Pancreatic polypeptide receptor 1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
imported>Ser Amantio di Nicolao
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Pancreatic polypeptide receptor 1''', also known as '''Neuropeptide Y receptor type 4''', is a [[protein]] that in humans is encoded by the ''PPYR1'' [[gene]].<ref name="pmid9417917">{{cite journal | vauthors = Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA | title = Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY | journal = Genomics | volume = 46 | issue = 2 | pages = 287–90 | date = Dec 1997 | pmid = 9417917 | pmc =  | doi = 10.1006/geno.1997.5024 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPYR1 pancreatic polypeptide receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5540| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Pancreatic polypeptide receptor 1
| HGNCid = 9329
| Symbol = PPYR1
| AltSymbols =; PP1; MGC116897; NPY4-R; NPY4R; Y4
| OMIM = 601790
| ECnumber = 
| Homologene = 38119
| MGIid = 105374
| GeneAtlas_image1 = PBB_GE_PPYR1_210956_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001601 |text = peptide YY receptor activity}} {{GNF_GO|id=GO:0001602 |text = pancreatic polypeptide receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5540
    | Hs_Ensembl = ENSG00000204174
    | Hs_RefseqProtein = XP_001129329
    | Hs_RefseqmRNA = XM_001129329
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 46503540
    | Hs_GenLoc_end = 46508326
    | Hs_Uniprot = P50391
    | Mm_EntrezGene = 19065
    | Mm_Ensembl = ENSMUSG00000048337
    | Mm_RefseqmRNA = NM_008919
    | Mm_RefseqProtein = NP_032945
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 32973084
    | Mm_GenLoc_end = 32981581
    | Mm_Uniprot = Q3UN46
  }}
}}
'''Pancreatic polypeptide receptor 1''', also known as '''PPYR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPYR1 pancreatic polypeptide receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5540| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Selective Ligands==
{{PBB_Summary
===Agonists===
| section_title =
* [[Pancreatic polypeptide]]
| summary_text =
* [[Neuropeptide Y]] (endogenous agonist, non subtype selective)
}}
* [[Peptide YY]]
* GR-231,118 (mixed NPY<sub>1</sub> antagonist / NPY<sub>4</sub> agonist, CAS# 158859-98-4)


==See also==
===Antagonists===
* [[UR-AK49]] <ref name="pmid17885919">{{cite journal | vauthors = Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A | title = Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence | journal = Journal of Receptor and Signal Transduction Research | volume = 27 | issue = 4 | pages = 217–33 | year = 2007 | pmid = 17885919 | doi = 10.1080/10799890701505206 }}</ref>
 
== See also ==
* [[Neuropeptide Y receptor]]
* [[Neuropeptide Y receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== External links ==
{{refbegin | 2}}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2370 | title = Neuropeptide Y Receptors: Y<sub>4</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
{{PBB_Further_reading
 
