Drug induced liver injury causes: Difference between revisions

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{{Drug-induced hepatitis}}
{{Drug induced liver injury}}
{{CMG}}
{{CMG}}; {{AE}} {{Rachita}}
 
==Overview==
Hundreds of prescription and nonprescription medications as well as supplements have been implicated in drug induced liver injury. A free searchable database of causative agents is available through the [https://livertox.nlm.nih.gov/ National Institute of Health].
 
==Causes==
==Causes==
===Common Causative Agents:===
*[[Acetaminophen]]
*[[Azithromycin]]
*[[Ethanol]]
*[[Statins]]
*[[Tetracycline]]
*[[Rosiglitazone]]
*[[Amiodarone]]
*[[Valproic Acid]]
*[[Methotrexate]]
*[[Isoniazid]]
*[[Rifampin]]
===Causes by Organ System===
===Causes by Organ System===
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[5-Azacytidine]], [[Abacavir]], [[Abiraterone]], [[Agomelatine]], [[Albendazole]], [[Allopurinol]], [[Altretamine]], [[Amineptine]], [[Amiodarone]], [[Amitriptyline]], [[Amoxicillin]], [[Amphotericin B]], [[Amprenavir]], [[Anabolic steroids]], [[Antituberculosis drugs]], [[Apixaban]], [[Arsenic trioxide]], [[Asafetida]], [[Asparaginase]], [[Atorvastatin]], [[Atovaquone]], [[Azathioprine]], [[Benoxaprofen]], [[Bexarotene]], [[Black cohosh extract]], [[Bosentan]], [[Bosutinib]], [[Bromfenac]], [[Bumetanide]], [[Carfilzomib]], [[Cascara]], [[Caspofungin]], [[Chaparral]], [[Chenodeoxycholic acid]], [[Chlormezanone]], [[Chlorzoxazone]], [[Ciprofloxacin]], [[Clofarabine]], [[Combined oral contraceptive pill]], [[Comfrey]], [[Crizotinib]], [[Cyclobenzaprine]], [[Dantrolene]], [[Daptomycin]], [[Dasatinib]], [[Deferasirox]], [[Desipramine]], [[Diclofenac]], [[Disulfiram]], [[Docetaxel]], [[Donepezil]], [[Dothiepin]], [[Dronedarone]], [[Eltrombopag]], [[Emtricitabine]], [[Entecavir]], [[Ephedra]], [[Erlotinib]], [[Erythromycin estolate]], [[Ethanol]], [[Ethinylestradiol]], [[Ethionamide]], [[Etretinate]], [[Febuxostat]], [[Felbamate]], [[Fenofibrate]], [[Fingolimod]], [[Fluconazole]], [[Flucytosine]], [[Fluoxymesterone]], [[Flutamide]], [[Fluvastatin]], [[Fosamprenavir]], [[Frusemide]], [[Fusidic acid]], [[Ganciclovir]], [[Gemcitabine]], [[Gemtuzumab ozogamicin]], [[Gold salts]], [[Golimumab]], [[Halothane]], [[Imatinib mesylate]], [[Imipenem]], [[Interferon alpha]], [[Interferon beta]], [[Interleukin 2]], [[Ipilimumab]], [[Isoniazid]], [[Isotretinoin]], [[Kava root extract]], [[Ketoconazole]], [[Lapatinib ditosylate]], [[Leflunomide]], [[Lovastatin]], [[Maraviroc]], [[Meropenem]], [[Mesalazine]], [[Methotrexate]], [[Methyldopa]], [[Methyldopa]], [[Methyldopate]], [[Micafungin]], [[Minocycline]], [[Mirtazapine]], [[Mithramycin]], [[Naltrexone]], [[Nandrolone]], [[Natalizumab]], [[Nelfinavir]], [[Nevirapine]], [[Niacin]], [[Nicotinic acid]], [[Nimesulide]], [[Nitisinone]], [[Nitrofurantoin]], [[Norfloxacin]], [[Nortriptyline]], [[Ondansetron]], [[Oxyphenisatine]], [[Paclitaxel]], [[Para-amino salicylic