva]]/[[vagina]]
-* Inflammation/irritation of vulva/vagina
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Chlamydia
+* [[Chlamydia infection|Chlamydia]]
-* Gonorrhea
+* [[Gonorrhea]]
-* Herpes simplex
+* [[Herpes simplex]]
-* Trichomonas vaginalis
+* [[Trichomonas vaginalis]]
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |To detect [[complications]] like [[PID]]
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |N/A
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |N/A
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |N/A
 | style="background: #F5F5F5; padding: 5px;" |
 * [[Nucleic acid amplification technique|Nucleic acid amplification tests]] ([[NAAT]]<nowiki/>s)
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Intrauterine device|IUD use]]<ref name="pmid347074">{{cite journal |vauthors=Trobough GE |title=Pelvic pain and the IUD |journal=J Reprod Med |volume=20 |issue=3 |pages=167–74 |date=March 1978 |pmid=347074 |doi= |url=}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Intrauterine device|IUD use]]<ref name="pmid347074">{{cite journal |vauthors=Trobough GE |title=Pelvic pain and the IUD |journal=J Reprod Med |volume=20 |issue=3 |pages=167–74 |date=March 1978 |pmid=347074 |doi= |url=}}</ref><ref>{{Cite journal
+ | author = [[D. Reinprayoon]], [[S. Taneepanichskul]], [[S. Niruthisard]] & [[S. Suwajanakon]]
+ | title = Uterine histopathologic changes after Cu-Fix intrauterine device insertion
+ | journal = [[Contraception]]
+ | volume = 59
+ | issue = 1
+ | pages = 63–65
+ | year = 1999
+ | month = January
+ | pmid = 10342087
+}}</ref><ref>{{Cite journal
+ | author = [[Seyma Fadiloglu]], [[B. Dilbaz]], [[E. Fadiloglu]] & [[S. Dilbaz]]
+ | title = Relationship between copper IUD complications and ultrasonographic findings
+ | journal = [[Archives of gynecology and obstetrics]]
+ | volume = 297
+ | issue = 4
+ | pages = 989–996
+ | year = 2018
+ | month = April
+ | doi = 10.1007/s00404-018-4711-y
+ | pmid = 29428979
+}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Heavy bleeidng
+* Heavy [[bleeding]]
 | style="background: #F5F5F5; padding: 5px;" |±
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Itching
+* [[Itching]]
 | style="background: #F5F5F5; padding: 5px;" |
-* Painful menstruation
+* [[Dysmenorrhea|Painful menstruation]]
 | style="background: #F5F5F5; padding: 5px;" |−
+| style="background: #F5F5F5; padding: 5px;" | +/-
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+* Strings of [[Intrauterine device|IUD]] device
+* Signs of [[inflammation]]
+* [[Discharge]]
+* [[Bleeding]]
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |±
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |To detect [[Intrauterine device|IUD]] location and [[pregnancy]]
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |N/A
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |N/A
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |N/A
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |[[Physical examination|Physical exam]] and [[ultrasound]]
 |-
 | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pelvic inflammatory disease|Pelvic inflammatory diseases]]<ref name="pmid30606817">{{cite journal |vauthors=Hoenderboom BM, van Benthem BHB, van Bergen JEAM, Dukers-Muijrers NHTM, Götz HM, Hoebe CJPA, Hogewoning AA, Land JA, van der Sande MAB, Morré SA, van den Broek IVF |title=Relation between Chlamydia trachomatis infection and pelvic inflammatory disease, ectopic pregnancy and tubal factor infertility in a Dutch cohort of women previously tested for chlamydia in a chlamydia screening trial |journal=Sex Transm Infect |volume= |issue= |pages= |date=January 2019 |pmid=30606817 |doi=10.1136/sextrans-2018-053778 |url=}}</ref><ref name="pmid21822367">{{cite journal |vauthors=Jaiyeoba O, Soper DE |title=A practical approach to the diagnosis of pelvic inflammatory disease |journal=Infect Dis Obstet Gynecol |volume=2011 |issue= |pages=753037 |date=2011 |pmid=21822367 |pmc=3148590 |doi=10.1155/2011/753037 |url=}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Bleeding after sex
+* [[Coitus|Postcoital]] [[bleeding]]
-* Intermenstrual bleeding
+* [[Abnormal uterine bleeding|Intermenstrual bleeding]]
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Itching/burning
+* [[Itching]]/burning
 | style="background: #F5F5F5; padding: 5px;" |
-* Pain during sex
+* [[Dyspareunia|Pain during sex]]
-* Painful menstruation
+* [[Dysmenorrhea|Painful menstruation]]
-* Burning sensation during urination
+* [[Burning during urination|Burning sensation during urination]]
-* Pain during bowel movement
+* [[Pain]] during [[bowel movement]]
 | style="background: #F5F5F5; padding: 5px;" |
 * Fever
-| style="background: #F5F5F5; padding: 5px;" |±Abdominal
+| style="background: #F5F5F5; padding: 5px;" |±[[Abdominal pain|Abdominal]]
-pain
+[[Abdominal pain|pain]]
-* Pelvic pain
+* [[Pelvic pain]]
 | style="background: #F5F5F5; padding: 5px;" |
-* Vaginal/vulvar  tender lesion depending on microbial cause
+* [[Vagina|Vaginal]]/[[Vulva|vulvar]]  tender lesion depending on microbial cause
