TTK (gene): Difference between revisions

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Latest revision as of 12:25, 15 September 2017

Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene.^[1]^[2]

References

↑ Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D (Aug 1992). "Expression of TTK, a novel human protein kinase, is associated with cell proliferation". J Biol Chem. 267 (22): 16000–6. PMID 1639825.
↑ "Entrez Gene: TTK TTK protein kinase".

Hanks SK, Quinn AM (1991). "Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members". Meth. Enzymol. Methods in Enzymology. 200: 38–62. doi:10.1016/0076-6879(91)00126-H. ISBN 978-0-12-182101-2. PMID 1956325.
Lindberg RA, Fischer WH, Hunter T (1993). "Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine". Oncogene. 8 (2): 351–9. PMID 7678926.
Lauzé E, Stoelcker B, Luca FC, et al. (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14 (8): 1655–63. PMC 398258. PMID 7737118.
Cahill DP, da Costa LT, Carson-Walter EB, et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
Stucke VM, Silljé HH, Arnaud L, Nigg EA (2002). "Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication". EMBO J. 21 (7): 1723–32. doi:10.1093/emboj/21.7.1723. PMC 125937. PMID 11927556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu ST, Chan GK, Hittle JC, et al. (2003). "Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores". Mol. Biol. Cell. 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMC 153128. PMID 12686615.
Fisk HA, Mattison CP, Winey M (2004). "Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 14875–80. doi:10.1073/pnas.2434156100. PMC 299837. PMID 14657364.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323.
Wei JH, Chou YF, Ou YH, et al. (2005). "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68". J. Biol. Chem. 280 (9): 7748–57. doi:10.1074/jbc.M410152200. PMID 15618221.
Camacho E, Beà S, Salaverría I, et al. (2006). "Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma". Int. J. Cancer. 118 (2): 357–63. doi:10.1002/ijc.21370. PMID 16080195.
Leng M, Chan DW, Luo H, et al. (2006). "MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11485–90. doi:10.1073/pnas.0601828103. PMC 1518802. PMID 16864798.
Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen". PLoS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMC 1831731. PMID 17388661.
Zhu S, Wang W, Clarke DC, Liu X (2007). "Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling". J. Biol. Chem. 282 (25): 18327–38. doi:10.1074/jbc.M700636200. PMID 17452325.
Kanai M, Ma Z, Izumi H, et al. (2007). "Physical and functional interaction between mortalin and Mps1 kinase". Genes Cells. 12 (6): 797–810. doi:10.1111/j.1365-2443.2007.01091.x. PMID 17573779.
Mattison CP, Old WM, Steiner E, et al. (2007). "Mps1 activation loop autophosphorylation enhances kinase activity". J. Biol. Chem. 282 (42): 30553–61. doi:10.1074/jbc.M707063200. PMID 17728254.

[pmid1639825-1] Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D (Aug 1992). "Expression of TTK, a novel human protein kinase, is associated with cell proliferation". J Biol Chem. 267 (22): 16000–6. PMID 1639825.

