Congestive heart failure acute pharmacotherapy: Difference between revisions

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| [[File:Siren.gif|30px|link= Congestive heart failure resident survival guide]]|| <br> || <br>
| [[Acute decompensated heart failure resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']]
|}
{{Congestive heart failure}}
{{Congestive heart failure}}
{{CMG}}
{{CMG}}
{{SK}} Acute heart failure; AHF; Heart failure; HF; BTB;  bridge to bridge; BTD; bridge to decision; BTR; bridge to recovery;


==Overview==
==Overview==
==Acute Pharmacotherapy==
Acute heart failure can occur in the setting of a new onset heart failure or worsening of an existing chronic heart failure (also known as [[acute decompensated heart failure]], [[flash pulmonary edema]], [[ADHF]]).  ADHF presents with acute shortness of breath due to the development of [[pulmonary edema]] (the rapid accumulation of [[fluid in the lung]]).  Other signs and symptoms of ADHF include [[hypotension]] with impaired and organ perfusion manifested by [[worsening renal function]], altered mentation and [[cold clammy extremities]].  ADHF associated with a poor prognosis if not treated aggressively.  Like chronic heart failure therapy, the goal is to improve symptoms but unlike chronic therapy the other goals are to improve oxygenation and hemodynamic stability.  The mainstays of the acute medical treatment in acute decompensated [[congestive heart failure]] include [[oxygen]] to improve [[hypoxia]], [[diuresis]] to reduce both [[preload]] and intravascular volume and vasodilators to reduce [[afterload]].  Some of the mainstays of [[chronic heart failure therapy]] are not initiated acutely ([[ACE inhibtors]],[[beta blockers]] and [[digoxin]]).
The goals of acute pharmacotherapy include:
 
* Reduce [[preload]]
 
* Reduce [[afterload]]
 
* Reduce intravascular volume
* Improve [[cardiac contractility]]


The following acute therapies are used in the acute management of heart failure and their mechanism of action are as follows
*[[Diuretics]] reduces [[preload]] and reduces intravascular volume
*[[Nitroprusside]] reduces [[afterload]] and reduces [[preload]]
*[[Nesiritide]] reduces [[afterload]] and reduces [[preload]]
*[[Milrinone]] increases contractility and reduces [[afterload]]
*[[Dobutamine]] increases contractility in reduces [[afterload]]
*[[Dopamine]] increases blood pressure and increases renal perfusion at low doses
*[[Nitroglycerine]] reduces [[afterload]] and reduces [[preload]]


==Chronic Pharmacotherapy==


==Diuretics==
* Provide symptomatic relief
* Slows the progression of ventricular remodeling by reducing ventricular filling pressure and wall stress
* No survival benefit and may cause [[azotemia]], [[hypokalemia]], [[metabolic alkalosis]] and elevation of neurohormones.
* Although [[thiazide]] [[diuretics]] are effective in mild [[heart failure]] they are usually inadequate for the treatment of severe [[heart failure]].
* [[Thiazide]] [[diuretics]] have also been associative with [[hyponatremia]].
* Fluid retention usually responds best to [[furosemide]] (Lasix) and at doses of 10 to 20 mg per day. The patient should be told to return to their physician in the next three to seven days for further assessment including assessment of their [[potassium]] concentration. Weight loss should not exceed 1 to 2 pounds/day.
* Higher lasix doses are associated with higher mortality, likely as a surrogate of disease severity rather than part of a causal pathway.
* If there is no response to the initial  dose then it can be increased by at least 50%. The maintenance dose of the [[diuretics]] lower than that required to initiate diuresis.
* If the patient gains more than two pounds and they are instructed to double the dose of their loop diuretic.
* Once the baseline weight has been re-established than they can resume their previous status.
* Intermittent use of [[metolazone]] into dose of 2.5 or 5 mg can be given if the patient is refractory to [[furosemide]] Lasix. [[Metolazone]] should be given in the inpatient setting.
* The role of [[potassium]] sparing diuretics such as [[spironolactone]] (Aldactone), [[amiloride]], or [[triamterene]] remains the subject of controversy. Spironolactone is currently recommended as third line therapy for congestive heart failure.
*Extreme caution is necessary when adding a [[potassium]] sparing agent to the regiment that includes [[ACE inhibitor]]s particularly when diabetes or renal disease is present because the patient can become [[hyperkalemic]].
===Electrolyte replacement===
*[[ACE inhibitor]]s reduce [[potassium]] excretion, but most patients with good renal function require [[potassium]] supplementation during daily therapy with the diuretics such as [[furosemide]] (Lasix) despite of [[ACE inhibitor]]s therapy.
* Dietary supplementation is rarely adequate.
* [[Hypokalemia]] can aggravate [[arrhythmias]] and precipitate [[muscle cramps]].
*[[Potassium]] levels >6 (particularly when occurs rapidly) can be associated with reduced [[myocardial contractility]].
*Patients are actually at higher risk of [[hyperkalemia]] and [[hypokalemia]]. The goal is to maintain a [[potassium]] between 3.8 and 4.5 mEq. 
*Unless the [[hypokalemia]] is very severe and at life-threatening level, [[potassium]] should be replaced by oral administration.
* Potassium should not be administered intravenously at a rate that exceeds 10 mEq per hour.
* Patients who use [[diuretics]] usually require approximately 20-60 mEq/day of oral [[potassium]].
* Extra [[potassium]] should be given after the patient has noted diuresis or weight change. If patient has lost more than two pounds, the electrolyte's level should be checked every three days.


=== Loop Diuretics ===
* Agents in this class include [[Furosemide]] or [[lasix]], [[bumetanide]], [[ethacrynic acid]] and [[torsemide]].
* Inhibit the Na+/K+/Cl- transporter.
* Furosemide IV reduces [[preload]]
* Relax pre-contracted pulmonary venules and thereby reduce the symptoms of [[pulmonary edema]]


=== Thiazide Diuretics ===
* Inhibit the Na+/Cl- co transporter in the distal convoluted tube.
* Recommended for management of mild chronic heart failure.


=== Potassium Sparing Diuretics ===
* [[Spironolactone]], [[amiloride]] and [[triamterene]].
* Inhibit principal cells in the distal convoluted tubule and cortical collecting duct.
* Inhibits Na reabsorbtion and [[Potassium]] secretion.
* Their significant side effect is [[hyperkalemia]].


==Renin-Angiotensin-Aldosterone Axis Inhibitors==
== 2022 AHA/ACC/HFSA Heart Failure Guideline Hospitalization of patients with acute heart failure ==
===Angiotensin converting enzyme inhibitor or ACE Inhibitors===
* [[ACE Inhibitor]]s ([[Angiotensin converting enzyme inhibitor|ACEI]]) should be considered as first-line therapy for the treatment of patients with clinical heart failure due to reduced left ventricular systolic dysfunction (LVSD), patients with asymptomatic LV dysfunction, and for patients who are at high risk for the development of heart failure due to the presence of coronary, cerebrovascular, or peripheral vascular disease.
* Treatment should not be deferred in patients with few or no symptoms because of the significant mortality benefit derived from [[Angiotensin converting enzyme inhibitor|ACEI]] therapy.
* Initial therapy usually consist of 12.5 mg tid of [[captopril]], 2.5 mg bid of [[enalapril]], or 2.5 mg daily lisinopril. The optimal dose is usually established by optimizing the dose every 4 to 6 weeks.
* ACE inhibitors are rarely adequate for the treatment of congestion without the use of [[diuretics]].
* 5-10 % patients cannot tolerate [[ACE inhibitors]] because of [[cough]]. [[Cough]] can be a sign of elevated left-sided filling pressures. Sometimes [[cough]] will diminish with the treatment of heart failure. A
* Renal artery stenosis should be considered if there's a decline in renal function with the initiation of [[ACE inhibitors]].
===Angiotensin receptor blockers (ARB)===
* * In the CHARM study [[candesartan]] reduced both hospitalization and mortality.