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Chlamydia
+* [[Chlamydia infection|Chlamydia]]
+* [[Gonorrhea]]
-* Gonorrhea
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
+* Enlarged [[fallopian tubes]]
+* [[Abscess]]
+* [[Hyperaemia|Hyperemia]]
+* [[Ectopic pregnancy]]/[[ovarian cyst]]/[[abscess]]
+| style="background: #F5F5F5; padding: 5px;" |Thickened fluid filled [[fallopian tubes]]
+| style="background: #F5F5F5; padding: 5px;" |N/A
+| style="background: #F5F5F5; padding: 5px;" |May show [[endometritis]]
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Pelvic inflammatory disease diagnostic criteria|CDC diagnostic criteria of PID]]
 |-
 | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Endometriosis]]<ref name="pmid20436318">{{cite journal |vauthors=Hsu AL, Khachikyan I, Stratton P |title=Invasive and noninvasive methods for the diagnosis of endometriosis |journal=Clin Obstet Gynecol |volume=53 |issue=2 |pages=413–9 |date=June 2010 |pmid=20436318 |pmc=2880548 |doi=10.1097/GRF.0b013e3181db7ce8 |url=}}</ref><ref name="ChamiéBlasbalg2011">{{cite journal|last1=Chamié|first1=Luciana Pardini|last2=Blasbalg|first2=Roberto|last3=Pereira|first3=Ricardo Mendes Alves|last4=Warmbrand|first4=Gisele|last5=Serafini|first5=Paulo Cesar|title=Findings of Pelvic Endometriosis at Transvaginal US, MR Imaging, and Laparoscopy|journal=RadioGraphics|volume=31|issue=4|year=2011|pages=E77–E100|issn=0271-5333|doi=10.1148/rg.314105193}}</ref><ref name="pmid18850447">{{cite journal |vauthors=Datta S, Kunde K |title=From vaginal discharge to endometriosis: an unusual case of endometriosis in pregnancy |journal=J Obstet Gynaecol |volume=28 |issue=5 |pages=552–3 |date=July 2008 |pmid=18850447 |doi=10.1080/01443610802247352 |url=}}</ref><ref name="ChamiéBlasbalg20112">{{cite journal|last1=Chamié|first1=Luciana Pardini|last2=Blasbalg|first2=Roberto|last3=Pereira|first3=Ricardo Mendes Alves|last4=Warmbrand|first4=Gisele|last5=Serafini|first5=Paulo Cesar|title=Findings of Pelvic Endometriosis at Transvaginal US, MR Imaging, and Laparoscopy|journal=RadioGraphics|volume=31|issue=4|year=2011|pages=E77–E100|issn=0271-5333|doi=10.1148/rg.314105193}}</ref><ref name="pmid14734195">{{cite journal |vauthors=Bedaiwy MA, Falcone T |title=Laboratory testing for endometriosis |journal=Clin. Chim. Acta |volume=340 |issue=1-2 |pages=41–56 |date=February 2004 |pmid=14734195 |doi= |url=}}</ref><ref name="pmid20503240">{{cite journal |vauthors=Van Holsbeke C, Van Calster B, Guerriero S, Savelli L, Paladini D, Lissoni AA, Czekierdowski A, Fischerova D, Zhang J, Mestdagh G, Testa AC, Bourne T, Valentin L, Timmerman D |title=Endometriomas: their ultrasound characteristics |journal=Ultrasound Obstet Gynecol |volume=35 |issue=6 |pages=730–40 |date=June 2010 |pmid=20503240 |doi=10.1002/uog.7668 |url=}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Heavy mentrual bleeding
+* [[Menometrorrhagia|Heavy mentrual bleeding]]
 | style="background: #F5F5F5; padding: 5px;" |±
 | style="background: #F5F5F5; padding: 5px;" |
-* Pelvic pain
+* [[Pelvic pain]]
-* Back pain
+* [[Back pain]]
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Painful menstruation
+* [[Dysmenorrhea|Painful menstruation]]
-* Burning/painful urination
+* [[Dysuria|Burning/painful urination]]
+* Painful [[bowel movement]]
-* Painful bowel movement
+* [[Dyspareunia|Pain during or after sex]]
+* [[Infertility]]
-* Pain during or after sex
-* Infertility
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Tender uterosacral nodularity
+* [[Tenderness|Tender]] [[Uterosacral ligaments|uterosacral]] nodularity
+* Immobile [[uterus]]
-* Immobile uterus
+* [[Cervical motion tenderness]]
-* Cervical motion tenderness
+* [[Retroverted uterus]]
-* Retroverted uterus
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
+* Unilocular/multilocular [[Cyst|cysts]] contating thin/thick septations
+* Increased [[vascularity]] showing increased doppler flow
 | style="background: #F5F5F5; padding: 5px;" |
+* Hyperintensity on T1 weighted images
+* Hypointensity on T2 weighted images
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Catamenial pneumothorax]], [[hemothorax]] & [[Pulmonary nodule|lung nodules]]
+| style="background: #F5F5F5; padding: 5px;" |Presence of [[Endometrium|endometrial tissue]] outside the [[uterus]]
 | style="background: #F5F5F5; padding: 5px;" |
-*
+* Visual [[Inspection (medicine)|inspection]] by [[laparoscopy]]
-| style="background: #F5F5F5; padding: 5px;" |
-* Visual inspection by laparascopy
