Interleukin-1 receptor: Difference between revisions
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{{See also|Interleukin-1 receptor family}} | |||
{{infobox protein | |||
{{protein | |||
| Name = [[interleukin 1 receptor, type I]] | | Name = [[interleukin 1 receptor, type I]] | ||
| caption = | | caption = | ||
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| LocusSupplementaryData = | | LocusSupplementaryData = | ||
}} | }} | ||
{{protein | {{infobox protein | ||
| Name = [[interleukin 1 receptor, type II]] | | Name = [[interleukin 1 receptor, type II]] | ||
| caption = | | caption = | ||
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| LocusSupplementaryData = | | LocusSupplementaryData = | ||
}} | }} | ||
{{protein | {{infobox protein | ||
| Name = [[IL1RAP|interleukin 1 receptor accessory protein]] | | Name = [[IL1RAP|interleukin 1 receptor accessory protein]] | ||
| caption = | | caption = | ||
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| LocusSupplementaryData = | | LocusSupplementaryData = | ||
}} | }} | ||
'''Interleukin-1 receptor''' (IL-1R) is a [[cytokine receptor]] which binds [[interleukin 1]].<ref name="pmid7964161">{{cite journal | | '''Interleukin-1 receptor''' ('''IL-1R''') is a [[cytokine receptor]] which binds [[interleukin 1]].<ref name="pmid7964161">{{cite journal |vauthors=Kuno K, Matsushima K | title = The IL-1 receptor signaling pathway | journal = J. Leukoc. Biol. | volume = 56 | issue = 5 | pages = 542–7 | year = 1994 | pmid = 7964161 | doi = | url = http://www.jleukbio.org/cgi/content/abstract/56/5/542 | format = abstract page }}</ref> Two forms of the receptor exist. The [[interleukin 1 receptor, type I|type I]] receptor is primarily responsible for transmitting the [[inflammation|inflammatory]] effects of interleukin-1 (IL-1) while [[interleukin 1 receptor, type II|type II]] receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.<ref name="pmid7964161"/> Also opposing the effects of IL-1 is the [[interleukin 1 receptor antagonist|IL-1 receptor antagonist]] (IL-1RA).<ref name="pmid1834696">{{cite journal | author = Arend WP | title = Interleukin 1 receptor antagonist. A new member of the interleukin 1 family | journal = J. Clin. Invest. | volume = 88 | issue = 5 | pages = 1445–51 | year = 1991 | pmid = 1834696 | doi = 10.1172/JCI115453 |pmc=295645 }}</ref> | ||
The IL-1 receptor accessory protein ([[IL1RAP]]) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.<ref name="pmid9065432">{{cite journal |vauthors=Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU | title = The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases) | journal = J. Biol. Chem. | volume = 272 | issue = 12 | pages = 7727–31 |date=March 1997 | pmid = 9065432 | doi = 10.1074/jbc.272.12.7727 | url = }}</ref> | |||
==References== | ==References== | ||
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* {{MeshName|Receptors,+Interleukin-1}} | * {{MeshName|Receptors,+Interleukin-1}} | ||
{{Cytokine receptors}} | |||
{{Interleukin receptor modulators}} | |||
[[Category:Immunoglobulin superfamily cytokine receptors]] | |||
{{ | {{membrane-protein-stub}} | ||
Latest revision as of 21:07, 8 July 2017
| interleukin 1 receptor, type I | |
|---|---|
| Identifiers | |
| Symbol | IL1R1 |
| Alt. symbols | IL1R, IL1RA |
| Entrez | 3554 |
| HUGO | 5993 |
| OMIM | 147810 |
| RefSeq | NM_000877 |
| UniProt | P14778 |
| Other data | |
| Locus | Chr. 2 q12 |
| interleukin 1 receptor, type II | |
|---|---|
| Identifiers | |
| Symbol | IL1R2 |
| Alt. symbols | IL1RB |
| Entrez | 7850 |
| HUGO | 5994 |
| OMIM | 147811 |
| RefSeq | NM_173343 |
| UniProt | P27930 |
| Other data | |
| Locus | Chr. 2 q12 |
| interleukin 1 receptor accessory protein | |
|---|---|
| Identifiers | |
| Symbol | IL1RAP |
| Alt. symbols | IL-1RAcP, IL1R3, C3orf13 |
| Entrez | 3556 |
| HUGO | 5995 |
| OMIM | 602626 |
| RefSeq | NM_134470 |
| UniProt | Q9NPH3 |
| Other data | |
| Locus | Chr. 3 q28 |
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]
The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]
References
- ↑ 1.0 1.1 Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway" (abstract page). J. Leukoc. Biol. 56 (5): 542–7. PMID 7964161.
- ↑ Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.
- ↑ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
External links
- Receptors,+Interleukin-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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