[entrez-2] "Entrez Gene: TTK TTK protein kinase".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Dual specificity protein kinase TTK''' also known as '''Mps1''' is an [[enzyme]] that in humans is encoded by the ''TTK'' [[gene]].<ref name="pmid1639825">{{cite journal |vauthors=Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D | title = Expression of TTK, a novel human protein kinase, is associated with cell proliferation | journal = J Biol Chem | volume = 267 | issue = 22 | pages = 16000–6 |date=Aug 1992 | pmid = 1639825 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TTK TTK protein kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7272| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = TTK protein kinase
- | HGNCid = 12401
- | Symbol = TTK
- | AltSymbols =; ESK; FLJ38280; MPS1L1; PYT
- | OMIM = 604092
- | ECnumber =
- | Homologene = 2489
- | MGIid = 1194921
- | GeneAtlas_image1 = PBB_GE_TTK_204822_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005819 |text = spindle}}
- | Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007052 |text = mitotic spindle organization and biogenesis}} {{GNF_GO|id=GO:0007094 |text = mitotic cell cycle spindle assembly checkpoint}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 7272
-    | Hs_Ensembl = ENSG00000112742
-    | Hs_RefseqProtein = NP_003309
-    | Hs_RefseqmRNA = NM_003318
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 80771076
-    | Hs_GenLoc_end = 80808958
-    | Hs_Uniprot = P33981
-    | Mm_EntrezGene = 22137
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA = NM_009445
-    | Mm_RefseqProtein = NP_033471
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''TTK protein kinase''', also known as '''TTK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TTK TTK protein kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7272| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
+{{PBB Summary
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 | summary_text =
@@ Line 55: / Line 8: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Mills GB, Schmandt R, McGill M, ''et al.'' |title=Expression of TTK, a novel human protein kinase, is associated with cell proliferation. |journal=J. Biol. Chem. |volume=267 |issue= 22 |pages= 16000-6 |year= 1992 |pmid= 1639825 |doi=  }}
+*{{cite journal  |vauthors=Hanks SK, Quinn AM |title=Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members |journal=Meth. Enzymol. |volume=200 |issue=  |pages= 38–62 |year= 1991 |pmid= 1956325 |doi=10.1016/0076-6879(91)00126-H  | series=Methods in Enzymology  | isbn=978-0-12-182101-2  }}
-*{{cite journal  | author=Hanks SK, Quinn AM |title=Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. |journal=Meth. Enzymol. |volume=200 |issue=  |pages= 38-62 |year= 1991 |pmid= 1956325 |doi=  }}
+*{{cite journal  |vauthors=Lindberg RA, Fischer WH, Hunter T |title=Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine |journal=Oncogene |volume=8 |issue= 2 |pages= 351–9 |year= 1993 |pmid= 7678926 |doi=  }}
-*{{cite journal  | author=Lindberg RA, Fischer WH, Hunter T |title=Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine. |journal=Oncogene |volume=8 |issue= 2 |pages= 351-9 |year= 1993 |pmid= 7678926 |doi=  }}
+*{{cite journal  | author=Lauzé E |title=Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase |journal=EMBO J. |volume=14 |issue= 8 |pages= 1655–63 |year= 1995 |pmid= 7737118 |doi=  | pmc=398258  |name-list-format=vanc| author2=Stoelcker B  | author3=Luca FC  | display-authors=3  | last4=Weiss  | first4=E  | last5=Schutz  | first5=AR  | last6=Winey  | first6=M  }}
-*{{cite journal  | author=Lauzé E, Stoelcker B, Luca FC, ''et al.'' |title=Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase. |journal=EMBO J. |volume=14 |issue= 8 |pages= 1655-63 |year= 1995 |pmid= 7737118 |doi=  }}
+*{{cite journal  | author=Cahill DP |title=Characterization of MAD2B and other mitotic spindle checkpoint genes |journal=Genomics |volume=58 |issue= 2 |pages= 181–7 |year= 1999 |pmid= 10366450 |doi= 10.1006/geno.1999.5831  |name-list-format=vanc| author2=da Costa LT  | author3=Carson-Walter EB  | display-authors=3  | last4=Kinzler  | first4=KW  | last5=Vogelstein  | first5=B  | last6=Lengauer  | first6=C }}