===Aldosterone Antagonists===
=== Assessment of Patients Hospitalized With Decompensated HF ===
* [[Spironolactone]] is third line therapy for CHF
{| class="wikitable" style="width:80%"
* An important side effect of spironolactone is [[hyperkalemia]]
|-
| colspan="1" style="text-align:center; background:LightGreen" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class I]]
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''1. I'''n patients hospitalized with HF, the severity of congestion and adequacy of perfusion should be assessed to guide triage and initial therapy (Level of Evidence C-LD).
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''2.''' In patients hospitalized with HF, the common precipitating factors and the overall patient trajectory should be assessed to guide appropriate therapy (Level of Evidence C-LD).
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''3.''' For patients admitted with HF, treatment should address reversible factors, establish optimal volume status, and advance GDMT toward targets for outpatient therapy (Level of Evidence C-LD).
|}
<ref name="pmid35363500">{{cite journal| author=Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM | display-authors=etal| title=2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. | journal=Circulation | year= 2022 | volume= 145 | issue= 18 | pages= e876-e894 | pmid=35363500 | doi=10.1161/CIR.0000000000001062 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=35363500  }}</ref>


==Nitrates==
=== Maintenance or Optimization of GDMT During Hospitalization ===
* A nitrate may be added to [[ACE inhibitor]]s to relieve symptoms of [[pulmonary edema]]
{| class="wikitable" style="width:80%"
* The addition of a [[nitrate]] to an [[ACE inhibitor]] may improve [[exercised tolerance]].
|-
* The combination of [[hydralazine]] and [[nitrates]] is useful when [[ACE inhibitor]]s are not well tolerated.
| colspan="1" style="text-align:center; background:LightGreen" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class I]]
* [[Hydralazine]] by itself is only an arterial vasodilator and does not reduce left ventricular filling pressures to the same extent as nitrates and [[ACE inhibitor]]s do. In fact when used alone it can stimulate sympathetic tone reflexively.  The combination of hydralazine and nitrates has been shown to decrease mortality as well as improve the left ventricular ejection fraction and exercise capacity in patients with [[heart failure]]. However the combination of [[hydralazine]] and [[nitrate]]s has been found to be less effective than [[ACE inhibitor]]s.
|-
* The major uses this combination is in those patients who are intolerant of [[ACE inhibitor]]s.
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''1.''' In patients with HFrEF requiring hospitalization, preexisting GDMT should be continued and optimized to improve outcomes, unless contraindicated (Level of Evidence B-NR)<nowiki>''</nowiki>.
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''2.''' In patients experiencing a mild decrease of renal function or asymptomatic reduction of blood pressure during HF hospitalization, diuresis, and other GDMT should not routinely be discontinued (Level of Evidence B-NR)<nowiki>''</nowiki>.
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''3.''' In patients with HFrEF, GDMT should be initiated during hospitalization after clinical stability is achieved. (Level of Evidence B-NR).
|-
| bgcolor="LightGreen" |<nowiki>''</nowiki>4. In patients with HFrEF, if discontinuation of GDMT is necessary during hospitalization, it should be reinitiated and further optimized as soon as possible (Level of Evidence B-NR)<nowiki>''</nowiki>
|}
<ref name="pmid35363500" />


==Anticoagulants==
=== Diuretics in Hospitalized Patients: Decongestion Strategy ===
* The annual incidence of systemic and [[pulmonary embolism]] in patients with [[heart failure]] is 2-5%. This is not that dissimilar from the risk of severe bleeding among patients to its anticoagulants which is 0.8-2.5% per year.
{| class="wikitable" style="width:80%"
|-
| colspan="1" style="text-align:center; background:LightGreen" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class I]]
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''1.''' Patients with HF admitted with evidence of significant fluid overload should be promptly treated with intravenous loop diuretics to improve symptoms and reduce morbidity (Level of Evidence B-NR)<nowiki>''</nowiki>.
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''2.''' For patients hospitalized with HF, therapy with diuretics and other guideline-directed medications should be titrated with the goal to resolve clinical evidence of congestion to reduce symptoms and rehospitalizations(Level of Evidence B-NR)<nowiki>''</nowiki>.
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''3.''' For patients requiring diuretic treatment during hospitalization for HF, the discharge regimen should include a plan for adjustment of diuretics to decrease rehospitalizations (Level of Evidence B-NR).
|}
<ref name="pmid35363500" />
{| class="wikitable" style="width:80%"
|-
| colspan="1" style="text-align:center; background:LemonChiffon" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIa]]
|-
| bgcolor="LemonChiffon" |"4'''.''' In patients hospitalized with HF when diuresis is inadequate to relieve symptoms and signs of congestion, it is reasonable to intensify the diuretic regimen using either: a. higher doses of intravenous loop diuretics or addition of a second diuretic''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: B-NR]])'' <nowiki>"</nowiki>
|}
<ref name="pmid35363500" />


* As a result anticoagulation is not routinely recommended in the current guidelines for the treatment of [[heart failure]]. However among those patients with a [[atrial fibrillation]], a history of emboli, or multiple intracardiac thrombi, or akinesis or dyskinesis detected on echo should be anticoagulated.
=== Parenteral Vasodilation Therapy in Patients Hospitalized With HF ===
{| class="wikitable" style="width:80%"
|-
| colspan="1" style="text-align:center; background:LemonChiffon" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIa]]
|-
| bgcolor="LemonChiffon" |"1'''.''' In patients who are admitted with decompensated HF, in the absence of systemic hypotension, intravenous nitroglycerin or nitroprusside may be considered as an adjuvant to diuretic therapy for relief of dyspnea''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: B-NR]])'' <nowiki>"</nowiki>
|}
<ref name="pmid35363500" />


* While hospitalized, patients with CHF should receive [[DVT prophylaxis]]
=== VTE Prophylaxis in Hospitalized Patients ===
{| class="wikitable" style="width:80%"
|-
| colspan="1" style="text-align:center; background:LightGreen" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class I]]
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''1.''' In patients hospitalized with HF, prophylaxis for VTE is recommended to prevent venous thromboembolic disease (Level of Evidence B-R)<nowiki>''</nowiki>.
|}
<ref name="pmid35363500" />


==Beta Blockers==
''Subcutaneous low-molecular-weight heparin, unfractionated heparin, fondaparinux, or approved DOAC are used for the prevention of clinically symptomatic deep vein thrombosis and pulmonary embolism<ref name="pmid35363500" />.''
*[[Metoprolol]], [[Carvedilol]] and [[Bisoprolol]] have FDA approved labeling for use in congestive heart failure.
* Blockade of compensatory sympathetic stimulation is associated with arrhythmic, ischemic, remodeling, and apoptotic benefits.
* Used as monotherapy or combined with conventional heart failure management, beta-blockers reduce the combined risk of morbidity and mortality.
* Initiate low starting dosing and titrate up to tolerated target doses.
* [[Lopressor]] should be used instead of [[atenolol]] in the patient with CHF


==Antiarrhythmic Drugs==
=== Evaluation and Management of Cardiogenic Shock ===
Antiarrhythmic therapy should be considered as a therapy to prevent [[sudden cardiac death]]. Over 50% of heart failure patients will have asymptomatic non-sustained [[ventricular tachycardia]] and there is no general indication for treatment of this arrhythmia. T here are multiple causes of the for [[sudden cardiac death]] in the patient with congestive heart failure which include not only [[arrhythmic]] causes, but also thrombotic and other causes:
{| class="wikitable" style="width:80%"
*Arrhythmic causes
|-
*:[[Ventricular tachycardia]]
| colspan="1" style="text-align:center; background:LightGreen" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class I]]
*:[[Ventricular fibrillation]]
|-
*:[[Bradyarrhythmias]]
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''1.''' In patients with cardiogenic shock, intravenous inotropic support should be used to maintain systemic perfusion and preserve end-organ performance(Level of Evidence B-R)<nowiki>''</nowiki>.
|}
<ref name="pmid35363500" />
{| class="wikitable" style="width:80%"
|-
| colspan="1" style="text-align:center; background:LemonChiffon" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIa]]
|-
| bgcolor="LemonChiffon" |" 2'''.''' In patients with cardiogenic shock, temporary MCS is reasonable when an end-organ function cannot be maintained by pharmacologic means to support cardiac function (Level of Evidence B-NR)".
|-
| bgcolor="LemonChiffon" |<nowiki>''</nowiki> 3. In patients with cardiogenic shock, management by a multidisciplinary team experienced in shock is reasonable(Level of Evidence C-NR)<nowiki>''</nowiki>
|}
<ref name="pmid35363500" />
{| class="wikitable" style="width:80%"
|-
| colspan="1" style="text-align:center; background:LemonChiffon" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIb]]
|-
| bgcolor="LemonChiffon" |" 4'''.''' In patients presenting with cardiogenic shock, placement of a PA line may be considered to define hemodynamic subsets and appropriate management strategies (Level of Evidence B-NR)".
|-
| bgcolor="LemonChiffon" |<nowiki>''</nowiki> 5. For patients who are not rapidly responding to initial shock measures, triage to centers that can provide temporary MCS may be considered to optimize management (Level of Evidence C-LD)<nowiki>''</nowiki>
|}
<ref name="pmid35363500" />


