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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase 4''' is an [[enzyme]] that in humans is encoded by the ''STK4'' [[gene]].<ref name="pmid8816758">{{cite journal | vauthors = Taylor LK, Wang HC, Erikson RL | title = Newly identified stress-responsive protein kinases, Krs-1 and Krs-2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 19 | pages = 10099–104  | date = November 1996 | pmid = 8816758 | pmc = 38343 | doi = 10.1073/pnas.93.19.10099 }}</ref><ref name="pmid9545236">{{cite journal | vauthors = Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG | title = Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1 | journal = EMBO J. | volume = 17 | issue = 8 | pages = 2224–34  | date = June 1998 | pmid = 9545236 | pmc = 1170567 | doi = 10.1093/emboj/17.8.2224 }}</ref><ref name="pmid11517310">{{cite journal | vauthors = Ura S, Masuyama N, Graves JD, Gotoh Y | title = Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 18 | pages = 10148–53  | date = August 2001 | pmid = 11517310 | pmc = 56930 | doi = 10.1073/pnas.181161698 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_STK4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2jo8.
| PDB = {{PDB2|2jo8}}
| Name = Serine/threonine kinase 4
| HGNCid = 11408
| Symbol = STK4
| AltSymbols =; MST1; DKFZp686A2068; KRS2; YSK3
| OMIM = 604965
| ECnumber = 
| Homologene = 55965
| MGIid = 1929004
| GeneAtlas_image1 = PBB_GE_STK4_205411_at_tn.png
| GeneAtlas_image2 = PBB_GE_STK4_211085_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0000902 |text = cell morphogenesis}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0018105 |text = peptidyl-serine phosphorylation}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6789
    | Hs_Ensembl = ENSG00000101109
    | Hs_RefseqProtein = NP_006273
    | Hs_RefseqmRNA = NM_006282
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 43028529
    | Hs_GenLoc_end = 43142014
    | Hs_Uniprot = Q13043
    | Mm_EntrezGene = 58231
    | Mm_Ensembl = ENSMUSG00000018209
    | Mm_RefseqmRNA = NM_021420
    | Mm_RefseqProtein = NP_067395
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 163765593
    | Mm_GenLoc_end = 163846964
    | Mm_Uniprot = Q61156
  }}
}}
'''Serine/threonine kinase 4''', also known as '''STK4''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes [[autophosphorylation]]. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.<ref name="entrez">{{cite web | title = Entrez Gene: STK4 serine/threonine kinase 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6789| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.<ref name="entrez">{{cite web | title = Entrez Gene: STK4 serine/threonine kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6789| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
STK4 has been shown to [[Protein-protein interaction|interact]] with [[PRKRIR]].<ref name=pmid12384512>{{cite journal | vauthors = Lin Y, Khokhlatchev A, Figeys D, Avruch J | title = Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis | journal = J. Biol. Chem. | volume = 277 | issue = 50 | pages = 47991–8001  | date = December 2002 | pmid = 12384512 | doi = 10.1074/jbc.M202630200 }}</ref>
 
