MAP2K3: Difference between revisions

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{{main|Mitogen-activated protein kinase kinase}}
{{main|Mitogen-activated protein kinase kinase}}
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{{Infobox_gene}}
{{GNF_Protein_box
'''Dual specificity mitogen-activated protein kinase kinase 3''' is an [[enzyme]] that in humans is encoded by the ''MAP2K3'' [[gene]].<ref name="pmid9465908">{{cite journal |vauthors=Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA | title = Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5 | journal = Cytogenet Cell Genet | volume = 78 | issue = 3–4 | pages = 301–3 |date=Mar 1998 | pmid = 9465908 | pmc =  | doi =  10.1159/000134677}}</ref>
| image = 
| image_source = 
| PDB =
| Name = Mitogen-activated protein kinase kinase 3
| HGNCid = 6843
| Symbol = MAP2K3
| AltSymbols =; MAPKK3; MEK3; MKK3; PRKMK3
| OMIM = 602315
| ECnumber = 
| Homologene = 56430
| MGIid = 1346868
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004708 |text = MAP kinase kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0045860 |text = positive regulation of protein kinase activity}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5606
    | Hs_Ensembl =
    | Hs_RefseqProtein = XP_001130488
    | Hs_RefseqmRNA = XM_001130488
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =   
    | Hs_GenLoc_start =   
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 26397
    | Mm_Ensembl = ENSMUSG00000018932
    | Mm_RefseqmRNA = NM_008928
    | Mm_RefseqProtein = NP_032954
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 60748250
    | Mm_GenLoc_end = 60769002
    | Mm_Uniprot = Q3TJG7
  }}
}}
'''Mitogen-activated protein kinase kinase 3''', also known as '''MAP2K3''', is a human [[gene]].


