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==Overview==
==Overview==
[[Fever]] and [[rash]] are [[symptoms]] commonly encountered in [[pediatrics]]. [[Disease states]] associated with these symptoms are varied. Therefore, a broad knowledge of these diseases is extremely invaluable. [[Febrile]] rashes can be classified based on [[morphology]], [[distribution of spread]], [[pattern]] of occurrence and cause.
[[Fever]] and [[rash]] are [[symptoms]] commonly encountered in [[pediatrics]]. [[Disease states]] associated with these symptoms are varied. Therefore, a broad knowledge of these diseases is extremely invaluable. [[Febrile]] rashes can be classified based on [[morphology]], [[distribution of spread]], [[pattern]] of occurrence and cause.
[[Fever]] results when [[exogenous]] ([[micro-organisms]]) and [[endogenous]] pyrogens interact with the Organum Vasculosum of the Lamina Terminalis (OVLT) causing a rise in body temperature as a result of an increase in the hypothalamic set point.
[[Fever]] results when [[exogenous]] ([[micro-organisms]]) and [[endogenous]] pyrogens interact with the Organum Vasculosum of the Lamina Terminalis (OVLT) causing a rise in body temperature as a result of an increase in the hypothalamic set point. This rise in the hypothalamic set point is due to the increased production of [[Prostaglandin E2]] (PGE2) by endothelial cells of the [[vascular]] OVLT located in the preoptic area of the [[anterior hypothalamus]].
*This rise in the hypothalamic set point is due to increased production of [[Prostaglandin E2]] (PGE2) by endothelial cells of the [[vascular]] OVLT located in the preoptic area of the [[anterior hypothalamus]].
[[Fever]] and [[rash]] in kids are caused by infectious (bacterial, viral, fungal, and protozoan) and non-infectious (drug-related eruptions and immune-mediated) causes.
[[Fever]] and [[rash]] in kids are caused by infectious (bacterial, viral, fungal, and protozoan) and non-infectious (drug-related eruptions and immune-mediated) causes.
Patients of all age groups may develop diseases that present with [[fever]] and [[rash]]. Most children become susceptible to some of the diseases from 6 months of age when maternal [[antibodies]] begin to wane.
Patients of all age groups may develop diseases that present with [[fever]] and [[rash]]. Most children become susceptible to some of the diseases from 6 months of age when maternal [[antibodies]] begin to wane.
Common [[risk factors]] for the development of diseases that present with [[fever]] and [[rash]] include contact with ill individuals, poor/depressed [[immunity]], lack of [[vaccination]], very young age (6 months-12 months) and poor [[hand washing]] habits.
Common [[risk factors]] for the development of diseases that present with [[fever]] and [[rash]] include contact with ill individuals, poor/depressed [[immunity]], lack of [[vaccination]], very young age (6 months-12 months) and poor [[hand washing]] habits.


==Classification==
==Classification==

Revision as of 00:24, 25 September 2020

Fever and rash in children Microchapters

Overview

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Risk Factors

Natural History, Complications, and Prognosis

Diagnosis

Treatment

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Anaya, M.D.[2]

Synonyms and keywords: Fever and rash in kids

Overview

Fever and rash are symptoms commonly encountered in pediatrics. Disease states associated with these symptoms are varied. Therefore, a broad knowledge of these diseases is extremely invaluable. Febrile rashes can be classified based on morphology, distribution of spread, pattern of occurrence and cause. Fever results when exogenous (micro-organisms) and endogenous pyrogens interact with the Organum Vasculosum of the Lamina Terminalis (OVLT) causing a rise in body temperature as a result of an increase in the hypothalamic set point. This rise in the hypothalamic set point is due to the increased production of Prostaglandin E2 (PGE2) by endothelial cells of the vascular OVLT located in the preoptic area of the anterior hypothalamus. Fever and rash in kids are caused by infectious (bacterial, viral, fungal, and protozoan) and non-infectious (drug-related eruptions and immune-mediated) causes. Patients of all age groups may develop diseases that present with fever and rash. Most children become susceptible to some of the diseases from 6 months of age when maternal antibodies begin to wane. Common risk factors for the development of diseases that present with fever and rash include contact with ill individuals, poor/depressed immunity, lack of vaccination, very young age (6 months-12 months) and poor hand washing habits.

