Dopamine receptor D2

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The correct title of this article is Dopamine receptor D2. It appears incorrectly here because of technical restrictions.
Dopamine receptor D2
Symbol(s) DRD2; D2DR; D2R
External IDs OMIM: 126450 MGI94924 Homologene22561
RNA expression pattern

PBB GE DRD2 216924 s at tn.png

PBB GE DRD2 206590 x at tn.png

PBB GE DRD2 211624 s at tn.png

More reference expression data

Human Mouse
Entrez 1813 13489
Ensembl ENSG00000149295 ENSMUSG00000032259
Uniprot P14416 Q0VGH9
Refseq NM_000795 (mRNA)
NP_000786 (protein)
NM_010077 (mRNA)
NP_034207 (protein)
Location Chr 11: 112.79 - 112.85 Mb Chr 9: 49.09 - 49.16 Mb
Pubmed search [1] [2]

Dopamine receptor D2, also known as DRD2, is a human gene.

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia.[1] Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.[2]

See also


Further reading

  • Missale C, Nash SR, Robinson SW; et al. (1998). "Dopamine receptors: from structure to function.". Physiol. Rev. 78 (1): 189–225. PMID 9457173. 
  • Sidhu A, Niznik HB (2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins.". Int. J. Dev. Neurosci. 18 (7): 669–77. PMID 10978845. 
  • Araki K, Kuwano R, Morii K; et al. (1993). "Structure and expression of human and rat D2 dopamine receptor genes.". Neurochem. Int. 21 (1): 91–8. PMID 1363862. 
  • Eubanks JH, Djabali M, Selleri L; et al. (1993). "Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23.". Genomics. 14 (4): 1010–8. PMID 1478642. 
  • Dearry A, Falardeau P, Shores C, Caron MG (1992). "D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA.". Cell. Mol. Neurobiol. 11 (5): 437–53. PMID 1835903. 
  • Sarkar G, Kapelner S, Grandy DK; et al. (1992). "Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor.". Genomics. 11 (1): 8–14. PMID 1837284. 
  • Stormann TM, Gdula DC, Weiner DM, Brann MR (1990). "Molecular cloning and expression of a dopamine D2 receptor from human retina.". Mol. Pharmacol. 37 (1): 1–6. PMID 2137193. 
  • Robakis NK, Mohamadi M, Fu DY; et al. (1990). "Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region.". Nucleic Acids Res. 18 (5): 1299. PMID 2138729. 
  • Selbie LA, Hayes G, Shine J (1990). "DNA homology screening: isolation and characterization of the human D2A dopamine receptor subtype.". Adv. Second Messenger Phosphoprotein Res. 24: 9–14. PMID 2144985. 
  • Monsma FJ, McVittie LD, Gerfen CR; et al. (1990). "Multiple D2 dopamine receptors produced by alternative RNA splicing.". Nature. 342 (6252): 926–9. PMID 2480527. doi:10.1038/342926a0. 
  • Dal Toso R, Sommer B, Ewert M; et al. (1990). "The dopamine D2 receptor: two molecular forms generated by alternative splicing.". EMBO J. 8 (13): 4025–34. PMID 2531656. 
  • Grandy DK, Marchionni MA, Makam H; et al. (1990). "Cloning of the cDNA and gene for a human D2 dopamine receptor.". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9762–6. PMID 2532362. 
  • Selbie LA, Hayes G, Shine J (1990). "The major dopamine D2 receptor: molecular analysis of the human D2A subtype.". DNA. 8 (9): 683–9. PMID 2533064. 
  • Leysen JE, Gommeren W, Mertens J; et al. (1995). "Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I] 2'-iodospiperone.". Psychopharmacology (Berl.). 110 (1-2): 27–36. PMID 7870895. 
  • Itokawa M, Arinami T, Futamura N; et al. (1994). "A structural polymorphism of human dopamine D2 receptor, D2(Ser311-->Cys).". Biochem. Biophys. Res. Commun. 196 (3): 1369–75. PMID 7902708. doi:10.1006/bbrc.1993.2404. 
  • Malmberg A, Jackson DM, Eriksson A, Mohell N (1993). "Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors.". Mol. Pharmacol. 43 (5): 749–54. PMID 8099194. 
  • Seeman P, Ohara K, Ulpian C; et al. (1993). "Schizophrenia: normal sequence in the dopamine D2 receptor region that couples to G-proteins. DNA polymorphisms in D2.". Neuropsychopharmacology. 8 (2): 137–42. PMID 8471125. 
  • Cravchik A, Sibley DR, Gejman PV (1996). "Functional analysis of the human D2 dopamine receptor missense variants.". J. Biol. Chem. 271 (42): 26013–7. PMID 8824240. 
  • Ho MK, Wong YH (1997). "Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.". J. Neurochem. 68 (6): 2514–22. PMID 9166747. 

External links

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.