5-HT1D receptor

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The correct title of this article is 5-HT1D receptor. It appears incorrectly here because of technical restrictions.

5-hydroxytryptamine (serotonin) receptor 1D
Symbol(s) HTR1D; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
External IDs OMIM: 182133 MGI96276 Homologene20240
RNA expression pattern

PBB GE HTR1D 207368 at tn.png

More reference expression data

Human Mouse
Entrez 3352 15552
Ensembl ENSG00000179546 ENSMUSG00000070687
Uniprot P28221 Q3ZB48
Refseq NM_000864 (mRNA)
NP_000855 (protein)
NM_008309 (mRNA)
NP_032335 (protein)
Location Chr 1: 23.39 - 23.39 Mb Chr 4: 135.7 - 135.72 Mb
Pubmed search [1] [2]

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.[1]

Agonists Antagonists

5-HT1D acts on the CNS, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain. Ergotamine works primarily through the 5-HT1B receptor, since the effect through the 5-HT1D receptor is contrary to the mode of action of ergotamine, i.e. vasoconstriction.

See also


  1. "Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D". 
  2. Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). "5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist". J. Med. Chem. 37 (18): 2828–30. PMID 8071931. doi:10.1021/jm00044a001. 

Further reading

  • Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (1992). "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.". Biochem. Biophys. Res. Commun. 184 (2): 752–9. PMID 1315531. 
  • Weinshank RL, Zgombick JM, Macchi MJ; et al. (1992). "Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3630–4. PMID 1565658. 
  • Hamblin MW, Metcalf MA (1991). "Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.". Mol. Pharmacol. 40 (2): 143–8. PMID 1652050. 
  • Libert F, Passage E, Parmentier M; et al. (1992). "Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor.". Genomics. 11 (1): 225–7. PMID 1662665. 
  • Libert F, Parmentier M, Lefort A; et al. (1989). "Selective amplification and cloning of four new members of the G protein-coupled receptor family.". Science. 244 (4904): 569–72. PMID 2541503. 
  • Cargill M, Altshuler D, Ireland J; et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. PMID 10391209. doi:10.1038/10290. 
  • Salim K, Fenton T, Bacha J; et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.". J. Biol. Chem. 277 (18): 15482–5. PMID 11854302. doi:10.1074/jbc.M201539200. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Bergen AW, van den Bree MB, Yeager M; et al. (2004). "Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.". Mol. Psychiatry. 8 (4): 397–406. PMID 12740597. doi:10.1038/sj.mp.4001318. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727. 
  • Li J, Zhang X, Wang Y; et al. (2007). "The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (8): 874–6. PMID 17099886. doi:10.1002/ajmg.b.30364. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub