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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''G protein-coupled receptor kinase 5''' is an [[enzyme]] that in humans is encoded by the ''GRK5'' [[gene]].<ref name="pmid7685906">{{cite journal | vauthors = Kunapuli P, Benovic JL | title = Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 12 | pages = 5588–92 | date = Jun 1993 | pmid = 7685906 | pmc = 46766 | doi = 10.1073/pnas.90.12.5588 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GRK5 G protein-coupled receptor kinase 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2869| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor kinase 5
| HGNCid = 4544
| Symbol = GRK5
| AltSymbols =; GPRK5
| OMIM = 600870
| ECnumber = 
| Homologene = 3879
| MGIid = 109161
| GeneAtlas_image1 = PBB_GE_GRK5_204396_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GRK5_204395_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004703 |text = G-protein coupled receptor kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005080 |text = protein kinase C binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0008277 |text = regulation of G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2869
    | Hs_Ensembl = ENSG00000198873
    | Hs_RefseqProtein = NP_005299
    | Hs_RefseqmRNA = NM_005308
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 120957091
    | Hs_GenLoc_end = 121205121
    | Hs_Uniprot = P34947
    | Mm_EntrezGene = 14773
    | Mm_Ensembl = ENSMUSG00000003228
    | Mm_RefseqmRNA = XM_977246
    | Mm_RefseqProtein = XP_982340
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 60945139
    | Mm_GenLoc_end = 61147005
    | Mm_Uniprot = Q3TST4
  }}
}}
'''G protein-coupled receptor kinase 5''', also known as '''GRK5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRK5 G protein-coupled receptor kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2869| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).<ref name="entrez">{{cite web | title = Entrez Gene: GRK5 G protein-coupled receptor kinase 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2869| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).<ref name="entrez">{{cite web | title = Entrez Gene: GRK5 G protein-coupled receptor kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2869| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Komolov KE, Bhardwaj A, Benovic JL | title = Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases | journal = The Journal of Biological Chemistry | volume = 290 | issue = 34 | pages = 20629–47 | date = Aug 2015 | pmid = 26032409 | doi = 10.1074/jbc.M115.647297 }}
| citations =
* {{cite journal | vauthors = Bullrich F, Druck T, Kunapuli P, Gomez J, Gripp KW, Schlegelberger B, Lasota J, Aronson M, Cannizzaro LA, Huebner K | title = Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6 | journal = Cytogenetics and Cell Genetics | volume = 70 | issue = 3-4 | pages = 250–4 | year = 1995 | pmid = 7789183 | doi = 10.1159/000134045 }}
*{{cite journal | author=Kunapuli P, Benovic JL |title=Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 12 |pages= 5588-92 |year= 1993 |pmid= 7685906 |doi= }}
* {{cite journal | vauthors = Kunapuli P, Gurevich VV, Benovic JL | title = Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 14 | pages = 10209–12 | date = Apr 1994 | pmid = 8144599 | doi =  }}
*{{cite journal | author=Bullrich F, Druck T, Kunapuli P, ''et al.'' |title=Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 250-4 |year= 1995 |pmid= 7789183 |doi= }}
* {{cite journal | vauthors = Kunapuli P, Onorato JJ, Hosey MM, Benovic JL | title = Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 2 | pages = 1099–105 | date = Jan 1994 | pmid = 8288567 | doi =  }}
*{{cite journal | author=Kunapuli P, Gurevich VV, Benovic JL |title=Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5. |journal=J. Biol. Chem. |volume=269 |issue= 14 |pages= 10209-12 |year= 1994 |pmid= 8144599 |doi=  }}
* {{cite journal | vauthors = Nagayama Y, Tanaka K, Hara T, Namba H, Yamashita S, Taniyama K, Niwa M | title = Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor | journal = The Journal of Biological Chemistry | volume = 271 | issue = 17 | pages = 10143–8 | date = Apr 1996 | pmid = 8626574 | doi = 10.1074/jbc.271.17.10143 }}
*{{cite journal | author=Kunapuli P, Onorato JJ, Hosey MM, Benovic JL |title=Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1099-105 |year= 1994 |pmid= 8288567 |doi=  }}
* {{cite journal | vauthors = Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ | title = Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C | journal = The Journal of Biological Chemistry | volume = 271 | issue = 22 | pages = 13266–72 | date = May 1996 | pmid = 8662816 | doi = 10.1074/jbc.271.22.13266 }}
*{{cite journal | author=Nagayama Y, Tanaka K, Hara T, ''et al.'' |title=Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10143-8 |year= 1996 |pmid= 8626574 |doi= }}
* {{cite journal | vauthors = Fredericks ZL, Pitcher JA, Lefkowitz RJ | title = Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor | journal = The Journal of Biological Chemistry | volume = 271 | issue = 23 | pages = 13796–803 | date = Jun 1996 | pmid = 8662852 | doi = 10.1074/jbc.271.23.13796 }}
*{{cite journal | author=Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ |title=Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 13266-72 |year= 1996 |pmid= 8662816 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Fredericks ZL, Pitcher JA, Lefkowitz RJ |title=Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. |journal=J. Biol. Chem. |volume=271 |issue= 23 |pages= 13796-803 |year= 1996 |pmid= 8662852 |doi= }}
