IFNB1: Difference between revisions

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Revision as of 05:05, 25 November 2017

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.^[1] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.^[2]

Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

References

Biron CA, Nguyen KB, Pien GC (2002). "Innate immune responses to LCMV infections: natural killer cells and cytokines". Curr. Top. Microbiol. Immunol. 263: 7–27. doi:10.1007/978-3-642-56055-2_2. PMID 11987821.
Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega". Growth Factors. 22 (4): 243–51. doi:10.1080/08977190400000833. PMID 15621727.
Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini reviews in medicinal chemistry. 5 (12): 1093–101. doi:10.2174/138955705774933383. PMID 16375755.
Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. PMID 1834641.
May LT, Sehgal PB (1985). "On the relationship between human interferon alpha 1 and beta 1 genes". J. Interferon Res. 5 (3): 521–6. PMID 2414376.
Francois DT, Katona IM, June CH, et al. (1988). "Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens". Clin. Immunol. Immunopathol. 48 (3): 297–306. doi:10.1016/0090-1229(88)90023-2. PMID 3135963.
Conradt HS, Egge H, Peter-Katalinic J, et al. (1987). "Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line". J. Biol. Chem. 262 (30): 14600–5. PMID 3667593.
Blank KJ, McKernan LN, Murasko DM (1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. doi:10.1089/jir.1985.5.215. PMID 3872918.
Derynck R, Content J, DeClercq E, et al. (1980). "Isolation and structure of a human fibroblast interferon gene". Nature. 285 (5766): 542–7. doi:10.1038/285542a0. PMID 6157094.
Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980). "The nucleotide sequence of human fibroblast interferon cDNA". Gene. 10 (1): 11–5. doi:10.1016/0378-1119(80)90138-9. PMID 6157601.
Houghton M, Easton MA, Stewart AG, et al. (1981). "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase". Nucleic Acids Res. 8 (13): 2885–94. doi:10.1093/nar/8.13.2885. PMC 324132. PMID 6159580.
Goeddel DV, Shepard HM, Yelverton E, et al. (1981). "Synthesis of human fibroblast interferon by E. coli". Nucleic Acids Res. 8 (18): 4057–74. doi:10.1093/nar/8.18.4057. PMC 324219. PMID 6159584.
Houghton M, Stewart AG, Doel SM, et al. (1981). "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers". Nucleic Acids Res. 8 (9): 1913–31. doi:10.1093/nar/8.9.1913. PMC 324047. PMID 6159597.
Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon". Nature. 289 (5798): 606–7. doi:10.1038/289606a0. PMID 6162107.
Lawn RM, Adelman J, Franke AE, et al. (1981). "Human fibroblast interferon gene lacks introns". Nucleic Acids Res. 9 (5): 1045–52. doi:10.1093/nar/9.5.1045. PMC 326735. PMID 6164984.
Shepard HM, Leung D, Stebbing N, Goeddel DV (1982). "A single amino acid change in IFN-beta1 abolishes its antiviral activity". Nature. 294 (5841): 563–5. doi:10.1038/294563a0. PMID 6171735.
Content J, De Wit L, Pierard D, et al. (1982). "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta". Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768–72. doi:10.1073/pnas.79.9.2768. PMC 346287. PMID 6178110.
Fiers W, Remaut E, Devos R, et al. (1983). "The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells". Philos. Trans. R. Soc. Lond. B Biol. Sci. 299 (1094): 29–38. doi:10.1098/rstb.1982.0103. PMID 6183692.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: IFNB1 interferon, beta 1, fibroblast".