*Thrombotic causes:
=== Integration of Care: Transitions and Team-Based Approaches ===
*:[[Acute MI]]
{| class="wikitable" style="width:80%"
*:[[Pulmonary embolism]]
|-
| colspan="1" style="text-align:center; background:LightGreen" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class I]]
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''1.''' n patients with high-risk HF, particularly those with recurrent hospitalizations for HFrEF, referral to multidisciplinary HF disease management programs is recommended to reduce the risk of hospitalization(Level of Evidence B-R)<nowiki>''</nowiki>.
|-
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''2.''' In patients hospitalized with worsening HF, patient-centered discharge instructions with a clear plan for transitional care should be provided before hospital discharge(Level of Evidence B-NR)<nowiki>''</nowiki>.
|}


*Other causes:
<ref name="pmid35363500" />
*:[[Hyperkalemia]]
{| class="wikitable" style="width:80%"
|-
| colspan="1" style="text-align:center; background:LemonChiffon" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIb]]
|-
| bgcolor="LemonChiffon" |" 3'''.''' In patients hospitalized with worsening HF, participation in systems that allow benchmark-ing to performance measures is reasonable to increase use of evidence-based therapy, and to improve quality of care.(Level of Evidence B-NR)".
|-
| bgcolor="LemonChiffon" |<nowiki>''</nowiki> 4. In patients being discharged after hospital-ization for worsening HF, an early follow-up, generally within 7 days of hospital discharge, is reasonable to optimize care and reduce rehospitalization (Level of Evidence B-NR)<nowiki>''</nowiki>
|}
 
<ref name="pmid35363500" />
==2021 ESC Guideline for management of [[acute heart failure]]==
<span style="font-size:85%">'''Abbreviations:'''
'''AHF:''' [[Acute heart failure]];
'''LMWH:''' [[Low-molecular-weight heparin]];
'''PaO2:''' [[Partial pressure of oxygen]] ;
'''SBP:''' [[Systolic blood pressure]];
'''SpO2:''' [[Transcutaneous oxygen saturation]];
</span>
<br>
{| style="cellpadding=0; cellspacing= 0; width: 600px;"
|-
| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF;" align=center |'''Recommendations for initial treatment of acute heart failure'''
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | '''[[Oxygen]], [[ventilation]] support  ([[ 2021 ESC guidelines classification scheme|Class I, Level of Evidence C]]):'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ [[Oxygen]] is recommended in [[hypoxic]] [[patients]] with  [[SpO2]]<90% or [[PaO2]] <60 mmHg<br>
❑ [[Intubation]] is recommended in the presence of progressive [[respiratory failure]] in spite of [[oxygen]] administration or non-invasive [[ventilation]]<br>
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | '''[[Oxygen]], [[ventilation]] support  ([[ 2021 ESC guidelines classification scheme|Class IIa, Level of Evidence B]]):'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ In [[patients]] with [[respiratory distress]] ([[respiratory rate]] >25 breaths/min, SpO2<90%), [[non-invasive]] [[positive pressure ventilation]] is recommended to decrease [[respiratory distress]] and reduce the rate of mechanical [[endotracheal intubation]]<br>
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''[[Diuretics]] :([[ESC guidelines classification scheme|Class I, Level of Evidence C]]) :'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ Intravenous [[loop diuretics]] are considered for all admitted [[patients]] with [[acute heart failure]] presented  with [[signs]], [[symptoms]] of [[fluid]] overload<br>
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''[[Diuretics]] : ([[ESC guidelines classification scheme|Class IIa, Level of Evidence B]])'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ In [[patients]] with resistant [[edema]] who do not respond to an increase in [[loop diuretic]] doses, combination of a [[loop diuretic]] with [[thiazide]] type [[diuretic]] should be considered <br>
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''[[Vasodilators]]: ([[ESC guidelines classification scheme|Class IIb, Level of Evidence B]])'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ In order to improve [[symptoms]] and reduce [[congestion]] in  [[patients]] with [[AHF]] and SBP >110 mmHg, [[vasodilators]] may be considered as initial therapy<br>
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''[[Inotropic agents]] : ([[ESC guidelines classification scheme|Class 2b, Level of Evidence C]])'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ [[Inotropic]] agents may be considered in [[patients]] with [[SBP]] <90 mmHg and evidence of [[hypoperfusion]] without response to fluid challenge, to improve peripheral
[[perfusion]] and maintain [[end-organ]] function<br>
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | '''[[Inotropic]] agents ([[ESC guidelines classification scheme|Class III, Level of Evidence C]]):'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑  Routinely administration of [[inotropic]] agents are not recommended , due to safety concerns, unless the [[patient]] has [[symptomatic hypotension]] and evidence of [[hypoperfusion]]<br>
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''[[Vasopressors]]: ([[ESC guidelines classification scheme|ClassIIb, Level of Evidence B]])'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ In [[patients]] with [[cardiogenic shock]], a [[vasopressor]], preferably [[norepinephrine]], may be indicated to increase [[blood pressure]] and vital [[organ]] perfusion<br>
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''[[Anticoagulant therapy]]: ([[ESC guidelines classification scheme|ClassI, Level of Evidence A]])'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ [[Thromboembolism prophylaxis]] such as [[LMWH]] is recommended in [[patients]] not already [[anticoagulated]] and no contraindication to [[anticoagulation]], to prevent the risk of [[deep venous thrombosis]] and [[pulmonary embolism]]<br>
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''[[Opiates]]: ([[ESC guidelines classification scheme|ClassIII, Level of Evidence C]])'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ [[Opiates]] is not routinely recommended, unless in selected [[patients]] with severe, intractable [[pain]] or [[anxiety]]<br>
|-
|}
{|
! colspan="2" style="background: PapayaWhip;" align="center" + |The above table adopted from 2021 ESC Guideline
|-
|}<ref name="pmid34447992">{{cite journal |vauthors=McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A |title=2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure |journal=Eur Heart J |volume=42 |issue=36 |pages=3599–3726 |date=September 2021 |pmid=34447992 |doi=10.1093/eurheartj/ehab368 |url=}}</ref>
===Pre-hospital setting===
*In the pre-hospital setting, [[AHF]] [[patients]] should be monitored by [[pulse oximetry]], [[BP]], [[heart rate]], [[respiratory rate]], and a continuous [[ECG]].
*[[Oxygen]] therapy may be given based on a clinical judgment unless [[oxygen saturation]] is <90% in which case it should be administered.
* Indication for [[non-invasive ventilation]]:  
*:[[Respiratory distress]]
*: [[Respiratory rate]] >25 breaths/min
* [[Oxygen saturation]] <90%
   
   
===Metabolism of Antiarrhythmics in the setting of Congestive Heart Failure===
===In-hospital management===
Metabolisms of following anti-arrhythmic drugs are significantly affected in patients with [[congestive heart failure]] and care should be taken regarding their administration:
*Specific causes of [[AHF]] should be searched including [[ACS]], [[ hypertensive emergency]], rapid [[arrhythmias]], severe [[bradycardia]], [[conduction disturbance]], acute [[valve regurgitation]], acute [[pulmonary embolism]], [[myocarditis]], [[tamponade]].
* After exclusion of these [[conditions]], which need to be treated, [[AHF]] should be managed according to the [[clinical]] presentations.


