Relaxin/insulin-like family peptide receptor 4: Difference between revisions

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{{Infobox_gene}}
'''Relaxin/insulin-like family peptide receptor 4''', also known as '''RXFP4''', is a human [[G-protein coupled receptor]].<ref name="entrez">{{cite web | title = Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=339403| accessdate = }}</ref>


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
== Function ==
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GPR100 is a member of the [[rhodopsin]] family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by [[OMIM]]]<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Relaxin/insulin-like family peptide receptor 4
| HGNCid = 14666
| Symbol = RXFP4
| AltSymbols =; GPCR142; GPR100; MGC126556; MGC126558; RLN3R2
| OMIM = 609043
| ECnumber = 
| Homologene = 18775
| MGIid = 2182926
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004945 |text = angiotensin type II receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 339403
    | Hs_Ensembl = ENSG00000173080
    | Hs_RefseqProtein = NP_871001
    | Hs_RefseqmRNA = NM_181885
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 154178125
    | Hs_GenLoc_end = 154179364
    | Hs_Uniprot = Q8TDU9
    | Mm_EntrezGene = 242093
    | Mm_Ensembl = ENSMUSG00000049741
    | Mm_RefseqmRNA = NM_181817
    | Mm_RefseqProtein = NP_861538
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 88737825
    | Mm_GenLoc_end = 88739069
    | Mm_Uniprot = Q3B805
  }}
}}
'''Relaxin/insulin-like family peptide receptor 4''', also known as '''RXFP4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=339403| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{PBB_Summary
* [[Relaxin receptor]]
| section_title =  
| summary_text = GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=339403| accessdate = }}</ref>
}}


==See also==
== References ==
* [[Relaxin receptor]]
{{reflist}}


==References==
== External links ==
{{reflist|2}}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3037 | title = Relaxin Family Peptide Receptors: RXFP4 | accessdate = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ | title = Receptors for relaxin family peptides | journal = Annals of the New York Academy of Sciences | volume = 1041 | issue =  | pages = 61–76 | date = May 2005 | pmid = 15956688 | doi = 10.1196/annals.1282.010 }}
| citations =
* {{cite journal | vauthors = Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ | title = International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides | journal = Pharmacological Reviews | volume = 58 | issue = 1 | pages = 7–31 | date = March 2006 | pmid = 16507880 | doi = 10.1124/pr.58.1.9 }}
*{{cite journal | author=Bathgate RA, Ivell R, Sanborn BM, ''et al.'' |title=Receptors for relaxin family peptides. |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue=  |pages= 61-76 |year= 2005 |pmid= 15956688 |doi= 10.1196/annals.1282.010 }}
* {{cite journal | vauthors = Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence | journal = FEBS Letters | volume = 520 | issue = 1-3 | pages = 97–101 | date = June 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 }}
*{{cite journal | author=Bathgate RA, Ivell R, Sanborn BM, ''et al.'' |title=International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. |journal=Pharmacol. Rev. |volume=58 |issue= 1 |pages= 7-31 |year= 2006 |pmid= 16507880 |doi= 10.1124/pr.58.1.9 }}
* {{cite journal | vauthors = Liu C, Chen J, Sutton S, Roland B, Kuei C, Farmer N, Sillard R, Lovenberg TW | title = Identification of relaxin-3/INSL7 as a ligand for GPCR142 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 50765–70 | date = December 2003 | pmid = 14522967 | doi = 10.1074/jbc.M308996200 }}
*{{cite journal | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi= }}
* {{cite journal | vauthors = Boels K, Schaller HC | title = Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor | journal = British Journal of Pharmacology | volume = 140 | issue = 5 | pages = 932–8 | date = November 2003 | pmid = 14530218 | pmc = 1574110 | doi = 10.1038/sj.bjp.0705521 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives | journal = FEBS Letters | volume = 554 | issue = 3 | pages = 381–8 | date = November 2003 | pmid = 14623098 | doi = 10.1016/S0014-5793(03)01196-7 }}
*{{cite journal | author=Liu C, Chen J, Sutton S, ''et al.'' |title=Identification of relaxin-3/INSL7 as a ligand for GPCR142. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 50765-70 |year= 2004 |pmid= 14522967 |doi= 10.1074/jbc.M308996200 }}
* {{cite journal | vauthors = Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW | title = Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7 | journal = Molecular Pharmacology | volume = 67 | issue = 1 | pages = 231–40 | date = January 2005 | pmid = 15465925 | doi = 10.1124/mol.104.006700 }}
*{{cite journal | author=Boels K, Schaller HC |title=Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor. |journal=Br. J. Pharmacol. |volume=140 |issue= 5 |pages= 932-8 |year= 2004 |pmid= 14530218 |doi= 10.1038/sj.bjp.0705521 }}
* {{cite journal | vauthors = Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW | title = INSL5 is a high affinity specific agonist for GPCR142 (GPR100) | journal = The Journal of Biological Chemistry | volume = 280 | issue = 1 | pages = 292–300 | date = January 2005 | pmid = 15525639 | doi = 10.1074/jbc.M409916200 }}
*{{cite journal | author=Fredriksson R, Höglund PJ, Gloriam DE, ''et al.'' |title=Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. |journal=FEBS Lett. |volume=554 |issue= 3 |pages= 381-8 |year= 2003 |pmid= 14623098 |doi= }}
*{{cite journal | author=Liu C, Chen J, Kuei C, ''et al.'' |title=Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 231-40 |year= 2005 |pmid= 15465925 |doi= 10.1124/mol.104.006700 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Liu C, Kuei C, Sutton S, ''et al.'' |title=INSL5 is a high affinity specific agonist for GPCR142 (GPR100). |journal=J. Biol. Chem. |volume=280 |issue= 1 |pages= 292-300 |year= 2005 |pmid= 15525639 |doi= 10.1074/jbc.M409916200 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Protein and peptide receptor modulators}}
 
 
{{DEFAULTSORT:Relaxin insulin-like family peptide receptor 4}}


{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 18:01, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.[1]

Function

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM][1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4".

External links

Further reading

  • Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (May 2005). "Receptors for relaxin family peptides". Annals of the New York Academy of Sciences. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688.
  • Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (March 2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacological Reviews. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
  • Liu C, Chen J, Sutton S, Roland B, Kuei C, Farmer N, Sillard R, Lovenberg TW (December 2003). "Identification of relaxin-3/INSL7 as a ligand for GPCR142". The Journal of Biological Chemistry. 278 (50): 50765–70. doi:10.1074/jbc.M308996200. PMID 14522967.
  • Boels K, Schaller HC (November 2003). "Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor". British Journal of Pharmacology. 140 (5): 932–8. doi:10.1038/sj.bjp.0705521. PMC 1574110. PMID 14530218.
  • Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (November 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Letters. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098.
  • Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW (January 2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Molecular Pharmacology. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925.
  • Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW (January 2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)". The Journal of Biological Chemistry. 280 (1): 292–300. doi:10.1074/jbc.M409916200. PMID 15525639.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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