ANGPT4: Difference between revisions

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Latest revision as of 18:01, 29 August 2017

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.^[1]^[2]^[3]

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells.

The protein encoded by this gene functions as an agonist and is an angiopoietin.^[3]

References

↑ Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (Apr 1999). "Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans". Proc Natl Acad Sci U S A. 96 (5): 1904–9. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.
↑ Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S (May 1999). "Angiopoietin-3, a novel member of the angiopoietin family". FEBS Lett. 448 (2–3): 254–6. doi:10.1016/S0014-5793(99)00381-6. PMID 10218486.
↑ ^3.0 ^3.1 "Entrez Gene: ANGPT4 angiopoietin 4".

External links

Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser.

Grosios K, Leek JP, Markham AF, et al. (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2): 118–20. doi:10.1159/000015235. PMID 10343124.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Ward EG, Grosios K, Markham AF, Jones PF (2002). "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3–4): 147–54. doi:10.1159/000048807. PMID 11856872.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
Yamakawa M, Liu LX, Belanger AJ, et al. (2004). "Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis". Am. J. Physiol. Renal Physiol. 287 (4): F649–57. doi:10.1152/ajprenal.00028.2004. PMID 15198927.
Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200–8. doi:10.1096/fj.03-1466com. PMID 15284220.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2". Cancer Cell. 6 (5): 507–16. doi:10.1016/j.ccr.2004.09.030. PMID 15542434.
Olsen MW, Ley CD, Junker N, et al. (2006). "Angiopoietin-4 Inhibits Angiogenesis and Reduces Interstitial Fluid Pressure". Neoplasia. 8 (5): 364–72. doi:10.1593/neo.06127. PMC 1592453. PMID 16790085.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[pmid10051567-1] Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD (Apr 1999). "Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans". Proc Natl Acad Sci U S A. 96 (5): 1904–9. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.

[pmid10218486-2] Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S (May 1999). "Angiopoietin-3, a novel member of the angiopoietin family". FEBS Lett. 448 (2–3): 254–6. doi:10.1016/S0014-5793(99)00381-6. PMID 10218486.