#[[Quinidine]]
===Pre-discharge phase===
#[[Procainamide]]
=== [[Oxygen]] therapy, [[ventilatory]] support===
#[[Disopyramide]]: Contraindicated in patients with [[heart failure]].
*In [[AHF]], [[oxygen]] should not be used routinely in non-[[hypoxaemic]] [[patients]] due to  [[vasoconstriction]] and a reduction in [[cardiac output]].
#[[Moricizine]]
* [[Oxygen]] therapy is recommended in [[patients]] with [[AHF]] SpO2 <90% or [[PaO2]] <60 mmHg to correct [[hypoxemia]].
#[[Lidocaine]]
*In [[chronic obstructive pulmonary disease]] ([[COPD]]), [[hyper-oxygenation]] may increase [[ventilation-perfusion mismatch]], suppress [[ventilation]] and
#[[Mexiletine]]
lead to [[hypercapnia]].
#[[Tocainide]]
* During [[oxygen]] therapy, [[acid-base balance]] and [[SpO2]] should be monitored.
#[[Flecainide]]
*[[Non-invasive positive pressure ventilation]], either continuous [[positive airway pressure]] and [[pressure]] support, improves [[respiratory failure]], increases [[oxygenation]] and [[pH]], and decreases the [[partial pressure]] of [[carbon dioxide]] ([[pCO2]]) and work of [[breathing]] and reduce the rate of [[endotracheal intubation]].  
#[[Propafenone]]
[[Non-invasive positive pressure ventilation ]] indicated to improve [[gas exchange]] and reduce the rate of [[endotracheal intubation]] in [[patients]] with:
#[[Amiodarone]]
:* [[Respiratory distress]] ([[respiratory rate]] >25 breaths/min
:* [[SpO2]] <90%
*[[FiO2]] should be increased up to 100%, if needed, based on  [[oxygen saturation]] level.
*[[Blood pressure]] should be monitored regularly during [[non-invasive positive pressure ventilation]].
*The increase in intrathoracic pressure with [[non-invasive positive pressure ventilation]] may lead to reduction in  [[venous return]], right and [[left ventricular]] preload, [[cardiac output]] and [[BP]].
* In the setting of [[RV]] dysfunction, the increase in [[pulmonary vascular resistance]] and [[RV]] afterload may be present.
* [[Intubation]] is indicative if there is progressive [[respiratory failure]] despite [[oxygen]] administration or [[non-invasive ventilation]].


Patients with congestive heart failure should not be treated with [[dronedarone]].
=== [[Diuretics]]===
*Intravenous [[diuretics]] are mainstay therapy of [[AHF]].
* Efficacy of [[diuretics]] are due to increase [[renal excretion]] of [[salt]] and [[water]] and reduce of [[fluid]] overload and [[congestion]].
* There was a greater relief of [[dyspnoea]], change in [[weight]] and net [[fluid]] loss (with no prognostic role for increases in serum [[creatinine]]) in the higher-dose regimen.
*High [[diuretic]] doses may associate with greater [[neurohormonal]] activation and electrolyte disturbance and poor [[outcomes]].
*  Treatment with [[diuretic]] should be started with an initial i.v. dose of [[furosemide]], or equivalent dose of [[bumetanide]] or [[torasemide]] to 1-2 times the daily oral dose taken by the [[patient]] before [[admission]].
*If the [[patient]] was not on oral [[diuretics]], a starting dose of 20-40 mg of [[furosemide]], or a bolus of 10-20 mg i.v [[torasemide]], can be used.
* [[Furosemide]] can be given as 2-3 daily boluses or as a continuous [[infusion]].
* Due to post-dosing [[sodium]] retention, daily single bolus administrations are not recommended.
* With continuous [[infusion]], a loading dose may be used to achieve steady-state earlier.
* Response to [[diuretic]] should be evaluated shortly after the start of [[diuretic]] therapy and may be measured by performing spot urine [[sodium ]] content  after 2 or
6 h and/or by measuring the hourly [[urine output]].
* A satisfactory [[diuretic]] response can be considered as a [[urine sodium]] content >50-70 mEq/L at 2 h and/or by a [[urine output]] >100-150 mL/h during the first 6 h.
* If there is an inadequate [[diuretic]] response, the [[loop diuretic]] i.v. dose can be doubled, with a further assessment of [[diuretic ]] response.
* If the [[diuretic]] response remains insufficient including <100 mL hourly [[diuresis]]in spite of doubling [[loop diuretic]] dose,  concomitant administration of other [[diuretics ]] such as  [[thiazides]] or [[metolazone]] or [[acetazolamide]] , may be considered.
*[[Serum]] [[electrolytes]] and [[renal function]] should be carefully monitored.
* Low doses of [[loop diuretics]], with frequent doses may be less likely to cause [[dehydration]] or increase in serum [[creatinine]].
* Oral treatment should be started after [[congestion ]] relief.
* Oral [[loop diuretics]] are continued at the lowest dose possible to avoid [[congestion]].
* Discharge of hospital with persistent [[congestion]] is a major predictor of increased deaths and [[rehospitalizations]].
* Appropriate long-term diuretic dose should be established before discharge.
===[[Vasodilators]]===
*Intravenous [[vasodilators]], namely [[nitrates]] or [[nitroprusside]]  with the effect of dilating venous and [[arterial]] [[vessels]] leading to a reduction in [[venous]] return to the [[heart]], less [[congestion]], lower [[afterload]], increased [[stroke volume]] and consequent relief of [[symptoms]].
*[[Nitrates]] act mainly on [[peripheral veins]] whereas the effect of [[nitroprusside]] is dilation of [[arterial]] and [[venule]].
* [[vasodilators]]  may be more effective than [[diuretics]] when acute [[pulmonary edema]] is due to increased [[afterload]] and fluid [[redistribution]] to the [[lungs]] in the absence or with minimal fluid accumulation.
* Intravenous [[vasodilators]] may be considered to relieve AHF [[symptoms ]] when [[SBP]] is >110 mmHg.
* They may be started at low doses and uptitrated to achieve clinical improvement and [[BP]] control.
* [[Nitrates]] are generally administered with an initial bolus followed by continuous [[infusion]] or repeated boluses.
* [[ Nitroglycerine]] can be given as 1-2 mg boluses in severely [[hypertensive]] [[patients]] with acute [[pulmonary edema]].
* [[BP]] monitoring is needed to avoid [[hypotension]] due to an excessive decrease in [[preload]] and [[afterload]].
* Caution should be exercised in [[patients]] with [[LVH]] and/or severe [[aortic stenosis]].
* [[Hemodynamic parameters]] should be monitored in [[patients]] with [[left ventricular]]  [[systolic dysfunction]] and [[aortic stenosis ]] when [[vasodilators]] are given.


==Positive Inotropics==
===[[Inotropes]]===
#Agents that increase intracellular cAMP
* [[Inotropes]] is recommended in [[patients]] with low [[cardiac output]] and [[hypotension]], [[left ventricular systolic dysfunction]] and poor [[organ perfusion]].
#*Alpha-adrenergic agonists
* [[Inotropes]] should be started under [[monitoring]].
#*[[Phosphodiesterase inhibitors]]  
* Common side effects of [[inotropes]] with [[adrnergic]] mechanism including [[sinus tachycardia]], increase [[ventricular rate]] in [[patients]] with [[AF]], induced [[myocardial ischemia]] and [[arrhythmias]], and increase [[mortality]].
#Agents that affect sarcolemmal ion pumps/channels
* [[Levosimendan]] or [[type-3-phosphodiesterase inhibitors]] may be preferred over [[dobutamine]] for [[patients]] on [[beta-blockers]].
#*[[Digoxin]]  
* [[Type-3-phosphodiesterase inhibitors]] or [[levosimendan]] may lead to [[peripheral vasodilation]] and [[hypotension]], especially when administrated at high doses.
#Agents that modulate intracellular calcium mechanisms by either:
===[[Vasopressors]]===
#*Release of [[sarcoplasmic reticulum]] [[calcium]] (IP3)
* [[Norepinephrin]] may be preferred in [[patients]] with severe [[hypotension]], due to [[peripheral vasoconstriction]], to increase [[perfusion ]] to vital [[organs]] at the expense of an increase in [[left ventricular]] [[afterload]].
#*Increased sensitization of the contractile proteins to [[calcium]]  
*In [[patients]] with advanced [[HF]] and [[cardiogenic shock]], a combination of [[norepinephrine]] and [[inotropic]] agents may be considered.
#Drugs having multiple mechanisms of action
* In some studies, the use of [[norepinephrine]] was the first choice, compared with [[dopamine]] or [[epinephrine]].
#*Pimobendan
*[[Dopamine]] was preferred to [[norepinephrine]] as a first-line [[vasopressor]] therapy in [[patients]] with [[shock]].
#*Vesnarinone
* Use of [[dopamin]] was associated with [[arrhythmic]] events and with ahigher [[mortality]] in [[patients]] with [[cardiogenic shock]] but not in those with [[hypovolaemic]] or [[septic shock]].
* Use of [[epinephrine]] in comparison  with [[norepinephrine]] in [[patients]] with [[cardiogenic shock]] due to acute [[MI]] was associated with higher [[heart rate]]and [[lactic acidosis]] and [[mortality]].


