Allobarbital

Allobarbital
Clinical data
Synonyms	5,5-Diallylbarbituric acid, Allobarbital
ATC code	N05CA21 (WHO) ;
Legal status
Legal status	CA: Schedule IV ; US: Schedule IV ;
Identifiers
	IUPAC name 5,5-diprop-2-enyl-1,3-diazinane-2,4,6-trione;
CAS Number	52-43-7 ;
PubChem CID	5842;
ChemSpider	5635 ;
UNII	8NT43GG2HA;
KEGG	D02817 ;
ChEMBL	ChEMBL267719 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C10H12N2O3
Molar mass	208.214 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C1NC(=O)NC(=O)C1(C\C=C)C\C=C;
	InChI InChI=1S/C10H12N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-4H,1-2,5-6H2,(H2,11,12,13,14,15) ; Key:FDQGNLOWMMVRQL-UHFFFAOYSA-N ;
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Allobarbital, also known as allobarbitone and branded as Cibalgine or Dial-Ciba (in combination with ethyl carbamate), is a barbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for CIBA. It was used primarily as an anticonvulsant^[1] although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity of analgesic drugs, and use in the treatment of insomnia and anxiety.

Allobarbital was never particularly widely used compared to better known barbiturates such as phenobarbital and secobarbital, although it saw more use in some European countries such as Bulgaria and Slovakia,^[2] and is still used in for example Poland, but only as compound.^[3]

References

↑ Chocholova L.; Radil-Weiss, T. (1971). "Effect of allobarbital on focal epilepsy in rats". Physiologia Bohemoslovaca. 20 (4): 325–34. PMID 4335127.
↑ Getova, D.; Georgiev, V. (1987). "GABA-ergic mechanisms in the anticonvulsive activity of newly synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists". Acta Physiologica et Pharmacologica Bulgarica. 13 (3): 43–50. PMID 3439474.
↑ "APTECZKA BABUNI - KROPLE ŻOŁĄDKOWE KROPLE 20 G". Domzdrowia.pl (in Polish). Archived from the original on October 31, 2007. Retrieved March 10, 2013. Unknown parameter |trans_title= ignored (help)

Template:GABAAR PAMs

[1] Chocholova L.; Radil-Weiss, T. (1971). "Effect of allobarbital on focal epilepsy in rats". Physiologia Bohemoslovaca. 20 (4): 325–34. PMID 4335127.

[2] Getova, D.; Georgiev, V. (1987). "GABA-ergic mechanisms in the anticonvulsive activity of newly synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists". Acta Physiologica et Pharmacologica Bulgarica. 13 (3): 43–50. PMID 3439474.

[3] "APTECZKA BABUNI - KROPLE ŻOŁĄDKOWE KROPLE 20 G". Domzdrowia.pl (in Polish). Archived from the original on October 31, 2007. Retrieved March 10, 2013. Unknown parameter |trans_title= ignored (help)

[1]

[2]

[3]

Allobarbital

References

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