acid]], [[Paracetamol]], [[Pazopanib]], [[Pegvisomant]], [[Pemoline]], [[Pentostatin]], [[Phenelzine]], [[Phenylbutazone]], [[Phenytoin]], [[Pralatrexate]], [[Pravastatin]], [[Procainamide]], [[Propylthiouracil]], [[Prothionamide]], [[Pyrazinamide]], [[Pyritinol]], [[Pyrrolizidine alkaloids]], [[Regorafenib]], [[Rifabutin]], [[Rifampicin]], [[Riluzole]], [[Ritonavir]], [[Rivaroxaban]], [[Rosuvastatin]], [[Saquinavir]], [[Simvastatin]], [[Sitaxentan]], [[Sorafenib]], [[Stanozolol]], [[Statins]], [[Succimer]], [[Suloctidil]], [[Sulphasalazine]], [[Sulphinpyrazone]], [[Tegafur]], [[Telithromycin]], [[Teriflunomide]], [[Thiabendazole]], [[Thioguanine]], [[Ticlopidine]], [[Tipranavir]], [[Tizanidine]], [[Tolbutamide]], [[Tolcapone]], [[Tolrestat]], [[Trabectedin]], [[Troglitazone]], [[Trovafloxacin]], [[Ursodeoxycholic acid]], [[Valganciclovir]], [[Valproic acid]], [[Velnacrine]], [[Verapamil]], [[Voriconazole]], [[Ximelagatran]], [[Zotepine]], [[Alcohol]]
|bgcolor="Beige"| [[5-Azacytidine]], [[Abacavir]], [[Abiraterone]], [[Acetaminophen]], [[Agomelatine]], [[Albendazole]], [[Allopurinol]], [[Altretamine]], [[Amineptine]], [[Amiodarone]], [[Amitriptyline]], [[Amoxicillin]], [[Amphotericin B]], [[Amprenavir]], [[Anabolic steroids]], [[Antituberculosis drugs]], [[Apixaban]], [[Arsenic trioxide]], [[Asafetida]], [[Asparaginase]], [[Atorvastatin]], [[Atovaquone]], [[Azathioprine]], [[Benoxaprofen]], [[Bexarotene]], [[Black cohosh extract]], [[Bosentan]], [[Bosutinib]], [[Bromfenac]], [[Bumetanide]], [[Carfilzomib]], [[Cascara]], [[Caspofungin]], [[Chaparral]], [[Chenodeoxycholic acid]], [[Chlormezanone]], [[Chlorzoxazone]], [[Ciprofloxacin]], [[Clofarabine]], [[Combined oral contraceptive pill]], [[Comfrey]], [[Crizotinib]], [[Cyclobenzaprine]], [[Dantrolene]], [[Daptomycin]], [[Dasatinib]], [[Deferasirox]], [[Desipramine]], [[Diclofenac]], [[Disulfiram]], [[Docetaxel]], [[Donepezil]], [[Dothiepin]], [[Dronedarone]], [[Eltrombopag]], [[Emtricitabine]], [[Entecavir]], [[Ephedra]], [[Erlotinib]], [[Erythromycin estolate]], [[Ethanol]], [[Ethinylestradiol]], [[Ethionamide]], [[Etretinate]], [[Febuxostat]], [[Felbamate]], [[Fenofibrate]], [[Fingolimod]], [[Fluconazole]], [[Flucytosine]], [[Fluoxymesterone]], [[Flutamide]], [[Fluvastatin]], [[Fosamprenavir]], [[Frusemide]], [[Fusidic acid]], [[Ganciclovir]], [[Gemcitabine]], [[Gemtuzumab ozogamicin]], [[Gold salts]], [[Golimumab]], [[Halothane]], [[Imatinib mesylate]], [[Imipenem]], [[Interferon alpha]], [[Interferon beta]], [[Interleukin 2]], [[Ipilimumab]], [[Isoniazid]], [[Isotretinoin]], [[Kava root extract]], [[Ketoconazole]], [[Lapatinib ditosylate]], [[Leflunomide]], [[Lovastatin]], [[Maraviroc]], [[Meropenem]], [[Mesalazine]], [[Methotrexate]], [[Methyldopa]], [[Methyldopate]], [[Micafungin]], [[Minocycline]], [[Mirtazapine]], [[Mithramycin]], [[Naltrexone]], [[Nandrolone]], [[Natalizumab]], [[Nelfinavir]], [[Nevirapine]], [[Niacin]], [[Nicotinic acid]], [[Nimesulide]], [[Nitisinone]], [[Nitrofurantoin]], [[Norfloxacin]], [[Nortriptyline]], [[Ondansetron]], [[Oxyphenisatine]], [[Paclitaxel]], [[Para-amino