ZAK: Difference between revisions

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Revision as of 01:03, 19 September 2017

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.^[1]

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

Interactions

ZAK has been shown to interact with ZNF33A.^[2]

References

↑ ^1.0 ^1.1 "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK".
↑ Yang, Jaw-Ji (Jan 2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. United States. 301 (1): 71–7. doi:10.1016/S0006-291X(02)02980-7. ISSN 0006-291X. PMID 12535642.

Liu TC, Huang CJ, Chu YC, et al. (2000). "Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif". Biochem. Biophys. Res. Commun. 274 (3): 811–6. doi:10.1006/bbrc.2000.3236. PMID 10924358.
Gotoh I, Adachi M, Nishida E (2001). "Identification and characterization of a novel MAP kinase kinase kinase, MLTK". J. Biol. Chem. 276 (6): 4276–86. doi:10.1074/jbc.M008595200. PMID 11042189.
Bloem LJ, Pickard TR, Acton S, et al. (2002). "Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase". J. Mol. Cell. Cardiol. 33 (9): 1739–50. doi:10.1006/jmcc.2001.1437. PMID 11549352.
Gross EA, Callow MG, Waldbaum L, et al. (2002). "MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest". J. Biol. Chem. 277 (16): 13873–82. doi:10.1074/jbc.M111994200. PMID 11836244.
Yang JJ (2002). "Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest". Biochem. Biophys. Res. Commun. 297 (1): 105–10. doi:10.1016/S0006-291X(02)02123-X. PMID 12220515.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yang JJ (2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. 301 (1): 71–7. doi:10.1016/S0006-291X(02)02980-7. PMID 12535642.
Takahashi M, Gotoh Y, Isagawa T, et al. (2004). "Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN". J. Biochem. 133 (2): 181–7. doi:10.1093/jb/mvg022. PMID 12761180.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cho YY, Bode AM, Mizuno H, et al. (2004). "A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development". Cancer Res. 64 (11): 3855–64. doi:10.1158/0008-5472.CAN-04-0201. PMID 15172994.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Tosti E, Waldbaum L, Warshaw G, et al. (2005). "The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway". J. Biol. Chem. 279 (46): 47652–60. doi:10.1074/jbc.M409961200. PMID 15342622.
Huang CY, Kuo WW, Chueh PJ, et al. (2004). "Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK". Biochem. Biophys. Res. Commun. 324 (1): 424–31. doi:10.1016/j.bbrc.2004.09.067. PMID 15465036.
Huang CY, Chueh PJ, Tseng CT, et al. (2004). "ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells". Biochem. Biophys. Res. Commun. 324 (3): 973–80. doi:10.1016/j.bbrc.2004.09.156. PMID 15485649.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Choi HS, Choi BY, Cho YY, et al. (2005). "Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha". J. Biol. Chem. 280 (14): 13545–53. doi:10.1074/jbc.M410521200. PMID 15684425.
Wang X, Mader MM, Toth JE, et al. (2005). "Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA". J. Biol. Chem. 280 (19): 19298–305. doi:10.1074/jbc.M413059200. PMID 15737997.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK".

[pmid12535642-2] Yang, Jaw-Ji (Jan 2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. United States. 301 (1): 71–7. doi:10.1016/S0006-291X(02)02980-7. ISSN 0006-291X. PMID 12535642.

