PHKB: Difference between revisions

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{{Infobox_gene}}
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'''Phosphorylase b kinase regulatory subunit beta''' is an [[enzyme]] that in humans is encoded by the ''PHKB'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PHKB phosphorylase kinase, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5257| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Phosphorylase kinase, beta
| HGNCid = 8927
| Symbol = PHKB
| AltSymbols =; DKFZp781E15103; FLJ41698
| OMIM = 172490
| ECnumber = 
| Homologene = 247
| MGIid = 97578
| Function = {{GNF_GO|id=GO:0004689 |text = phosphorylase kinase activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0008607 |text = phosphorylase kinase regulator activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0005980 |text = glycogen catabolic process}} {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5257
    | Hs_Ensembl = ENSG00000102893
    | Hs_RefseqProtein = NP_000284
    | Hs_RefseqmRNA = NM_000293
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 46052739
    | Hs_GenLoc_end = 46291657
    | Hs_Uniprot = Q93100
    | Mm_EntrezGene = 102093
    | Mm_Ensembl = ENSMUSG00000036879
    | Mm_RefseqmRNA = NM_199446
    | Mm_RefseqProtein = NP_955517
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 88731107
    | Mm_GenLoc_end = 88950754
    | Mm_Uniprot = Q3U6H6
  }}
}}
'''Phosphorylase kinase, beta''', also known as '''PHKB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PHKB phosphorylase kinase, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5257| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Brushia RJ, Walsh DA |title=Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure. |journal=Front. Biosci. |volume=4 |issue=  |pages= D618-41 |year= 1999 |pmid= 10487978 |doi=  }}
*{{cite journal  |vauthors=Brushia RJ, Walsh DA |title=Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure. |journal=Front. Biosci. |volume=4 |issue=  |pages= D618–41 |year= 1999 |pmid= 10487978 |doi=10.2741/Brushia }}
*{{cite journal  | author=Daube H, Billich A, Mann K, Schramm HJ |title=Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 3 |pages= 892-8 |year= 1991 |pmid= 1872871 |doi=  }}
*{{cite journal  |vauthors=Daube H, Billich A, Mann K, Schramm HJ |title=Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 3 |pages= 892–8 |year= 1991 |pmid= 1872871 |doi=10.1016/0006-291X(91)90975-D }}
*{{cite journal  | author=Francke U, Darras BT, Zander NF, Kilimann MW |title=Assignment of human genes for phosphorylase kinase subunits alpha (PHKA) to Xq12-q13 and beta (PHKB) to 16q12-q13. |journal=Am. J. Hum. Genet. |volume=45 |issue= 2 |pages= 276-82 |year= 1989 |pmid= 2757032 |doi=  }}
*{{cite journal  |vauthors=Francke U, Darras BT, Zander NF, Kilimann MW |title=Assignment of human genes for phosphorylase kinase subunits alpha (PHKA) to Xq12-q13 and beta (PHKB) to 16q12-q13. |journal=Am. J. Hum. Genet. |volume=45 |issue= 2 |pages= 276–82 |year= 1989 |pmid= 2757032 |doi= | pmc=1683359 }}
*{{cite journal  | author=Wüllrich-Schmoll A, Kilimann MW |title=Structure of the human gene encoding the phosphorylase kinase beta subunit (PHKB). |journal=Eur. J. Biochem. |volume=238 |issue= 2 |pages= 374-80 |year= 1996 |pmid= 8681948 |doi=  }}
*{{cite journal  |vauthors=Wüllrich-Schmoll A, Kilimann MW |title=Structure of the human gene encoding the phosphorylase kinase beta subunit (PHKB). |journal=Eur. J. Biochem. |volume=238 |issue= 2 |pages= 374–80 |year= 1996 |pmid= 8681948 |doi=10.1111/j.1432-1033.1996.0374z.x }}
*{{cite journal | author=Burwinkel B, Maichele AJ, Aagenaes O, ''et al.'' |title=Autosomal glycogenosis of liver and muscle due to phosphorylase kinase deficiency is caused by mutations in the phosphorylase kinase beta subunit (PHKB). |journal=Hum. Mol. Genet. |volume=6 |issue= 7 |pages= 1109-15 |year= 1997 |pmid= 9215682 |doi=  }}
