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{{Infobox_gene}}
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'''Thiamin pyrophosphokinase 1''' is an [[enzyme]] that in humans is encoded by the ''TPK1'' [[gene]].<ref name="pmid11342111">{{cite journal |vauthors=Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T | title = Isolation and characterization of a human thiamine pyrophosphokinase cDNA | journal = Biochim Biophys Acta | volume = 1517 | issue = 2 | pages = 293–7 |date=May 2001 | pmid = 11342111 | pmc =  | doi =  10.1016/s0167-4781(00)00247-5}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TPK1 thiamin pyrophosphokinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27010| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Thiamin pyrophosphokinase 1
| HGNCid = 17358
| Symbol = TPK1
| AltSymbols =; HTPK1; PP20
| OMIM = 606370
| ECnumber = 
| Homologene = 6960
| MGIid = 1352500
| GeneAtlas_image1 = PBB_GE_TPK1_221218_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004788 |text = thiamin diphosphokinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =  
  | Process = {{GNF_GO|id=GO:0006772 |text = thiamin metabolic process}} {{GNF_GO|id=GO:0009229 |text = thiamin diphosphate biosynthetic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27010
    | Hs_Ensembl = ENSG00000196511
    | Hs_RefseqProtein = NP_001035947
    | Hs_RefseqmRNA = NM_001042482
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 143779976
    | Hs_GenLoc_end = 144164066
    | Hs_Uniprot = Q9H3S4
    | Mm_EntrezGene = 29807
    | Mm_Ensembl = ENSMUSG00000029735
    | Mm_RefseqmRNA = NM_013861
    | Mm_RefseqProtein = NP_038889
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 43276389
    | Mm_GenLoc_end = 43540993
    | Mm_Uniprot = Q9R0M5
  }}
}}
'''Thiamin pyrophosphokinase 1''', also known as '''TPK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TPK1 thiamin pyrophosphokinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27010| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: TPK1 thiamin pyrophosphokinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27010| accessdate = }}</ref>
| summary_text = This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional [[splice variant]]s, encoding different isoforms, have been characterized.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Egi Y, Koyama S, Shioda T, ''et al.'' |title=Identification, purification and reconstitution of thiamin metabolizing enzymes in human red blood cells. |journal=Biochim. Biophys. Acta |volume=1160 |issue= 2 |pages= 171-8 |year= 1992 |pmid= 1332781 |doi=  }}
*{{cite journal  | author=Egi Y |title=Identification, purification and reconstitution of thiamin metabolizing enzymes in human red blood cells |journal=Biochim. Biophys. Acta |volume=1160 |issue= 2 |pages= 171–8 |year= 1992 |pmid= 1332781 |doi=10.1016/0167-4838(92)90004-W |name-list-format=vanc| author2=Koyama S | author3=Shioda T  | display-authors=3  | last4=Yamada  | first4=K  | last5=Kawasaki  | first5=T }}
*{{cite journal | author=Bohn H, Winckler W |title=Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21). |journal=Arch. Gynecol. |volume=236 |issue= 4 |pages= 235-42 |year= 1985 |pmid= 3896163 |doi=  }}
*{{cite journal  |vauthors=Bohn H, Winckler W |title=Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21) |journal=Arch. Gynecol. |volume=236 |issue= 4 |pages= 235–42 |year= 1985 |pmid= 3896163 |doi=10.1007/BF02133941  }}
*{{cite journal  | author=Iwashima A, Kinugasa A, Nose Y |title=Radiometric assay for thiamine pyrophosphokinase activity in human leukocytes. |journal=Acta Vitaminol. Enzymol. |volume=5 |issue= 1 |pages= 41-5 |year= 1983 |pmid= 6303095 |doi= }}
*{{cite journal  |vauthors=Iwashima A, Kinugasa A, Nose Y |title=Radiometric assay for thiamine pyrophosphokinase activity in human leukocytes |journal=Acta Vitaminol. Enzymol. |volume=5 |issue= 1 |pages= 41–5 |year= 1983 |pmid= 6303095 |doi=  }}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal  |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097  | author1= <Please add first missing authors to populate metadata.>}}
*{{cite journal  | author=Nosaka K, Onozuka M, Nishino H, ''et al.'' |title=Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. |journal=J. Biol. Chem. |volume=274 |issue= 48 |pages= 34129-33 |year= 1999 |pmid= 10567383 |doi=  }}
*{{cite journal  | author=Nosaka K |title=Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA |journal=J. Biol. Chem. |volume=274 |issue= 48 |pages= 34129–33 |year= 1999 |pmid= 10567383 |doi=10.1074/jbc.274.48.34129 |name-list-format=vanc| author2=Onozuka M | author3=Nishino H  | display-authors=3  | last4=Nishimura  | first4=H  | last5=Kawasaki  | first5=Y  | last6=Ueyama  | first6=H }}