Classification

Fever + Rash Morphology Disease
Non-blanching lesions (Petechiae, Purpura and Ecchymoses) a. Meningococcemia

b. Rocky Mountain Spotted Fever (RMSF)

c. Hemolytic Uremic Syndrome (HUS)

d. Henoch-Schonlein Purpura (HSP)

Blanching rash a. Kawasaki disease

b. Juvenile Rheumatoid Arthritis

c. Juvenile Dermatomyositis

Vesicular or bullous lesions a. Erythema multiforme

b. Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)

c. Staphylococcal Scalded Skin Syndrome (SSSS)

d. Disseminated gonococcal disease in adolescents

e. HSV I & II

Umbilicated papules and pustules a. Molluscum contagiosum

b. Varicella/Chickenpox

Sandpaper rash a. Scarlet fever
Viral syndromes(mostly maculopaular) a. Measles (Rubeola)

b. Rubella (German measles)

c. Erythema infectiosum (Parvovirus B19)

d. Herpangina (Coxsackie)

e. Hand-foot-and-mouth disease (Coxsackie)

f. Roseola infantum (Human Herpes Virus types 6 or 7)

Limited to certain geographical areas a. Babesiosis

b. Blastomycosis

c. Coccidiodomycosis

d. Histoplasmosis

e. Lyme disease

f. Relapsing fever

g. Colorado Tick Fever

Pathophysiology

Causes

  • Common causes of fever and rash in kids may include:
Infectious Disease Causative Organism
Viral Measles

German Measles

Erythema infectiosum

Roseola infantum

Herpangina

Hand-foot-and-mouth disease

Molluscum contagiosum

Chickenpox

Rubeola

Rubella

Parvovirus B19

Human Herpes Virus 6 & 7

Coxsackie virus

Coxsackie virus

Poxvirus

Varicella Zoster virus

Bacterial Meningococcemia
Neisseria meningitidis

Hemophilus influenzae

Streptococcus pneumoniae

RMSF Rickettsia rickettsii
HUS Enterohemorrhagic E.coli (EHEC)
Scarlet Fever Streptococcus pyogenes (Group A Streptococci, GAS)
Disseminated gonococcal disease in adolescents Neisseria gonorrhoea
SSSS

TSS

Staphylococcus aureus
Lyme disease Borrelia burgdorferi
Relapsing fever Borrelia recurrentis
Protozoan Babesiosis Babesia microti
Fungal Histoplasmosis

Blastomycosis

Coccidiodomycosis

Paracoccidiodomycosis

Histoplasma capsulatum

Blastomyces dermatitidis

Coccidioides immitis

Paracoccidioides brasiliensis


Non-Infectious Disease
Immune-mediated/Autoimmune Kawasaki Disease

Henoch-Schonlein Purpura

Juvenile Rheumatoid Arthritis

Juvenile Dermatomyositis

Drug-related eruptions Erythema multiforme

SJS

TEN

Epidemiology and Demographics

Age

  • Patients of all age groups may develop diseases that present with fever and rash.

Race

  • There is no racial predilection to diseases that present with fever and rash.

Gender

  • No known gender predilection.
  • Most children become susceptible to some of the diseases from 6 months of age when maternal antibodies begin to wane. [9]

Risk Factors

Natural History, Complications, and Prognosis

Natural History

  • The symptoms of diseases associated with fever and rash usually develop in the first few days from contact. The stages/phases of most infectious processes include the:
    • Incubation period (between exposure to an infection and the appearance of the first symptoms).
    • Prodromal phase (period of early symptoms of a disease)
    • Illness (characteristic symptoms of the disease appear at this stage)
    • Decline and
    • Convalescence

Complications

  • Common complications of diseases presenting with fever and rash include:
    • Febrille seizures
    • Rhabdomyolysis
    • Shock (septic or hypovolemic)
    • Disseminated Intravascular Coagulation (in Meningococcemia)
    • Reye syndrome (especially in children that have been given aspirin).

