Alpha-1D adrenergic receptor

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Adrenergic, alpha-1D-, receptor
Symbol(s) ADRA1D; ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2
External IDs OMIM: 104219 MGI106673 Homologene551
RNA expression pattern

PBB GE ADRA1D 210961 s at tn.png

PBB GE ADRA1D 210960 at tn.png

More reference expression data

Human Mouse
Entrez 146 11550
Ensembl ENSG00000171873 ENSMUSG00000027335
Uniprot P25100 P97714
Refseq NM_000678 (mRNA)
NP_000669 (protein)
NM_013460 (mRNA)
NP_038488 (protein)
Location Chr 20: 4.15 - 4.18 Mb Chr 2: 131.24 - 131.25 Mb
Pubmed search [1] [2]

The alpha-1D adrenergic receptor1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[1]


There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.


This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.[1]

See also


Further reading

  • Schwinn DA, Lomasney JW (1992). "Pharmacologic characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype.". Eur. J. Pharmacol. 227 (4): 433–6. PMID 1359975. 
  • Bruno JF, Whittaker J, Song JF, Berelowitz M (1991). "Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor.". Biochem. Biophys. Res. Commun. 179 (3): 1485–90. PMID 1656955. 
  • Esbenshade TA, Hirasawa A, Tsujimoto G; et al. (1995). "Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.". Mol. Pharmacol. 47 (5): 977–85. PMID 7746284. 
  • Schwinn DA, Johnston GI, Page SO; et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325. 
  • Weinberg DH, Trivedi P, Tan CP; et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. PMID 8024574. 
  • Loftus SK, Shiang R, Warrington JA; et al. (1994). "Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5.". Cytogenet. Cell Genet. 67 (2): 69–74. PMID 8039425. 
  • Yang-Feng TL, Han H, Lomasney JW, Caron MG (1994). "Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13.". Cytogenet. Cell Genet. 66 (3): 170–1. PMID 8125015. 
  • Forray C, Bard JA, Wetzel JM; et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.". Mol. Pharmacol. 45 (4): 703–8. PMID 8183249. 
  • Minneman KP, Lee D, Zhong H; et al. (2000). "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes.". J. Neurochem. 74 (6): 2392–400. PMID 10820200. 
  • Keffel S, Alexandrov A, Goepel M, Michel MC (2000). "alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells.". Biochem. Biophys. Res. Commun. 272 (3): 906–11. PMID 10860850. doi:10.1006/bbrc.2000.2850. 
  • Kyprianou N, Benning CM (2000). "Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis.". Cancer Res. 60 (16): 4550–5. PMID 10969806. 
  • Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature. 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a. 
  • Shibata K, Katsuma S, Koshimizu T; et al. (2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.". J. Biol. Chem. 278 (1): 672–8. PMID 12409310. doi:10.1074/jbc.M201375200. 
  • Pupo AS, Minneman KP (2004). "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.". J. Recept. Signal Transduct. Res. 23 (2-3): 185–95. PMID 14626446. 
  • Hague C, Uberti MA, Chen Z; et al. (2004). "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.". J. Biol. Chem. 279 (15): 15541–9. PMID 14736874. doi:10.1074/jbc.M314014200. 
  • Gonzalez-Cabrera PJ, Shi T, Yun J; et al. (2004). "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.". Endocrinology. 145 (11): 5157–67. PMID 15297446. doi:10.1210/en.2004-0728. 
  • Zhang T, Xu Q, Chen FR; et al. (2005). "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors.". Acta Pharmacol. Sin. 25 (11): 1471–8. PMID 15525470. 
  • Sigala S, Dellabella M, Milanese G; et al. (2005). "Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter.". Neurourol. Urodyn. 24 (2): 142–8. PMID 15690361. doi:10.1002/nau.20097. 
  • Chen Z, Hague C, Hall RA, Minneman KP (2006). "Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.". J. Biol. Chem. 281 (18): 12414–20. PMID 16533813. doi:10.1074/jbc.M508651200. 
  • Michelotti GA, Brinkley DM, Morris DP; et al. (2007). "Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation.". FASEB J. 21 (9): 1979–93. PMID 17384146. doi:10.1096/fj.06-7118com.