Wee1-like protein kinase: Difference between revisions

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{{see also|Wee1}}
{{PBB_Controls
{{Infobox_gene}}
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'''WEE1 homolog (''S. pombe'')''', also known as '''WEE1''', is a [[protein]] which in humans is encoded by the ''WEE1'' [[gene]].<ref name="pmid1840647">{{cite journal |vauthors=Igarashi M, Nagata A, Jinno S, Suto K, Okayama H | title = Wee1(+)-like gene in human cells | journal = Nature | volume = 353 | issue = 6339 | pages = 80–3 |date=September 1991 | pmid = 1840647 | doi = 10.1038/353080a0 | url = | bibcode =1991Natur.353...80I }}</ref>
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== Function ==
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a nuclear protein, which is a [[tyrosine kinase]] belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine [[phosphorylation]] of [[Cdk1|CDC2]]/cyclin B kinase, and appears to coordinate the transition between [[DNA replication]] and [[mitosis]] by protecting the nucleus from cytoplasmically activated CDC2 kinase.<ref name="entrez">{{cite web | title = Entrez Gene: WEE1 WEE1 homolog (S. pombe)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7465| accessdate = }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_WEE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x8b.
| PDB = {{PDB2|1x8b}}
| Name = WEE1 homolog (S. pombe)
| HGNCid = 12761
| Symbol = WEE1
| AltSymbols =; DKFZp686I18166; FLJ16446; WEE1hu
| OMIM = 193525
| ECnumber = 
| Homologene = 31152
| MGIid = 103075
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7465
    | Hs_Ensembl = ENSG00000166483
    | Hs_RefseqProtein = NP_003381
    | Hs_RefseqmRNA = NM_003390
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 9552057
    | Hs_GenLoc_end = 9566725
    | Hs_Uniprot = P30291
    | Mm_EntrezGene = 22390
    | Mm_Ensembl = ENSMUSG00000031016
    | Mm_RefseqmRNA = NM_009516
    | Mm_RefseqProtein = NP_033542
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 109913527
    | Mm_GenLoc_end = 109933289
    | Mm_Uniprot = P47810
  }}
}}
'''WEE1 homolog (S. pombe)''', also known as '''WEE1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
Wee1-like protein kinase has been shown to [[Protein-protein interaction|interact]] with [[YWHAB]]<ref name=pmid10775038>{{cite journal |last=Wang |first=Y |authorlink= |author2=Jacobs C |author3=Hook K E |author4=Duan H |author5=Booher R N |author6=Sun Y  |date=April 2000  |title=Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population |journal=Cell Growth Differ. |volume=11 |issue=4 |pages=211–9 |publisher= |location = UNITED STATES| issn = 1044-9523| pmid = 10775038 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[PIN1]].<ref name=pmid9499405>{{cite journal |doi=10.1101/gad.12.5.706 |last=Shen |first=M |authorlink= |author2=Stukenberg P T |author3=Kirschner M W |author4=Lu K P  |date=March 1998  |title=The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins |journal=Genes Dev. |volume=12 |issue=5 |pages=706–20 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 9499405 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=316589 }}</ref>
| section_title =  
| summary_text = This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.<ref name="entrez">{{cite web | title = Entrez Gene: WEE1 WEE1 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7465| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{MeshName|WEE1+protein,+human}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193-205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal  |vauthors=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal  | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue=  |pages= 153-67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }}
*{{cite journal  |vauthors=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue=  |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 |bibcode=2004NYASA1024..153K }}
*{{cite journal  | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
*{{cite journal  |vauthors=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 | pmc=554975 }}
*{{cite journal  | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143-9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
*{{cite journal  |vauthors=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
*{{cite journal  | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270-86 |year= 2005 |pmid= 15817944 |doi=  }}
*{{cite journal  |vauthors=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi=  }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
*{{cite journal   |vauthors=Li L, Li HS, Pauza CD, etal |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923–34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
*{{cite journal | author=Igarashi M, Nagata A, Jinno S, ''et al.'' |title=Wee1(+)-like gene in human cells. |journal=Nature |volume=353 |issue= 6339 |pages= 80-3 |year= 1991 |pmid= 1840647 |doi= 10.1038/353080a0 }}
*{{cite journal   |vauthors=Igarashi M, Nagata A, Jinno S, etal |title=Wee1(+)-like gene in human cells. |journal=Nature |volume=353 |issue= 6339 |pages= 80–3 |year= 1991 |pmid= 1840647 |doi= 10.1038/353080a0 |bibcode=1991Natur.353...80I }}
*{{cite journal  | author=Baldin V, Ducommun B |title=Subcellular localisation of human wee1 kinase is regulated during the cell cycle. |journal=J. Cell. Sci. |volume=108 ( Pt 6) |issue=  |pages= 2425-32 |year= 1995 |pmid= 7673359 |doi=  }}
*{{cite journal  |vauthors=Baldin V, Ducommun B |title=Subcellular localisation of human wee1 kinase is regulated during the cell cycle. |journal=J. Cell Sci. |volume=108 |issue=  6|pages= 2425–32 |year= 1995 |pmid= 7673359 |doi=  }}
*{{cite journal  | author=Watanabe N, Broome M, Hunter T |title=Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. |journal=EMBO J. |volume=14 |issue= 9 |pages= 1878-91 |year= 1995 |pmid= 7743995 |doi=  }}