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| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MAP2K3 mitogen-activated protein kinase kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5606| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MAP2K3 mitogen-activated protein kinase kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5606| accessdate = }}</ref>
}}
}}
==Interactions==
MAP2K3 has been shown to [[Protein-protein interaction|interact]] with [[TAOK2]]<ref name=pmid11279118>{{cite journal |last=Chen |first=Z |authorlink= |author2=Cobb M H  |date=May 2001 |title=Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2 |journal=J. Biol. Chem. |volume=276 |issue=19 |pages=16070–5 |publisher= |location = United States| issn = 0021-9258| pmid = 11279118 |doi = 10.1074/jbc.M100681200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[PLCB2]].<ref name=pmid12054652>{{cite journal |last=Barr |first=Alastair J |authorlink= |author2=Marjoram Robin |author3=Xu Jing |author4=Snyderman Ralph  |date=Apr 2002 |title=Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3 |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue=1 |pages=647–52 |publisher= |location = United States| issn = 0006-291X| pmid = 12054652 |doi = 10.1016/S0006-291X(02)00259-0 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Ben-Levy R, Hooper S, Wilson R, ''et al.'' |title=Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. |journal=Curr. Biol. |volume=8 |issue= 19 |pages= 1049-57 |year= 1999 |pmid= 9768359 |doi=  }}
*{{cite journal   |vauthors=Ben-Levy R, Hooper S, Wilson R, etal |title=Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2 |journal=Curr. Biol. |volume=8 |issue= 19 |pages= 1049–57 |year= 1999 |pmid= 9768359 |doi=10.1016/S0960-9822(98)70442-7 }}
*{{cite journal | author=Doza YN, Cuenda A, Thomas GM, ''et al.'' |title=Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells. |journal=FEBS Lett. |volume=364 |issue= 2 |pages= 223-8 |year= 1995 |pmid= 7750576 |doi=  }}
*{{cite journal   |vauthors=Doza YN, Cuenda A, Thomas GM, etal |title=Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells |journal=FEBS Lett. |volume=364 |issue= 2 |pages= 223–8 |year= 1995 |pmid= 7750576 |doi=10.1016/0014-5793(95)00346-B }}
*{{cite journal | author=Dérijard B, Raingeaud J, Barrett T, ''et al.'' |title=Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. |journal=Science |volume=267 |issue= 5198 |pages= 682-5 |year= 1995 |pmid= 7839144 |doi= }}
*{{cite journal   |vauthors=Dérijard B, Raingeaud J, Barrett T, etal |title=Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms |journal=Science |volume=267 |issue= 5198 |pages= 682–5 |year= 1995 |pmid= 7839144 |doi=10.1126/science.7839144  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Zheng CF, Guan KL |title=Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 23933-9 |year= 1993 |pmid= 8226933 |doi=  }}
*{{cite journal  |vauthors=Zheng CF, Guan KL |title=Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 23933–9 |year= 1993 |pmid= 8226933 |doi=  }}
*{{cite journal | author=Raingeaud J, Whitmarsh AJ, Barrett T, ''et al.'' |title=MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1247-55 |year= 1996 |pmid= 8622669 |doi=  }}
*{{cite journal   |vauthors=Raingeaud J, Whitmarsh AJ, Barrett T, etal |title=MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1247–55 |year= 1996 |pmid= 8622669 |doi= 10.1128/mcb.16.3.1247| pmc=231107 }}
*{{cite journal | author=Stein B, Brady H, Yang MX, ''et al.'' |title=Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11427-33 |year= 1996 |pmid= 8626699 |doi=  }}
*{{cite journal   |vauthors=Stein B, Brady H, Yang MX, etal |title=Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11427–33 |year= 1996 |pmid= 8626699 |doi=10.1074/jbc.271.19.11427 }}
*{{cite journal | author=Moriguchi T, Toyoshima F, Gotoh Y, ''et al.'' |title=Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2. |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 26981-8 |year= 1996 |pmid= 8900184 |doi=  }}
*{{cite journal   |vauthors=Moriguchi T, Toyoshima F, Gotoh Y, etal |title=Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2 |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 26981–8 |year= 1996 |pmid= 8900184 |doi=10.1074/jbc.271.43.26981 }}
*{{cite journal | author=Han J, Wang X, Jiang Y, ''et al.'' |title=Identification and characterization of a predominant isoform of human MKK3. |journal=FEBS Lett. |volume=403 |issue= 1 |pages= 19-22 |year= 1997 |pmid= 9038352 |doi=  }}
*{{cite journal   |vauthors=Han J, Wang X, Jiang Y, etal |title=Identification and characterization of a predominant isoform of human MKK3 |journal=FEBS Lett. |volume=403 |issue= 1 |pages= 19–22 |year= 1997 |pmid= 9038352 |doi=10.1016/S0014-5793(97)00021-5 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  | author=Rampoldi L, Zimbello R, Bortoluzzi S, ''et al.'' |title=Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5. |journal=Cytogenet. Cell Genet. |volume=78 |issue= 3-4 |pages= 301-3 |year= 1998 |pmid= 9465908 |doi=  }}
*{{cite journal  |vauthors=Hutchison M, Berman KS, Cobb MH |title=Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 28625–32 |year= 1998 |pmid= 9786855 |doi=10.1074/jbc.273.44.28625 }}
*{{cite journal  | author=Hutchison M, Berman KS, Cobb MH |title=Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 28625-32 |year= 1998 |pmid= 9786855 |doi=  }}
*{{cite journal  |vauthors=Chan-Hui PY, Weaver R |title=Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades |journal=Biochem. J. |volume=336 |issue= Pt 3|pages= 599–609 |year= 1999 |pmid= 9841871 |doi= 10.1042/bj3360599| pmc=1219910 }}
*{{cite journal  | author=Chan-Hui PY, Weaver R |title=Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades. |journal=Biochem. J. |volume=336 ( Pt 3) |issue= |pages= 599-609 |year= 1999 |pmid= 9841871 |doi= }}
*{{cite journal  |vauthors=Chen Z, Hutchison M, Cobb MH |title=Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28803–7 |year= 1999 |pmid= 10497253 |doi=10.1074/jbc.274.40.28803  }}
*{{cite journal  | author=Chen Z, Hutchison M, Cobb MH |title=Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain. |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28803-7 |year= 1999 |pmid= 10497253 |doi= }}
*{{cite journal  | author=Kurata S |title=Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23413–6 |year= 2000 |pmid= 10856288 |doi= 10.1074/jbc.C000308200 }}
*{{cite journal  | author=Kurata S |title=Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23413-6 |year= 2000 |pmid= 10856288 |doi= 10.1074/jbc.C000308200 }}
*{{cite journal  |vauthors=Majka M, Ratajczak J, Kowalska MA, Ratajczak MZ |title=Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT |journal=Eur. J. Haematol. |volume=64 |issue= 3 |pages= 164–72 |year= 2000 |pmid= 10997882 |doi=10.1034/j.1600-0609.2000.90112.x  }}
*{{cite journal | author=Majka M, Ratajczak J, Kowalska MA, Ratajczak MZ |title=Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT. |journal=Eur. J. Haematol. |volume=64 |issue= 3 |pages= 164-72 |year= 2000 |pmid= 10997882 |doi=  }}
*{{cite journal   |vauthors=Fleming Y, Armstrong CG, Morrice N, etal |title=Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7 |journal=Biochem. J. |volume=352 Pt 1 |issue= Pt 1|pages= 145–54 |year= 2001 |pmid= 11062067 |doi=  10.1042/0264-6021:3520145| pmc=1221441 }}
*{{cite journal  | author=Fleming Y, Armstrong CG, Morrice N, ''et al.'' |title=Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. |journal=Biochem. J. |volume=352 Pt 1 |issue=  |pages= 145-54 |year= 2001 |pmid= 11062067 |doi=  }}
*{{cite journal   |vauthors=Venter JC, Adams MD, Myers EW, etal |title=The sequence of the human genome |journal=Science |volume=291 |issue= 5507 |pages= 1304–51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 }}
*{{cite journal | author=Venter JC, Adams MD, Myers EW, ''et al.'' |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304-51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 }}
*{{cite journal  |vauthors=Chen Z, Cobb MH |title=Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2 |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16070–5 |year= 2001 |pmid= 11279118 |doi= 10.1074/jbc.M100681200 }}
*{{cite journal  | author=Chen Z, Cobb MH |title=Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16070-5 |year= 2001 |pmid= 11279118 |doi= 10.1074/jbc.M100681200 }}
}}
}}
{{refend}}
{{refend}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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Revision as of 06:04, 4 September 2017

Main article: Mitogen-activated protein kinase kinase
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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View/Edit Human

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.[1]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.[2]

Interactions

MAP2K3 has been shown to interact with TAOK2[3] and PLCB2.[4]

References

  1. ↑ Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet Cell Genet. 78 (3–4): 301–3. doi:10.1159/000134677. PMID 9465908.
  2. ↑ "Entrez Gene: MAP2K3 mitogen-activated protein kinase kinase 3".
  3. ↑ Chen, Z; Cobb M H (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. United States. 276 (19): 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118.
  4. ↑ Barr, Alastair J; Marjoram Robin; Xu Jing; Snyderman Ralph (Apr 2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. United States. 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. ISSN 0006-291X. PMID 12054652.

Further reading


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