Cyclin-dependent kinase 10: Difference between revisions

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{{Infobox_gene}}
-->{{PBB_Controls
'''Cell division protein kinase 10''' is an [[enzyme]] that in humans is encoded by the ''CDK10'' [[gene]].<ref name="pmid8208557">{{cite journal | vauthors = Graña X, Claudio PP, De Luca A, Sang N, Giordano A | title = PISSLRE, a human novel CDC2-related protein kinase | journal = Oncogene | volume = 9 | issue = 7 | pages = 2097–103 | date = Jul 1994 | pmid = 8208557 | pmc =  | doi =  }}</ref><ref name="pmid8084611">{{cite journal | vauthors = Brambilla R, Draetta G | title = Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases | journal = Oncogene | volume = 9 | issue = 10 | pages = 3037–41 | date = Oct 1994 | pmid = 8084611 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8558| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cyclin-dependent kinase (CDC2-like) 10
| HGNCid = 1770
| Symbol = CDK10
| AltSymbols =; PISSLRE
| OMIM = 603464
| ECnumber =
  | Homologene = 55769
| MGIid = 2448549
| GeneAtlas_image1 = PBB_GE_CDK10_203469_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_CDK10_203468_at_tn.png
  | GeneAtlas_image3 = PBB_GE_CDK10_210622_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004693 |text = cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
  | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007089 |text = traversing start control point of mitotic cell cycle}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8558
    | Hs_Ensembl = ENSG00000185324
    | Hs_RefseqProtein = NP_443714
    | Hs_RefseqmRNA = NM_052988
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 88280579
    | Hs_GenLoc_end = 88290260
    | Hs_Uniprot = Q15131
    | Mm_EntrezGene = 234854
    | Mm_Ensembl = ENSMUSG00000033862
    | Mm_RefseqmRNA = NM_194444
    | Mm_RefseqProtein = NP_919426
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 126110931
    | Mm_GenLoc_end = 126118348
    | Mm_Uniprot = Q0VGZ8
  }}
}}
'''Cyclin-dependent kinase (CDC2-like) 10''', also known as '''CDK10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8558| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.<ref name="entrez">{{cite web | title = Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8558| accessdate = }}</ref>
}}