salicylic acid]], [[Pazopanib]], [[Pegvisomant]], [[Pemoline]], [[Pentostatin]], [[Phenelzine]], [[Phenylbutazone]], [[Phenytoin]], [[Pralatrexate]], [[Pravastatin]], [[Procainamide]], [[Propylthiouracil]], [[Prothionamide]], [[Pyrazinamide]], [[Pyritinol]], [[Pyrrolizidine alkaloids]], [[Regorafenib]], [[Rifabutin]], [[Rifampicin]], [[Riluzole]], [[Ritonavir]], [[Rivaroxaban]], [[Rosuvastatin]], [[Saquinavir]], [[Simvastatin]], [[Sitaxentan]], [[Sorafenib]], [[Stanozolol]], [[Statins]], [[Succimer]], [[Suloctidil]], [[Sulphasalazine]], [[Sulphinpyrazone]], [[Tegafur]], [[Telithromycin]], [[Teriflunomide]], [[Thiabendazole]], [[Thioguanine]], [[Ticlopidine]], [[Tipranavir]], [[Tizanidine]], [[Tolbutamide]], [[Tolcapone]], [[Tolrestat]], [[Trabectedin]], [[Troglitazone]], [[Trovafloxacin]], [[Ursodeoxycholic acid]], [[Valganciclovir]], [[Valproic acid]], [[Velnacrine]], [[Verapamil]], [[Voriconazole]], [[Ximelagatran]], [[Zotepine]], [[Alcohol]], [[Carbimazole]], [[Phenothiazines]], [[Clofibrate]], [[Tetracyclines]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|}
|}
===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
{{MultiCol}}
*[[5-Azacytidine]]
*[[5-Azacytidine]]
*[[Abacavir]]
*[[Abacavir]]
*[[Abiraterone]]
*[[Abiraterone]]
*[[Acetaminophen]]
*[[Agomelatine]]
*[[Agomelatine]]
*[[Albendazole]]
*[[Albendazole]]
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*[[Bromfenac]]
*[[Bromfenac]]
*[[Bumetanide]]
*[[Bumetanide]]
*[[Carbimazole]]
*[[Carfilzomib]]
*[[Carfilzomib]]
*[[Cascara]]
*[[Cascara]]
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*[[Ciprofloxacin]]
*[[Ciprofloxacin]]
*[[Clofarabine]]
*[[Clofarabine]]
*[[Clofibrate]]
*[[Combined oral contraceptive pill]]
*[[Combined oral contraceptive pill]]
*[[Comfrey]]
*[[Comfrey]]
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*[[Ipilimumab]]
*[[Ipilimumab]]
*[[Isoniazid]]
*[[Isoniazid]]
{{ColBreak}}
*[[Isotretinoin]]
*[[Isotretinoin]]
*[[Kava root extract]]
*[[Kava root extract]]
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*[[Mesalazine]]
*[[Mesalazine]]
*[[Methotrexate]]
*[[Methotrexate]]
*[[Methyldopa]]
*[[Methyldopa]]
*[[Methyldopa]]
*[[Methyldopate]]
*[[Methyldopate]]
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*[[Paclitaxel]]
*[[Paclitaxel]]
*[[Para-amino salicylic acid]]
*[[Para-amino salicylic acid]]
*[[Paracetamol]]
*[[Pazopanib]]
*[[Pazopanib]]
*[[Pegvisomant]]
*[[Pegvisomant]]
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*[[Pentostatin]]
*[[Pentostatin]]
*[[Phenelzine]]
*[[Phenelzine]]
*[[Phenothiazines]]
*[[Phenylbutazone]]
*[[Phenylbutazone]]
*[[Phenytoin]]
*[[Phenytoin]]
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*[[Telithromycin]]
*[[Telithromycin]]
*[[Teriflunomide]]
*[[Teriflunomide]]
*[[Tetracyclines]]
*[[Thiabendazole]]
*[[Thiabendazole]]
*[[Thioguanine]]
*[[Thioguanine]]
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*[[Ximelagatran]]
*[[Ximelagatran]]
*[[Zotepine]]
*[[Zotepine]]
 