| citations =
== Further reading ==
*{{cite journal | author=Keire DA, Bowers CW, Solomon TE, Reeve JR |title=Structure and receptor binding of PYY analogs. |journal=Peptides |volume=23 |issue= 2 |pages= 305-21 |year= 2002 |pmid= 11825645 |doi= }}
{{refbegin |33em}}
*{{cite journal | author=Balasubramaniam A |title=Clinical potentials of neuropeptide Y family of hormones. |journal=Am. J. Surg. |volume=183 |issue= 4 |pages= 430-4 |year= 2002 |pmid= 11975932 |doi= }}
* {{cite journal | vauthors = Keire DA, Bowers CW, Solomon TE, Reeve JR | title = Structure and receptor binding of PYY analogs | journal = Peptides | volume = 23 | issue = 2 | pages = 305–21 | date = Feb 2002 | pmid = 11825645 | doi = 10.1016/S0196-9781(01)00602-7 }}
*{{cite journal | author=Parker E, Van Heek M, Stamford A |title=Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. |journal=Eur. J. Pharmacol. |volume=440 |issue= 2-3 |pages= 173-87 |year= 2002 |pmid= 12007534 |doi= }}
* {{cite journal | vauthors = Balasubramaniam A | title = Clinical potentials of neuropeptide Y family of hormones | journal = American Journal of Surgery | volume = 183 | issue = 4 | pages = 430–4 | date = Apr 2002 | pmid = 11975932 | doi = 10.1016/S0002-9610(02)00803-6 }}
*{{cite journal | author=Benaim G, Villalobo A |title=Phosphorylation of calmodulin. Functional implications. |journal=Eur. J. Biochem. |volume=269 |issue= 15 |pages= 3619-31 |year= 2002 |pmid= 12153558 |doi= }}
* {{cite journal | vauthors = Parker E, Van Heek M, Stamford A | title = Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status | journal = European Journal of Pharmacology | volume = 440 | issue = 2-3 | pages = 173–87 | date = Apr 2002 | pmid = 12007534 | doi = 10.1016/S0014-2999(02)01427-9 }}
*{{cite journal | author=Lundell I, Blomqvist AG, Berglund MM, ''et al.'' |title=Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. |journal=J. Biol. Chem. |volume=270 |issue= 49 |pages= 29123-8 |year= 1996 |pmid= 7493937 |doi= }}
* {{cite journal | vauthors = Benaim G, Villalobo A | title = Phosphorylation of calmodulin. Functional implications | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 15 | pages = 3619–31 | date = Aug 2002 | pmid = 12153558 | doi = 10.1046/j.1432-1033.2002.03038.x }}
*{{cite journal | author=Bard JA, Walker MW, Branchek TA, Weinshank RL |title=Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 26762-5 |year= 1995 |pmid= 7592911 |doi= }}
* {{cite journal | vauthors = Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D | title = Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY | journal = The Journal of Biological Chemistry | volume = 270 | issue = 49 | pages = 29123–8 | date = Dec 1995 | pmid = 7493937 | doi = 10.1074/jbc.270.49.29123 }}
*{{cite journal | author=Yan H, Yang J, Marasco J, ''et al.'' |title=Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4661-5 |year= 1996 |pmid= 8643460 |doi= }}
* {{cite journal | vauthors = Bard JA, Walker MW, Branchek TA, Weinshank RL | title = Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY | journal = The Journal of Biological Chemistry | volume = 270 | issue = 45 | pages = 26762–5 | date = Nov 1995 | pmid = 7592911 | doi = 10.1074/jbc.270.45.26762 }}
*{{cite journal | author=Kawabe T, Muslin AJ, Korsmeyer SJ |title=HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. |journal=Nature |volume=385 |issue= 6615 |pages= 454-8 |year= 1997 |pmid= 9009195 |doi= 10.1038/385454a0 }}
* {{cite journal | vauthors = Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W | title = Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 10 | pages = 4661–5 | date = May 1996 | pmid = 8643460 | pmc = 39335 | doi = 10.1073/pnas.93.10.4661 }}
*{{cite journal | author=Lutz CM, Richards JE, Scott KL, ''et al.'' |title=Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. |journal=Genomics |volume=46 |issue= 2 |pages= 287-90 |year= 1998 |pmid= 9417917 |doi= 10.1006/geno.1997.5024 }}
* {{cite journal | vauthors = Kawabe T, Muslin AJ, Korsmeyer SJ | title = HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint | journal = Nature | volume = 385 | issue = 6615 | pages = 454–8 | date = Jan 1997 | pmid = 9009195 | doi = 10.1038/385454a0 }}
*{{cite journal  | author=Darby K, Eyre HJ, Lapsys N, ''et al.'' |title=Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14. |journal=Genomics |volume=46 |issue= 3 |pages= 513-5 |year= 1998 |pmid= 9441761 |doi= 10.1006/geno.1997.5071 }}