* {{cite journal | vauthors = Pronin AN, Carman CV, Benovic JL | title = Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation | journal = The Journal of Biological Chemistry | volume = 273 | issue = 47 | pages = 31510–8 | date = Nov 1998 | pmid = 9813065 | doi = 10.1074/jbc.273.47.31510 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ | title = beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 24 | pages = 14082–7 | date = Nov 1998 | pmid = 9826657 | pmc = 24330 | doi = 10.1073/pnas.95.24.14082 }}
*{{cite journal | author=Pronin AN, Carman CV, Benovic JL |title=Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation. |journal=J. Biol. Chem. |volume=273 |issue= 47 |pages= 31510-8 |year= 1998 |pmid= 9813065 |doi= }}
* {{cite journal | vauthors = Carman CV, Lisanti MP, Benovic JL | title = Regulation of G protein-coupled receptor kinases by caveolin | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8858–64 | date = Mar 1999 | pmid = 10085129 | doi = 10.1074/jbc.274.13.8858 }}
*{{cite journal | author=Premont RT, Claing A, Vitale N, ''et al.'' |title=beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 24 |pages= 14082-7 |year= 1998 |pmid= 9826657 |doi= }}
* {{cite journal | vauthors = Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S | title = Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium | journal = The Journal of Endocrinology | volume = 162 | issue = 3 | pages = 401–8 | date = Sep 1999 | pmid = 10467231 | doi = 10.1677/joe.0.1620401 }}
*{{cite journal  | author=Carman CV, Lisanti MP, Benovic JL |title=Regulation of G protein-coupled receptor kinases by caveolin. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8858-64 |year= 1999 |pmid= 10085129 |doi= }}
* {{cite journal | vauthors = Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C | title = Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein | journal = The Journal of Biological Chemistry | volume = 275 | issue = 1 | pages = 390–7 | date = Jan 2000 | pmid = 10617630 | doi = 10.1074/jbc.275.1.390 }}
*{{cite journal | author=Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S |title=Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium. |journal=J. Endocrinol. |volume=162 |issue= 3 |pages= 401-8 |year= 1999 |pmid= 10467231 |doi= }}
* {{cite journal | vauthors = Pronin AN, Morris AJ, Surguchov A, Benovic JL | title = Synucleins are a novel class of substrates for G protein-coupled receptor kinases | journal = The Journal of Biological Chemistry | volume = 275 | issue = 34 | pages = 26515–22 | date = Aug 2000 | pmid = 10852916 | doi = 10.1074/jbc.M003542200 }}
*{{cite journal | author=Okochi M, Walter J, Koyama A, ''et al.'' |title=Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 390-7 |year= 2000 |pmid= 10617630 |doi= }}
* {{cite journal | vauthors = Berrada K, Plesnicher CL, Luo X, Thibonnier M | title = Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation | journal = The Journal of Biological Chemistry | volume = 275 | issue = 35 | pages = 27229–37 | date = Sep 2000 | pmid = 10858434 | doi = 10.1074/jbc.M002288200 }}
*{{cite journal | author=Pronin AN, Morris AJ, Surguchov A, Benovic JL |title=Synucleins are a novel class of substrates for G protein-coupled receptor kinases. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26515-22 |year= 2000 |pmid= 10852916 |doi= 10.1074/jbc.M003542200 }}
* {{cite journal | vauthors = Zhou H, Yan F, Tai HH | title = Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 298 | issue = 3 | pages = 1243–51 | date = Sep 2001 | pmid = 11504827 | doi =  }}
*{{cite journal | author=Berrada K, Plesnicher CL, Luo X, Thibonnier M |title=Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27229-37 |year= 2000 |pmid= 10858434 |doi= 10.1074/jbc.M002288200 }}
* {{cite journal | vauthors = Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I | title = Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function | journal = The Journal of Biological Chemistry | volume = 276 | issue = 44 | pages = 40431–40 | date = Nov 2001 | pmid = 11517230 | doi = 10.1074/jbc.M107024200 }}
*{{cite journal | author=Zhou H, Yan F, Tai HH |title=Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases. |journal=J. Pharmacol. Exp. Ther. |volume=298 |issue= 3 |pages= 1243-51 |year= 2001 |pmid= 11504827 |doi=  }}
* {{cite journal | vauthors = Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ | title = G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 2 | pages = 1607–13 | date = Jan 2002 | pmid = 11700307 | doi = 10.1074/jbc.M107297200 }}
*{{cite journal | author=Blaukat A, Pizard A, Breit A, ''et al.'' |title=Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40431-40 |year= 2001 |pmid= 11517230 |doi= 10.1074/jbc.M107024200 }}
* {{cite journal | vauthors = Warabi K, Richardson MD, Barry WT, Yamaguchi K, Roush ED, Nishimura K, Kwatra MM | title = Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro | journal = FEBS Letters | volume = 521 | issue = 1-3 | pages = 140–4 | date = Jun 2002 | pmid = 12067742 | doi = 10.1016/S0014-5793(02)02858-2 }}
*{{cite journal | author=Hu LA, Chen W, Premont RT, ''et al.'' |title=G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1607-13 |year= 2002 |pmid= 11700307 |doi= 10.1074/jbc.M107297200 }}
*{{cite journal | author=Warabi K, Richardson MD, Barry WT, ''et al.'' |title=Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 140-4 |year= 2002 |pmid= 12067742 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