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Adenomyosis]]<ref name="pmid30486633">{{cite journal |vauthors=Filip G, Balzano A, Cagnacci A |title=Histological evaluation of the prevalence of adenomyosis, myomas and of their concomitance |journal=Minerva Ginecol |volume= |issue= |pages= |date=November 2018 |pmid=30486633 |doi=10.23736/S0026-4784.18.04291-0 |url=}}</ref><ref name="pmid1492806">{{cite journal |vauthors=Fujino T, Watanabe T, Shinmura R, Hahn L, Nagata Y, Hasui K |title=Acute abdomen due to adenomyosis of the uterus: a case report |journal=Asia Oceania J Obstet Gynaecol |volume=18 |issue=4 |pages=333–7 |date=December 1992 |pmid=1492806 |doi= |url=}}</ref><ref name="pmid14928062">{{cite journal |vauthors=Fujino T, Watanabe T, Shinmura R, Hahn L, Nagata Y, Hasui K |title=Acute abdomen due to adenomyosis of the uterus: a case report |journal=Asia Oceania J Obstet Gynaecol |volume=18 |issue=4 |pages=333–7 |date=December 1992 |pmid=1492806 |doi= |url=}}</ref><ref name="pmid9275451">{{cite journal |vauthors=Zhou Y, Wu B, Li H |title=[The value of serum CA125 assays in the diagnosis of uterine adenomyosis] |language=Chinese |journal=Zhonghua Fu Chan Ke Za Zhi |volume=31 |issue=10 |pages=590–3 |date=October 1996 |pmid=9275451 |doi= |url=}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Adenomyosis]]<ref name="pmid30486633">{{cite journal |vauthors=Filip G, Balzano A, Cagnacci A |title=Histological evaluation of the prevalence of adenomyosis, myomas and of their concomitance |journal=Minerva Ginecol |volume= |issue= |pages= |date=November 2018 |pmid=30486633 |doi=10.23736/S0026-4784.18.04291-0 |url=}}</ref><ref name="pmid1492806">{{cite journal |vauthors=Fujino T, Watanabe T, Shinmura R, Hahn L, Nagata Y, Hasui K |title=Acute abdomen due to adenomyosis of the uterus: a case report |journal=Asia Oceania J Obstet Gynaecol |volume=18 |issue=4 |pages=333–7 |date=December 1992 |pmid=1492806 |doi= |url=}}</ref><ref name="pmid14928062">{{cite journal |vauthors=Fujino T, Watanabe T, Shinmura R, Hahn L, Nagata Y, Hasui K |title=Acute abdomen due to adenomyosis of the uterus: a case report |journal=Asia Oceania J Obstet Gynaecol |volume=18 |issue=4 |pages=333–7 |date=December 1992 |pmid=1492806 |doi= |url=}}</ref><ref name="pmid9275451">{{cite journal |vauthors=Zhou Y, Wu B, Li H |title=[The value of serum CA125 assays in the diagnosis of uterine adenomyosis] |language=Chinese |journal=Zhonghua Fu Chan Ke Za Zhi |volume=31 |issue=10 |pages=590–3 |date=October 1996 |pmid=9275451 |doi= |url=}}</ref><ref>{{Cite journal
+ | author = [[Courtney A. Woodfield]], [[Evan S. Siegelman]], [[Beverly G. Coleman]] & [[Drew A. Torigian]]
+ | title = CT features of adenomyosis
+ | journal = [[European journal of radiology]]
+ | volume = 72
+ | issue = 3
+ | pages = 464–469
+ | year = 2009
+ | month = December
+ | doi = 10.1016/j.ejrad.2008.08.002
+ | pmid = 18804933
+}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Abnormal uterine bleeding
+* [[Abnormal uterine bleeding]]
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Painful menstruation
+* [[Dysmenorrhea|Painful menstruation]]
 | style="background: #F5F5F5; padding: 5px;" |−
+| style="background: #F5F5F5; padding: 5px;" | +/-
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+* Polypoid [[mass]] protruding into the [[Endocervix|endocervical canal.]]
-* Polypoid mass protruding into the endocervical canal.
+| style="background: #F5F5F5; padding: 5px;" | +/-
-| style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Transvaginal ultrasound|Transvaginal US]] shows poorly marginated hypoechoic & heterogenous areas within [[myometrium]]
+* [[Myometrium|Myometrial]] [[Cyst|cysts]]
+* Globular/enlarged [[uterus]] with asymmetry
+| style="background: #F5F5F5; padding: 5px;" |'''[[Magnetic resonance imaging|MRI]]:'''
+* Thickened junctional zone
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Enlarged uterus|Uterine enlargement]]
+* Thickened inner [[myometrium]]
+* [[Myometrium|Myometrial]] [[Cyst|cysts]]
 | style="background: #F5F5F5; padding: 5px;" |
+* Presence of [[ectopic]] [[Endometrium|endometrial]] [[Gland|glands]] into the [[myometrium]].
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Histology]] findings post [[hysterectomy]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Ectopic pregnancy|Cervical ectopic pregnancy]]<ref name="pmid28955106">{{cite journal |vauthors=Mouhajer M, Obed S, Okpala AM |title=Cervical Ectopic Pregnancy in Resource Deprived Areas: A Rare and Difficult Diagnosis |journal=Ghana Med J |volume=51 |issue=2 |pages=94–97 |date=June 2017 |pmid=28955106 |pmc=5611908 |doi= |url=}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Ectopic pregnancy|Cervical ectopic pregnancy]]<ref name="pmid28955106">{{cite journal |vauthors=Mouhajer M, Obed S, Okpala AM |title=Cervical Ectopic Pregnancy in Resource Deprived Areas: A Rare and Difficult Diagnosis |journal=Ghana Med J |volume=51 |issue=2 |pages=94–97 |date=June 2017 |pmid=28955106 |pmc=5611908 |doi= |url=}}</ref><ref name="RathodSamal2015">{{cite journal|last1=Rathod|first1=Setu|last2=Samal|first2=SunilKumar|title=Cervical ectopic pregnancy|journal=Journal of Natural Science, Biology and Medicine|volume=6|issue=1|year=2015|pages=257|issn=0976-9668|doi=10.4103/0976-9668.149221}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Amennorhea
+* [[Amenorrhea]]
+* [[Bleeding]] after [[Pelvic examination|pelvic exam]]
-* Bleeding after pelvic exam
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Pelvic pain
+* [[Pelvic pain]]
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Soft and disporportionally enlarged uterus.
+* Soft and disporportionally [[enlarged uterus]].
