Drug induced liver injury liver biopsy

Jump to navigation Jump to search

Drug induced liver injury Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Drug Induced Liver Injury from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Biopsy

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Drug Induced Liver Injury On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Drug induced liver injury

All Images
induced liver injury X-ray X-rays
induced liver injury Ultrasound Echo & Ultrasound
induced liver injury CT CT Images
induced liver injury MRI MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Drug induced liver injury

CDC on Drug induced liver injury

Drug induced liver injury in the news

Blogs on Drug induced liver injury

Directions to Hospitals Treating Drug induced liver injury

Risk calculators and risk factors for Drug induced liver injury

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Rachita Navara, M.D. [2]

Overview

There are no specific liver biopsy findings diagnostic of drug induced injury, but there are several broad histological patterns that reflect the type of injury caused by the inciting drug. Moreover, the same medication can induce a different pattern of liver injury depending on the patient.

Liver Biopsy

The most common histological patterns seen in the drug induced liver injury network are as follows:

On biopsy, drug induced liver injury is characterized by hepatocellular injury and severe inflammation, necrosis, hemorrhage, and rosette formation. Patients with cholestatic injury tend to have more bile plugs and duct paucity. Certain findings on biopsy are predictive of severe and even fatal hepatic injury, including higher degrees of necrosis, microvesicular steatosis, [[fibrosis], and duct reactions. In contrast, eosinophils and granulomas are associated with milder injury.[1]

References

  1. Kleiner DE, Chalasani NP, Lee WM, Fontana RJ, Bonkovsky HL, Watkins PB; et al. (2014). "Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations". Hepatology. 59 (2): 661–70. doi:10.1002/hep.26709. PMC 3946736. PMID 24037963.