STK4 has also been shown to prevent, through Yap1 coactivator modulation, haematological tumor cell apoptosis. {{cite journal | vauthors = Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G | title = Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers | journal = Nat. Med. | volume = 20 | issue = 6 | pages = 599–606  | date = 2014 | pmid = 24813251 | doi = 10.1038/nm.3562 | pmc=4057660}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Choi J, Oh S, Lee D, Oh HJ, Park JY, Lee SB, Lim DS | title = Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice | journal = PLoS ONE | volume = 4 | issue = 11 | pages = e8011 | year = 2009 | pmid = 19956688 | pmc = 2776980 | doi = 10.1371/journal.pone.0008011 | editor1-last = Kaeberlein | editor1-first = Matt }}
| citations =  
* {{cite journal | vauthors = de Souza PM, Lindsay MA | title = Mammalian Sterile20-like kinase 1 and the regulation of apoptosis | journal = Biochem. Soc. Trans. | volume = 32 | issue = Pt3 | pages = 485–8 | year = 2004 | pmid = 15157167 | doi = 10.1042/BST0320485 }}
*{{cite journal | author=de Souza PM, Lindsay MA |title=Mammalian Sterile20-like kinase 1 and the regulation of apoptosis. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt3 |pages= 485-8 |year= 2005 |pmid= 15157167 |doi= 10.1042/BST0320485 }}
* {{cite journal | vauthors = Han S, Stuart LA, Degen SJ | title = Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor | journal = Biochemistry | volume = 30 | issue = 40 | pages = 9768–80 | year = 1991 | pmid = 1655021 | doi = 10.1021/bi00104a029 }}
*{{cite journal | author=Han S, Stuart LA, Degen SJ |title=Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. |journal=Biochemistry |volume=30 |issue= 40 |pages= 9768-80 |year= 1991 |pmid= 1655021 |doi= }}
* {{cite journal | vauthors = Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI | title = Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel | journal = Am. J. Hum. Genet. | volume = 43 | issue = 4 | pages = 442–51 | year = 1988 | pmid = 2902784 | pmc = 1715492 | doi =  }}
*{{cite journal | author=Gerber MJ, Drabkin HA, Firnhaber C, ''et al.'' |title=Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel. |journal=Am. J. Hum. Genet. |volume=43 |issue= 4 |pages= 442-51 |year= 1988 |pmid= 2902784 |doi=  }}
* {{cite journal | vauthors = Creasy CL, Chernoff J | title = Cloning and characterization of a human protein kinase with homology to Ste20 | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21695–700 | year = 1995 | pmid = 7665586 | doi = 10.1074/jbc.270.37.21695 }}
*{{cite journal | author=Creasy CL, Chernoff J |title=Cloning and characterization of a human protein kinase with homology to Ste20. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21695-700 |year= 1995 |pmid= 7665586 |doi= }}
* {{cite journal | vauthors = Schultz SJ, Nigg EA | title = Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans | journal = Cell Growth Differ. | volume = 4 | issue = 10 | pages = 821–30 | year = 1993 | pmid = 8274451 | doi =  }}
*{{cite journal | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821-30 |year= 1994 |pmid= 8274451 |doi=  }}
* {{cite journal | vauthors = Creasy CL, Chernoff J | title = Cloning and characterization of a member of the MST subfamily of Ste20-like kinases | journal = Gene | volume = 167 | issue = 1–2 | pages = 303–6 | year = 1995 | pmid = 8566796 | doi = 10.1016/0378-1119(95)00653-2 }}
*{{cite journal | author=Creasy CL, Chernoff J |title=Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. |journal=Gene |volume=167 |issue= 1-2 |pages= 303-6 |year= 1996 |pmid= 8566796 |doi= }}
* {{cite journal | vauthors = Creasy CL, Ambrose DM, Chernoff J | title = The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain | journal = J. Biol. Chem. | volume = 271 | issue = 35 | pages = 21049–53 | year = 1996 | pmid = 8702870 | doi = 10.1074/jbc.271.35.21049 }}
*{{cite journal | author=Creasy CL, Ambrose DM, Chernoff J |title=The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21049-53 |year= 1996 |pmid= 8702870 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal  | author=Taylor LK, Wang HC, Erikson RL |title=Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 19 |pages= 10099-104 |year= 1996 |pmid= 8816758 |doi=  }}
* {{cite journal | vauthors = Lee KK, Ohyama T, Yajima N, Tsubuki S, Yonehara S | title = MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19276–85 | year = 2001 | pmid = 11278283 | doi = 10.1074/jbc.M005109200 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
* {{cite journal | vauthors = Graves JD, Draves KE, Gotoh Y, Krebs EG, Clark EA | title = Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis | journal = J. Biol. Chem. | volume = 276 | issue = 18 | pages = 14909–15 | year = 2001 | pmid = 11278782 | doi = 10.1074/jbc.M010905200 }}