-*{{cite journal  | author=Cahill DP, da Costa LT, Carson-Walter EB, ''et al.'' |title=Characterization of MAD2B and other mitotic spindle checkpoint genes. |journal=Genomics |volume=58 |issue= 2 |pages= 181-7 |year= 1999 |pmid= 10366450 |doi= 10.1006/geno.1999.5831 }}
+*{{cite journal  | author=Weinmann AS |title=Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis |journal=Genes Dev. |volume=16 |issue= 2 |pages= 235–44 |year= 2002 |pmid= 11799066 |doi= 10.1101/gad.943102  | pmc=155318  |name-list-format=vanc| author2=Yan PS  | author3=Oberley MJ  | display-authors=3  | last4=Huang  | first4=TH  | last5=Farnham  | first5=PJ }}
-*{{cite journal  | author=Weinmann AS, Yan PS, Oberley MJ, ''et al.'' |title=Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 235-44 |year= 2002 |pmid= 11799066 |doi= 10.1101/gad.943102 }}
+*{{cite journal  |vauthors=Stucke VM, Silljé HH, Arnaud L, Nigg EA |title=Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication |journal=EMBO J. |volume=21 |issue= 7 |pages= 1723–32 |year= 2002 |pmid= 11927556 |doi= 10.1093/emboj/21.7.1723  | pmc=125937 }}
-*{{cite journal  | author=Stucke VM, Silljé HH, Arnaud L, Nigg EA |title=Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication. |journal=EMBO J. |volume=21 |issue= 7 |pages= 1723-32 |year= 2002 |pmid= 11927556 |doi= 10.1093/emboj/21.7.1723 }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Liu ST |title=Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores |journal=Mol. Biol. Cell |volume=14 |issue= 4 |pages= 1638–51 |year= 2003 |pmid= 12686615 |doi= 10.1091/mbc.02-05-0074  | pmc=153128  |name-list-format=vanc| author2=Chan GK  | author3=Hittle JC  | display-authors=3  | last4=Fujii  | first4=G  | last5=Lees  | first5=E  | last6=Yen  | first6=TJ }}
-*{{cite journal  | author=Liu ST, Chan GK, Hittle JC, ''et al.'' |title=Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores. |journal=Mol. Biol. Cell |volume=14 |issue= 4 |pages= 1638-51 |year= 2003 |pmid= 12686615 |doi= 10.1091/mbc.02-05-0074 }}
+*{{cite journal  |vauthors=Fisk HA, Mattison CP, Winey M |title=Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 25 |pages= 14875–80 |year= 2004 |pmid= 14657364 |doi= 10.1073/pnas.2434156100  | pmc=299837 }}
-*{{cite journal  | author=Fisk HA, Mattison CP, Winey M |title=Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 25 |pages= 14875-80 |year= 2004 |pmid= 14657364 |doi= 10.1073/pnas.2434156100 }}
+*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | author=Dou Z |title=TTK kinase is essential for the centrosomal localization of TACC2 |journal=FEBS Lett. |volume=572 |issue= 1–3 |pages= 51–6 |year= 2004 |pmid= 15304323 |doi= 10.1016/j.febslet.2004.06.092  |name-list-format=vanc| author2=Ding X  | author3=Zereshki A  | display-authors=3  | last4=Zhang  | first4=Ying  | last5=Zhang  | first5=Jie  | last6=Wang  | first6=Feng  | last7=Sun  | first7=Jie  | last8=Huang  | first8=He  | last9=Yao  | first9=Xuebiao }}
-*{{cite journal  | author=Dou Z, Ding X, Zereshki A, ''et al.'' |title=TTK kinase is essential for the centrosomal localization of TACC2. |journal=FEBS Lett. |volume=572 |issue= 1-3 |pages= 51-6 |year= 2004 |pmid= 15304323 |doi= 10.1016/j.febslet.2004.06.092 }}
+*{{cite journal  | author=Wei JH |title=TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68 |journal=J. Biol. Chem. |volume=280 |issue= 9 |pages= 7748–57 |year= 2005 |pmid= 15618221 |doi= 10.1074/jbc.M410152200  |name-list-format=vanc| author2=Chou YF  | author3=Ou YH  | display-authors=3  | last4=Yeh  | first4=YH  | last5=Tyan  | first5=SW  | last6=Sun  | first6=TP  | last7=Shen  | first7=CY  | last8=Shieh  | first8=SY }}
-*{{cite journal  | author=Wei JH, Chou YF, Ou YH, ''et al.'' |title=TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68. |journal=J. Biol. Chem. |volume=280 |issue= 9 |pages= 7748-57 |year= 2005 |pmid= 15618221 |doi= 10.1074/jbc.M410152200 }}
+*{{cite journal  | author=Camacho E |title=Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma |journal=Int. J. Cancer |volume=118 |issue= 2 |pages= 357–63 |year= 2006 |pmid= 16080195 |doi= 10.1002/ijc.21370  |name-list-format=vanc| author2=Beà S  | author3=Salaverría I  | display-authors=3  | last4=López-Guillermo  | first4=Armando  | last5=Puig  | first5=Xavier  | last6=Benavente  | first6=Yolanda  | last7=De Sanjosé  | first7=Silvia  | last8=Campo  | first8=Elias  | last9=Hernández  | first9=Luis }}
