MAP3K10: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Mitogen-activated protein kinase kinase kinase 10''' is an [[enzyme]] that in humans is encoded by the ''MAP3K10'' [[gene]].<ref name="pmid8536694">{{cite journal | vauthors = Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ | title = Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2 | journal = Eur J Biochem | volume = 234 | issue = 2 | pages = 492–500 | date = February 1996 | pmid = 8536694 | pmc =  | doi = 10.1111/j.1432-1033.1995.492_b.x }}</ref><ref name="pmid7731697">{{cite journal | vauthors = Katoh M, Hirai M, Sugimura T, Terada M | title = Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain | journal = Oncogene | volume = 10 | issue = 7 | pages = 1447–51 | date = May 1995 | pmid = 7731697 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4294| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitogen-activated protein kinase kinase kinase 10
| HGNCid = 6849
| Symbol = MAP3K10
| AltSymbols =; MLK2; MST
| OMIM = 600137
| ECnumber = 
| Homologene = 1834
| MGIid = 1346879
| GeneAtlas_image1 = PBB_GE_MAP3K10_206362_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004706 |text = JUN kinase kinase kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007257 |text = activation of JNK activity}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4294
    | Hs_Ensembl = ENSG00000130758
    | Hs_RefseqProtein = NP_002437
    | Hs_RefseqmRNA = NM_002446
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 45389491
    | Hs_GenLoc_end = 45413314
    | Hs_Uniprot = Q02779
    | Mm_EntrezGene = 269881
    | Mm_Ensembl = ENSMUSG00000040390
    | Mm_RefseqmRNA = XM_001000402
    | Mm_RefseqProtein = XP_001000402
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 27365137
    | Mm_GenLoc_end = 27382380
    | Mm_Uniprot = 
  }}
}}
'''Mitogen-activated protein kinase kinase kinase 10''', also known as '''MAP3K10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4294| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4294| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAP3K10 has been shown to [[Protein-protein interaction|interact]] with:
* [[CDC42]],<ref name = pmid9427749/>
* [[Huntingtin]],<ref name = pmid10801775>{{cite journal | vauthors = Liu YF, Dorow D, Marshall J | title = Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin | journal = J. Biol. Chem. | volume = 275 | issue = 25 | pages = 19035–40 | date = June 2000 | pmid = 10801775 | doi = 10.1074/jbc.C000180200 }}</ref>
* [[KIF3A]],<ref name = pmid9427749>{{cite journal | vauthors = ((Nagata Ki)), Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A | title = The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 | journal = EMBO J. | volume = 17 | issue = 1 | pages = 149–58 | date = January 1998 | pmid = 9427749 | pmc = 1170366 | doi = 10.1093/emboj/17.1.149 }}</ref>
* [[MAPK8IP1]],<ref name = pmid10490659>{{cite journal | vauthors = Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ | title = The JIP group of mitogen-activated protein kinase scaffold proteins | journal = Mol. Cell. Biol. | volume = 19 | issue = 10 | pages = 7245–54 | date = October 1999 | pmid = 10490659 | pmc = 84717 | doi =  10.1128/mcb.19.10.7245}}</ref>
* [[MAPK8IP2]],<ref name = pmid10490659/> and
* [[NEUROD1]].<ref name = pmid12881483>{{cite journal | vauthors = Marcora E, Gowan K, Lee JE | title = Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 16 | pages = 9578–83 | date = August 2003 | pmid = 12881483 | pmc = 170960 | doi = 10.1073/pnas.1133382100 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ | title = Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity | journal = J. Biol. Chem. | volume = 269 | issue = 21 | pages = 15092–100 | year = 1994 | pmid = 8195146 | doi =  }}
| citations =
* {{cite journal | vauthors = Dorow DS, Devereux L, Dietzsch E, De Kretser T | title = Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains | journal = Eur. J. Biochem. | volume = 213 | issue = 2 | pages = 701–10 | year = 1993 | pmid = 8477742 | doi = 10.1111/j.1432-1033.1993.tb17810.x }}
*{{cite journal | author=Katoh M, Hirai M, Sugimura T, Terada M |title=Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. |journal=Oncogene |volume=10 |issue= 7 |pages= 1447-51 |year= 1995 |pmid= 7731697 |doi=  }}
