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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Interferon-alpha/beta receptor beta chain''' is a [[protein]] that in humans is encoded by the ''IFNAR2'' [[gene]].<ref name="pmid8181059">{{cite journal | vauthors = Novick D, Cohen B, Rubinstein M | title = The human interferon alpha/beta receptor: characterization and molecular cloning | journal = Cell | volume = 77 | issue = 3 | pages = 391–400  | date = June 1994 | pmid = 8181059 | pmc =  | doi = 10.1016/0092-8674(94)90154-6 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IFNAR2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n6u.
| Name = Interferon (alpha, beta and omega) receptor 2
| HGNCid = 5433
| Symbol = IFNAR2
| AltSymbols =; IFN-alpha-REC; IFN-R; IFNABR; IFNARB
| OMIM = 602376
| ECnumber = 
| Homologene = 49242
| MGIid = 1098243
| GeneAtlas_image1 = PBB_GE_IFNAR2_204786_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IFNAR2_204785_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004905 |text = interferon-alpha/beta receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
  | Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3455
    | Hs_Ensembl = ENSG00000159110
    | Hs_RefseqProtein = NP_000865
    | Hs_RefseqmRNA = NM_000874
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 33524076
    | Hs_GenLoc_end = 33559839
    | Hs_Uniprot = P48551
    | Mm_EntrezGene = 15976
    | Mm_Ensembl = ENSMUSG00000022971
    | Mm_RefseqmRNA = NM_010509
    | Mm_RefseqProtein = NP_034639
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 91261758
    | Mm_GenLoc_end = 91294444
    | Mm_Uniprot = Q3UCC3
  }}
}}
{{CMG}}
__NOTOC__


== Function ==


==Overview==
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3455| accessdate = }}</ref>


'''Interferon (alpha, beta and omega) receptor 2''', also known as '''IFNAR2''', is a human [[gene]].
== Interactions ==


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
IFNAR2 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[GNB2L1]],<ref name = pmid11301323/><ref name = pmid11046044>{{cite journal | vauthors = Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O | title = Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor | journal = J. Immunol. | volume = 165 | issue = 9 | pages = 5127–32  | date = November 2000 | pmid = 11046044 | doi = 10.4049/jimmunol.165.9.5127}}</ref>  
| section_title =  
* [[IFNA2]],<ref name = pmid10339405>{{cite journal | vauthors = Piehler J, Schreiber G | title = Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2 | journal = J. Mol. Biol. | volume = 289 | issue = 1 | pages = 57–67  | date = May 1999 | pmid = 10339405 | doi = 10.1006/jmbi.1999.2726 }}</ref>
| summary_text = The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3455| accessdate = }}</ref>
* [[STAT1]],<ref name = pmid11301323>{{cite journal | vauthors = Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O | title = The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22948–53  | date = June 2001 | pmid = 11301323 | doi = 10.1074/jbc.M100087200 }}</ref><ref name = pmid9121453/>  and
}}
* [[STAT2]].<ref name = pmid9121453>{{cite journal | vauthors = Li X, Leung S, Kerr IM, Stark GR | title = Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 2048–56  | date = April 1997 | pmid = 9121453 | pmc = 232052 | doi =  10.1128/mcb.17.4.2048}}</ref><ref name = pmid11786546>{{cite journal | vauthors = Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ | title = Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling | journal = J. Biol. Chem. | volume = 277 | issue = 12 | pages = 9713–21  | date = March 2002 | pmid = 11786546 | doi = 10.1074/jbc.M111161200 }}</ref>