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |−
@@ Line 418: / Line 484: @@
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Empty uterine
+* Empty [[uterus]]
-* Thickened endometrium
+* Thickened [[endometrium]]
-| style="background: #F5F5F5; padding: 5px;" | '''T2-weighted MRI''':
+| style="background: #F5F5F5; padding: 5px;" | '''T2-weighted [[Magnetic resonance imaging|MRI]]''':
-* Hypointense large mass
+* Hypointense large [[mass]]
-'''T1-weighted MRI''':
+'''T1-weighted [[Magnetic resonance imaging|MRI]]''':
-* Partially hyperintense mass
+* Partially hyperintense [[mass]]
+| style="background: #F5F5F5; padding: 5px;" |N/A
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Necrosis|Necrotic]] [[hemorrhagic]] [[mass]] with [[chorionic villus]]
 | style="background: #F5F5F5; padding: 5px;" |
-* Necrotic hemorrhagic mass with chorionic villus
+* [[Hysterectomy]] and [[biopsy]]
-| style="background: #F5F5F5; padding: 5px;" |
-* Hysterectomy and biopsy
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[DES|DES exposure]] (Clear cell adenocarcinoma)<ref name="pmid28275694">{{cite journal |vauthors=Tantitamit T, Hamontri S, Rangsiratanakul L |title=Clear cell adenocarcinoma of the cervix in second generation young women who are without maternal exposure to diethylstilbestrol: A case report |journal=Gynecol Oncol Rep |volume=20 |issue= |pages=34–36 |date=May 2017 |pmid=28275694 |pmc=5328756 |doi=10.1016/j.gore.2017.02.008 |url=}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[DES|DES exposure]] (Clear cell adenocarcinoma)<ref name="pmid28275694">{{cite journal |vauthors=Tantitamit T, Hamontri S, Rangsiratanakul L |title=Clear cell adenocarcinoma of the cervix in second generation young women who are without maternal exposure to diethylstilbestrol: A case report |journal=Gynecol Oncol Rep |volume=20 |issue= |pages=34–36 |date=May 2017 |pmid=28275694 |pmc=5328756 |doi=10.1016/j.gore.2017.02.008 |url=}}</ref><ref>{{Cite journal
+ | author = [[Subrata Pal]], [[Sritanu Jana]] & [[Kingshuk Bose]]
+ | title = Clear cell carcinoma of cervix in a postmenopausal woman: A case report
+ | journal = [[Journal of mid-life health]]
+ | volume = 6
+ | issue = 2
+ | pages = 85–87
+ | year = 2015
+ | month = April-June
+ | doi = 10.4103/0976-7800.158964
+ | pmid = 26167060
+}}</ref><ref>{{Cite journal
+ | author = [[Mary G. Dandulakis]], [[Aidas J. Mattis]], [[Andrea R. Hagemann]] & [[Ian S. Hagemann]]
+ | title = Cervical clear cell adenocarcinoma with an exceptionally low proliferation index: Report of a case
+ | journal = [[Gynecologic oncology reports]]
+ | volume = 23
+ | pages = 16–19
+ | year = 2018
+ | month = February
+ | doi = 10.1016/j.gore.2017.12.006
+ | pmid = 29326971
+}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Postcoital bleeding
+* [[Coitus|Postcoital]] [[bleeding]]
+* [[Postmenopausal bleeding]]
 | style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +/-
+| style="background: #F5F5F5; padding: 5px;" | +/-
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal pain]]
+* [[Melena|Blood in feces]]
+| style="background: #F5F5F5; padding: 5px;" | +/-
+| style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+* Normal looking [[cervix]]
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Cervical]] exophytic lesions
-| style="background: #F5F5F5; padding: 5px;" |
+* Barrel shaped [[cervix]]
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
+| style="background: #F5F5F5; padding: 5px;" |To determine [[Uterus|uterine]] extent
+| style="background: #F5F5F5; padding: 5px;" |To detect [[Metastasis|metastases]]
 | style="background: #F5F5F5; padding: 5px;" |
+* Irregular dense [[mass]] occupying inferior lip of [[cervix]] and [[posterior fornix]]
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Tumor cell|Tumor cells]] with abundant clear [[cytoplasm]] and round [[nuclei]]
+* [[Nucleus]] show hyperchromasia, moderate [[pleomorphism]] & prominent [[nucleoli]]
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Biopsy]]
-| style="background: #F5F5F5; padding: 5px;" |
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |Paget's disease of vulva to cervix<ref name="van der LindenMeeuwis2016">{{cite journal|last1=van der Linden|first1=M.|last2=Meeuwis|first2=K.A.P.|last3=Bulten|first3=J.|last4=Bosse|first4=T.|last5=van Poelgeest|first5=M.I.E.|last6=de Hullu|first6=J.A.|title=Paget disease of the vulva|journal=Critical Reviews in Oncology/Hematology|volume=101|year=2016|pages=60–74|issn=10408428|doi=10.1016/j.critrevonc.2016.03.008}}</ref><ref name="pmid10605411">{{cite journal |vauthors=Lloyd J, Evans DJ, Flanagan AM |title=Extension of extramammary Paget disease of the vulva to the cervix |journal=J. Clin. Pathol. |volume=52 |issue=7 |pages=538–40 |date=July 1999 |pmid=10605411 |pmc=501500 |doi= |url=}}</ref><ref name="pmid19952933">{{cite journal |vauthors=Shaco-Levy R, Bean SM, Vollmer RT, Papalas JA, Bentley RC, Selim MA, Robboy SJ |title=Paget disease of the vulva: a histologic study of 56 cases correlating pathologic features and disease course |journal=Int. J. Gynecol. Pathol. |volume=29 |issue=1 |pages=69–78 |date=January 2010 |pmid=19952933 |doi=10.1097/PGP.0b013e3181b1cc5e |url=}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |Paget's disease of [[vulva]] to [[cervix]]<ref name="van der LindenMeeuwis2016">{{cite journal|last1=van der Linden|first1=M.|last2=Meeuwis|first2=K.A.P.|last3=Bulten|first3=J.|last4=Bosse|first4=T.|last5=van Poelgeest|first5=M.I.E.|last6=de Hullu|first6=J.A.|title=Paget disease of the vulva|journal=Critical Reviews in Oncology/Hematology|volume=101|year=2016|pages=60–74|issn=10408428|doi=10.1016/j.critrevonc.2016.03.008}}</ref><ref name="pmid10605411">{{cite journal |vauthors=Lloyd J, Evans DJ, Flanagan AM |title=Extension of extramammary Paget disease of the vulva to the cervix |journal=J. Clin. Pathol. |volume=52 |issue=7 |pages=538–40 |date=July 1999 |pmid=10605411 |pmc=501500 |doi= |url=}}</ref><ref name="pmid19952933">{{cite journal |vauthors=Shaco-Levy R, Bean SM, Vollmer RT, Papalas JA, Bentley RC, Selim MA, Robboy SJ |title=Paget disease of the vulva: a histologic study of 56 cases correlating pathologic features and disease course |journal=Int. J. Gynecol. Pathol. |volume=29 |issue=1 |pages=69–78 |date=January 2010 |pmid=19952933 |doi=10.1097/PGP.0b013e3181b1cc5e |url=}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Bleeding from lesion
+* [[Bleeding]] from [[lesion]]
-* Oozing
+* [[Oozing]]
 | style="background: #F5F5F5; padding: 5px;" |±
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Itching/burning
+* [[Itching]]/burning
-* Pain in vulva
+* [[Pain]] in [[vulva]]
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
@@ Line 465: / Line 562: @@
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Scaly eczematoid lesion in vulva.