[genesource-2] "IFNB1 recombinant protein".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Interferon beta''' is a [[protein]] that in humans is encoded by the ''IFNB1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IFNB1 interferon, beta 1, fibroblast| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3456| accessdate = }}</ref> The natural and [[recombinant protein]] forms have antiviral, antibacterial, and anticancer properties.<ref name ="genesource">{{cite web | title = IFNB1 recombinant protein| url = http://www.mybiosource.com/datasheet.php?products_id=232060| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_IFNB1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1au1.
- | PDB = {{PDB2|1au1}}
- | Name = Interferon, beta 1, fibroblast
- | HGNCid = 5434
- | Symbol = IFNB1
- | AltSymbols =; IFB; IFF; IFNB; MGC96956
- | OMIM = 147640
- | ECnumber =
- | Homologene = 1640
- | MGIid = 107657
- | GeneAtlas_image1 = PBB_GE_IFNB1_208173_at_tn.png
- | Function = {{GNF_GO|id=GO:0005132 |text = interferon-alpha/beta receptor binding}}
- | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
- | Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}} {{GNF_GO|id=GO:0042100 |text = B cell proliferation}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0045089 |text = positive regulation of innate immune response}} {{GNF_GO|id=GO:0045343 |text = regulation of MHC class I biosynthetic process}} {{GNF_GO|id=GO:0046597 |text = negative regulation of virion penetration into host}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3456
-    | Hs_Ensembl = ENSG00000171855
-    | Hs_RefseqProtein = NP_002167
-    | Hs_RefseqmRNA = NM_002176
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 9
-    | Hs_GenLoc_start = 21067104
-    | Hs_GenLoc_end = 21067962
-    | Hs_Uniprot = P01574
-    | Mm_EntrezGene = 15977
-    | Mm_Ensembl = ENSMUSG00000048806
-    | Mm_RefseqmRNA = NM_010510
-    | Mm_RefseqProtein = NP_034640
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 4
-    | Mm_GenLoc_start = 87993457
-    | Mm_GenLoc_end = 87994005
-    | Mm_Uniprot = Q0VE17
-  }}
-}}
-'''Interferon, beta 1, fibroblast''', also known as '''IFNB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IFNB1 interferon, beta 1, fibroblast| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3456| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
@@ Line 53: / Line 6: @@
 | summary_text =
 }}
+[[Interferon beta 1a]] (tradenames: Avonex and Rebif) and [[Interferon beta 1b]] (tradenames: Betaseron/Betaferon) are used as drugs.
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Biron CA, Nguyen KB, Pien GC |title=Innate immune responses to LCMV infections: natural killer cells and cytokines. |journal=Curr. Top. Microbiol. Immunol. |volume=263 |issue=  |pages= 7-27 |year= 2002 |pmid= 11987821 |doi=  }}
+*{{cite journal  |vauthors=Biron CA, Nguyen KB, Pien GC |title=Innate immune responses to LCMV infections: natural killer cells and cytokines. |journal=Curr. Top. Microbiol. Immunol. |volume=263 |issue=  |pages= 7–27 |year= 2002 |pmid= 11987821 |doi=  10.1007/978-3-642-56055-2_2}}
-*{{cite journal  | author=Conti L, Fantuzzi L, Del Cornò M, ''et al.'' |title=Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. |journal=Immunobiology |volume=209 |issue= 1-2 |pages= 99-115 |year= 2005 |pmid= 15481145 |doi=  }}
+*{{cite journal   |vauthors=Conti L, Fantuzzi L, Del Cornò M, etal |title=Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. |journal=Immunobiology |volume=209 |issue= 1–2 |pages= 99–115 |year= 2005 |pmid= 15481145 |doi=10.1016/j.imbio.2004.02.008  }}
-*{{cite journal  | author=Bekisz J, Schmeisser H, Hernandez J, ''et al.'' |title=Human interferons alpha, beta and omega. |journal=Growth Factors |volume=22 |issue= 4 |pages= 243-51 |year= 2005 |pmid= 15621727 |doi= 10.1080/08977190400000833 }}
+*{{cite journal   |vauthors=Bekisz J, Schmeisser H, Hernandez J, etal |title=Human interferons alpha, beta and omega |journal=Growth Factors |volume=22 |issue= 4 |pages= 243–51 |year= 2005 |pmid= 15621727 |doi= 10.1080/08977190400000833 }}