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
+'''Sterile alpha motif and leucine zipper containing kinase AZK''', also known as '''ZAK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51776| accessdate = }}</ref>
+{{PBB_Summary
+| section_title =
+| summary_text = This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez" />
+}}
+== Interactions ==
+ZAK has been shown to [[Protein-protein interaction|interact]] with [[ZNF33A]].<ref name=pmid12535642>{{cite journal |doi=10.1016/S0006-291X(02)02980-7 |last=Yang |first=Jaw-Ji |date=Jan 2003 |title=A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue=1 |pages=71–7 |publisher= |location = United States| issn = 0006-291X| pmid = 12535642 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
+== References ==
+{{reflist}}
+== Further reading ==
+{{refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+* {{cite journal   |vauthors=Liu TC, Huang CJ, Chu YC, etal |title=Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 3 |pages= 811–6 |year= 2000 |pmid= 10924358 |doi= 10.1006/bbrc.2000.3236 }}
+* {{cite journal  |vauthors=Gotoh I, Adachi M, Nishida E |title=Identification and characterization of a novel MAP kinase kinase kinase, MLTK. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4276–86 |year= 2001 |pmid= 11042189 |doi= 10.1074/jbc.M008595200 }}
+* {{cite journal   |vauthors=Bloem LJ, Pickard TR, Acton S, etal |title=Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. |journal=J. Mol. Cell. Cardiol. |volume=33 |issue= 9 |pages= 1739–50 |year= 2002 |pmid= 11549352 |doi= 10.1006/jmcc.2001.1437 }}
+* {{cite journal   |vauthors=Gross EA, Callow MG, Waldbaum L, etal |title=MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13873–82 |year= 2002 |pmid= 11836244 |doi= 10.1074/jbc.M111994200 }}
+* {{cite journal  | author=Yang JJ |title=Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 1 |pages= 105–10 |year= 2002 |pmid= 12220515 |doi=10.1016/S0006-291X(02)02123-X  }}
+* {{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+* {{cite journal  | author=Yang JJ |title=A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 71–7 |year= 2003 |pmid= 12535642 |doi=10.1016/S0006-291X(02)02980-7  }}
+* {{cite journal   |vauthors=Takahashi M, Gotoh Y, Isagawa T, etal |title=Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 181–7 |year= 2004 |pmid= 12761180 |doi=10.1093/jb/mvg022  }}
+* {{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+* {{cite journal   |vauthors=Cho YY, Bode AM, Mizuno H, etal |title=A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development. |journal=Cancer Res. |volume=64 |issue= 11 |pages= 3855–64 |year= 2004 |pmid= 15172994 |doi= 10.1158/0008-5472.CAN-04-0201 }}
+* {{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
+* {{cite journal   |vauthors=Tosti E, Waldbaum L, Warshaw G, etal |title=The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway. |journal=J. Biol. Chem. |volume=279 |issue= 46 |pages= 47652–60 |year= 2005 |pmid= 15342622 |doi= 10.1074/jbc.M409961200 }}
+* {{cite journal   |vauthors=Huang CY, Kuo WW, Chueh PJ, etal |title=Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 1 |pages= 424–31 |year= 2004 |pmid= 15465036 |doi= 10.1016/j.bbrc.2004.09.067 }}
+* {{cite journal   |vauthors=Huang CY, Chueh PJ, Tseng CT, etal |title=ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 3 |pages= 973–80 |year= 2004 |pmid= 15485649 |doi= 10.1016/j.bbrc.2004.09.156 }}
+* {{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
+* {{cite journal   |vauthors=Choi HS, Choi BY, Cho YY, etal |title=Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13545–53 |year= 2005 |pmid= 15684425 |doi= 10.1074/jbc.M410521200 }}
+* {{cite journal   |vauthors=Wang X, Mader MM, Toth JE, etal |title=Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 19298–305 |year= 2005 |pmid= 15737997 |doi= 10.1074/jbc.M413059200 }}
+* {{cite journal   |vauthors=Benzinger A, Muster N, Koch HB, etal |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
+* {{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
+* {{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+}}
+{{refend}}
+{{Serine/threonine-specific protein kinases}}
+{{Enzymes}}
+{{Portal bar|Molecular and Cellular Biology|border=no}}
 {{PBB_Controls
 | update_page = yes
 | require_manual_inspection = no
 | update_protein_box = yes
 | update_summary = yes
@@ Line 8: / Line 52: @@
 }}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{DEFAULTSORT:Zak}}
