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{{Infobox_gene}}
{{Infobox_gene}}
'''5'-AMP-activated protein kinase subunit gamma-1''' is an [[enzyme]] that in humans is encoded by the ''PRKAG1'' [[gene]].<ref name="pmid8557660">{{cite journal |vauthors=Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE | title = Mammalian AMP-activated protein kinase subfamily | journal = J Biol Chem | volume = 271 | issue = 2 | pages = 611–4 |date=February 1996 | pmid = 8557660 | pmc =  | doi =10.1074/jbc.271.2.611 }}</ref><ref name="pmid8621499">{{cite journal |vauthors=Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR, Kemp BE, Witters LA | title = Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase | journal = J Biol Chem | volume = 271 | issue = 15 | pages = 8675–81 |date=June 1996 | pmid = 8621499 | pmc =  | doi =10.1074/jbc.271.15.8675 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5571| accessdate = }}</ref>
'''5'-AMP-activated protein kinase subunit gamma-1''' is an [[enzyme]] that in humans is encoded by the ''PRKAG1'' [[gene]].<ref name="pmid8557660">{{cite journal | vauthors = Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE | title = Mammalian AMP-activated protein kinase subfamily | journal = The Journal of Biological Chemistry | volume = 271 | issue = 2 | pages = 611–4 | date = January 1996 | pmid = 8557660 | pmc =  | doi = 10.1074/jbc.271.2.611 }}</ref><ref name="pmid8621499">{{cite journal | vauthors = Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR, Kemp BE, Witters LA | title = Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase | journal = The Journal of Biological Chemistry | volume = 271 | issue = 15 | pages = 8675–81 | date = April 1996 | pmid = 8621499 | pmc =  | doi = 10.1074/jbc.271.15.8675 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5571| access-date = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = The protein encoded by this gene is a regulatory subunit of the [[AMP-activated protein kinase]] (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref name="entrez"/>
}}


==Interactions==
The protein encoded by this gene is a regulatory subunit of the [[AMP-activated protein kinase]] (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus [[phosphorylation|phosphorylates]] and inactivates [[acetyl-CoA carboxylase]] (ACC) and [[HMG-CoA reductase|beta-hydroxy beta-methylglutaryl-CoA reductase]] (HMGCR), key enzymes involved in regulating de novo biosynthesis of [[fatty acid]] and [[cholesterol]]. This subunit is one of the gamma regulatory subunits of AMPK. [[Alternative splicing|Alternatively spliced]] transcript variants encoding distinct [[Protein isoform|isoforms]] have been observed.<ref name="entrez"/>
PRKAG1 has been shown to [[Protein-protein interaction|interact]] with [[PRKAB2]]<ref name=pmid10698692>{{cite journal |last=Cheung |first=P C |authorlink= |author2=Salt I P |author3=Davies S P |author4=Hardie D G |author5=Carling D  |date=March 2000  |title=Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding |journal=Biochem. J. |volume=346 Pt 3 |issue= 3|pages=659–69 |publisher= |location = ENGLAND| issn = 0264-6021| pmid = 10698692 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1220898 | doi=10.1042/0264-6021:3460659}}</ref> and [[PRKAB1]].<ref name=pmid10698692/>