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A | title = Alpha-interferon and its effects on signal transduction pathways | journal = J. Cell. Physiol. | volume = 202 | issue = 2 | pages = 323–35 | year = 2005 | pmid = 15389589 | doi = 10.1002/jcp.20137 }}
| citations =
* {{cite journal | vauthors = Raz R, Cheung K, Ling L, Levy DE | title = Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness | journal = Somat. Cell Mol. Genet. | volume = 21 | issue = 2 | pages = 139–45 | year = 1995 | pmid = 7570186 | doi = 10.1007/BF02255789 }}
*{{cite journal | author=Caraglia M, Marra M, Pelaia G, ''et al.'' |title=Alpha-interferon and its effects on signal transduction pathways. |journal=J. Cell. Physiol. |volume=202 |issue= 2 |pages= 323-35 |year= 2005 |pmid= 15389589 |doi= 10.1002/jcp.20137 }}
* {{cite journal | vauthors = Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE | title = Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster | journal = EMBO J. | volume = 14 | issue = 20 | pages = 5100–8 | year = 1995 | pmid = 7588638 | pmc = 394613 | doi =  }}
*{{cite journal | author=Raz R, Cheung K, Ling L, Levy DE |title=Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness. |journal=Somat. Cell Mol. Genet. |volume=21 |issue= 2 |pages= 139-45 |year= 1995 |pmid= 7570186 |doi= }}
* {{cite journal | vauthors = Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR | title = Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21606–11 | year = 1995 | pmid = 7665574 | doi = 10.1074/jbc.270.37.21606 }}
*{{cite journal | author=Lutfalla G, Holland SJ, Cinato E, ''et al.'' |title=Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. |journal=EMBO J. |volume=14 |issue= 20 |pages= 5100-8 |year= 1995 |pmid= 7588638 |doi=  }}
* {{cite journal | vauthors = Novick D, Cohen B, Tal N, Rubinstein M | title = Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor | journal = J. Leukoc. Biol. | volume = 57 | issue = 5 | pages = 712–8 | year = 1995 | pmid = 7759950 | doi =  }}
*{{cite journal | author=Domanski P, Witte M, Kellum M, ''et al.'' |title=Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21606-11 |year= 1995 |pmid= 7665574 |doi= }}
* {{cite journal | vauthors = Platanias LC, Uddin S, Domanski P, Colamonici OR | title = Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor | journal = J. Biol. Chem. | volume = 271 | issue = 39 | pages = 23630–3 | year = 1996 | pmid = 8798579 | doi = 10.1074/jbc.271.39.23630 }}
*{{cite journal | author=Novick D, Cohen B, Tal N, Rubinstein M |title=Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. |journal=J. Leukoc. Biol. |volume=57 |issue= 5 |pages= 712-8 |year= 1995 |pmid= 7759950 |doi=  }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Novick D, Cohen B, Rubinstein M |title=The human interferon alpha/beta receptor: characterization and molecular cloning. |journal=Cell |volume=77 |issue= 3 |pages= 391-400 |year= 1994 |pmid= 8181059 |doi= }}
* {{cite journal | vauthors = Croze E, Russell-Harde D, Wagner TC, Pu H, Pfeffer LM, Perez HD | title = The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein | journal = J. Biol. Chem. | volume = 271 | issue = 52 | pages = 33165–8 | year = 1996 | pmid = 8969169 | doi = 10.1074/jbc.271.52.33165 }}
*{{cite journal | author=Platanias LC, Uddin S, Domanski P, Colamonici OR |title=Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 23630-3 |year= 1996 |pmid= 8798579 |doi= }}
* {{cite journal | vauthors = Li X, Leung S, Kerr IM, Stark GR | title = Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 2048–56 | year = 1997 | pmid = 9121453 | pmc = 232052 | doi =  10.1128/mcb.17.4.2048}}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Piehler J, Schreiber G | title = Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2 | journal = J. Mol. Biol. | volume = 289 | issue = 1 | pages = 57–67 | year = 1999 | pmid = 10339405 | doi = 10.1006/jmbi.1999.2726 }}
*{{cite journal | author=Croze E, Russell-Harde D, Wagner TC, ''et al.'' |title=The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein. |journal=J. Biol. Chem. |volume=271 |issue= 52 |pages= 33165-8 |year= 1997 |pmid= 8969169 |doi=  }}
* {{cite journal | vauthors = Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K | title = Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2 | journal = J. Immunol. | volume = 163 | issue = 2 | pages = 766–73 | year = 1999 | pmid = 10395669 | doi = }}
*{{cite journal | author=Li X, Leung S, Kerr IM, Stark GR |title=Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 2048-56 |year= 1997 |pmid= 9121453 |doi= }}
* {{cite journal | vauthors = Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML | title = The DNA sequence of human chromosome 21 | journal = Nature | volume = 405 | issue = 6784 | pages = 311–9 | year = 2000 | pmid = 10830953 | doi = 10.1038/35012518 }}
*{{cite journal | author=Piehler J, Schreiber G |title=Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2. |journal=J. Mol. Biol. |volume=289 |issue= 1 |pages= 57-67 |year= 1999 |pmid= 10339405 |doi= 10.1006/jmbi.1999.2726 }}
* {{cite journal | vauthors = Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O | title = Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor | journal = J. Immunol. | volume = 165 | issue = 9 | pages = 5127–32 | year = 2000 | pmid = 11046044 | doi = 10.4049/jimmunol.165.9.5127 }}
*{{cite journal | author=Chuntharapai A, Gibbs V, Lu J, ''et al.'' |title=Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2. |journal=J. Immunol. |volume=163 |issue= 2 |pages= 766-73 |year= 1999 |pmid= 10395669 |doi=  }}
* {{cite journal | vauthors = Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O | title = The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22948–53 | year = 2001 | pmid = 11301323 | doi = 10.1074/jbc.M100087200 }}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
* {{cite journal | vauthors = Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ | title = Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling | journal = J. Biol. Chem. | volume = 277 | issue = 12 | pages = 9713–21 | year = 2002 | pmid = 11786546 | doi = 10.1074/jbc.M111161200 }}
*{{cite journal | author=Croze E, Usacheva A, Asarnow D, ''et al.'' |title=Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor. |journal=J. Immunol. |volume=165 |issue= 9 |pages= 5127-32 |year= 2000 |pmid= 11046044 |doi= }}
* {{cite journal | vauthors = Chill JH, Nivasch R, Levy R, Albeck S, Schreiber G, Anglister J | title = The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening | journal = Biochemistry | volume = 41 | issue = 11 | pages = 3575–85 | year = 2002 | pmid = 11888273 | doi = 10.1021/bi011778f }}
*{{cite journal | author=Usacheva A, Smith R, Minshall R, ''et al.'' |title=The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22948-53 |year= 2001 |pmid= 11301323 |doi= 10.1074/jbc.M100087200 }}
* {{cite journal | vauthors = Velichko S, Wagner TC, Turkson J, Jove R, Croze E | title = STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues | journal = J. Biol. Chem. | volume = 277 | issue = 38 | pages = 35635–41 | year = 2002 | pmid = 12105218 | doi = 10.1074/jbc.M204578200 }}
*{{cite journal | author=Nguyen VP, Saleh AZ, Arch AE, ''et al.'' |title=Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9713-21 |year= 2002 |pmid= 11786546 |doi= 10.1074/jbc.M111161200 }}
* {{cite journal | vauthors = Usacheva A, Kotenko S, Witte MM, Colamonici OR | title = Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors | journal = J. Immunol. | volume = 169 | issue = 3 | pages = 1302–8 | year = 2002 | pmid = 12133952 | doi = 10.4049/jimmunol.169.3.1302 }}
*{{cite journal | author=Chill JH, Nivasch R, Levy R, ''et al.'' |title=The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening. |journal=Biochemistry |volume=41 |issue= 11 |pages= 3575-85 |year= 2002 |pmid= 11888273 |doi= }}
* {{cite journal | vauthors = Gauzzi MC, Canini I, Eid P, Belardelli F, Gessani S | title = Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells | journal = J. Immunol. | volume = 169 | issue = 6 | pages = 3038–45 | year = 2002 | pmid = 12218119 | doi = 10.4049/jimmunol.169.6.3038 }}
*{{cite journal | author=Velichko S, Wagner TC, Turkson J, ''et al.'' |title=STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35635-41 |year= 2002 |pmid= 12105218 |doi= 10.1074/jbc.M204578200 }}
*{{cite journal | author=Usacheva A, Kotenko S, Witte MM, Colamonici OR |title=Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors. |journal=J. Immunol. |volume=169 |issue= 3 |pages= 1302-8 |year= 2002 |pmid= 12133952 |doi= }}
*{{cite journal | author=Gauzzi MC, Canini I, Eid P, ''et al.'' |title=Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells. |journal=J. Immunol. |volume=169 |issue= 6 |pages= 3038-45 |year= 2002 |pmid= 12218119 |doi=  }}
}}
{{refend}}
{{refend}}