-{{GNF_Protein_box
+[[Category:EC 2.7.11]]
- | image =
- | image_source =
- | PDB =
- | Name = Sterile alpha motif and leucine zipper containing kinase AZK
- | HGNCid =
- | Symbol = ZAK
- | AltSymbols =; MLT; MRK; AZK; MLK7; MLTK; mlklak
- | OMIM = 609479
- | ECnumber =
- | Homologene = 32331
- | MGIid = 2443258
- | GeneAtlas_image1 = PBB_GE_ZAK_218833_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004709 |text = MAP kinase kinase kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0000077 |text = DNA damage checkpoint}} {{GNF_GO|id=GO:0000186 |text = activation of MAPKK activity}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0007257 |text = activation of JNK activity}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009314 |text = response to radiation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 51776
-    | Hs_Ensembl = ENSG00000091436
-    | Hs_RefseqProtein = NP_057737
-    | Hs_RefseqmRNA = NM_016653
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 173648811
-    | Hs_GenLoc_end = 173840986
-    | Hs_Uniprot = Q9NYL2
-    | Mm_EntrezGene = 65964
-    | Mm_Ensembl = ENSMUSG00000004085
-    | Mm_RefseqmRNA = NM_023057
-    | Mm_RefseqProtein = NP_075544
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 72086605
-    | Mm_GenLoc_end = 72243269
-    | Mm_Uniprot = Q9ESL4
-  }}
-}}
-'''Sterile alpha motif and leucine zipper containing kinase AZK''', also known as '''ZAK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51776| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51776| accessdate = }}</ref>
-}}
-==References==
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Liu TC, Huang CJ, Chu YC, ''et al.'' |title=Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 3 |pages= 811-6 |year= 2000 |pmid= 10924358 |doi= 10.1006/bbrc.2000.3236 }}
-*{{cite journal  | author=Gotoh I, Adachi M, Nishida E |title=Identification and characterization of a novel MAP kinase kinase kinase, MLTK. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4276-86 |year= 2001 |pmid= 11042189 |doi= 10.1074/jbc.M008595200 }}
-*{{cite journal  | author=Bloem LJ, Pickard TR, Acton S, ''et al.'' |title=Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. |journal=J. Mol. Cell. Cardiol. |volume=33 |issue= 9 |pages= 1739-50 |year= 2002 |pmid= 11549352 |doi= 10.1006/jmcc.2001.1437 }}
-*{{cite journal  | author=Gross EA, Callow MG, Waldbaum L, ''et al.'' |title=MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13873-82 |year= 2002 |pmid= 11836244 |doi= 10.1074/jbc.M111994200 }}
-*{{cite journal  | author=Yang JJ |title=Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 1 |pages= 105-10 |year= 2002 |pmid= 12220515 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Yang JJ |title=A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 71-7 |year= 2003 |pmid= 12535642 |doi=  }}
-*{{cite journal  | author=Takahashi M, Gotoh Y, Isagawa T, ''et al.'' |title=Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 181-7 |year= 2004 |pmid= 12761180 |doi=  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Cho YY, Bode AM, Mizuno H, ''et al.'' |title=A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development. |journal=Cancer Res. |volume=64 |issue= 11 |pages= 3855-64 |year= 2004 |pmid= 15172994 |doi= 10.1158/0008-5472.CAN-04-0201 }}
-*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
-*{{cite journal  | author=Tosti E, Waldbaum L, Warshaw G, ''et al.'' |title=The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway. |journal=J. Biol. Chem. |volume=279 |issue= 46 |pages= 47652-60 |year= 2005 |pmid= 15342622 |doi= 10.1074/jbc.M409961200 }}
-*{{cite journal  | author=Huang CY, Kuo WW, Chueh PJ, ''et al.'' |title=Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 1 |pages= 424-31 |year= 2004 |pmid= 15465036 |doi= 10.1016/j.bbrc.2004.09.067 }}
-*{{cite journal  | author=Huang CY, Chueh PJ, Tseng CT, ''et al.'' |title=ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 3 |pages= 973-80 |year= 2004 |pmid= 15485649 |doi= 10.1016/j.bbrc.2004.09.156 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Choi HS, Choi BY, Cho YY, ''et al.'' |title=Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13545-53 |year= 2005 |pmid= 15684425 |doi= 10.1074/jbc.M410521200 }}
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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

ZAK: Difference between revisions

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