CXCL13 is a small [[cytokine]] belonging to the [[Chemokine#CXC chemokines|CXC chemokine family]]. As its name suggests, this chemokine is selectively [[chemotactic]] for [[B cell]]s belonging to both the [[B-1 cell|B-1]] and [[B cell#B cell types|B-2 subsets]], and elicits its effects by interacting with [[chemokine receptor]] [[CXCR5]].<ref name="pmid9463416"/><ref name="pmid11825566">{{cite journal | vauthors = Ansel KM, Harris RB, Cyster JG | title = CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity | journal = Immunity | volume = 16 | issue = 1 | pages = 67–76 |date=January 2002 | pmid = 11825566 | doi = 10.1016/S1074-7613(01)00257-6| url = | issn = }}</ref> CXCL13 and its receptor CXCR5 control the organization of B cells within [[lymph follicle|follicles]] of [[lymphoid tissue]]s.<ref name="pmid10917533">{{cite journal | vauthors = Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG | title = A chemokine-driven positive feedback loop organizes lymphoid follicles | journal = Nature | volume = 406 | issue = 6793 | pages = 309–14 |date=July 2000 | pmid = 10917533 | doi = 10.1038/35018581 | url = | issn = }}</ref> and is expressed highly in the [[liver]], [[spleen]], [[lymph node]]s, and [[Gut (zoology)|gut]] of [[human]]s.<ref name="pmid9463416"/> The [[gene]] for CXCL13 is located on human [[chromosome 4]] in a cluster of other CXC chemokines.<ref name="pmid9486651"/>
CXCL13 is a small [[chemokine]] belonging to the [[Chemokine#CXC chemokines|CXC chemokine family]]. As its name suggests, this chemokine is selectively [[chemotactic]] for [[B cell]]s belonging to both the [[B-1 cell|B-1]] and [[B cell#B cell types|B-2 subsets]], and elicits its effects by interacting with [[chemokine receptor]] [[CXCR5]].<ref name="pmid9463416"/><ref name="pmid11825566">{{cite journal | vauthors = Ansel KM, Harris RB, Cyster JG | title = CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity | journal = Immunity | volume = 16 | issue = 1 | pages = 67–76 |date=January 2002 | pmid = 11825566 | doi = 10.1016/S1074-7613(01)00257-6| url = | issn = }}</ref> CXCL13 and its receptor CXCR5 control the organization of B cells within [[lymph follicle|follicles]] of [[lymphoid tissue]]s.<ref name="pmid10917533">{{cite journal | vauthors = Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG | title = A chemokine-driven positive feedback loop organizes lymphoid follicles | journal = Nature | volume = 406 | issue = 6793 | pages = 309–14 |date=July 2000 | pmid = 10917533 | doi = 10.1038/35018581 | url = | issn = }}</ref> and is expressed highly in the [[liver]], [[spleen]], [[lymph node]]s, and [[Gut (zoology)|gut]] of [[human]]s.<ref name="pmid9463416"/> The [[gene]] for CXCL13 is located on human [[chromosome 4]] in a cluster of other CXC chemokines.<ref name="pmid9486651"/>
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called [[follicular B helper T cells]] (or T<sub>FH</sub> cells). Hence, expression of CXCL13 in T-cell lymphomas, such as Angioimmunoblastic T-cell Lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.<ref name="pmid17284527">{{cite journal | vauthors = de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P | title = The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells | journal = Blood | volume = 109 | issue = 11 | pages = 4952–63 |date=June 2007 | pmid = 17284527 | doi = 10.1182/blood-2006-10-055145 | url = | issn = }}</ref>
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called [[follicular B helper T cells]] (or T<sub>FH</sub> cells). Hence, expression of CXCL13 in T-cell lymphomas, such as Angioimmunoblastic T-cell Lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.<ref name="pmid17284527">{{cite journal | vauthors = de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P | title = The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells | journal = Blood | volume = 109 | issue = 11 | pages = 4952–63 |date=June 2007 | pmid = 17284527 | doi = 10.1182/blood-2006-10-055145 | url = | issn = }}</ref>
chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a proteinligand that in humans is encoded by the CXCL13gene.[1][2]
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as Angioimmunoblastic T-cell Lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.[5]