*{{cite journal  |vauthors=Watanabe N, Broome M, Hunter T |title=Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. |journal=EMBO J. |volume=14 |issue= 9 |pages= 1878–91 |year= 1995 |pmid= 7743995 |doi= | pmc=398287 }}
*{{cite journal  | author=McGowan CH, Russell P |title=Cell cycle regulation of human WEE1. |journal=EMBO J. |volume=14 |issue= 10 |pages= 2166-75 |year= 1995 |pmid= 7774574 |doi=  }}
*{{cite journal  |vauthors=McGowan CH, Russell P |title=Cell cycle regulation of human WEE1. |journal=EMBO J. |volume=14 |issue= 10 |pages= 2166–75 |year= 1995 |pmid= 7774574 |doi= | pmc=398322 }}
*{{cite journal | author=Kharbanda S, Yuan ZM, Taneja N, ''et al.'' |title=p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C. |journal=Oncogene |volume=9 |issue= 10 |pages= 3005-11 |year= 1994 |pmid= 8084605 |doi=  }}
*{{cite journal   |vauthors=Kharbanda S, Yuan ZM, Taneja N, etal |title=p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C. |journal=Oncogene |volume=9 |issue= 10 |pages= 3005–11 |year= 1994 |pmid= 8084605 |doi=  }}
*{{cite journal  | author=Heald R, McLoughlin M, McKeon F |title=Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. |journal=Cell |volume=74 |issue= 3 |pages= 463-74 |year= 1993 |pmid= 8348613 |doi= }}
*{{cite journal  |vauthors=Heald R, McLoughlin M, McKeon F |title=Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. |journal=Cell |volume=74 |issue= 3 |pages= 463–74 |year= 1993 |pmid= 8348613 |doi=10.1016/0092-8674(93)80048-J  }}
*{{cite journal  | author=McGowan CH, Russell P |title=Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. |journal=EMBO J. |volume=12 |issue= 1 |pages= 75-85 |year= 1993 |pmid= 8428596 |doi=  }}
*{{cite journal  |vauthors=McGowan CH, Russell P |title=Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. |journal=EMBO J. |volume=12 |issue= 1 |pages= 75–85 |year= 1993 |pmid= 8428596 |doi= | pmc=413177 }}
*{{cite journal  | author=Taviaux SA, Demaille JG |title=Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization. |journal=Genomics |volume=15 |issue= 1 |pages= 194-6 |year= 1993 |pmid= 8432534 |doi= 10.1006/geno.1993.1032 }}
*{{cite journal  |vauthors=Taviaux SA, Demaille JG |title=Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization. |journal=Genomics |volume=15 |issue= 1 |pages= 194–6 |year= 1993 |pmid= 8432534 |doi= 10.1006/geno.1993.1032 }}
*{{cite journal  | author=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300-6 |year= 1997 |pmid= 9268380 |doi= }}
*{{cite journal  |vauthors=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=10.1074/jbc.272.35.22300  }}
*{{cite journal  | author=Zhou BB, Li H, Yuan J, Kirschner MW |title=Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6785-90 |year= 1998 |pmid= 9618490 |doi=  }}
*{{cite journal  |vauthors=Zhou BB, Li H, Yuan J, Kirschner MW |title=Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6785–90 |year= 1998 |pmid= 9618490 |doi=10.1073/pnas.95.12.6785  | pmc=22635 |bibcode=1998PNAS...95.6785Z }}
*{{cite journal | author=Taylor WR, DePrimo SE, Agarwal A, ''et al.'' |title=Mechanisms of G2 arrest in response to overexpression of p53. |journal=Mol. Biol. Cell |volume=10 |issue= 11 |pages= 3607-22 |year= 1999 |pmid= 10564259 |doi=  }}
*{{cite journal   |vauthors=Taylor WR, DePrimo SE, Agarwal A, etal |title=Mechanisms of G2 arrest in response to overexpression of p53. |journal=Mol. Biol. Cell |volume=10 |issue= 11 |pages= 3607–22 |year= 1999 |pmid= 10564259 |doi= 10.1091/mbc.10.11.3607| pmc=25646 }}
*{{cite journal | author=Wang Y, Jacobs C, Hook KE, ''et al.'' |title=Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population. |journal=Cell Growth Differ. |volume=11 |issue= 4 |pages= 211-9 |year= 2000 |pmid= 10775038 |doi=  }}
*{{cite journal   |vauthors=Wang Y, Jacobs C, Hook KE, etal |title=Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population. |journal=Cell Growth Differ. |volume=11 |issue= 4 |pages= 211–9 |year= 2000 |pmid= 10775038 |doi=  }}
*{{cite journal | author=Cichutek A, Brueckmann T, Seipel B, ''et al.'' |title=Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). |journal=Cytogenet. Cell Genet. |volume=93 |issue= 3-4 |pages= 277-83 |year= 2001 |pmid= 11528126 |doi=  }}
*{{cite journal   |vauthors=Cichutek A, Brueckmann T, Seipel B, etal |title=Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). |journal=Cytogenet. Cell Genet. |volume=93 |issue= 3-4 |pages= 277–83 |year= 2001 |pmid= 11528126 |doi=10.1159/000056998 }}
*{{cite journal | author=Elder RT, Yu M, Chen M, ''et al.'' |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359-70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 }}
*{{cite journal   |vauthors=Elder RT, Yu M, Chen M, etal |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7465}}
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[[Category:EC 2.7.11]]


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Latest revision as of 01:20, 27 June 2018

See also: Wee1
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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Wikidata
View/Edit Human

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.[1]

Function

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.[2]

Interactions

Wee1-like protein kinase has been shown to interact with YWHAB[3] and PIN1.[4]

References

  1. ↑ Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID 1840647.
  2. ↑ "Entrez Gene: WEE1 WEE1 homolog (S. pombe)".
  3. ↑ Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. UNITED STATES. 11 (4): 211–9. ISSN 1044-9523. PMID 10775038.
  4. ↑ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.

External links

Further reading


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