-*{{cite journal  | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines. |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093-101 |year= 2006 |pmid= 16375755 |doi=  }}
+*{{cite journal  | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093–101 |year= 2006 |pmid= 16375755 |doi=10.2174/138955705774933383  }}
-*{{cite journal  | author=Silverman RH, Sengupta DN |title=Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes. |journal=J. Exp. Pathol. |volume=5 |issue= 2 |pages= 69-77 |year= 1991 |pmid= 1708818 |doi=  }}
+*{{cite journal  |vauthors=Silverman RH, Sengupta DN |title=Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes |journal=J. Exp. Pathol. |volume=5 |issue= 2 |pages= 69–77 |year= 1991 |pmid= 1708818 |doi=  }}
-*{{cite journal  | author=Flores I, Mariano TM, Pestka S |title=Human interferon omega (omega) binds to the alpha/beta receptor. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 19875-7 |year= 1991 |pmid= 1834641 |doi=  }}
+*{{cite journal  |vauthors=Flores I, Mariano TM, Pestka S |title=Human interferon omega (omega) binds to the alpha/beta receptor |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 19875–7 |year= 1991 |pmid= 1834641 |doi=  }}
-*{{cite journal  | author=May LT, Sehgal PB |title=On the relationship between human interferon alpha 1 and beta 1 genes. |journal=J. Interferon Res. |volume=5 |issue= 3 |pages= 521-6 |year= 1985 |pmid= 2414376 |doi=  }}
+*{{cite journal  |vauthors=May LT, Sehgal PB |title=On the relationship between human interferon alpha 1 and beta 1 genes |journal=J. Interferon Res. |volume=5 |issue= 3 |pages= 521–6 |year= 1985 |pmid= 2414376 |doi=  }}
-*{{cite journal  | author=Francois DT, Katona IM, June CH, ''et al.'' |title=Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens. |journal=Clin. Immunol. Immunopathol. |volume=48 |issue= 3 |pages= 297-306 |year= 1988 |pmid= 3135963 |doi=  }}
+*{{cite journal   |vauthors=Francois DT, Katona IM, June CH, etal |title=Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens |journal=Clin. Immunol. Immunopathol. |volume=48 |issue= 3 |pages= 297–306 |year= 1988 |pmid= 3135963 |doi=10.1016/0090-1229(88)90023-2  }}
-*{{cite journal  | author=Conradt HS, Egge H, Peter-Katalinic J, ''et al.'' |title=Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line. |journal=J. Biol. Chem. |volume=262 |issue= 30 |pages= 14600-5 |year= 1987 |pmid= 3667593 |doi=  }}
+*{{cite journal   |vauthors=Conradt HS, Egge H, Peter-Katalinic J, etal |title=Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line |journal=J. Biol. Chem. |volume=262 |issue= 30 |pages= 14600–5 |year= 1987 |pmid= 3667593 |doi=  }}
-*{{cite journal  | author=Blank KJ, McKernan LN, Murasko DM |title=Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation. |journal=J. Interferon Res. |volume=5 |issue= 1 |pages= 215-21 |year= 1985 |pmid= 3872918 |doi=  }}
+*{{cite journal  |vauthors=Blank KJ, McKernan LN, Murasko DM |title=Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation |journal=J. Interferon Res. |volume=5 |issue= 1 |pages= 215–21 |year= 1985 |pmid= 3872918 |doi=  10.1089/jir.1985.5.215}}
-*{{cite journal  | author=Derynck R, Content J, DeClercq E, ''et al.'' |title=Isolation and structure of a human fibroblast interferon gene. |journal=Nature |volume=285 |issue= 5766 |pages= 542-7 |year= 1980 |pmid= 6157094 |doi=  }}
+*{{cite journal   |vauthors=Derynck R, Content J, DeClercq E, etal |title=Isolation and structure of a human fibroblast interferon gene |journal=Nature |volume=285 |issue= 5766 |pages= 542–7 |year= 1980 |pmid= 6157094 |doi=10.1038/285542a0  }}
-*{{cite journal  | author=Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M |title=The nucleotide sequence of human fibroblast interferon cDNA. |journal=Gene |volume=10 |issue= 1 |pages= 11-5 |year= 1980 |pmid= 6157601 |doi=  }}
+*{{cite journal  |vauthors=Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M |title=The nucleotide sequence of human fibroblast interferon cDNA |journal=Gene |volume=10 |issue= 1 |pages= 11–5 |year= 1980 |pmid= 6157601 |doi=10.1016/0378-1119(80)90138-9  }}