=== Digoxin ===
===[[Opiates]]===
* Inhibits Na,K+-ATPase resulting in an increase in intracellular Na+, extracellular Ca2+ exchange increasing the velocity and extent of [[sarcomere]] shortening.
*[[Opiates]] relieve [[dyspnea]] and [[anxiety]].  
* ACC/AHA recommend [[digoxin]] for symptomatic patients with left ventricular systolic dysfunction.  
*They may be used as sedative agents during [[non-invasive positive pressure ventilation]] to improve [[patient]] adaptation.  
* Commonly used in patients with [[heart failure]] and [[atrial fibrillation]] to reduce the ventricular response rate.
*Dose-dependent side effects including [[nausea]], [[hypotension]], [[bradycardia]], and [[respiratory depression]].  
* Mortality has not been shown to be improved with use of [[digoxin]], but the use of [[digoxin]] has been associated with a reduction in hospitalization in the RALES study.
* Administration of [[morphine]]  is associated with a higher frequency of [[mechanical ventilation]], prolonged [[hospitalization]], more [[intensive care unit admissions]], and increased [[mortality]].
* There is no need to load a CHF patient with [[digoxin]].  For the majority of patients with normal renal function, a daily dose of 0.25 mg of [[digoxin]] is usually adequate. In the older patient or in those patients with renal impairment, a dose of 0.125 mg per day may be adequate.
*So, routine use of [[opiates]] in [[AHF]] is not recommended.
* Drugs that increase the concentration of [[digoxin]] include antibiotics and anticholinergic agents as well as [[amiodarone]], [[quinidine]] and [[verapamil]].
* Use of [[morphine]] is recommended in selected [[patients]] with severe/intractable [[pain]] or [[anxiety]] or in the setting of [[palliation]].
* In the RALES study, a level of < 1 ng/ml was associated with efficacy.  Levels above 1 ng/ml were not associated with greater efficacy and were associated with higher mortality.
===[[ Digoxin]]===
*[[Digoxin]] should be considered in patients with [[AF]] with a rapid [[ventricular rate ]] (>110 b.p.m.) despite [[beta-blockers]].
* [[Digoxin]] can be given in boluses of 0.25-0.5 mg i.v., if not used previously.
* In [[patients]] with comorbidities (i.e. [[CKD]]) or other factors affecting [[digoxin]] metabolism (including other drugs) and/or the [[elderly]], the maintenance dose may be difficult to estimate.
* [[Serum]] concentration of [[digoxin]] should be measured.


===Dobutamine===
===[[Thromboembolism]] prophylaxis===
* Activates beta-1 receptors resulting in enhanced [[cardiac contractility]].
*[[Thromboembolism]] prophylaxis with [[heparin]],  [[low-molecular weight heparin]] or another [[anticoagulant]] is recommended, unless contraindicated or existing therapy with oral [[anticoagulants]].
* Long-term dobutamine infusions are arrhythmogenic and increase mortality.
* Dobutamine also slightly reduces afterload


===Dopamine===
* Unique dose dependent mechanism of action.
* '''At low doses: (≤2 µg/kg/min),''' selective dilation of splanchnic and renal arterial beds. assists in increasing renal perfusion.
* '''At intermediate doses: (2 to 10 µg/kg/min),''' increased norepinephrine secretion results in increased [[cardiac contractility]], [[heart rate]] and [[systemic vascular resistance]].
* '''At higher doses: (5 to 20 µg/kg/min),''' direct alpha-adrenergic receptor stimulation increases [[systemic vascular resistance]].


===Milrinone===
* [[Phosphodiesterase-III inhibitor]] that enhances [[cardiac contractility]] by increasing intracellular cyclic adenosine monophosphate (cAMP).
* Potent pulmonary vasodilator that may benefit some patients with [[pulmonary hypertension]].
* Unlike dobutamine milrinone is beneficial in decompensated heart failure patients who are on beta-blocker therapy.
* Long term milrinone infusions are arrhythmogenic, and increase mortality.


==Metformin==
*[[Metformin]] use in [[diabetics]] with [[CHF]] is associated with lower mortality


==Ca Channel Blockers==
* Although calcium channel blockers cause [[vasodilation]] their overall benefit is minimized by the fact that they have a [[negative inotropic]] effect and by the reflex activation of the sympathetic nervous system.


* These agents are not recommended as vasodilators in patients with congestive heart failure, however they may be useful as antihypertensive agents in patients with [[diastolic dysfunction]].


==Drugs to Avoid in CHF==
* [[Dronedarone]] should be avoided in patients who were hospitalized with CHF (this is a boxed warning)
* [[Sotalol]] (has a negative inotropic effect)


==Biventricular Pacing or Cardiac Resynchronization Therapy (CRT)==


* Cardiac resynchronization therapy should only be undertaken if the blood pressure is low and if the heart failure medicines have been optimized
* CRT is indicated for symptomatic patients with NYHA III-IV heart failure and wide QRS complex (>120ms) who are him normal sinus rhythm.
* 70% of patients receiving synchronous ventricular contraction report significant symptomatic improvements.
===ACC / AHA Guidelines - Recommendations for Cardiac Resynchronization Therapy in Patients with Severe Systolic Heart Failure (DO NOT EDIT)<ref name="pmid18483207">{{cite journal |author=Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO, Smith SC, Jacobs AK, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Faxon DP, Halperin JL, Hiratzka LF, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Ornato JP, Page RL, Riegel B, Tarkington LG, Yancy CW |title=ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons |journal=[[Circulation]] |volume=117 |issue=21 |pages=e350–408 |year=2008 |month=May |pmid=18483207 |doi=10.1161/CIRCUALTIONAHA.108.189742 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=18483207 |issn= |accessdate=2011-01-15}}</ref>===
{{cquote|
====[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class I]]====


'''1.'''  For patients who have LVEF less than or equal to 35%, a QRS duration greater than or equal to 0.12 seconds, and sinus rhythm, CRT with or without an ICD is indicated for the treatment of NYHA functional Class III or ambulatory Class IV heart failure symptoms with optimal recommended medical therapy. ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: A]])


====[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIa]]====


'''1.''' For patients who have LVEF less than or equal to 35%, a QRS duration greater than or equal to 0.12 seconds, and AF, CRT with or without an ICD is reasonable for the treatment of NYHA functional Class III or ambulatory Class IV heart failure symptoms on optimal recommended medical therapy. ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: B]])


'''2.''' For patients with LVEF less than or equal to 35% with NYHA functional Class III or ambulatory Class IV symptoms who are receiving optimal recommended medical therapy and who have frequent dependence on ventricular pacing, CRT is reasonable. ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C]])


====[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIb]]====


'''1.''' For patients with LVEF less than or equal to 35% with NYHA functional Class I or II symptoms who are receiving optimal recommended medical therapy and who are undergoing implantation of a permanent pacemaker and/or ICD with anticipated frequent ventricular pacing, CRT may be considered. ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C]])}}