+* Scaly [[eczema|eczematoid]] lesion in [[vulva]].
-* Erythematous plaques with white scaling.
+* [[Erythematous plaques]] with white scaling.
-* Inguinal lymphadenopathy in case of metastases.
+* Inguinal lymphadenopathy in case of [[metastases]].
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
+| style="background: #F5F5F5; padding: 5px;" |N/A
+| style="background: #F5F5F5; padding: 5px;" |'''[[MRI]]:'''
+* Hyperintense on diffusion weighted images
 | style="background: #F5F5F5; padding: 5px;" |
+* May show bilateral enlarged [[inguinal lymph nodes]]
 | style="background: #F5F5F5; padding: 5px;" |
+* Thickened [[vulva|vulvar]] [[skin]]
+* "Cake-icing effect", [[pathognomonic]] for [[vulva|vulva]]vulvar paget's disease
+* Intraepidermal [[adenocarcinoma]] which involves [[epidermis]]
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Biopsy]] of lesion
-* Intraepidermal adenocarcinoma which involves epidermis
-| style="background: #F5F5F5; padding: 5px;" |
-* Biopsy of lesion
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Vaginal cancer]]<ref name="pmid25045355">{{cite journal |vauthors=Tarney CM, Han J |title=Postcoital bleeding: a review on etiology, diagnosis, and management |journal=Obstet Gynecol Int |volume=2014 |issue= |pages=192087 |date=2014 |pmid=25045355 |pmc=4086375 |doi=10.1155/2014/192087 |url=}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Vaginal cancer]]<ref name="pmid25045355">{{cite journal |vauthors=Tarney CM, Han J |title=Postcoital bleeding: a review on etiology, diagnosis, and management |journal=Obstet Gynecol Int |volume=2014 |issue= |pages=192087 |date=2014 |pmid=25045355 |pmc=4086375 |doi=10.1155/2014/192087 |url=}}</ref><ref name="MiccòSala20152">{{cite journal|last1=Miccò|first1=Maura|last2=Sala|first2=Evis|last3=Lakhman|first3=Yulia|last4=Hricak|first4=Hedvig|last5=Vargas|first5=Hebert Alberto|title=Imaging Features of Uncommon Gynecologic Cancers|journal=American Journal of Roentgenology|volume=205|issue=6|year=2015|pages=1346–1359|issn=0361-803X|doi=10.2214/AJR.14.12695}}</ref><ref name="KimSong2013">{{cite journal|last1=Kim|first1=Hwi-Gon|last2=Song|first2=Yong Jung|last3=Na|first3=Yong Jin|last4=Choi|first4=Ook-Hwan|title=A Case of Vaginal Cancer with Uterine Prolapse|journal=Journal of Menopausal Medicine|volume=19|issue=3|year=2013|pages=139|issn=2288-6478|doi=10.6118/jmm.2013.19.3.139}}</ref><ref name="pmid17139994">{{cite journal |vauthors=Karateke A, Tugrul S, Yakut Y, Gürbüz A, Cam C |title=Management of a case of primary vaginal cancer with irreducible massive uterine prolapse--a case report |journal=Eur. J. Gynaecol. Oncol. |volume=27 |issue=5 |pages=528–30 |date=2006 |pmid=17139994 |doi= |url=}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Postcoital bleeding
+* [[coitus|Postcoital]] [[bleeding]]
 | style="background: #F5F5F5; padding: 5px;" |
 +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +/-
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Tenesmus]]
+* [[Dysuria]]
+* [[Urinary frequency]]
+* [[Constipation]]
+* [[Pelvic pain]]
+| style="background: #F5F5F5; padding: 5px;" | +/-
+| style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
+* [[vagina|Vaginal]] [[lump]]
+* Inguinal [[lymphadenopathy]]
 | style="background: #F5F5F5; padding: 5px;" |
-* Tenesmus
+* In case of [[metastases]] to internal organs
-* Dysuria
-* Urinary frequency
-* Constipation
-* Pelvic pain
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-* Vaginal lump
-* Inguinal lymphadenopathy
-| style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
+| style="background: #F5F5F5; padding: 5px;" |'''[[Ultrasound]]:'''
+* [[Hydronephrosis]] in case of [[pelvis|pelvic]] [[metastases]]
+* Multiple [[liver]] [[metastases]]
+| style="background: #F5F5F5; padding: 5px;" |'''[[MRI]]:'''
+* Isointense on T1-weighted images
+* Soft-tissue [[mass]] with intermediate-to-high signal intensity on T2-weighted images
 | style="background: #F5F5F5; padding: 5px;" |
+* Provide information about size shape and location of [[tumor]]
+* Detects [[metastases]]
+* Detects [[lymph node]] involvement
+| style="background: #F5F5F5; padding: 5px;" |'''[[Biopsy]] findings:'''
+* [[Squamous cell carcinoma]] of [[vagina]]
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Biopsy]]
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Nabothian cyst]]<ref name="pmid21270291">{{cite journal |vauthors=Casey PM, Long ME, Marnach ML |title=Abnormal cervical appearance: what to do, when to worry? |journal=Mayo Clin. Proc. |volume=86 |issue=2 |pages=147–50; quiz 151 |date=February 2011 |pmid=21270291 |pmc=3031439 |doi=10.4065/mcp.2010.0512 |url=}}</ref><ref name="Bin ParkLee2010">{{cite journal|last1=Bin Park|first1=Sung|last2=Lee|first2=Jong Hwa|last3=Lee|first3=Young Ho|last4=Song|first4=Mi Jin|last5=Choi|first5=Hye Jeong|title=Multilocular Cystic Lesions in the Uterine Cervix: Broad Spectrum of Imaging Features and Pathologic Correlation|journal=American Journal of Roentgenology|volume=195|issue=2|year=2010|pages=517–523|issn=0361-803X|doi=10.2214/AJR.09.3619}}</ref><ref name="OkamotoTanaka2003">{{cite journal|last1=Okamoto|first1=Yoshikazu|last2=Tanaka|first2=Yumiko O.