{{EndMultiCol}}


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Needs content]]
[[Category:Disease]]
[[Category:Hepatology]]
[[Category:Gastroenterology]]
[[Category:Needs causes]]

Latest revision as of 20:26, 24 October 2016

Drug induced liver injury Microchapters

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Risk calculators and risk factors for Drug induced liver injury

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rachita Navara, M.D. [2]

Overview

Hundreds of prescription and nonprescription medications as well as supplements have been implicated in drug induced liver injury. A free searchable database of causative agents is available through the National Institute of Health.

Causes

Common Causative Agents:

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect 5-Azacytidine, Abacavir, Abiraterone, Acetaminophen, Agomelatine, Albendazole, Allopurinol, Altretamine, Amineptine, Amiodarone, Amitriptyline, Amoxicillin, Amphotericin B, Amprenavir, Anabolic steroids, Antituberculosis drugs, Apixaban, Arsenic trioxide, Asafetida, Asparaginase, Atorvastatin, Atovaquone, Azathioprine, Benoxaprofen, Bexarotene, Black cohosh extract, Bosentan, Bosutinib, Bromfenac, Bumetanide, Carfilzomib, Cascara, Caspofungin, Chaparral, Chenodeoxycholic acid, Chlormezanone, Chlorzoxazone, Ciprofloxacin, Clofarabine, Combined oral contraceptive pill, Comfrey, Crizotinib, Cyclobenzaprine, Dantrolene, Daptomycin, Dasatinib, Deferasirox, Desipramine, Diclofenac, Disulfiram, Docetaxel, Donepezil, Dothiepin, Dronedarone, Eltrombopag, Emtricitabine, Entecavir, Ephedra, Erlotinib, Erythromycin estolate, Ethanol, Ethinylestradiol, Ethionamide, Etretinate, Febuxostat, Felbamate, Fenofibrate, Fingolimod, Fluconazole, Flucytosine, Fluoxymesterone, Flutamide, Fluvastatin, Fosamprenavir, Frusemide, Fusidic acid, Ganciclovir, Gemcitabine, Gemtuzumab ozogamicin, Gold salts, Golimumab, Halothane, Imatinib mesylate, Imipenem, Interferon alpha, Interferon beta, Interleukin 2, Ipilimumab, Isoniazid, Isotretinoin, Kava root extract, Ketoconazole, Lapatinib ditosylate, Leflunomide, Lovastatin, Maraviroc, Meropenem, Mesalazine, Methotrexate, Methyldopa, Methyldopate, Micafungin, Minocycline, Mirtazapine, Mithramycin, Naltrexone, Nandrolone, Natalizumab, Nelfinavir, Nevirapine, Niacin, Nicotinic acid, Nimesulide, Nitisinone, Nitrofurantoin, Norfloxacin, Nortriptyline, Ondansetron, Oxyphenisatine, Paclitaxel, Para-amino salicylic acid, Pazopanib, Pegvisomant, Pemoline, Pentostatin, Phenelzine, Phenylbutazone, Phenytoin, Pralatrexate, Pravastatin, Procainamide, Propylthiouracil, Prothionamide, Pyrazinamide, Pyritinol, Pyrrolizidine alkaloids, Regorafenib, Rifabutin, Rifampicin, Riluzole, Ritonavir, Rivaroxaban, Rosuvastatin, Saquinavir, Simvastatin, Sitaxentan, Sorafenib, Stanozolol, Statins, Succimer, Suloctidil, Sulphasalazine, Sulphinpyrazone, Tegafur, Telithromycin, Teriflunomide, Thiabendazole, Thioguanine, Ticlopidine, Tipranavir, Tizanidine, Tolbutamide, Tolcapone, Tolrestat, Trabectedin, Troglitazone, Trovafloxacin, Ursodeoxycholic acid, Valganciclovir, Valproic acid, Velnacrine, Verapamil, Voriconazole, Ximelagatran, Zotepine, Alcohol, Carbimazole, Phenothiazines, Clofibrate, Tetracyclines
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order


References