==Implantation of Intracardiac Defibrillator==


*50% of heart failure patients die of [[sudden cardiac death]].  
{{Family tree/start}}
*ICDs are indicated for patients with previous myocardial infarction and LVEF <30%, sustained ventricular tachycardia, inducible ventricular tachycardia.  
{{Family tree | | | | A01 | | | |A01= Management of [[acute heart failure]] }}
*Morbidity/mortality benefit of ICD placement vs. anti-arrhythmic drug therapy is controversial.
{{Family tree | | | | |!| | | | | }}
{{Family tree | | | | B01 | | | |B01= [[Cardiogenic shock]], [[respiratory failure]]}}
{{Family tree | |,|-|-|^|-|-|.| | }}
{{Family tree | C01 | | | | C02 |C01= NO| C02= Yes}}
{{Family tree | |!| | | | | |!| | | | | | | | | | | |}}
{{Family tree |  G1 | | | |  F2 | | | | | | | | | | |F2=
[[Pharmacologic therapy]]
* [[Ventilatory support]]
* [[Mechanical circulatory support]]| G1= Identifying acute causes}}
{{Family tree | |!| | | | | | | | | | | | | | | | | | }}
{{Family tree |  G2 | | | | | | | | | | | | | | | |G2=
[[Acute Coronary syndrome]]
*[[Hypertension]] emergency
*[[Arrhythmia]]
*[[Mechanical]] causea
*[[Pulmonary embolism]]
*[[Infections]]
*[[Tamponade]]}}
{{Family tree |,|^|-|-|.| | | | | | | | | | | | | | |}}
{{Family tree | Z1| | Z2| | | | | | | | | Z2=NO| |Z1= Yes}}
{{Family tree | |!| | |!| | | | | | | | | | | | | | | }}
{{Family tree | P1| |C  | | | | | | | | | | P1= Immediate initiation of specific treatment |C= Further treatment | | | | }}
{{Family tree/end}}
{|
! colspan="2" style="background: PapayaWhip;" align="center" + |The above algorithm adopted from 2021 ESC Guideline
|-
|}<ref name="pmid34447992">{{cite journal |vauthors=McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A |title=2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure |journal=Eur Heart J |volume=42 |issue=36 |pages=3599–3726 |date=September 2021 |pmid=34447992 |doi=10.1093/eurheartj/ehab368 |url=}}</ref>


==Ultrafiltration==
* [[Ultrafiltration]] has been associated with a reduced incidence of hospitalization compared with diuretics in the UNLOAD trial. There was no difference in mortality.
* The process of ultrafiltration consists of the production of plasma water from whole blood across a semipermeable membrane (hemofilter) in response to a transmembrane pressure gradient. Possible benefits of ultrafiltration include:
*Provides fluid regulation
:* Relieve [[pulmonary edema]]
:* Reduce [[ascites]] and/or [[peripheral edema]]
:* Hemodynamic stabilization
:* Improve oxygenation
:* Facilitates blood product replacement without excess volume
:* Enable [[parenteral nutritional]] support without excess volume
* Improves solute regulation
:* Correct [[acid-base balance]]
:* Correct serum sodium content
:* Eliminate myocardial depressant factors or known toxins
:* Correct [[uremia]]
:* Correct [[hyperkalemia]]
:* Correct other [[electrolyte disturbances]]
* Helps to establish homeostasis
:* Reset [[water omostat]]
:* Restore diuretic responsiveness
:* Reduce [[neurohormonal activation]]


==Cardiac Surgery==
* Resection of non-viable myocardium or aneurymectoymay be an option to improve left ventricular geometry
* Revascularization without resection of non-viable myocardium may be helpful if there is hibernating myocardium


==Left Ventricular Assist Devices (LVADs)==
===Short-term [[mechanical circulatory support]]===
* LVADs are temporary devices to bridge end stage patients to cardiac transplantation.
*In [[patients]] presenting with [[cardiogenic shock]], short-term [[MCS]] may be considered to increase [[cardiac output]] and support end-organ [[perfusion]].
* The use of LVADs as a destination device rather than as a bridge is investigational at present
*Short-term [[MCS]] can be used as a  [[bridge to recovery]] ([[BTR]]), [[bridge to decision]] (BTD) or [[bridge to bridge]] ([[BTB]]).
*The initial improvements in [[cardiac output]], [[BP]] and [[arterial]] [[lactate]] may be affected by significant [[complications]].
*Close monitoring of [[hemodynamics]] and [[lactate]] as the markers of [[end-organ damage]] may improve [[survival]].
* Use of The [[Intra-aortic Balloon Pump]] in [[Cardiogenic shock]] was not associated with the reduced long-term [[mortality]] compared with [[medical therapy]].
* [[IABP]] is not routinely recommended in [[cardiogenic shock]] post-[[MI]].
* However, it may still be considered in [[cardiogenic shock]], especially if not due to [[ACS]], and refractory to drug therapy, as a BTD, [[BTR]], or [[BTB]].
*  [[Patients]] with [[cardiogenic shock]] or [[cardiac arrest]] treated with [[venoarterial ]] [[VA-ECMO]] showed favorable [[outcome]].
* In cases of [[fulminant myocarditis]] and other [[conditions]] causing severe [[cardiogenic shock]], [[VA-ECMO]] may also be considered.
* Depending on the severity of [[myocardial dysfunction]] and/or concomitant [[mitral regurgitation]] or [[aortic regurgitation]], [[VA-ECMO]] may increase [[LV]] afterload with an increase in [[LV end-diastolic pressure]] and [[pulmonary congestion]].
* In these cases, [[LV unloading]] such as [[Impella]] is considered.
 
==2021 ESC Guideline for management of [[pulmonary edema]]==
 
{{Family tree/start}}
{{Family tree | | | | A01 | | | |A01= Management of [[patients]] with [[pulmonary edema]]}}
{{Family tree | | | | |!| | | | | }}
{{Family tree | | | | A01 | | | |A01= [[Oxygen]] (Class I) or [[ventilatory support]] (Class IIa)}}
{{Family tree | | | | |!| | | | | }}
{{Family tree | | | | B01 | | | |B01= [[Systolic blood pressure]] ≥110 mmHg}}
{{Family tree | |,|-|-|^|-|-|.| | }}
{{Family tree | C01 | | | | C02 |C01= Yes| C02= NO}}
{{Family tree | |!| | | | | |!| | }}
{{Family tree |  A6 | | | | | A7| | |A6= [[Loop diuretics]] (Class I) and/or [[vasodilators]] (Class IIb)|A7=[[Signs]] of [[hypoperfusion]] }}
{{Family tree | |:| | | | |,|-|^|-|.| | | |}}
{{Family tree | |:| | | | | A8| |A9 | | |A8=Yes|A9=NO}}
{{Family tree | |:| | | | |!| | | |!| | | }}
{{Family tree | |:| | | | |A10| |A11| |A10=[[Loop diuretics]] (Class I) and [[inotropes]]/[[vasopressors]](Class IIb)|A11=[[Loop diuretics]] (Class I)}}
{{Family tree | |`|-|-|-|-|v|-|-|-|'| | | | }}
{{Family tree | | | | | | | A12 | | | A12=[[Congestion]] relief}}
{{Family tree | | | | | |,|-|^|-|.| | |}}
{{Family tree | | | | | |A13| |A14| | |A13=Yes|A14=NO}}
{{Family tree | | | | | |!| | | |!| |}}
{{Family tree | | | | | |A15| |A16| | A15= Optimized [[medical therapy]]| A16= [[Renal replacement therapy]]
*[[ Mechanical circulatory support]]
* [[Palliative therapy]]}}
{{Family tree/end}}
{|
! colspan="2" style="background: PapayaWhip;" align="center" + |The above algorithm adopted from 2021 ESC Guideline
|-
|}
 


==Cardiac Transplantation==
*[[Acute pulmonary edema]] is related to [[lung]] [[congestion]].
* Cardiac transplantation is reserved for patients with end-stage congestive heart failure despite all interventions.
* Clinical characteristics include  [[dyspnea]] with [[orthopnea]], [[respiratory failure]] ([[hypoxemia]]-[[hypercapnia]]), [[tachypnea]] >25 breaths/min, and increased work of [[breathing]].
*:AHA/ACC Guidelines: Indications for heart transplantation:
*Treatment including as follows:
*::Any hemodynamic compromise due to heart failure.
* [[Oxygen]], given as [[continuous positive airway pressure]], non-invasive positive pressure-[[ventilation]] and/or high-flow nasal cannula
*::Requiring IV inotropic support to maintain adequate organ perfusion.
* [[Diuretics]] 
*::Peak Vo2 <10 ml/kg/min.
*[[Vasodilators]]  if [[systolic BP]] ([[SBP]]) is high, to reduce [[LV]] [[afterload]]
*::NYHA Class IV symptoms not amenable to any other intervention.
*:: In the setting of [[acute pulmonary edema]] with low [[cardiac output]] state, [[inotropes]], [[vasopressors]], and/or [[MCS]] are indicated to restore [[organ]] [[perfusion]].
*::Recurrence of symptomatic ventricular arrhythmias refractory to all therapeutic intervention.
* 80% 1 year survival, and 60% 5 year survival.
* Lifelong immunosuppressive therapy to prevent (or postpone) rejection, increased risk for opportunistic infections and malignancies.