|last3=Nishida|first3=Masato|last4=Tsunoda|first4=Hajime|last5=Yoshikawa|first5=Hiroyuki|last6=Itai|first6=Yuji|title=MR Imaging of the Uterine Cervix: Imaging-Pathologic Correlation|journal=RadioGraphics|volume=23|issue=2|year=2003|pages=425–445|issn=0271-5333|doi=10.1148/rg.232025065}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Nabothian cyst]]<ref name="pmid21270291">{{cite journal |vauthors=Casey PM, Long ME, Marnach ML |title=Abnormal cervical appearance: what to do, when to worry? |journal=Mayo Clin. Proc. |volume=86 |issue=2 |pages=147–50; quiz 151 |date=February 2011 |pmid=21270291 |pmc=3031439 |doi=10.4065/mcp.2010.0512 |url=}}</ref><ref name="Bin ParkLee2010">{{cite journal|last1=Bin Park|first1=Sung|last2=Lee|first2=Jong Hwa|last3=Lee|first3=Young Ho|last4=Song|first4=Mi Jin|last5=Choi|first5=Hye Jeong|title=Multilocular Cystic Lesions in the Uterine Cervix: Broad Spectrum of Imaging Features and Pathologic Correlation|journal=American Journal of Roentgenology|volume=195|issue=2|year=2010|pages=517–523|issn=0361-803X|doi=10.2214/AJR.09.3619}}</ref><ref name="Torky2016">{{cite journal|last1=Torky|first1=Haitham A.|title=Huge Nabothian cyst causing Hematometra (case report)|journal=European Journal of Obstetrics & Gynecology and Reproductive Biology|volume=207|year=2016|pages=238–240|issn=03012115|doi=10.1016/j.ejogrb.2016.10.042}}</ref><ref name="OkamotoTanaka2003">{{cite journal|last1=Okamoto|first1=Yoshikazu|last2=Tanaka|first2=Yumiko O.|last3=Nishida|first3=Masato|last4=Tsunoda|first4=Hajime|last5=Yoshikawa|first5=Hiroyuki|last6=Itai|first6=Yuji|title=MR Imaging of the Uterine Cervix: Imaging-Pathologic Correlation|journal=RadioGraphics|volume=23|issue=2|year=2003|pages=425–445|issn=0271-5333|doi=10.1148/rg.232025065}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Postcoital bleeding
+* [[Coitus|Postcoital]] [[bleeding]]
 | style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
-* Pain during sex
+* [[Dyspareunia|Pain during sex]]
 | style="background: #F5F5F5; padding: 5px;" |−
+| style="background: #F5F5F5; padding: 5px;" | -
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+* [[Cyst|Cystic]] [[mass]] on exam
-* Cystic mass on exam
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |−
@@ Line 526: / Line 636: @@
 | style="background: #F5F5F5; padding: 5px;" |−
 | style="background: #F5F5F5; padding: 5px;" |
+* An echoic well defined [[Cyst|cystic]] [[Mass|masses]]
 | style="background: #F5F5F5; padding: 5px;" |
 * Intermediate or slightly high signal intensity on T1-weighted
 * High signal intensity on T2-weighted images
 | style="background: #F5F5F5; padding: 5px;" |
+* Small [[Cyst|cysts]] not visible on [[Computed tomography|CT]]
+* Large [[Cyst|cysts]] seen as focal low attenuation region
 | style="background: #F5F5F5; padding: 5px;" |
+* Multiple [[benign]] [[Cyst|cystic]] [[Mass|masses]], usually few millimeters in diameter
 | style="background: #F5F5F5; padding: 5px;" |
+* [[Histological]] exam if large [[cystic]] [[Mass|masses]]
 |-
 | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Rectal cancer]]<ref>{{Cite journal
@@ Line 587: / Line 701: @@
   | pmid = 26034724
 }}</ref>
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
 | style="background: #F5F5F5; padding: 5px;" |
-* Constipation/diarrhea
+* [[Constipation]]/[[diarrhea]]
-* Absent bowel sounds
+* [[Absent bowel sounds]]
-* Rectal mass/bleeding
+* [[Rectal mass]]/[[bleeding]]
-* Abdominal tenderness
+* [[Abdominal tenderness]]
-| style="background: #F5F5F5; padding: 5px;" |Weight loss +
+| style="background: #F5F5F5; padding: 5px;" |[[Weight loss]] +
-| style="background: #F5F5F5; padding: 5px;" |LLQ +
+| style="background: #F5F5F5; padding: 5px;" |[[Left lower quadrant abdominal pain resident survival guide|LLQ]] +
 | style="background: #F5F5F5; padding: 5px;" |NL
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |+/-
+| style="background: #F5F5F5; padding: 5px;" | +/-
-| style="background: #F5F5F5; padding: 5px;" |Endoscopic/transrectal US detects tumor extent
+| style="background: #F5F5F5; padding: 5px;" |[[Endoscopic ultrasound|Endoscopic]]/[[Transrectal ultrasonography|transrectal US]] detects [[tumor]] extent
-| style="background: #F5F5F5; padding: 5px;" |Determine tumor stage
+| style="background: #F5F5F5; padding: 5px;" |Determine [[tumor]] stage
-| style="background: #F5F5F5; padding: 5px;" |Determine tumor stage
+| style="background: #F5F5F5; padding: 5px;" |Determine [[tumor]] stage
 | style="background: #F5F5F5; padding: 5px;" |
-* Sheets or cords of malignant cells
+* Sheets or cords of [[malignant]] [[cells]]
-* Cellular atypia & pleomorphism
+* [[Cell (biology)|Cellular]] [[atypia]] & [[pleomorphism]]
-* High mitotic rate
+* High [[Mitosis|mitotic rate]]
-* Necrotic debris in glandular lumina
+* [[Necrosis|Necrotic]] debris in [[Gland|glandular]] lumina
-| style="background: #F5F5F5; padding: 5px;" |Colonoscopy with biopsy
+| style="background: #F5F5F5; padding: 5px;" |[[Colonoscopy]] with [[biopsy]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |Submucous uterine leiomyoma<ref>{{Cite journal
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Uterine leiomyoma|Submucous uterine leiomyoma]]<ref>{{Cite journal
   | author = [[Jacques Donnez]] & [[Marie-Madeleine Dolmans]]
   | title = Uterine fibroid management: from the present to the future
@@ Line 647: / Line 761: @@
   | pmid = 18372219
 }}</ref>
-| style="background: #F5F5F5; padding: 5px;" |Menorrhagia
+| style="background: #F5F5F5; padding: 5px;" |[[Menorrhagia]]