==References==
== Interactions ==
 
PRKAG1 has been shown to [[Protein-protein interaction|interact]] with [[PRKAB2]]<ref name=pmid10698692>{{cite journal | vauthors = Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D | title = Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding | journal = The Biochemical Journal | volume = 346 Pt 3 | issue = 3 | pages = 659–69 | date = March 2000 | pmid = 10698692 | pmc = 1220898 | doi = 10.1042/0264-6021:3460659 }}</ref> and [[PRKAB1]].<ref name=pmid10698692/>
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL | title = HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism | journal = Journal of Immunology | volume = 145 | issue = 11 | pages = 3699–705 | date = December 1990 | pmid = 1978848 | doi =  }}
| citations =
* {{cite journal | vauthors = Beebe SJ, Oyen O, Sandberg M, Frøysa A, Hansson V, Jahnsen T | title = Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase | journal = Molecular Endocrinology | volume = 4 | issue = 3 | pages = 465–75 | date = March 1990 | pmid = 2342480 | doi = 10.1210/mend-4-3-465 }}
*{{cite journal   |vauthors=Hofmann B, Nishanian P, Baldwin RL, etal |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi=  }}
* {{cite journal | vauthors = Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL | title = Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 14 | pages = 6676–80 | date = July 1993 | pmid = 7688126 | pmc = 46995 | doi = 10.1073/pnas.90.14.6676 | bibcode = 1993PNAS...90.6676H }}
*{{cite journal   |vauthors=Beebe SJ, Oyen O, Sandberg M, etal |title=Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase |journal=Mol. Endocrinol. |volume=4 |issue= 3 |pages= 465–75 |year= 1990 |pmid= 2342480 |doi=10.1210/mend-4-3-465 }}
* {{cite journal | vauthors = Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL | title = HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro | journal = AIDS | volume = 8 | issue = 7 | pages = 1016–7 | date = July 1994 | pmid = 7946090 | doi = 10.1097/00002030-199407000-00025 }}
*{{cite journal   |vauthors=Hofmann B, Nishanian P, Nguyen T, etal |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=10.1073/pnas.90.14.6676 | pmc=46995  }}
* {{cite journal | vauthors = Woods A, Cheung PC, Smith FC, Davison MD, Scott J, Beri RK, Carling D | title = Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro | journal = The Journal of Biological Chemistry | volume = 271 | issue = 17 | pages = 10282–90 | date = April 1996 | pmid = 8626596 | doi = 10.1074/jbc.271.48.30517 }}
*{{cite journal   |vauthors=Hofmann B, Nishanian P, Fan J, etal |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=10.1097/00002030-199407000-00025 }}
* {{cite journal | vauthors = Dyck JR, Gao G, Widmer J, Stapleton D, Fernandez CS, Kemp BE, Witters LA | title = Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits | journal = The Journal of Biological Chemistry | volume = 271 | issue = 30 | pages = 17798–803 | date = July 1996 | pmid = 8663446 | doi = 10.1074/jbc.271.30.17798 }}
*{{cite journal   |vauthors=Woods A, Cheung PC, Smith FC, etal |title=Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10282–90 |year= 1996 |pmid= 8626596 |doi= 10.1074/jbc.271.48.30517}}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal   |vauthors=Dyck JR, Gao G, Widmer J, etal |title=Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 17798–803 |year= 1996 |pmid= 8663446 |doi=10.1074/jbc.271.30.17798 }}
* {{cite journal | vauthors = Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D | title = The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix | journal = Journal of Virology | volume = 71 | issue = 6 | pages = 4372–7 | date = June 1997 | pmid = 9151826 | pmc = 191654 | doi =  }}
*{{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE | title = AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location | journal = FEBS Letters | volume = 409 | issue = 3 | pages = 452–6 | date = June 1997 | pmid = 9224708 | doi = 10.1016/S0014-5793(97)00569-3 }}
*{{cite journal   |vauthors=Swingler S, Gallay P, Camaur D, etal |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372–7 |year= 1997 |pmid= 9151826 |doi= | pmc=191654 }}
* {{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases | journal = The Journal of Biological Chemistry | volume = 272 | issue = 36 | pages = 22385–8 | date = September 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 }}
*{{cite journal   |vauthors=Stapleton D, Woollatt E, Mitchelhill KI, etal |title=AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location |journal=FEBS Lett. |volume=409 |issue= 3 |pages= 452–6 |year= 1997 |pmid= 9224708 |doi=10.1016/S0014-5793(97)00569-3 }}
* {{cite journal | vauthors = Reinton N, Haugen TB, Orstavik S, Skålhegg BS, Hansson V, Jahnsen T, Taskén K | title = The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon | journal = Genomics | volume = 49 | issue = 2 | pages = 290–7 | date = April 1998 | pmid = 9598317 | doi = 10.1006/geno.1998.5240 }}