-*{{cite journal  | author=Camacho E, Beà S, Salaverría I, ''et al.'' |title=Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma. |journal=Int. J. Cancer |volume=118 |issue= 2 |pages= 357-63 |year= 2006 |pmid= 16080195 |doi= 10.1002/ijc.21370 }}
+*{{cite journal  | author=Leng M |title=MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 31 |pages= 11485–90 |year= 2006 |pmid= 16864798 |doi= 10.1073/pnas.0601828103  | pmc=1518802  |name-list-format=vanc| author2=Chan DW  | author3=Luo H  | display-authors=3  | last4=Zhu  | first4=C  | last5=Qin  | first5=J  | last6=Wang  | first6=Y }}
-*{{cite journal  | author=Leng M, Chan DW, Luo H, ''et al.'' |title=MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 31 |pages= 11485-90 |year= 2006 |pmid= 16864798 |doi= 10.1073/pnas.0601828103 }}
+*{{cite journal  | author=Bertheau P |title=Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen |journal=PLoS Med. |volume=4 |issue= 3 |pages= e90 |year= 2007 |pmid= 17388661 |doi= 10.1371/journal.pmed.0040090  | pmc=1831731  |name-list-format=vanc| author2=Turpin E  | author3=Rickman DS  | display-authors=3  | last4=Espié  | first4=Marc  | last5=De Reyniès  | first5=Aurélien  | last6=Feugeas  | first6=Jean-Paul  | last7=Plassa  | first7=Louis-François  | last8=Soliman  | first8=Hany  | last9=Varna  | first9=Mariana }}
-*{{cite journal  | author=Bertheau P, Turpin E, Rickman DS, ''et al.'' |title=Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen. |journal=PLoS Med. |volume=4 |issue= 3 |pages= e90 |year= 2007 |pmid= 17388661 |doi= 10.1371/journal.pmed.0040090 }}
+*{{cite journal  |vauthors=Zhu S, Wang W, Clarke DC, Liu X |title=Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling |journal=J. Biol. Chem. |volume=282 |issue= 25 |pages= 18327–38 |year= 2007 |pmid= 17452325 |doi= 10.1074/jbc.M700636200 }}
-*{{cite journal  | author=Zhu S, Wang W, Clarke DC, Liu X |title=Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling. |journal=J. Biol. Chem. |volume=282 |issue= 25 |pages= 18327-38 |year= 2007 |pmid= 17452325 |doi= 10.1074/jbc.M700636200 }}
+*{{cite journal  | author=Kanai M |title=Physical and functional interaction between mortalin and Mps1 kinase |journal=Genes Cells |volume=12 |issue= 6 |pages= 797–810 |year= 2007 |pmid= 17573779 |doi= 10.1111/j.1365-2443.2007.01091.x  |name-list-format=vanc| author2=Ma Z  | author3=Izumi H  | display-authors=3  | last4=Kim  | first4=Song-Hee  | last5=Mattison  | first5=Christopher P.  | last6=Winey  | first6=Mark  | last7=Fukasawa  | first7=Kenji }}
-*{{cite journal  | author=Kanai M, Ma Z, Izumi H, ''et al.'' |title=Physical and functional interaction between mortalin and Mps1 kinase. |journal=Genes Cells |volume=12 |issue= 6 |pages= 797-810 |year= 2007 |pmid= 17573779 |doi= 10.1111/j.1365-2443.2007.01091.x }}
+*{{cite journal  | author=Mattison CP |title=Mps1 activation loop autophosphorylation enhances kinase activity |journal=J. Biol. Chem. |volume=282 |issue= 42 |pages= 30553–61 |year= 2007 |pmid= 17728254 |doi= 10.1074/jbc.M707063200  |name-list-format=vanc| author2=Old WM  | author3=Steiner E  | display-authors=3  | last4=Huneycutt  | first4=B. J.  | last5=Resing  | first5=K. A.  | last6=Ahn  | first6=N. G.  | last7=Winey  | first7=M. }}
-*{{cite journal  | author=Mattison CP, Old WM, Steiner E, ''et al.'' |title=Mps1 activation loop autophosphorylation enhances kinase activity. |journal=J. Biol. Chem. |volume=282 |issue= 42 |pages= 30553-61 |year= 2007 |pmid= 17728254 |doi= 10.1074/jbc.M707063200 }}
 }}
 {{refend}}
-{{protein-stub}}
+{{Serine/threonine-specific protein kinases}}
-{{WikiDoc Sources}}
+{{Enzymes}}
+{{Portal bar|Molecular and Cellular Biology|border=no}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+[[Category:EC 2.7.11]]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

TTK (gene): Difference between revisions

Latest revision as of 12:25, 15 September 2017

References

Further reading

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