*{{cite journal   |vauthors=Burwinkel B, Maichele AJ, Aagenaes O, etal |title=Autosomal glycogenosis of liver and muscle due to phosphorylase kinase deficiency is caused by mutations in the phosphorylase kinase beta subunit (PHKB). |journal=Hum. Mol. Genet. |volume=6 |issue= 7 |pages= 1109–15 |year= 1997 |pmid= 9215682 |doi=10.1093/hmg/6.7.1109 }}
*{{cite journal | author=van den Berg IE, van Beurden EA, de Klerk JB, ''et al.'' |title=Autosomal recessive phosphorylase kinase deficiency in liver, caused by mutations in the gene encoding the beta subunit (PHKB). |journal=Am. J. Hum. Genet. |volume=61 |issue= 3 |pages= 539-46 |year= 1997 |pmid= 9326319 |doi=  }}
*{{cite journal   |vauthors=van den Berg IE, van Beurden EA, de Klerk JB, etal |title=Autosomal recessive phosphorylase kinase deficiency in liver, caused by mutations in the gene encoding the beta subunit (PHKB). |journal=Am. J. Hum. Genet. |volume=61 |issue= 3 |pages= 539–46 |year= 1997 |pmid= 9326319 |doi=10.1086/515502  | pmc=1715950 }}
*{{cite journal  | author=Burwinkel B, Moses SW, Kilimann MW |title=Phosphorylase-kinase-deficient liver glycogenosis with an unusual biochemical phenotype in blood cells associated with a missense mutation in the beta subunit gene (PHKB). |journal=Hum. Genet. |volume=101 |issue= 2 |pages= 170-4 |year= 1998 |pmid= 9402963 |doi=  }}
*{{cite journal  |vauthors=Burwinkel B, Moses SW, Kilimann MW |title=Phosphorylase-kinase-deficient liver glycogenosis with an unusual biochemical phenotype in blood cells associated with a missense mutation in the beta subunit gene (PHKB). |journal=Hum. Genet. |volume=101 |issue= 2 |pages= 170–4 |year= 1998 |pmid= 9402963 |doi=10.1007/s004390050608 }}
*{{cite journal  | author=Burwinkel B, Kilimann MW |title=Unequal homologous recombination between LINE-1 elements as a mutational mechanism in human genetic disease. |journal=J. Mol. Biol. |volume=277 |issue= 3 |pages= 513-7 |year= 1998 |pmid= 9533876 |doi= 10.1006/jmbi.1998.1641 }}
*{{cite journal  |vauthors=Burwinkel B, Kilimann MW |title=Unequal homologous recombination between LINE-1 elements as a mutational mechanism in human genetic disease. |journal=J. Mol. Biol. |volume=277 |issue= 3 |pages= 513–7 |year= 1998 |pmid= 9533876 |doi= 10.1006/jmbi.1998.1641 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Burwinkel B, Hu B, Schroers A, ''et al.'' |title=Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases. |journal=Eur. J. Hum. Genet. |volume=11 |issue= 7 |pages= 516-26 |year= 2004 |pmid= 12825073 |doi= 10.1038/sj.ejhg.5200996 }}
*{{cite journal   |vauthors=Burwinkel B, Hu B, Schroers A, etal |title=Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases. |journal=Eur. J. Hum. Genet. |volume=11 |issue= 7 |pages= 516–26 |year= 2004 |pmid= 12825073 |doi= 10.1038/sj.ejhg.5200996 }}
*{{cite journal  | author=Pallen MJ |title=Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase. |journal=Protein Sci. |volume=12 |issue= 8 |pages= 1804-7 |year= 2004 |pmid= 12876330 |doi=  }}
*{{cite journal  | author=Pallen MJ |title=Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase. |journal=Protein Sci. |volume=12 |issue= 8 |pages= 1804–7 |year= 2004 |pmid= 12876330 |doi=10.1110/ps.0371103  | pmc=2323967 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


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==External links==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/books/NBK55061/  GeneReviews/NCBI/NIH/UW entry on Phosphorylase Kinase Deficiency, Glycogen Storage Disease Type IX]
 
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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[[Category:EC 2.7.11]]
 
 
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Revision as of 18:03, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphorylase b kinase regulatory subunit beta is an enzyme that in humans is encoded by the PHKB gene.[1]


References

  1. ↑ "Entrez Gene: PHKB phosphorylase kinase, beta".

Further reading

External links


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