==Invasive Monitoring==
==2021 ESC Guideline for management of [[cardiogenic shock]]==
* Based upon the results of the ESCAPE trial, there is no benefit in clinical outcomes with the use of a pulmonary artery line in patients with decompensated CHF.


==Obstructive Sleep Apnea in the Patient with CHF==
{{Family tree/start}}
*[[Central sleep apnea]] in the patient with CHF is due to the compensatory [[respiratory alkalosis]] that is present in the patient with CHF and [[tachypnea]]
{{Family tree | | | | A01 | | | |A01=Management of [[patients]] with [[cardiogenic shock]] }}
{{Family tree | | | | |!| | | | | }}
{{Family tree | | | | B01 | | | |B01= [[Acute coronary syndrome]] ([[ACS]]), [[mechanical complications]] }}
{{Family tree | |,|-|-|^|-|-|.| | }}
{{Family tree | C01 | | | | C02 |C01=Yes| C02= NO}}
{{Family tree | |!| | | | | |!| | }}
{{Family tree |  A5| | | |  A6 | | | A5=[[Emergency PCI]] or [[surgical]] treatment|A6=Identifying and treatment of other specific causes}}
{{Family tree | | |`|-|v|-|-|'| | }}
{{Family tree | | | | |A7 | | | | | A7=[[Oxygen]] therapy (Class I) or [[ventilatory]] support (Class IIa)
* [[Inotropes]], [[vasopressors]] (Class IIb)
* Short-term [[mechanical circulatory support]] (Class IIa)}}
{{Family tree | | | | |!| | | | | }}
{{Family tree | | | | |A8 | | | | | A8=Improvement of [[hypoperfusion]] and [[organ]] dysfunction}}
{{Family tree | | |,|-|^|-|.| | | }}
{{Family tree | | | A9| |A10| | | | A9=Yes|A10=NO}}
{{Family tree | | | |!| | |!| | | }}
{{Family tree | | A11 | |A12| | | |A11=Weaning from [[inotropes]]/[[vasopressors]] and/or [[mechanical circulatory support]]
*Treatment of underlying etiology and [[medical therapy]] optimization (Class I )|A12=[[Mechanical circulatory support]](Class IIa)
*[[Renal replacement therapy]] (Class IIa)
*[[Palliative care]] }}


==Exercise and Daily Activities==
{{Family tree/end}}
* Patient should have uninterrupted exercise at least four days a week including a walking program.
{|
* Patients with heart failure should avoid weightlifting which increases [[afterload]].
! colspan="2" style="background: PapayaWhip;" align="center" + |The above algorithm adopted from 2021 ESC Guideline
* The patient should not routinely lift more than 20 pounds, again which may increase [[afterload]]. 
|-
* Patients can continue their sexual activity. Some patients take 2.5 or 5.0 mg of sublingual [[nitroglycerine]] before sexual activity.
|}


==References==
==References==
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{{WikiDoc Sources}}
{{WikiDoc Sources}}


[[Category:Cardiology]]
[[Category:Disease]]
[[Category:Disease]]
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[[Category:Up-To-Date cardiology]]

Latest revision as of 16:18, 1 December 2022



Resident
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Nutritional Supplements
Hormonal Therapies
Drugs to Avoid
Drug Interactions
Treatment of underlying causes
Associated conditions

Exercise Training

Surgical Therapy:

Biventricular Pacing or Cardiac Resynchronization Therapy (CRT)
Implantation of Intracardiac Defibrillator
Ultrafiltration
Cardiac Surgery
Left Ventricular Assist Devices (LVADs)
Cardiac Transplantation

ACC/AHA Guideline Recommendations

Initial and Serial Evaluation of the HF Patient
Hospitalized Patient
Patients With a Prior MI
Sudden Cardiac Death Prevention
Surgical/Percutaneous/Transcather Interventional Treatments of HF
Patients at high risk for developing heart failure (Stage A)
Patients with cardiac structural abnormalities or remodeling who have not developed heart failure symptoms (Stage B)
Patients with current or prior symptoms of heart failure (Stage C)
Patients with refractory end-stage heart failure (Stage D)
Coordinating Care for Patients With Chronic HF
Quality Metrics/Performance Measures

Implementation of Practice Guidelines

Congestive heart failure end-of-life considerations

Specific Groups:

Special Populations
Patients who have concomitant disorders
Obstructive Sleep Apnea in the Patient with CHF
NSTEMI with Heart Failure and Cardiogenic Shock

Congestive heart failure acute pharmacotherapy On the Web

Most recent articles

Most cited articles

Review articles

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Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Congestive heart failure acute pharmacotherapy

CDC on Congestive heart failure acute pharmacotherapy

Congestive heart failure acute pharmacotherapy in the news

Blogs on Congestive heart failure acute pharmacotherapy

Directions to Hospitals Treating Congestive heart failure acute pharmacotherapy

Risk calculators and risk factors for Congestive heart failure acute pharmacotherapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Acute heart failure; AHF; Heart failure; HF; BTB; bridge to bridge; BTD; bridge to decision; BTR; bridge to recovery;

Overview

Acute heart failure can occur in the setting of a new onset heart failure or worsening of an existing chronic heart failure (also known as acute decompensated heart failure, flash pulmonary edema, ADHF). ADHF presents with acute shortness of breath due to the development of pulmonary edema (the rapid accumulation of fluid in the lung). Other signs and symptoms of ADHF include hypotension with impaired and organ perfusion manifested by worsening renal function, altered mentation and cold clammy extremities. ADHF associated with a poor prognosis if not treated aggressively. Like chronic heart failure therapy, the goal is to improve symptoms but unlike chronic therapy the other goals are to improve oxygenation and hemodynamic stability. The mainstays of the acute medical treatment in acute decompensated congestive heart failure include oxygen to improve hypoxia, diuresis to reduce both preload and intravascular volume and vasodilators to reduce afterload. Some of the mainstays of chronic heart failure therapy are not initiated acutely (ACE inhibtors,beta blockers and digoxin).






2022 AHA/ACC/HFSA Heart Failure Guideline Hospitalization of patients with acute heart failure

Assessment of Patients Hospitalized With Decompensated HF

Class I
"1. In patients hospitalized with HF, the severity of congestion and adequacy of perfusion should be assessed to guide triage and initial therapy (Level of Evidence C-LD).
"2. In patients hospitalized with HF, the common precipitating factors and the overall patient trajectory should be assessed to guide appropriate therapy (Level of Evidence C-LD).
"3. For patients admitted with HF, treatment should address reversible factors, establish optimal volume status, and advance GDMT toward targets for outpatient therapy (Level of Evidence C-LD).

[1]

Maintenance or Optimization of GDMT During Hospitalization

Class I
"1. In patients with HFrEF requiring hospitalization, preexisting GDMT should be continued and optimized to improve outcomes, unless contraindicated (Level of Evidence B-NR)''.
"2. In patients experiencing a mild decrease of renal function or asymptomatic reduction of blood pressure during HF hospitalization, diuresis, and other GDMT should not routinely be discontinued (Level of Evidence B-NR)''.
"3. In patients with HFrEF, GDMT should be initiated during hospitalization after clinical stability is achieved. (Level of Evidence B-NR).
''4. In patients with HFrEF, if discontinuation of GDMT is necessary during hospitalization, it should be reinitiated and further optimized as soon as possible (Level of Evidence B-NR)''

[1]

Diuretics in Hospitalized Patients: Decongestion Strategy

Class I
"1. Patients with HF admitted with evidence of significant fluid overload should be promptly treated with intravenous loop diuretics to improve symptoms and reduce morbidity (Level of Evidence B-NR)''.
"2. For patients hospitalized with HF, therapy with diuretics and other guideline-directed medications should be titrated with the goal to resolve clinical evidence of congestion to reduce symptoms and rehospitalizations(Level of Evidence B-NR)''.
"3. For patients requiring diuretic treatment during hospitalization for HF, the discharge regimen should include a plan for adjustment of diuretics to decrease rehospitalizations (Level of Evidence B-NR).