==References==
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.<ref name="entrez"/>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
Cyclin-dependent kinase 10 has been shown to [[Protein-protein interaction|interact]] with [[ETS2]].<ref name=pmid11313931>{{cite journal | vauthors = Kasten M, Giordano A | title = Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity | journal = Oncogene | volume = 20 | issue = 15 | pages = 1832–8  | date = Apr 2001 | pmid = 11313931 | doi = 10.1038/sj.onc.1204295 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Li S, MacLachlan TK, De Luca A, Claudio PP, Condorelli G, Giordano A | title = The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle | journal = Cancer Res. | volume = 55 | issue = 18 | pages = 3992–5 | year = 1995 | pmid = 7664269 | doi =  }}
| citations =
* {{cite journal | vauthors = Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese ML, Allen SL, Chiorazzi N, Koff A, Heubner K, Croce CM | title = Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer | journal = Cancer Res. | volume = 55 | issue = 6 | pages = 1199–205 | year = 1995 | pmid = 7882308 | doi =  }}
*{{cite journal | author=Li S, MacLachlan TK, De Luca A, ''et al.'' |title=The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. |journal=Cancer Res. |volume=55 |issue= 18 |pages= 3992-5 |year= 1995 |pmid= 7664269 |doi=  }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Bullrich F, MacLachlan TK, Sang N, ''et al.'' |title=Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. |journal=Cancer Res. |volume=55 |issue= 6 |pages= 1199-205 |year= 1995 |pmid= 7882308 |doi=  }}
* {{cite journal | vauthors = Crawford J, Ianzano L, Savino M, Whitmore S, Cleton-Jansen AM, Settasatian C, d'apolito M, Seshadri R, Pronk JC, Auerbach AD, Verlander PC, Mathew CG, Tipping AJ, Doggett NA, Zelante L, Callen DF, Savoia A | title = The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer | journal = Genomics | volume = 56 | issue = 1 | pages = 90–7 | year = 1999 | pmid = 10036189 | doi = 10.1006/geno.1998.5676 }}
*{{cite journal | author=Brambilla R, Draetta G |title=Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. |journal=Oncogene |volume=9 |issue= 10 |pages= 3037-41 |year= 1994 |pmid= 8084611 |doi=  }}
* {{cite journal | vauthors = Sergère JC, Thuret JY, Le Roux G, Carosella ED, Leteurtre F | title = Human CDK10 gene isoforms | journal = Biochem. Biophys. Res. Commun. | volume = 276 | issue = 1 | pages = 271–7 | year = 2000 | pmid = 11006117 | doi = 10.1006/bbrc.2000.3395 }}
*{{cite journal  | author=Graña X, Claudio PP, De Luca A, ''et al.'' |title=PISSLRE, a human novel CDC2-related protein kinase. |journal=Oncogene |volume=9 |issue= 7 |pages= 2097-103 |year= 1994 |pmid= 8208557 |doi=  }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Kasten M, Giordano A | title = Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity | journal = Oncogene | volume = 20 | issue = 15 | pages = 1832–8 | year = 2001 | pmid = 11313931 | doi = 10.1038/sj.onc.1204295 }}
*{{cite journal | author=Crawford J, Ianzano L, Savino M, ''et al.'' |title=The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer. |journal=Genomics |volume=56 |issue= 1 |pages= 90-7 |year= 1999 |pmid= 10036189 |doi= 10.1006/geno.1998.5676 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2136–44 | year = 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Sergère JC, Thuret JY, Le Roux G, ''et al.'' |title=Human CDK10 gene isoforms. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 271-7 |year= 2000 |pmid= 11006117 |doi= 10.1006/bbrc.2000.3395 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Res. | volume = 34 | issue = Database issue | pages = D415-8 | year = 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H | title = Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry | journal = Mol. Cell. Proteomics | volume = 6 | issue = 3 | pages = 537–47 | year = 2007 | pmid = 17192257 | doi = 10.1074/mcp.T600062-MCP200 }}
*{{cite journal | author=Kasten M, Giordano A |title=Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity. |journal=Oncogene |volume=20 |issue= 15 |pages= 1832-8 |year= 2001 |pmid= 11313931 |doi= 10.1038/sj.onc.1204295 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Wissing J, Jänsch L, Nimtz M, ''et al.'' |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537-47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|CDK10+protein,+human}}
* {{MeshName|CDK10+protein,+human}}


{{gene-16-stub}}
{{Cell cycle proteins}}
{{Cell cycle proteins}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}


[[Category:Cell cycle]]
[[Category:Cell cycle]]
[[Category:EC 2.7.11]]
{{gene-16-stub}}

Latest revision as of 17:59, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.[1][2][3]

Function

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.[3]

Interactions

Cyclin-dependent kinase 10 has been shown to interact with ETS2.[4]

References

  1. ↑ Graña X, Claudio PP, De Luca A, Sang N, Giordano A (Jul 1994). "PISSLRE, a human novel CDC2-related protein kinase". Oncogene. 9 (7): 2097–103. PMID 8208557.
  2. ↑ Brambilla R, Draetta G (Oct 1994). "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene. 9 (10): 3037–41. PMID 8084611.
  3. ↑ 3.0 3.1 "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10".
  4. ↑ Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931.

Further reading

  • Li S, MacLachlan TK, De Luca A, Claudio PP, Condorelli G, Giordano A (1995). "The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle". Cancer Res. 55 (18): 3992–5. PMID 7664269.
  • Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese ML, Allen SL, Chiorazzi N, Koff A, Heubner K, Croce CM (1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6): 1199–205. PMID 7882308.
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Crawford J, Ianzano L, Savino M, Whitmore S, Cleton-Jansen AM, Settasatian C, d'apolito M, Seshadri R, Pronk JC, Auerbach AD, Verlander PC, Mathew CG, Tipping AJ, Doggett NA, Zelante L, Callen DF, Savoia A (1999). "The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer". Genomics. 56 (1): 90–7. doi:10.1006/geno.1998.5676. PMID 10036189.
  • Sergère JC, Thuret JY, Le Roux G, Carosella ED, Leteurtre F (2000). "Human CDK10 gene isoforms". Biochem. Biophys. Res. Commun. 276 (1): 271–7. doi:10.1006/bbrc.2000.3395. PMID 11006117.
  • Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Kasten M, Giordano A (2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

External links


Retrieved from "https://www.wikidoc.org/index.php?title=Cyclin-dependent_kinase_10&oldid=1417429"