*{{cite journal  | author=Graves JD, Gotoh Y, Draves KE, ''et al.'' |title=Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. |journal=EMBO J. |volume=17 |issue= 8 |pages= 2224-34 |year= 1998 |pmid= 9545236 |doi= 10.1093/emboj/17.8.2224 }}
* {{cite journal | vauthors = Lee KK, Yonehara S | title = Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST) | journal = J. Biol. Chem. | volume = 277 | issue = 14 | pages = 12351–8 | year = 2002 | pmid = 11805089 | doi = 10.1074/jbc.M108138200 }}
*{{cite journal | author=Lee KK, Ohyama T, Yajima N, ''et al.'' |title=MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19276-85 |year= 2001 |pmid= 11278283 |doi= 10.1074/jbc.M005109200 }}
* {{cite journal | vauthors = Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J | title = Identification of a novel Ras-regulated proapoptotic pathway | journal = Curr. Biol. | volume = 12 | issue = 4 | pages = 253–65 | year = 2002 | pmid = 11864565 | doi = 10.1016/S0960-9822(02)00683-8 }}
*{{cite journal | author=Graves JD, Draves KE, Gotoh Y, ''et al.'' |title=Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14909-15 |year= 2001 |pmid= 11278782 |doi= 10.1074/jbc.M010905200 }}
* {{cite journal | vauthors = De Souza PM, Kankaanranta H, Michael A, Barnes PJ, Giembycz MA, Lindsay MA | title = Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis | journal = Blood | volume = 99 | issue = 9 | pages = 3432–8 | year = 2002 | pmid = 11964314 | doi = 10.1182/blood.V99.9.3432 }}
*{{cite journal | author=Ura S, Masuyama N, Graves JD, Gotoh Y |title=Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 18 |pages= 10148-53 |year= 2001 |pmid= 11517310 |doi= 10.1073/pnas.181161698 }}
* {{cite journal | vauthors = Glantschnig H, Rodan GA, Reszka AA | title = Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 42987–96 | year = 2002 | pmid = 12223493 | doi = 10.1074/jbc.M208538200 }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Lin Y, Khokhlatchev A, Figeys D, Avruch J | title = Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis | journal = J. Biol. Chem. | volume = 277 | issue = 50 | pages = 47991–8001 | year = 2002 | pmid = 12384512 | doi = 10.1074/jbc.M202630200 }}
*{{cite journal  | author=Lee KK, Yonehara S |title=Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12351-8 |year= 2002 |pmid= 11805089 |doi= 10.1074/jbc.M108138200 }}
*{{cite journal | author=Khokhlatchev A, Rabizadeh S, Xavier R, ''et al.'' |title=Identification of a novel Ras-regulated proapoptotic pathway. |journal=Curr. Biol. |volume=12 |issue= 4 |pages= 253-65 |year= 2002 |pmid= 11864565 |doi= }}
*{{cite journal | author=De Souza PM, Kankaanranta H, Michael A, ''et al.'' |title=Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis. |journal=Blood |volume=99 |issue= 9 |pages= 3432-8 |year= 2002 |pmid= 11964314 |doi= }}
*{{cite journal | author=Glantschnig H, Rodan GA, Reszka AA |title=Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42987-96 |year= 2003 |pmid= 12223493 |doi= 10.1074/jbc.M208538200 }}
*{{cite journal | author=Lin Y, Khokhlatchev A, Figeys D, Avruch J |title=Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 47991-8001 |year= 2003 |pmid= 12384512 |doi= 10.1074/jbc.M202630200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


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Revision as of 07:12, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.[1][2][3]

Function

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.[4]

Interactions

STK4 has been shown to interact with PRKRIR.[5]

STK4 has also been shown to prevent, through Yap1 coactivator modulation, haematological tumor cell apoptosis. Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G (2014). "Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers". Nat. Med. 20 (6): 599–606. doi:10.1038/nm.3562. PMC 4057660. PMID 24813251.

References

  1. ↑ Taylor LK, Wang HC, Erikson RL (November 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10099–104. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
  2. ↑ Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG (June 1998). "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1". EMBO J. 17 (8): 2224–34. doi:10.1093/emboj/17.8.2224. PMC 1170567. PMID 9545236.
  3. ↑ Ura S, Masuyama N, Graves JD, Gotoh Y (August 2001). "Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10148–53. doi:10.1073/pnas.181161698. PMC 56930. PMID 11517310.
  4. ↑ "Entrez Gene: STK4 serine/threonine kinase 4".
  5. ↑ Lin Y, Khokhlatchev A, Figeys D, Avruch J (December 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50): 47991–8001. doi:10.1074/jbc.M202630200. PMID 12384512.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=STK4&oldid=1419485"