[entrez-3] 3.0 ^3.1 "Entrez Gene: ANGPT4 angiopoietin 4".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Angiopoietin-4''' is a [[protein]] that in humans is encoded by the ''ANGPT4'' [[gene]].<ref name="pmid10051567">{{cite journal | vauthors = Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD | title = Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 5 | pages = 1904–9 |date=Apr 1999 | pmid = 10051567 | pmc = 26709 | doi =10.1073/pnas.96.5.1904  }}</ref><ref name="pmid10218486">{{cite journal | vauthors = Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S | title = Angiopoietin-3, a novel member of the angiopoietin family | journal = FEBS Lett | volume = 448 | issue = 2–3 | pages = 254–6 |date=May 1999 | pmid = 10218486 | pmc =  | doi =10.1016/S0014-5793(99)00381-6  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ANGPT4 angiopoietin 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51378| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Angiopoietin 4
- | HGNCid = 487
- | Symbol = ANGPT4
- | AltSymbols =; AGP4; ANG-3; ANG4; MGC138181; MGC138183
- | OMIM = 603705
- | ECnumber =
- | Homologene = 36302
- | MGIid = 1336887
- | GeneAtlas_image1 = PBB_GE_ANGPT4_221134_at_tn.png
-  | Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0030297 |text = transmembrane receptor protein tyrosine kinase activator activity}}
- | Component =
- | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 51378
-    | Hs_Ensembl = ENSG00000101280
-    | Hs_RefseqProtein = NP_057069
-    | Hs_RefseqmRNA = NM_015985
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 20
-    | Hs_GenLoc_start = 801296
-    | Hs_GenLoc_end = 844960
-    | Hs_Uniprot = Q9Y264
-    | Mm_EntrezGene = 11602
-    | Mm_Ensembl = ENSMUSG00000027460
-    | Mm_RefseqmRNA = NM_009641
-    | Mm_RefseqProtein = NP_033771
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 151602773
-    | Mm_GenLoc_end = 151636095
-    | Mm_Uniprot = Q3U486
-  }}
-}}
-'''Angiopoietin 4''', also known as '''ANGPT4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANGPT4 angiopoietin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51378| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin.<ref name="entrez">{{cite web | title = Entrez Gene: ANGPT4 angiopoietin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51378| accessdate = }}</ref>
+| summary_text = [[Angiopoietin]]s are proteins with important roles in [[vascular]] development and [[angiogenesis]].
+All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein [[kinase]] [[Receptor (biochemistry)|receptor]].
+The mechanism by which they contribute to angiogenesis is thought to involve regulation of [[endothelial cell]] interactions with supporting [[Pericyte|perivascular cells]].
+The protein encoded by this gene functions as an [[agonist]] and is an angiopoietin.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|ANGPT4}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Valenzuela DM, Griffiths JA, Rojas J, ''et al.'' |title=Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1904-9 |year= 1999 |pmid= 10051567 |doi=  }}
+*{{cite journal  | author=Grosios K |title=Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1–2 |pages= 118–20 |year= 1999 |pmid= 10343124 |doi=10.1159/000015235  | name-list-format=vanc | author2=Leek JP  | author3=Markham AF  | display-authors=3  | last4=Yancopoulos  | first4=G.D.  | last5=Jones  | first5=P.F.  }}
-*{{cite journal  | author=Nishimura M, Miki T, Yashima R, ''et al.'' |title=Angiopoietin-3, a novel member of the angiopoietin family. |journal=FEBS Lett. |volume=448 |issue= 2-3 |pages= 254-6 |year= 1999 |pmid= 10218486 |doi=  }}
+*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
-*{{cite journal  | author=Grosios K, Leek JP, Markham AF, ''et al.'' |title=Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 118-20 |year= 1999 |pmid= 10343124 |doi=  }}
+*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a  | name-list-format=vanc | author2=Matthews LH  | author3=Ashurst J  | display-authors=3  | last4=Burton  | first4=J.  | last5=Gilbert  | first5=J. G. R.  | last6=Jones  | first6=M.  | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P.  | last9=Babbage  | first9=A. K. }}
-*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
+*{{cite journal  | vauthors=Ward EG, Grosios K, Markham AF, Jones PF |title=Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2 |journal=Cytogenet. Cell Genet. |volume=94 |issue= 3–4 |pages= 147–54 |year= 2002 |pmid= 11856872 |doi=10.1159/000048807  }}
-*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  | name-list-format=vanc | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