* {{cite journal | vauthors = ((Hirai Si)), Katoh M, Terada M, Kyriakis JM, Zon LI, Rana A, Avruch J, Ohno S | title = MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase | journal = J. Biol. Chem. | volume = 272 | issue = 24 | pages = 15167–73 | year = 1997 | pmid = 9182538 | doi = 10.1074/jbc.272.24.15167 }}
*{{cite journal  | author=Gallo KA, Mark MR, Scadden DT, ''et al.'' |title=Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. |journal=J. Biol. Chem. |volume=269 |issue= 21 |pages= 15092-100 |year= 1994 |pmid= 8195146 |doi=  }}
* {{cite journal | vauthors = ((Hirai Si)), Noda K, Moriguchi T, Nishida E, Yamashita A, Deyama T, Fukuyama K, Ohno S | title = Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2 | journal = J. Biol. Chem. | volume = 273 | issue = 13 | pages = 7406–12 | year = 1998 | pmid = 9516438 | doi = 10.1074/jbc.273.13.7406 }}
*{{cite journal | author=Dorow DS, Devereux L, Dietzsch E, De Kretser T |title=Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. |journal=Eur. J. Biochem. |volume=213 |issue= 2 |pages= 701-10 |year= 1993 |pmid= 8477742 |doi= }}
* {{cite journal | vauthors = Rasmussen RK, Ji H, Eddes JS, Moritz RL, Reid GE, Simpson RJ, Dorow DS | title = Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins | journal = Electrophoresis | volume = 19 | issue = 5 | pages = 809–17 | year = 1998 | pmid = 9629920 | doi = 10.1002/elps.1150190535 }}
*{{cite journal  | author=Dorow DS, Devereux L, Tu GF, ''et al.'' |title=Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. |journal=Eur. J. Biochem. |volume=234 |issue= 2 |pages= 492-500 |year= 1996 |pmid= 8536694 |doi=  }}
* {{cite journal | vauthors = Rasmussen RK, Rusak J, Price G, Robinson PJ, Simpson RJ, Dorow DS | title = Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid | journal = Biochem. J. | volume = 335 | issue = Pt 1 | pages = 119–24 | year = 1998 | pmid = 9742220 | pmc = 1219759 | doi =  10.1042/bj3350119}}
*{{cite journal | author=Hirai S, Katoh M, Terada M, ''et al.'' |title=MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15167-73 |year= 1997 |pmid= 9182538 |doi=  }}
* {{cite journal | vauthors = Liu YF, Dorow D, Marshall J | title = Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin | journal = J. Biol. Chem. | volume = 275 | issue = 25 | pages = 19035–40 | year = 2000 | pmid = 10801775 | doi = 10.1074/jbc.C000180200 }}
*{{cite journal  | author=Nagata K, Puls A, Futter C, ''et al.'' |title=The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. |journal=EMBO J. |volume=17 |issue= 1 |pages= 149-58 |year= 1998 |pmid= 9427749 |doi= 10.1093/emboj/17.1.149 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA Cloning Using In Vitro Site-Specific Recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Hirai S, Noda K, Moriguchi T, ''et al.'' |title=Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7406-12 |year= 1998 |pmid= 9516438 |doi= }}
* {{cite journal | vauthors = Savinainen A, Garcia EP, Dorow D, Marshall J, Liu YF | title = Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95 | journal = J. Biol. Chem. | volume = 276 | issue = 14 | pages = 11382–6 | year = 2001 | pmid = 11152698 | doi = 10.1074/jbc.M100190200 }}
*{{cite journal | author=Rasmussen RK, Ji H, Eddes JS, ''et al.'' |title=Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins. |journal=Electrophoresis |volume=19 |issue= 5 |pages= 809-17 |year= 1998 |pmid= 9629920 |doi= 10.1002/elps.1150190535 }}
* {{cite journal | vauthors = Xu Z, Maroney AC, Dobrzanski P, Kukekov NV, Greene LA | title = The MLK Family Mediates c-Jun N-Terminal Kinase Activation in Neuronal Apoptosis | journal = Mol. Cell. Biol. | volume = 21 | issue = 14 | pages = 4713–24 | year = 2001 | pmid = 11416147 | pmc = 87148 | doi = 10.1128/MCB.21.14.4713-4724.2001 }}
*{{cite journal | author=Rasmussen RK, Rusak J, Price G, ''et al.'' |title=Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid. |journal=Biochem. J. |volume=335 ( Pt 1) |issue= |pages= 119-24 |year= 1998 |pmid= 9742220 |doi=  }}
* {{cite journal | vauthors = Poy MN, Yang Y, Rezaei K, Fernström MA, Lee AD, Kido Y, Erickson SK, Najjar SM | title = CEACAM1 regulates insulin clearance in liver | journal = Nat. Genet. | volume = 30 | issue = 3 | pages = 270–6 | year = 2002 | pmid = 11850617 | doi = 10.1038/ng840 }}
*{{cite journal | author=Liu YF, Dorow D, Marshall J |title=Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19035-40 |year= 2000 |pmid= 10801775 |doi= 10.1074/jbc.C000180200 }}