[1]

Class IIa
"4. In patients hospitalized with HF when diuresis is inadequate to relieve symptoms and signs of congestion, it is reasonable to intensify the diuretic regimen using either: a. higher doses of intravenous loop diuretics or addition of a second diuretic(Level of Evidence: B-NR) "

[1]

Parenteral Vasodilation Therapy in Patients Hospitalized With HF

Class IIa
"1. In patients who are admitted with decompensated HF, in the absence of systemic hypotension, intravenous nitroglycerin or nitroprusside may be considered as an adjuvant to diuretic therapy for relief of dyspnea(Level of Evidence: B-NR) "

[1]

VTE Prophylaxis in Hospitalized Patients

Class I
"1. In patients hospitalized with HF, prophylaxis for VTE is recommended to prevent venous thromboembolic disease (Level of Evidence B-R)''.

[1]

Subcutaneous low-molecular-weight heparin, unfractionated heparin, fondaparinux, or approved DOAC are used for the prevention of clinically symptomatic deep vein thrombosis and pulmonary embolism[1].

Evaluation and Management of Cardiogenic Shock

Class I
"1. In patients with cardiogenic shock, intravenous inotropic support should be used to maintain systemic perfusion and preserve end-organ performance(Level of Evidence B-R)''.

[1]

Class IIa
" 2. In patients with cardiogenic shock, temporary MCS is reasonable when an end-organ function cannot be maintained by pharmacologic means to support cardiac function (Level of Evidence B-NR)".
'' 3. In patients with cardiogenic shock, management by a multidisciplinary team experienced in shock is reasonable(Level of Evidence C-NR)''

[1]

Class IIb
" 4. In patients presenting with cardiogenic shock, placement of a PA line may be considered to define hemodynamic subsets and appropriate management strategies (Level of Evidence B-NR)".
'' 5. For patients who are not rapidly responding to initial shock measures, triage to centers that can provide temporary MCS may be considered to optimize management (Level of Evidence C-LD)''

[1]

Integration of Care: Transitions and Team-Based Approaches

Class I
"1. n patients with high-risk HF, particularly those with recurrent hospitalizations for HFrEF, referral to multidisciplinary HF disease management programs is recommended to reduce the risk of hospitalization(Level of Evidence B-R)''.
"2. In patients hospitalized with worsening HF, patient-centered discharge instructions with a clear plan for transitional care should be provided before hospital discharge(Level of Evidence B-NR)''.

[1]

Class IIb
" 3. In patients hospitalized with worsening HF, participation in systems that allow benchmark-ing to performance measures is reasonable to increase use of evidence-based therapy, and to improve quality of care.(Level of Evidence B-NR)".
'' 4. In patients being discharged after hospital-ization for worsening HF, an early follow-up, generally within 7 days of hospital discharge, is reasonable to optimize care and reduce rehospitalization (Level of Evidence B-NR)''

[1]

2021 ESC Guideline for management of acute heart failure

Abbreviations: AHF: Acute heart failure; LMWH: Low-molecular-weight heparin; PaO2: Partial pressure of oxygen ; SBP: Systolic blood pressure; SpO2: Transcutaneous oxygen saturation;

Recommendations for initial treatment of acute heart failure
Oxygen, ventilation support (Class I, Level of Evidence C):

Oxygen is recommended in hypoxic patients with SpO2<90% or PaO2 <60 mmHg
Intubation is recommended in the presence of progressive respiratory failure in spite of oxygen administration or non-invasive ventilation

Oxygen, ventilation support (Class IIa, Level of Evidence B):

❑ In patients with respiratory distress (respiratory rate >25 breaths/min, SpO2<90%), non-invasive positive pressure ventilation is recommended to decrease respiratory distress and reduce the rate of mechanical endotracheal intubation

Diuretics :(Class I, Level of Evidence C) :

❑ Intravenous loop diuretics are considered for all admitted patients with acute heart failure presented with signs, symptoms of fluid overload

Diuretics : (Class IIa, Level of Evidence B)

❑ In patients with resistant edema who do not respond to an increase in loop diuretic doses, combination of a loop diuretic with thiazide type diuretic should be considered

Vasodilators: (Class IIb, Level of Evidence B)

❑ In order to improve symptoms and reduce congestion in patients with AHF and SBP >110 mmHg, vasodilators may be considered as initial therapy

Inotropic agents : (Class 2b, Level of Evidence C)

Inotropic agents may be considered in patients with SBP <90 mmHg and evidence of hypoperfusion without response to fluid challenge, to improve peripheral perfusion and maintain end-organ function

Inotropic agents (Class III, Level of Evidence C):

❑ Routinely administration of inotropic agents are not recommended , due to safety concerns, unless the patient has symptomatic hypotension and evidence of hypoperfusion

Vasopressors: (ClassIIb, Level of Evidence B)

❑ In patients with cardiogenic shock, a vasopressor, preferably norepinephrine, may be indicated to increase blood pressure and vital organ perfusion

Anticoagulant therapy: (ClassI, Level of Evidence A)

Thromboembolism prophylaxis such as LMWH is recommended in patients not already anticoagulated and no contraindication to anticoagulation, to prevent the risk of deep venous thrombosis and pulmonary embolism

Opiates: (ClassIII, Level of Evidence C)

Opiates is not routinely recommended, unless in selected patients with severe, intractable pain or anxiety

The above table adopted from 2021 ESC Guideline

[2]

Pre-hospital setting

In-hospital management

Pre-discharge phase

Oxygen therapy, ventilatory support

lead to hypercapnia.

Diuretics

6 h and/or by measuring the hourly urine output.

Vasodilators

Inotropes

Vasopressors

Opiates

Digoxin

  • Digoxin should be considered in patients with AF with a rapid ventricular rate (>110 b.p.m.) despite beta-blockers.
  • Digoxin can be given in boluses of 0.25-0.5 mg i.v., if not used previously.
  • In patients with comorbidities (i.e. CKD) or other factors affecting digoxin metabolism (including other drugs) and/or the elderly, the maintenance dose may be difficult to estimate.
  • Serum concentration of digoxin should be measured.

Thromboembolism prophylaxis









 
 
 
Management of acute heart failure
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Cardiogenic shock, respiratory failure
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NO
 
 
 
Yes
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Identifying acute causes
 
 
 
Pharmacologic therapy
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Acute Coronary syndrome
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Yes
 
NO
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Immediate initiation of specific treatment
 
Further treatment
 
 
 
 
 
 
 
 
 
 
 
 
 
The above algorithm adopted from 2021 ESC Guideline

[2]


Short-term mechanical circulatory support

2021 ESC Guideline for management of pulmonary edema

 
 
 
Management of patients with pulmonary edema
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Oxygen (Class I) or ventilatory support (Class IIa)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Systolic blood pressure ≥110 mmHg
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Yes
 
 
 
NO
 
 
 
 
 
 
 
 
 
 
 
 
Loop diuretics (Class I) and/or vasodilators (Class IIb)
 
 
 
 
Signs of hypoperfusion
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Yes
 
NO
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Loop diuretics (Class I) and inotropes/vasopressors(Class IIb)
 
Loop diuretics (Class I)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Congestion relief
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Yes
 
NO
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Optimized medical therapy
 
Renal replacement therapy
 
The above algorithm adopted from 2021 ESC Guideline


2021 ESC Guideline for management of cardiogenic shock

 
 
 
Management of patients with cardiogenic shock
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Acute coronary syndrome (ACS), mechanical complications
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Yes
 
 
 
NO
 
 
 
 
 
 
 
 
 
 
 
 
Emergency PCI or surgical treatment
 
 
 
Identifying and treatment of other specific causes
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Oxygen therapy (Class I) or ventilatory support (Class IIa)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Improvement of hypoperfusion and organ dysfunction
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Yes
 
NO
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Weaning from inotropes/vasopressors and/or mechanical circulatory support
  • Treatment of underlying etiology and medical therapy optimization (Class I )
 
Mechanical circulatory support(Class IIa)
  • Renal replacement therapy (Class IIa)
  • Palliative care
  •  
     
     
    The above algorithm adopted from 2021 ESC Guideline

    References

    1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM; et al. (2022). "2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines". Circulation. 145 (18): e876–e894. doi:10.1161/CIR.0000000000001062. PMID 35363500 Check |pmid= value (help).
    2. 2.0 2.1 McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland J, Coats A, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam C, Lyon AR, McMurray J, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano G, Ruschitzka F, Kathrine Skibelund A (September 2021). "2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure". Eur Heart J. 42 (36): 3599–3726. doi:10.1093/eurheartj/ehab368. PMID 34447992 Check |pmid= value (help). Vancouver style error: initials (help)

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