Prognosis

  • Prognosis is generally excellent for viral syndromes. Prompt diagnosis, treatment and close follow-up of patients presenting with other causes of fever and rash also results in good prognosis.

Diagnosis

Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

  • There are no ECG findings associated with fever and rash.

X-ray

  • Might be useful in managing severely ill individuals to look for complications but not routinely needed to make diagnosis.

Echocardiography or Ultrasound

CT scan

  • There are no CT scan findings associated with any of the diseases.

MRI

  • There are no MRI findings associated with fever and rash.

Other Imaging Findings

  • There are no other imaging findings associated with fever and rash in children.

Treatment

Medical therapy

Surgery

  • Surgical intervention is not recommended for the management of fever and rash in children.

Prevention

  • Effective measures for primary prevention of fever and rash in children may include:
    • Vaccination done in a timely manner can prevent occurrence of many childhood illnesses presenting with fever and rash such as the viral symdromes. [13]
    • Hand washing frequently and thoroughly with soap and water.
    • Sneeze and cough into elbows and/or tissues(which should be thrown away).
    • Avoid contact with infected individuals and contaminated surfaces.
    • Wearing clothes to cover upper and lower limbs preventing tick bites.

References

  1. 1.0 1.1 Kang JH (2015). "Febrile Illness with Skin Rashes". Infect Chemother. 47 (3): 155–66. doi:10.3947/ic.2015.47.3.155. PMC 4607768. PMID 26483989.
  2. https://www.consultant360.com/articles/rashes-and-fever-children-sorting-out-potentially-dangerous-part-1
  3. https://www.consultant360.com/articles/rashes-and-fever-children-sorting-out-potentially-dangerous-part-2
  4. https://www.consultant360.com/articles/rashes-and-fever-children-sorting-out-potentially-dangerous-part-3
  5. https://www.consultant360.com/articles/rashes-and-fever-children-sorting-out-potentially-dangerous-part-4
  6. 6.0 6.1 6.2 Schortgen F (2012). "Fever in sepsis". Minerva Anestesiol. 78 (11): 1254–64. PMID 22772856.
  7. 7.0 7.1 7.2 Walter EJ, Hanna-Jumma S, Carraretto M, Forni L (2016). "The pathophysiological basis and consequences of fever". Crit Care. 20 (1): 200. doi:10.1186/s13054-016-1375-5. PMC 4944485. PMID 27411542.
  8. 8.0 8.1 8.2 Mims CA (1966). "Pathogenesis of rashes in virus diseases". Bacteriol Rev. 30 (4): 739–60. PMC 441013. PMID 5342519.
  9. Tesini BL, Epstein LG, Caserta MT (2014). "Clinical impact of primary infection with roseoloviruses". Curr Opin Virol. 9: 91–6. doi:10.1016/j.coviro.2014.09.013. PMC 4267952. PMID 25462439.
  10. McQuiston JH, Wiedeman C, Singleton J, Carpenter LR, McElroy K, Mosites E; et al. (2014). "Inadequacy of IgM antibody tests for diagnosis of Rocky Mountain Spotted Fever". Am J Trop Med Hyg. 91 (4): 767–70. doi:10.4269/ajtmh.14-0123. PMC 4183402. PMID 25092818.
  11. Jensen HE, Schønheyder HC, Hotchi M, Kaufman L (1996). "Diagnosis of systemic mycoses by specific immunohistochemical tests". APMIS. 104 (4): 241–58. doi:10.1111/j.1699-0463.1996.tb00714.x. PMID 8645463.
  12. Parija SC, Kp D, Venugopal H (2015). "Diagnosis and management of human babesiosis". Trop Parasitol. 5 (2): 88–93. doi:10.4103/2229-5070.162489. PMC 4557163. PMID 26629450.
  13. Fölster-Holst R, Kreth HW (2009). "Viral exanthems in childhood--infectious (direct) exanthems. Part 1: Classic exanthems". J Dtsch Dermatol Ges. 7 (4): 309–16. doi:10.1111/j.1610-0387.2008.06868.x. PMID 18803578.