* {{cite journal | vauthors = Akbarzadeh S, Ji H, Frecklington D, Marmy-Conus N, Mok YF, Bowes L, Devereux L, Linsenmeyer M, Simpson RJ, Dorow DS | title = Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking | journal = J. Biol. Chem. | volume = 277 | issue = 39 | pages = 36280–7 | year = 2002 | pmid = 12105200 | doi = 10.1074/jbc.M204626200 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Figueroa C, Tarras S, Taylor J, Vojtek AB | title = Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex | journal = J. Biol. Chem. | volume = 278 | issue = 48 | pages = 47922–7 | year = 2004 | pmid = 14504284 | doi = 10.1074/jbc.M307357200 }}
*{{cite journal | author=Savinainen A, Garcia EP, Dorow D, ''et al.'' |title=Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. |journal=J. Biol. Chem. |volume=276 |issue= 14 |pages= 11382-6 |year= 2001 |pmid= 11152698 |doi= 10.1074/jbc.M100190200 }}
* {{cite journal | vauthors = Eckey M, Tenbaum SP, Muñoz A, Baniahmad A | title = Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors | journal = Mol. Cell. Endocrinol. | volume = 213 | issue = 1 | pages = 71–8 | year = 2004 | pmid = 15062575 | doi = 10.1016/j.mce.2003.10.035 }}
*{{cite journal | author=Xu Z, Maroney AC, Dobrzanski P, ''et al.'' |title=The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4713-24 |year= 2001 |pmid= 11416147 |doi= 10.1128/MCB.21.14.4713-4724.2001 }}
* {{cite journal | vauthors = Jaffe AB, Hall A, Schmidt A | title = Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho | journal = Curr. Biol. | volume = 15 | issue = 5 | pages = 405–12 | year = 2005 | pmid = 15753034 | doi = 10.1016/j.cub.2004.12.082 }}
*{{cite journal | author=Poy MN, Yang Y, Rezaei K, ''et al.'' |title=CEACAM1 regulates insulin clearance in liver. |journal=Nat. Genet. |volume=30 |issue= 3 |pages= 270-6 |year= 2002 |pmid= 11850617 |doi= 10.1038/ng840 }}
* {{cite journal | vauthors = Kollers S, Musilova P, Rubes J, Rocha D | title = Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13 | journal = Anim. Genet. | volume = 37 | issue = 6 | pages = 595–6 | year = 2007 | pmid = 17121608 | doi = 10.1111/j.1365-2052.2006.01516.x }}
*{{cite journal | author=Akbarzadeh S, Ji H, Frecklington D, ''et al.'' |title=Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36280-7 |year= 2002 |pmid= 12105200 |doi= 10.1074/jbc.M204626200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Figueroa C, Tarras S, Taylor J, Vojtek AB |title=Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47922-7 |year= 2004 |pmid= 14504284 |doi= 10.1074/jbc.M307357200 }}
*{{cite journal | author=Eckey M, Tenbaum SP, Muñoz A, Baniahmad A |title=Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors. |journal=Mol. Cell. Endocrinol. |volume=213 |issue= 1 |pages= 71-8 |year= 2004 |pmid= 15062575 |doi= 10.1016/j.mce.2003.10.035 }}
*{{cite journal | author=Jaffe AB, Hall A, Schmidt A |title=Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. |journal=Curr. Biol. |volume=15 |issue= 5 |pages= 405-12 |year= 2005 |pmid= 15753034 |doi= 10.1016/j.cub.2004.12.082 }}
*{{cite journal | author=Kollers S, Musilova P, Rubes J, Rocha D |title=Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13. |journal=Anim. Genet. |volume=37 |issue= 6 |pages= 595-6 |year= 2007 |pmid= 17121608 |doi= 10.1111/j.1365-2052.2006.01516.x }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:05, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.[3]

Interactions

MAP3K10 has been shown to interact with:

References

  1. ↑ Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ (February 1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem. 234 (2): 492–500. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694.
  2. ↑ Katoh M, Hirai M, Sugimura T, Terada M (May 1995). "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene. 10 (7): 1447–51. PMID 7731697.
  3. ↑ 3.0 3.1 "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10".
  4. ↑ 4.0 4.1 Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
  5. ↑ Liu YF, Dorow D, Marshall J (June 2000). "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem. 275 (25): 19035–40. doi:10.1074/jbc.C000180200. PMID 10801775.
  6. ↑ 6.0 6.1 Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (October 1999). "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659.
  7. ↑ Marcora E, Gowan K, Lee JE (August 2003). "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proc. Natl. Acad. Sci. U.S.A. 100 (16): 9578–83. doi:10.1073/pnas.1133382100. PMC 170960. PMID 12881483.

Further reading


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