Captodiame

Captodiame

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	N05BB02 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Excretion	Renal
Identifiers
IUPAC name 2-[(4-butylsulfanylphenyl)-phenyl-methyl]sulfanyl-N,N-dimethylethanamine
CAS Number	486-17-9 Y
PubChem CID	10240
DrugBank	DB09014 N
ChemSpider	9823 Y
UNII	H93K9455DD
KEGG	D07316 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C21H29NS2
Molar mass	359.594 g/mol
3D model (JSmol)	Interactive image
SMILES S(c1ccc(cc1)C(SCCN(C)C)c2ccccc2)CCCC
InChI InChI=1S/C21H29NS2/c1-4-5-16-23-20-13-11-19(12-14-20)21(24-17-15-22(2)3)18-9-7-6-8-10-18/h6-14,21H,4-5,15-17H2,1-3H3 Y Key:IZLPZXSZLLELBJ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

WikiDoc Resources for Captodiame
Articles
Most recent articles on Captodiame Most cited articles on Captodiame Review articles on Captodiame Articles on Captodiame in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Captodiame Images of Captodiame Photos of Captodiame Podcasts & MP3s on Captodiame Videos on Captodiame
Evidence Based Medicine
Cochrane Collaboration on Captodiame Bandolier on Captodiame TRIP on Captodiame
Clinical Trials
Ongoing Trials on Captodiame at Clinical Trials.gov Trial results on Captodiame Clinical Trials on Captodiame at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Captodiame NICE Guidance on Captodiame NHS PRODIGY Guidance FDA on Captodiame CDC on Captodiame
Books
Books on Captodiame
News
Captodiame in the news Be alerted to news on Captodiame News trends on Captodiame
Commentary
Blogs on Captodiame
Definitions
Definitions of Captodiame
Patient Resources / Community
Patient resources on Captodiame Discussion groups on Captodiame Patient Handouts on Captodiame Directions to Hospitals Treating Captodiame Risk calculators and risk factors for Captodiame
Healthcare Provider Resources
Symptoms of Captodiame Causes & Risk Factors for Captodiame Diagnostic studies for Captodiame Treatment of Captodiame
Continuing Medical Education (CME)
CME Programs on Captodiame
International
Captodiame en Espanol Captodiame en Francais
Business
Captodiame in the Marketplace Patents on Captodiame
Experimental / Informatics
List of terms related to Captodiame

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Captodiame (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. It is a derivative of diphenhydramine.

A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.

In addition to its actions as an antihistamine, captodiamine has been found to act as a 5-HT_2C receptor antagonist and σ₁ receptor and D₃ receptor agonist. It produces antidepressant-like effects in rats. However, captodiamine is unique among antidepressant-like drugs in that it increases brain-derived neurotrophic factor (BDNF) levels in the hypothalamus but not in the frontal cortex or hippocampus. This unique action may be related to its ability to attenuate stress-induced anhedonia and corticotropin-releasing factor (CRF) signaling in the hypothalamus.

See also

• Hydroxyzine
• Cyproheptadine