* {{cite journal | vauthors = Darby K, Eyre HJ, Lapsys N, Copeland NG, Gilbert DJ, Couzens M, Antonova O, Sutherland GR, Jenkins NA, Herzog H | title = Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14 | journal = Genomics | volume = 46 | issue = 3 | pages = 513–5 | date = Dec 1997 | pmid = 9441761 | doi = 10.1006/geno.1997.5071 }}
*{{cite journal | author=Hsieh-Wilson LC, Allen PB, Watanabe T, ''et al.'' |title=Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. |journal=Biochemistry |volume=38 |issue= 14 |pages= 4365-73 |year= 1999 |pmid= 10194355 |doi= 10.1021/bi982900m }}
* {{cite journal | vauthors = Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P | title = Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 | journal = Biochemistry | volume = 38 | issue = 14 | pages = 4365–73 | date = Apr 1999 | pmid = 10194355 | doi = 10.1021/bi982900m }}
*{{cite journal | author=Smith FD, Oxford GS, Milgram SL |title=Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19894-900 |year= 1999 |pmid= 10391935 |doi= }}
* {{cite journal | vauthors = Smith FD, Oxford GS, Milgram SL | title = Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein | journal = The Journal of Biological Chemistry | volume = 274 | issue = 28 | pages = 19894–900 | date = Jul 1999 | pmid = 10391935 | doi = 10.1074/jbc.274.28.19894 }}
*{{cite journal | author=Marx SO, Reiken S, Hisamatsu Y, ''et al.'' |title=PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. |journal=Cell |volume=101 |issue= 4 |pages= 365-76 |year= 2000 |pmid= 10830164 |doi= }}
* {{cite journal | vauthors = Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR | title = PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts | journal = Cell | volume = 101 | issue = 4 | pages = 365–76 | date = May 2000 | pmid = 10830164 | doi = 10.1016/S0092-8674(00)80847-8 }}
*{{cite journal | author=Connor JH, Weiser DC, Li S, ''et al.'' |title=Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6841-50 |year= 2001 |pmid= 11564868 |doi= 10.1128/MCB.21.20.6841-6850.2001 }}
* {{cite journal | vauthors = Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S | title = Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 | journal = Molecular and Cellular Biology | volume = 21 | issue = 20 | pages = 6841–50 | date = Oct 2001 | pmid = 11564868 | pmc = 99861 | doi = 10.1128/MCB.21.20.6841-6850.2001 }}
*{{cite journal | author=Cavadas C, Silva AP, Mosimann F, ''et al.'' |title=NPY regulates catecholamine secretion from human adrenal chromaffin cells. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 12 |pages= 5956-63 |year= 2001 |pmid= 11739470 |doi= }}
* {{cite journal | vauthors = Cavadas C, Silva AP, Mosimann F, Cotrim MD, Ribeiro CA, Brunner HR, Grouzmann E | title = NPY regulates catecholamine secretion from human adrenal chromaffin cells | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 86 | issue = 12 | pages = 5956–63 | date = Dec 2001 | pmid = 11739470 | doi = 10.1210/jc.86.12.5956 }}
*{{cite journal | author=Cox HM, Tough IR |title=Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. |journal=Br. J. Pharmacol. |volume=135 |issue= 6 |pages= 1505-12 |year= 2002 |pmid= 11906964 |doi= 10.1038/sj.bjp.0704604 }}
* {{cite journal | vauthors = Cox HM, Tough IR | title = Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa | journal = British Journal of Pharmacology | volume = 135 | issue = 6 | pages = 1505–12 | date = Mar 2002 | pmid = 11906964 | pmc = 1573267 | doi = 10.1038/sj.bjp.0704604 }}
*{{cite journal | author=Wu DY, Tkachuck DC, Roberson RS, Schubach WH |title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27706-15 |year= 2002 |pmid= 12016208 |doi= 10.1074/jbc.M200955200 }}
* {{cite journal | vauthors = Wu DY, Tkachuck DC, Roberson RS, Schubach WH | title = The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27706–15 | date = Aug 2002 | pmid = 12016208 | doi = 10.1074/jbc.M200955200 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{transmembranereceptor-stub}}
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g1}}
[[Category:G protein coupled receptors]]
{{Neuropeptidergics}}
{{WikiDoc Sources}}
 
[[Category:G protein-coupled receptors]]

Latest revision as of 18:01, 24 September 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene.[1][2]


Selective Ligands

Agonists

Antagonists

See also

References

  1. ↑ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
  2. ↑ "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".
  3. ↑ Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research. 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919.

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=Pancreatic_polypeptide_receptor_1&oldid=1527316"