*{{cite journal |vauthors=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=10.1074/jbc.272.36.22385 }}
* {{cite journal | vauthors = Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F | title = Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways | journal = AIDS Research and Human Retroviruses | volume = 14 | issue = 10 | pages = 825–33 | date = July 1998 | pmid = 9671211 | doi = 10.1089/aid.1998.14.825 }}
*{{cite journal   |vauthors=Reinton N, Haugen TB, Orstavik S, etal |title=The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon |journal=Genomics |volume=49 |issue= 2 |pages= 290–7 |year= 1998 |pmid= 9598317 |doi= 10.1006/geno.1998.5240 }}
* {{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease | journal = Neuroimmunomodulation | volume = 5 | issue = 3-4 | pages = 184–92 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 }}
*{{cite journal   |vauthors=Zidovetzki R, Wang JL, Chen P, etal |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825–33 |year= 1998 |pmid= 9671211 |doi=10.1089/aid.1998.14.825 }}
* {{cite journal | vauthors = Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D | title = Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding | journal = The Biochemical Journal | volume = 346 Pt 3 | issue = 3 | pages = 659–69 | date = March 2000 | pmid = 10698692 | pmc = 1220898 | doi = 10.1042/0264-6021:3460659 }}
*{{cite journal   |vauthors=Mayne M, Bratanich AC, Chen P, etal |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease |journal=Neuroimmunomodulation |volume=5 |issue= 3–4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=10.1159/000026336 }}
* {{cite journal | vauthors = Hamilton SR, Stapleton D, O'Donnell JB, Kung JT, Dalal SR, Kemp BE, Witters LA | title = An activating mutation in the gamma1 subunit of the AMP-activated protein kinase | journal = FEBS Letters | volume = 500 | issue = 3 | pages = 163–8 | date = July 2001 | pmid = 11445078 | doi = 10.1016/S0014-5793(01)02602-3 }}
*{{cite journal   |vauthors=Cheung PC, Salt IP, Davies SP, etal |title=Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding |journal=Biochem. J. |volume=346 Pt 3 |issue= 3|pages= 659–69 |year= 2000 |pmid= 10698692 |doi=10.1042/0264-6021:3460659 | pmc=1220898  }}
* {{cite journal | vauthors = Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB | title = AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus | journal = Nature | volume = 428 | issue = 6982 | pages = 569–74 | date = April 2004 | pmid = 15058305 | doi = 10.1038/nature02440 | bibcode = 2004Natur.428..569M }}
*{{cite journal   |vauthors=Hamilton SR, Stapleton D, O'Donnell JB, etal |title=An activating mutation in the gamma1 subunit of the AMP-activated protein kinase |journal=FEBS Lett. |volume=500 |issue= 3 |pages= 163–8 |year= 2001 |pmid= 11445078 |doi=10.1016/S0014-5793(01)02602-3 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Minokoshi Y, Alquier T, Furukawa N, etal |title=AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus |journal=Nature |volume=428 |issue= 6982 |pages= 569–74 |year= 2004 |pmid= 15058305 |doi= 10.1038/nature02440 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5571}}
{{PDB Gallery|geneid=5571}}
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{{Enzymes}}
{{Enzymes}}
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{{Portal bar|Molecular and Cellular Biology|border=no}}
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[[Category:EC 2.7.11]]
[[Category:EC 2.7.11]]

Latest revision as of 17:38, 9 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

5'-AMP-activated protein kinase subunit gamma-1 is an enzyme that in humans is encoded by the PRKAG1 gene.[1][2][3]

Function

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[3]

Interactions

PRKAG1 has been shown to interact with PRKAB2[4] and PRKAB1.[4]

References

  1. ↑ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (January 1996). "Mammalian AMP-activated protein kinase subfamily". The Journal of Biological Chemistry. 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660.
  2. ↑ Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR, Kemp BE, Witters LA (April 1996). "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase". The Journal of Biological Chemistry. 271 (15): 8675–81. doi:10.1074/jbc.271.15.8675. PMID 8621499.
  3. ↑ 3.0 3.1 "Entrez Gene: PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit".
  4. ↑ 4.0 4.1 Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D (March 2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". The Biochemical Journal. 346 Pt 3 (3): 659–69. doi:10.1042/0264-6021:3460659. PMC 1220898. PMID 10698692.

Further reading


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