-*{{cite journal  | author=Houghton M, Easton MA, Stewart AG, ''et al.'' |title=The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase. |journal=Nucleic Acids Res. |volume=8 |issue= 13 |pages= 2885-94 |year= 1981 |pmid= 6159580 |doi=  }}
+*{{cite journal   |vauthors=Houghton M, Easton MA, Stewart AG, etal |title=The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase |journal=Nucleic Acids Res. |volume=8 |issue= 13 |pages= 2885–94 |year= 1981 |pmid= 6159580 |doi=10.1093/nar/8.13.2885  | pmc=324132  }}
-*{{cite journal  | author=Goeddel DV, Shepard HM, Yelverton E, ''et al.'' |title=Synthesis of human fibroblast interferon by E. coli. |journal=Nucleic Acids Res. |volume=8 |issue= 18 |pages= 4057-74 |year= 1981 |pmid= 6159584 |doi=  }}
+*{{cite journal   |vauthors=Goeddel DV, Shepard HM, Yelverton E, etal |title=Synthesis of human fibroblast interferon by E. coli |journal=Nucleic Acids Res. |volume=8 |issue= 18 |pages= 4057–74 |year= 1981 |pmid= 6159584 |doi=10.1093/nar/8.18.4057  | pmc=324219  }}
-*{{cite journal  | author=Houghton M, Stewart AG, Doel SM, ''et al.'' |title=The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers. |journal=Nucleic Acids Res. |volume=8 |issue= 9 |pages= 1913-31 |year= 1981 |pmid= 6159597 |doi=  }}
+*{{cite journal   |vauthors=Houghton M, Stewart AG, Doel SM, etal |title=The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers |journal=Nucleic Acids Res. |volume=8 |issue= 9 |pages= 1913–31 |year= 1981 |pmid= 6159597 |doi=10.1093/nar/8.9.1913  | pmc=324047  }}
-*{{cite journal  | author=Wetzel R |title=Assignment of the disulphide bonds of leukocyte interferon. |journal=Nature |volume=289 |issue= 5798 |pages= 606-7 |year= 1981 |pmid= 6162107 |doi=  }}
+*{{cite journal  | author=Wetzel R |title=Assignment of the disulphide bonds of leukocyte interferon |journal=Nature |volume=289 |issue= 5798 |pages= 606–7 |year= 1981 |pmid= 6162107 |doi=10.1038/289606a0  }}
-*{{cite journal  | author=Lawn RM, Adelman J, Franke AE, ''et al.'' |title=Human fibroblast interferon gene lacks introns. |journal=Nucleic Acids Res. |volume=9 |issue= 5 |pages= 1045-52 |year= 1981 |pmid= 6164984 |doi=  }}
+*{{cite journal   |vauthors=Lawn RM, Adelman J, Franke AE, etal |title=Human fibroblast interferon gene lacks introns |journal=Nucleic Acids Res. |volume=9 |issue= 5 |pages= 1045–52 |year= 1981 |pmid= 6164984 |doi=10.1093/nar/9.5.1045  | pmc=326735  }}
-*{{cite journal  | author=Shepard HM, Leung D, Stebbing N, Goeddel DV |title=A single amino acid change in IFN-beta1 abolishes its antiviral activity. |journal=Nature |volume=294 |issue= 5841 |pages= 563-5 |year= 1982 |pmid= 6171735 |doi=  }}
+*{{cite journal  |vauthors=Shepard HM, Leung D, Stebbing N, Goeddel DV |title=A single amino acid change in IFN-beta1 abolishes its antiviral activity |journal=Nature |volume=294 |issue= 5841 |pages= 563–5 |year= 1982 |pmid= 6171735 |doi=10.1038/294563a0  }}
-*{{cite journal  | author=Content J, De Wit L, Pierard D, ''et al.'' |title=Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 9 |pages= 2768-72 |year= 1982 |pmid= 6178110 |doi=  }}
+*{{cite journal   |vauthors=Content J, De Wit L, Pierard D, etal |title=Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 9 |pages= 2768–72 |year= 1982 |pmid= 6178110 |doi=10.1073/pnas.79.9.2768  | pmc=346287  }}
-*{{cite journal  | author=Fiers W, Remaut E, Devos R, ''et al.'' |title=The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=299 |issue= 1094 |pages= 29-38 |year= 1983 |pmid= 6183692 |doi=  }}
+*{{cite journal   |vauthors=Fiers W, Remaut E, Devos R, etal |title=The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells |journal=Philos. Trans. R. Soc. Lond. B Biol. Sci. |volume=299 |issue= 1094 |pages= 29–38 |year= 1983 |pmid= 6183692 |doi= 10.1098/rstb.1982.0103  }}
 }}
 {{refend}}
-{{protein-stub}}
+{{PDB Gallery|geneid=3456}}
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{Cytokines}}
+{{Cytokine receptor modulators}}
+{{gene-9-stub}}

IFNB1: Difference between revisions

Revision as of 05:05, 25 November 2017

References

Further reading

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