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
 | style="background: #F5F5F5; padding: 5px;" |
-* Constipation
+* [[Constipation]]
-* Urinary frequency/incontinence
+* [[Polyuria|Urinary frequency]]/[[Urinary incontinence|incontinence]]
-* Hydronephrosis
+* [[Hydronephrosis]]
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |Enlarged, irregular, firm, nontender uterus
+| style="background: #F5F5F5; padding: 5px;" |Enlarged, irregular, firm, nontender [[uterus]]
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
 | style="background: #F5F5F5; padding: 5px;" |
-* Trans vaginal US: well defined hypoechoic
+* [[Transvaginal ultrasound|Trans vaginal US]]: well defined hypoechoic
-* Saline US: for submucous fibroids/polypoi
+* Saline US: for [[submucous]] [[Leiomyoma|fibroids]]/polypoi
-| style="background: #F5F5F5; padding: 5px;" |Provides information on no: of fibroids, size, vascularization, relationship with endometrial cavity & serosal surface
+| style="background: #F5F5F5; padding: 5px;" |Provides information on no: of [[Leiomyoma|fibroids]], size, vascularization, relationship with [[Endometrium|endometrial cavity]] & [[Serosa|serosal surface]]
 | style="background: #F5F5F5; padding: 5px;" |Not required
 | style="background: #F5F5F5; padding: 5px;" |Not required
-| style="background: #F5F5F5; padding: 5px;" |Physical examination with Ultrasound
+| style="background: #F5F5F5; padding: 5px;" |[[Physical examination]] with [[Ultrasound]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |Uterine cancer<ref name="pmid16055605">{{cite journal |vauthors= |title=ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer |journal=Obstet Gynecol |volume=106 |issue=2 |pages=413–25 |date=August 2005 |pmid=16055605 |doi= |url=}}</ref><ref name="pmid195920792">{{cite journal |vauthors=Boruta DM, Gehrig PA, Fader AN, Olawaiye AB |title=Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review |journal=Gynecol. Oncol. |volume=115 |issue=1 |pages=142–153 |date=October 2009 |pmid=19592079 |doi=10.1016/j.ygyno.2009.06.011 |url=}}</ref><ref name="pmid6822361">{{cite journal |vauthors=Bokhman JV |title=Two pathogenetic types of endometrial carcinoma |journal=Gynecol. Oncol. |volume=15 |issue=1 |pages=10–7 |date=February 1983 |pmid=6822361 |doi= |url=}}</ref><ref name="pmid20628804">{{cite journal |vauthors=Felix AS, Weissfeld JL, Stone RA, Bowser R, Chivukula M, Edwards RP, Linkov F |title=Factors associated with Type I and Type II endometrial cancer |journal=Cancer Causes Control |volume=21 |issue=11 |pages=1851–6 |date=November 2010 |pmid=20628804 |pmc=2962676 |doi=10.1007/s10552-010-9612-8 |url=}}</ref>
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Uterine cancer]]<ref name="pmid16055605">{{cite journal |vauthors= |title=ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer |journal=Obstet Gynecol |volume=106 |issue=2 |pages=413–25 |date=August 2005 |pmid=16055605 |doi= |url=}}</ref><ref name="pmid195920792">{{cite journal |vauthors=Boruta DM, Gehrig PA, Fader AN, Olawaiye AB |title=Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review |journal=Gynecol. Oncol. |volume=115 |issue=1 |pages=142–153 |date=October 2009 |pmid=19592079 |doi=10.1016/j.ygyno.2009.06.011 |url=}}</ref><ref name="pmid6822361">{{cite journal |vauthors=Bokhman JV |title=Two pathogenetic types of endometrial carcinoma |journal=Gynecol. Oncol. |volume=15 |issue=1 |pages=10–7 |date=February 1983 |pmid=6822361 |doi= |url=}}</ref><ref name="pmid20628804">{{cite journal |vauthors=Felix AS, Weissfeld JL, Stone RA, Bowser R, Chivukula M, Edwards RP, Linkov F |title=Factors associated with Type I and Type II endometrial cancer |journal=Cancer Causes Control |volume=21 |issue=11 |pages=1851–6 |date=November 2010 |pmid=20628804 |pmc=2962676 |doi=10.1007/s10552-010-9612-8 |url=}}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Menometorrhagia
+* [[Menorrhagia|Menometorrhagia]]
-* Intermenstrual bleeding
+* [[Abnormal uterine bleeding|Intermenstrual bleeding]]
-* Postcoital bleeding
+* [[Coitus|Postcoital]] [[bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
 | style="background: #F5F5F5; padding: 5px;" |
-* Polyuria
+* [[Polyuria]]
-* Dysuria
+* [[Dysuria]]
 | style="background: #F5F5F5; padding: 5px;" |
-* Fatigue
+* [[Fatigue]]
-* Weight loss
+* [[Weight loss]]
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Enlarged uterus
+* Enlarged [[uterus]]
-* Lymphadenpathy
+* [[Lymphadenopathy]]
-* Mesenteric nodules (metastases)
+* Mesenteric nodules ([[Metastasis|metastases]])
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |Thickened endometrial lining >4cm
+| style="background: #F5F5F5; padding: 5px;" |Thickened [[Endometrium|endometrial lining]] >4cm
 | style="background: #F5F5F5; padding: 5px;" |
-* Endometrial thickening
+* [[Endometrium|Endometrial]] thickening
-* Lymph node involvement
+* [[Lymph node]] involvement
-* Pelvic metastases
+* [[Pelvis|Pelvic]] [[Metastasis|metastases]]
 | style="background: #F5F5F5; padding: 5px;" |Not required
 | style="background: #F5F5F5; padding: 5px;" |
-* Endometrial malignant cells
+* [[Endometrium|Endometrial]] [[malignant]] [[Cell (biology)|cells]]
 * Low grade type 1
 * High grade type 2
-| style="background: #F5F5F5; padding: 5px;" |Histologic diagnosis