-*{{cite journal  | author=Ward EG, Grosios K, Markham AF, Jones PF |title=Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2. |journal=Cytogenet. Cell Genet. |volume=94 |issue= 3-4 |pages= 147-54 |year= 2002 |pmid= 11856872 |doi=  }}
+*{{cite journal  | author=Zeng L |title=Identification of a novel human angiopoietin-like gene expressed mainly in heart |journal=J. Hum. Genet. |volume=48 |issue= 3 |pages= 159–62 |year= 2003 |pmid= 12624729 |doi= 10.1007/s100380300025  | name-list-format=vanc | author2=Dai J  | author3=Ying K  | display-authors=3  | last4=Zhao  | first4=E  | last5=Jin  | first5=W  | last6=Ye  | first6=Y  | last7=Dai  | first7=J  | last8=Xu  | first8=J  | last9=Xie  | first9=Y }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Yamakawa M |title=Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis |journal=Am. J. Physiol. Renal Physiol. |volume=287 |issue= 4 |pages= F649–57 |year= 2004 |pmid= 15198927 |doi= 10.1152/ajprenal.00028.2004  | name-list-format=vanc | author2=Liu LX  | author3=Belanger AJ  | display-authors=3  | last4=Date  | first4=T  | last5=Kuriyama  | first5=T  | last6=Goldberg  | first6=MA  | last7=Cheng  | first7=SH  | last8=Gregory  | first8=RJ  | last9=Jiang  | first9=C }}
-*{{cite journal  | author=Zeng L, Dai J, Ying K, ''et al.'' |title=Identification of a novel human angiopoietin-like gene expressed mainly in heart. |journal=J. Hum. Genet. |volume=48 |issue= 3 |pages= 159-62 |year= 2003 |pmid= 12624729 |doi= 10.1007/s100380300025 }}
+*{{cite journal  | author=Lee HJ |title=Biological characterization of angiopoietin-3 and angiopoietin-4 |journal=FASEB J. |volume=18 |issue= 11 |pages= 1200–8 |year= 2005 |pmid= 15284220 |doi= 10.1096/fj.03-1466com  | name-list-format=vanc | author2=Cho CH  | author3=Hwang SJ  | display-authors=3  | last4=Choi  | first4=HH  | last5=Kim  | first5=KT  | last6=Ahn  | first6=SY  | last7=Kim  | first7=JH  | last8=Oh  | first8=JL  | last9=Lee  | first9=GM }}
-*{{cite journal  | author=Yamakawa M, Liu LX, Belanger AJ, ''et al.'' |title=Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. |journal=Am. J. Physiol. Renal Physiol. |volume=287 |issue= 4 |pages= F649-57 |year= 2004 |pmid= 15198927 |doi= 10.1152/ajprenal.00028.2004 }}
+*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  | name-list-format=vanc | author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
-*{{cite journal  | author=Lee HJ, Cho CH, Hwang SJ, ''et al.'' |title=Biological characterization of angiopoietin-3 and angiopoietin-4. |journal=FASEB J. |volume=18 |issue= 11 |pages= 1200-8 |year= 2005 |pmid= 15284220 |doi= 10.1096/fj.03-1466com }}
+*{{cite journal  | author=Oliner J |title=Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2 |journal=Cancer Cell |volume=6 |issue= 5 |pages= 507–16 |year= 2004 |pmid= 15542434 |doi= 10.1016/j.ccr.2004.09.030  | name-list-format=vanc | author2=Min H  | author3=Leal J  | display-authors=3  | last4=Yu  | first4=Dongyin  | last5=Rao  | first5=Shashirekha  | last6=You  | first6=Edward  | last7=Tang  | first7=Xiu  | last8=Kim  | first8=Haejin  | last9=Meyer  | first9=Susanne }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | author=Olsen MW |title=Angiopoietin-4 Inhibits Angiogenesis and Reduces Interstitial Fluid Pressure |journal=Neoplasia |volume=8 |issue= 5 |pages= 364–72 |year= 2006 |pmid= 16790085 |doi= 10.1593/neo.06127  | pmc=1592453  | name-list-format=vanc | author2=Ley CD  | author3=Junker N  | display-authors=3  | last4=Hansen  | first4=Anker J  | last5=Lund  | first5=Eva L.  | last6=Kristjansen  | first6=PE }}
-*{{cite journal  | author=Oliner J, Min H, Leal J, ''et al.'' |title=Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. |journal=Cancer Cell |volume=6 |issue= 5 |pages= 507-16 |year= 2004 |pmid= 15542434 |doi= 10.1016/j.ccr.2004.09.030 }}
-*{{cite journal  | author=Olsen MW, Ley CD, Junker N, ''et al.'' |title=Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure. |journal=Neoplasia |volume=8 |issue= 5 |pages= 364-72 |year= 2006 |pmid= 16790085 |doi= 10.1593/neo.06127 }}
 }}
 {{refend}}
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+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
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+| update_protein_box = yes
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+| update_citations = yes
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ANGPT4: Difference between revisions

Latest revision as of 18:01, 29 August 2017

References

External links

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