*{{cite journal  | author=Nosaka K, Onozuka M, Kakazu N, ''et al.'' |title=Isolation and characterization of a human thiamine pyrophosphokinase cDNA. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 2 |pages= 293-7 |year= 2001 |pmid= 11342111 |doi=  }}
*{{cite journal  |vauthors=Zhao R, Gao F, Goldman ID |title=Molecular cloning of human thiamin pyrophosphokinase |journal=Biochim. Biophys. Acta |volume=1517 |issue= 2 |pages= 320–2 |year= 2001 |pmid= 11342117 |doi= 10.1016/s0167-4781(00)00264-5}}
*{{cite journal | author=Zhao R, Gao F, Goldman ID |title=Molecular cloning of human thiamin pyrophosphokinase. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 2 |pages= 320-2 |year= 2001 |pmid= 11342117 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins | first6=FS | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Scherer SW |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961  |name-list-format=vanc| author2=Cheung J  | author3=MacDonald JR  | display-authors=3  | last4=Osborne  | first4=LR  | last5=Nakabayashi  | first5=K  | last6=Herbrick  | first6=JA  | last7=Carson  | first7=AR  | last8=Parker-Katiraee  | first8=L  | last9=Skaug  | first9=J }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  |vauthors=Onozuka M, Nosaka K |title=Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase |journal=J. Nutr. Sci. Vitaminol. |volume=49 |issue= 3 |pages= 156–62 |year= 2004 |pmid= 12953792 |doi= 10.3177/jnsv.49.156}}
*{{cite journal | author=Onozuka M, Nosaka K |title=Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase. |journal=J. Nutr. Sci. Vitaminol. |volume=49 |issue= 3 |pages= 156-62 |year= 2004 |pmid= 12953792 |doi=  }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Bellyei S |title=Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK) |journal=Placenta |volume=26 |issue= 1 |pages= 34–46 |year= 2005 |pmid= 15664409 |doi= 10.1016/j.placenta.2004.03.008  |name-list-format=vanc| author2=Szigeti A  | author3=Boronkai A  | display-authors=3  | last4=Szabo  | first4=Z.  | last5=Bene  | first5=J.  | last6=Janaky  | first6=T.  | last7=Barna  | first7=L.  | last8=Sipos  | first8=K.  | last9=Minik  | first9=O. }}
*{{cite journal | author=Bellyei S, Szigeti A, Boronkai A, ''et al.'' |title=Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK). |journal=Placenta |volume=26 |issue= 1 |pages= 34-46 |year= 2005 |pmid= 15664409 |doi= 10.1016/j.placenta.2004.03.008 }}
*{{cite journal  | author=Toyoshima M |title=Thiamine-responsive congenital lactic acidosis: clinical and biochemical studies |journal=Pediatr. Neurol. |volume=33 |issue= 2 |pages= 98–104 |year= 2005 |pmid= 16087053 |doi= 10.1016/j.pediatrneurol.2005.02.007  |name-list-format=vanc| author2=Oka A  | author3=Egi Y  | display-authors=3  | last4=Yamamoto  | first4=T  | last5=Onozuka  | first5=M  | last6=Nosaka  | first6=K  | last7=Naito  | first7=E  | last8=Yamada  | first8=K }}
*{{cite journal  | author=Toyoshima M, Oka A, Egi Y, ''et al.'' |title=Thiamine-responsive congenital lactic acidosis: clinical and biochemical studies. |journal=Pediatr. Neurol. |volume=33 |issue= 2 |pages= 98-104 |year= 2005 |pmid= 16087053 |doi= 10.1016/j.pediatrneurol.2005.02.007 }}
*{{cite journal  | author=Onozuka M |title=Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene |journal=J. Nutr. Sci. Vitaminol. |volume=51 |issue= 4 |pages= 274–7 |year= 2006 |pmid= 16262001 |doi=  10.3177/jnsv.51.274|name-list-format=vanc| author2=Konno H  | author3=Akaji K  | display-authors=3  | last4=Nishino  | first4=H  | last5=Nosaka  | first5=K  }}
*{{cite journal  | author=Onozuka M, Konno H, Akaji K, ''et al.'' |title=Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene. |journal=J. Nutr. Sci. Vitaminol. |volume=51 |issue= 4 |pages= 274-7 |year= 2006 |pmid= 16262001 |doi=  }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  |vauthors=Fradin D, Bougneres P |title=Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight |journal=Ann. Hum. Genet. |volume=71 |issue= Pt 5 |pages= 578–85 |year= 2007 |pmid= 17295612 |doi= 10.1111/j.1469-1809.2007.00348.x }}
*{{cite journal  | author=Fradin D, Bougneres P |title=Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight. |journal=Ann. Hum. Genet. |volume=71 |issue= Pt 5 |pages= 578-85 |year= 2007 |pmid= 17295612 |doi= 10.1111/j.1469-1809.2007.00348.x }}
}}
}}
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Latest revision as of 12:12, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene.[1][2]

This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

References

  1. ↑ Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T (May 2001). "Isolation and characterization of a human thiamine pyrophosphokinase cDNA". Biochim Biophys Acta. 1517 (2): 293–7. doi:10.1016/s0167-4781(00)00247-5. PMID 11342111.
  2. ↑ 2.0 2.1 "Entrez Gene: TPK1 thiamin pyrophosphokinase 1".

Further reading


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