+| style="background: #F5F5F5; padding: 5px;" |[[Histologic]] [[diagnosis]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |Vaginal lymphoma<ref>{{Cite journal
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |Vaginal [[lymphoma]]<ref>{{Cite journal
   | author = [[Vera Silva]], [[Paulo Correia]], [[Nuno Oliveira]] & [[Luis Sa]]
   | title = Primary Vaginal Non-Hodgkin's Lymphoma: Report of a Rare Clinical Entity
@@ Line 739: / Line 853: @@
   | pmid = 22584110
 }}</ref>
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |Abdominal/pelvic pain
+| style="background: #F5F5F5; padding: 5px;" |[[Abdominal pain|Abdominal]]/[[pelvic pain]]
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |Palpable mass between rectum & vagina
+| style="background: #F5F5F5; padding: 5px;" |[[Palpable]] [[mass]] between [[rectum]] & [[vagina]]
-| style="background: #F5F5F5; padding: 5px;" |+/-
+| style="background: #F5F5F5; padding: 5px;" | +/-
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |Diffuse mass in external cervical orifice & invading the vagina
+| style="background: #F5F5F5; padding: 5px;" |Diffuse [[mass]] in external [[Cervix|cervical]] orifice & invading the [[vagina]]
-| style="background: #F5F5F5; padding: 5px;" |Diffuse mass in external cervical orifice & invading the vagina
+| style="background: #F5F5F5; padding: 5px;" |Diffuse [[mass]] in external [[Cervix|cervical]] orifice & invading the [[vagina]]
 | style="background: #F5F5F5; padding: 5px;" |Not required
-| style="background: #F5F5F5; padding: 5px;" |CD20 & CD79a positive
+| style="background: #F5F5F5; padding: 5px;" |[[CD20]] & [[CD79|CD79a]] positive
-| style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry & biopsy
+| style="background: #F5F5F5; padding: 5px;" |[[Immunohistochemistry]] & [[biopsy]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |Vaginal polyp<ref>{{Cite journal
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |Vaginal [[polyp]]<ref>{{Cite journal
   | author = [[A. I. al-Nafussi]], [[G. Rebello]], [[D. Hughes]] & [[K. Blessing]]
   | title = Benign vaginal polyp: a histological, histochemical and immunohistochemical study of 20 polyps with comparison to normal vaginal subepithelial layer
@@ Line 799: / Line 913: @@
   | doi = 10.1177/1066896916666676
   | pmid =}}</ref>
-| style="background: #F5F5F5; padding: 5px;" |Postmenopausal bleeding
+| style="background: #F5F5F5; padding: 5px;" |[[Postmenopausal bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
-* Dysperunia
+* [[Dyspareunia]]
-* Postcoidal bleeding
+* [[Coitus|Postcoidal]] [[bleeding]]
-* Dysuria
+* [[Dysuria]]
-* Constipation
+* [[Constipation]]
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |+
+| style="background: #F5F5F5; padding: 5px;" | +
-| style="background: #F5F5F5; padding: 5px;" |Mass protruding from vagina
+| style="background: #F5F5F5; padding: 5px;" |[[Mass]] protruding from [[vagina]]
-| style="background: #F5F5F5; padding: 5px;" |+/-
+| style="background: #F5F5F5; padding: 5px;" | +/-
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |To exclude uterine hyperplasia/carcinoma
+| style="background: #F5F5F5; padding: 5px;" |To exclude [[Uterus|uterine]] [[hyperplasia]]/[[Uterine cancer|carcinoma]]
 | style="background: #F5F5F5; padding: 5px;" |To determine the extent
 | style="background: #F5F5F5; padding: 5px;" |N/A
-| style="background: #F5F5F5; padding: 5px;" |Benign tissue/premalignant cells
+| style="background: #F5F5F5; padding: 5px;" |[[Benign]] [[Tissue (biology)|tissue]]/[[premalignant]] [[Cell (biology)|cells]]
-| style="background: #F5F5F5; padding: 5px;" |Excisional biopsy
+| style="background: #F5F5F5; padding: 5px;" |[[Excisional biopsy]]
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |Vaginal adenosis<ref>{{Cite journal
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Vagina|Vaginal adenosis]]<ref>{{Cite journal
   | author = [[Marguerite B. Vigliani]]
   | title = A Report of Two Cases of Age-Related Changes in Cervical Morphology in Postmenopausal Women with Vaginal Adenosis
@@ Line 844: / Line 958: @@
 }}</ref>
 | style="background: #F5F5F5; padding: 5px;" |
-* Intermenstrual bleeding
+* [[Abnormal uterine bleeding|Intermenstrual bleeding]]
-* Postmenopausal bleeding
+* [[Postmenopausal bleeding]]
-| style="background: #F5F5F5; padding: 5px;" |+/-
+| style="background: #F5F5F5; padding: 5px;" | +/-
-| style="background: #F5F5F5; padding: 5px;" |+/-
+| style="background: #F5F5F5; padding: 5px;" | +/-
-| style="background: #F5F5F5; padding: 5px;" |+/-
+| style="background: #F5F5F5; padding: 5px;" | +/-
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |Palpable cysts,nodularity or ulcers
+| style="background: #F5F5F5; padding: 5px;" |[[Palpable]] [[Cyst|cysts]],nodularity or [[Ulcer|ulcers]]
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
-| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | -
 | style="background: #F5F5F5; padding: 5px;" |N/A
 | style="background: #F5F5F5; padding: 5px;" |N/A
 | style="background: #F5F5F5; padding: 5px;" |N/A
-| style="background: #F5F5F5; padding: 5px;" |Columnar cells in the ectocervix
+| style="background: #F5F5F5; padding: 5px;" |Columnar cells in the [[ectocervix]]
-| style="background: #F5F5F5; padding: 5px;" |Biopsy with histopathological examination
+| style="background: #F5F5F5; padding: 5px;" |[[Biopsy]] with [[Histopathology|histopathological]] examination
 |}