Alpha-1A adrenergic receptor

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Adrenergic, alpha-1A-, receptor
External IDs OMIM: 104221 MGI104773 Homologene68078
RNA expression pattern

PBB GE ADRA1A 211492 s at tn.png

PBB GE ADRA1A 211490 at tn.png

PBB GE ADRA1A 211491 at tn.png

More reference expression data

Human Mouse
Entrez 148 11549
Ensembl ENSG00000120907 ENSMUSG00000045875
Uniprot P35348 Q8BUE5
Refseq NM_000680 (mRNA)
NP_000671 (protein)
NM_013461 (mRNA)
NP_038489 (protein)
Location Chr 8: 26.66 - 26.78 Mb Chr 14: 65.59 - 65.69 Mb
Pubmed search [1] [2]

The alpha-1A adrenergic receptor1A adrenoreceptor), also known as ADRA1A, formerly known as the alpha-1C adrenergic receptor[1], is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[2]


There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation.


This gene encodes the alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.[2]


Alpha-blockers specific for 1A include tamsulosin (in benign prostatic hyperplasia.

See also


  1. Langer SZ (1998). "Nomenclature and state of the art on alpha1-adrenoceptors". Eur. Urol. 33 Suppl 2: 2–6. PMID 9556189. 
  2. 2.0 2.1 "Entrez Gene: ADRA1A adrenergic, alpha-1A-, receptor". 

Further reading

  • Mátyus P, Horváth K (1998). "Alpha-adrenergic approach in the medical management of benign prostatic hyperplasia.". Med Res Rev. 17 (6): 523–35. PMID 9359081. 
  • Hoehe MR, Berrettini WH, Schwinn DA, Hsieh WT (1993). "A two-allele PstI RFLP for the alpha-1C adrenergic receptor gene (ADRA1C).". Hum. Mol. Genet. 1 (5): 349. PMID 1363873. 
  • Schwinn DA, Lomasney JW, Lorenz W; et al. (1990). "Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.". J. Biol. Chem. 265 (14): 8183–9. PMID 1970822. 
  • Hirasawa A, Shibata K, Horie K; et al. (1995). "Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants.". FEBS Lett. 363 (3): 256–60. PMID 7737411. 
  • Diehl NL, Shreeve SM (1995). "Identification of the alpha 1c-adrenoceptor in rabbit arteries and the human saphenous vein using the polymerase chain reaction.". Eur. J. Pharmacol. 268 (3): 393–8. PMID 7805763. 
  • Schwinn DA, Johnston GI, Page SO; et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325. 
  • Weinberg DH, Trivedi P, Tan CP; et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. PMID 8024574. 
  • Forray C, Bard JA, Wetzel JM; et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.". Mol. Pharmacol. 45 (4): 703–8. PMID 8183249. 
  • Hirasawa A, Horie K, Tanaka T; et al. (1993). "Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor.". Biochem. Biophys. Res. Commun. 195 (2): 902–9. PMID 8396931. doi:10.1006/bbrc.1993.2130. 
  • Tseng-Crank J, Kost T, Goetz A; et al. (1996). "The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types.". Br. J. Pharmacol. 115 (8): 1475–85. PMID 8564208. 
  • Shibata K, Hirasawa A, Moriyama N; et al. (1997). "Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy.". Br. J. Pharmacol. 118 (6): 1403–8. PMID 8832064. 
  • Chang DJ, Chang TK, Yamanishi SS; et al. (1998). "Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms.". FEBS Lett. 422 (2): 279–83. PMID 9490024. 
  • Daniels DV, Gever JR, Jasper JR; et al. (1999). "Human cloned alpha1A-adrenoceptor isoforms display alpha1L-adrenoceptor pharmacology in functional studies.". Eur. J. Pharmacol. 370 (3): 337–43. PMID 10334511. 
  • Cogé F, Guenin SP, Renouard-Try A; et al. (1999). "Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors.". Biochem. J. 343 Pt 1: 231–9. PMID 10493934. 
  • Rudner XL, Berkowitz DE, Booth JV; et al. (1999). "Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.". Circulation. 100 (23): 2336–43. PMID 10587338. 
  • Ballou LM, Cross ME, Huang S; et al. (2000). "Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblasts.". J. Biol. Chem. 275 (7): 4803–9. PMID 10671514. 
  • Keffel S, Alexandrov A, Goepel M, Michel MC (2000). "alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells.". Biochem. Biophys. Res. Commun. 272 (3): 906–11. PMID 10860850. doi:10.1006/bbrc.2000.2850. 
  • Richman JG, Brady AE, Wang Q; et al. (2001). "Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin.". J. Biol. Chem. 276 (18): 15003–8. PMID 11154706. doi:10.1074/jbc.M011679200. 
  • Shibata K, Katsuma S, Koshimizu T; et al. (2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.". J. Biol. Chem. 278 (1): 672–8. PMID 12409310. doi:10.1074/jbc.M201375200.