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[[Category:EC 2.7.11]]

Revision as of 01:56, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G protein-coupled receptor kinase 5 is an enzyme that in humans is encoded by the GRK5 gene.[1][2]

Function

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).[2]

References

  1. ↑ Kunapuli P, Benovic JL (Jun 1993). "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family". Proceedings of the National Academy of Sciences of the United States of America. 90 (12): 5588–92. doi:10.1073/pnas.90.12.5588. PMC 46766. PMID 7685906.
  2. ↑ 2.0 2.1 "Entrez Gene: GRK5 G protein-coupled receptor kinase 5".

Further reading

  • Komolov KE, Bhardwaj A, Benovic JL (Aug 2015). "Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases". The Journal of Biological Chemistry. 290 (34): 20629–47. doi:10.1074/jbc.M115.647297. PMID 26032409.
  • Bullrich F, Druck T, Kunapuli P, Gomez J, Gripp KW, Schlegelberger B, Lasota J, Aronson M, Cannizzaro LA, Huebner K (1995). "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6". Cytogenetics and Cell Genetics. 70 (3–4): 250–4. doi:10.1159/000134045. PMID 7789183.
  • Kunapuli P, Gurevich VV, Benovic JL (Apr 1994). "Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5". The Journal of Biological Chemistry. 269 (14): 10209–12. PMID 8144599.
  • Kunapuli P, Onorato JJ, Hosey MM, Benovic JL (Jan 1994). "Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5". The Journal of Biological Chemistry. 269 (2): 1099–105. PMID 8288567.
  • Nagayama Y, Tanaka K, Hara T, Namba H, Yamashita S, Taniyama K, Niwa M (Apr 1996). "Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor". The Journal of Biological Chemistry. 271 (17): 10143–8. doi:10.1074/jbc.271.17.10143. PMID 8626574.
  • Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ (May 1996). "Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C". The Journal of Biological Chemistry. 271 (22): 13266–72. doi:10.1074/jbc.271.22.13266. PMID 8662816.
  • Fredericks ZL, Pitcher JA, Lefkowitz RJ (Jun 1996). "Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor". The Journal of Biological Chemistry. 271 (23): 13796–803. doi:10.1074/jbc.271.23.13796. PMID 8662852.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Pronin AN, Carman CV, Benovic JL (Nov 1998). "Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation". The Journal of Biological Chemistry. 273 (47): 31510–8. doi:10.1074/jbc.273.47.31510. PMID 9813065.
  • Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ (Nov 1998). "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proceedings of the National Academy of Sciences of the United States of America. 95 (24): 14082–7. doi:10.1073/pnas.95.24.14082. PMC 24330. PMID 9826657.
  • Carman CV, Lisanti MP, Benovic JL (Mar 1999). "Regulation of G protein-coupled receptor kinases by caveolin". The Journal of Biological Chemistry. 274 (13): 8858–64. doi:10.1074/jbc.274.13.8858. PMID 10085129.
  • Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S (Sep 1999). "Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium". The Journal of Endocrinology. 162 (3): 401–8. doi:10.1677/joe.0.1620401. PMID 10467231.
  • Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (Jan 2000). "Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein". The Journal of Biological Chemistry. 275 (1): 390–7. doi:10.1074/jbc.275.1.390. PMID 10617630.
  • Pronin AN, Morris AJ, Surguchov A, Benovic JL (Aug 2000). "Synucleins are a novel class of substrates for G protein-coupled receptor kinases". The Journal of Biological Chemistry. 275 (34): 26515–22. doi:10.1074/jbc.M003542200. PMID 10852916.
  • Berrada K, Plesnicher CL, Luo X, Thibonnier M (Sep 2000). "Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation". The Journal of Biological Chemistry. 275 (35): 27229–37. doi:10.1074/jbc.M002288200. PMID 10858434.
  • Zhou H, Yan F, Tai HH (Sep 2001). "Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases". The Journal of Pharmacology and Experimental Therapeutics. 298 (3): 1243–51. PMID 11504827.
  • Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I (Nov 2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function". The Journal of Biological Chemistry. 276 (44): 40431–40. doi:10.1074/jbc.M107024200. PMID 11517230.
  • Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ (Jan 2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". The Journal of Biological Chemistry. 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307.
  • Warabi K, Richardson MD, Barry WT, Yamaguchi K, Roush ED, Nishimura K, Kwatra MM (Jun 2002). "Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro". FEBS Letters. 521 (1–3): 140–4. doi:10.1016/S0014-5793(02)02858-2. PMID 12067742.
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