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Latest revision as of 00:31, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.[1]

Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.[2]

Interactions

IFNAR2 has been shown to interact with:

References

  1. ↑ Novick D, Cohen B, Rubinstein M (June 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell. 77 (3): 391–400. doi:10.1016/0092-8674(94)90154-6. PMID 8181059.
  2. ↑ "Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2".
  3. ↑ 3.0 3.1 Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. 276 (25): 22948–53. doi:10.1074/jbc.M100087200. PMID 11301323.
  4. ↑ Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (November 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. doi:10.4049/jimmunol.165.9.5127. PMID 11046044.
  5. ↑ Piehler J, Schreiber G (May 1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID 10339405.
  6. ↑ 6.0 6.1 Li X, Leung S, Kerr IM, Stark GR (April 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
  7. ↑ Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (March 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. 277 (12): 9713–21. doi:10.1074/jbc.M111161200. PMID 11786546.

Further reading

  • Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A (2005). "Alpha-interferon and its effects on signal transduction pathways". J. Cell. Physiol. 202 (2): 323–35. doi:10.1002/jcp.20137. PMID 15389589.
  • Raz R, Cheung K, Ling L, Levy DE (1995). "Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness". Somat. Cell Mol. Genet. 21 (2): 139–45. doi:10.1007/BF02255789. PMID 7570186.
  • Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE (1995). "Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster". EMBO J. 14 (20): 5100–8. PMC 394613. PMID 7588638.
  • Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995). "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling". J. Biol. Chem. 270 (37): 21606–11. doi:10.1074/jbc.270.37.21606. PMID 7665574.
  • Novick D, Cohen B, Tal N, Rubinstein M (1995). "Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor". J. Leukoc. Biol. 57 (5): 712–8. PMID 7759950.
  • Platanias LC, Uddin S, Domanski P, Colamonici OR (1996). "Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor". J. Biol. Chem. 271 (39): 23630–3. doi:10.1074/jbc.271.39.23630. PMID 8798579.
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Croze E, Russell-Harde D, Wagner TC, Pu H, Pfeffer LM, Perez HD (1996). "The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein". J. Biol. Chem. 271 (52): 33165–8. doi:10.1074/jbc.271.52.33165. PMID 8969169.
  • Li X, Leung S, Kerr IM, Stark GR (1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
  • Piehler J, Schreiber G (1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID 10339405.
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