TRPC6

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
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UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).

Interactions

TRPC6 has been shown to interact with:

• FYN,
• TRPC2, and
• TRPC3.

Ligands

Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin. These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6. Recent results with hyperforin have cast doubt on these findings as similar currents are seen upon Hyperforin treatment regardless of the presence of TRPC6.

Further reading

• Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes". Cell Calcium. 33 (5–6): 533–40. doi:10.1016/S0143-4160(03)00058-7. PMID 12765698.
• Walz G (September 2005). "Slit or pore? A mutation of the ion channel TRPC6 causes FSGS". Nephrology, Dialysis, Transplantation. 20 (9): 1777–9. doi:10.1093/ndt/gfh961. PMID 15998650.
• Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
• Schlöndorff JS, Pollak MR (December 2006). "TRPC6 in glomerular health and disease: what we know and what we believe". Seminars in Cell & Developmental Biology. 17 (6): 667–74. doi:10.1016/j.semcdb.2006.11.003. PMC 2705932. PMID 17116414.
• Dietrich A, Gudermann T (2007). "TRPC6". Handbook of Experimental Pharmacology. Handbook of Experimental Pharmacology. 179 (179): 125–41. doi:10.1007/978-3-540-34891-7_7. ISBN 978-3-540-34889-4. PMID 17217054.

External links

• TRPC6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)