Jump to navigation Jump to search
Clomethiazole Wiki Str.png
Clinical data
Routes of
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass161.653 g/mol

WikiDoc Resources for Clomethiazole


Most recent articles on Clomethiazole

Most cited articles on Clomethiazole

Review articles on Clomethiazole

Articles on Clomethiazole in N Eng J Med, Lancet, BMJ


Powerpoint slides on Clomethiazole

Images of Clomethiazole

Photos of Clomethiazole

Podcasts & MP3s on Clomethiazole

Videos on Clomethiazole

Evidence Based Medicine

Cochrane Collaboration on Clomethiazole

Bandolier on Clomethiazole

TRIP on Clomethiazole

Clinical Trials

Ongoing Trials on Clomethiazole at Clinical

Trial results on Clomethiazole

Clinical Trials on Clomethiazole at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Clomethiazole

NICE Guidance on Clomethiazole


FDA on Clomethiazole

CDC on Clomethiazole


Books on Clomethiazole


Clomethiazole in the news

Be alerted to news on Clomethiazole

News trends on Clomethiazole


Blogs on Clomethiazole


Definitions of Clomethiazole

Patient Resources / Community

Patient resources on Clomethiazole

Discussion groups on Clomethiazole

Patient Handouts on Clomethiazole

Directions to Hospitals Treating Clomethiazole

Risk calculators and risk factors for Clomethiazole

Healthcare Provider Resources

Symptoms of Clomethiazole

Causes & Risk Factors for Clomethiazole

Diagnostic studies for Clomethiazole

Treatment of Clomethiazole

Continuing Medical Education (CME)

CME Programs on Clomethiazole


Clomethiazole en Espanol

Clomethiazole en Francais


Clomethiazole in the Marketplace

Patents on Clomethiazole

Experimental / Informatics

List of terms related to Clomethiazole

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]}


Clomethiazole (also called Chlormethiazole) is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease in the elderly. In the U.S, it is sold under the brand, Distraneurin® (AstraZeneca Pharmaceuticals) and in the U.K, Heminevrin® (AstraZeneca Pharmaceuticals). Another brand name includes Nevrin® (in Romania). The drug is marketed either a the freebase in an oily suspension containing 192mg (presumably 3 grains) as capsules or clomethiasole edisylate (ethane disulfonate) syrup.


Chlormethiazole acts on GABA receptors, which cause the release of the neurotransmitter GABA. GABA is a major inhibitory chemical in the brain involved in causing sleepiness and controlling anxiety and panic attacks. It acts by increasing the activity of GABA, thereby reducing the functioning of certain areas of the brain. This results in sleepiness, a decrease in anxiety and relaxation of muscles. It also inhibits the enzyme alcohol dehydrogenase, which is responsible for breaking down alcohol in the body. This slows the rate of elimination of alcohol from the body, which helps to relieve the sudden effects of alcohol withdrawal in alcoholics.

Adverse effects

When misused, chlormethiazole can cause tolerance and physical dependence. Abrupt withdrawal may result in symptoms similar to those of sudden withdrawal of alcohol.


-The Who drummer, Keith Moon, died from an overdose of chlormethiazole. The coroner discovered 32 partially digested capsules in his stomach. -Abuse of this drug involves the freebase being placed in a syringe and injected. This must be done quickly as the freebase is known to melt plastic.