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Amiloride-sensitive cation channel 3
Symbols ACCN3 ; ASIC3; SLNAC1; TNaC1
External IDs HomoloGene20999
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Amiloride-sensitive cation channel 3, also known as ACCN3, is a human gene.[1]

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.[1]


  1. 1.0 1.1 "Entrez Gene: ACCN3 amiloride-sensitive cation channel 3".

Further reading

  • Ishibashi K, Marumo F (1998). "Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis". Biochem. Biophys. Res. Commun. 245 (2): 589–93. doi:10.1006/bbrc.1998.8483. PMID 9571199.
  • de Weille JR, Bassilana F, Lazdunski M, Waldmann R (1998). "Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel". FEBS Lett. 433 (3): 257–60. PMID 9744806.
  • Babinski K, Lê KT, Séguéla P (1999). "Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties". J. Neurochem. 72 (1): 51–7. PMID 9886053.
  • Babinski K, Catarsi S, Biagini G, Séguéla P (2000). "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+". J. Biol. Chem. 275 (37): 28519–25. doi:10.1074/jbc.M004114200. PMID 10842183.
  • Catarsi S, Babinski K, Séguéla P (2001). "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF". Neuropharmacology. 41 (5): 592–600. PMID 11587714.
  • Alvarez de la Rosa D, Zhang P, Shao D; et al. (2002). "Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 2326–31. doi:10.1073/pnas.042688199. PMID 11842212.
  • Anzai N, Deval E, Schaefer L; et al. (2002). "The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons". J. Biol. Chem. 277 (19): 16655–61. doi:10.1074/jbc.M201087200. PMID 11872753.
  • Chen CC, Zimmer A, Sun WH; et al. (2002). "A role for ASIC3 in the modulation of high-intensity pain stimuli". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8992–7. doi:10.1073/pnas.122245999. PMID 12060708.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Leonard AS, Yermolaieva O, Hruska-Hageman A; et al. (2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. doi:10.1073/pnas.252782799. PMID 12578970.
  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
  • Hruska-Hageman AM, Benson CJ, Leonard AS; et al. (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
  • Price MP, Thompson RJ, Eshcol JO; et al. (2005). "Stomatin modulates gating of acid-sensing ion channels". J. Biol. Chem. 279 (51): 53886–91. doi:10.1074/jbc.M407708200. PMID 15471860.
  • Jones NG, Slater R, Cadiou H; et al. (2005). "Acid-induced pain and its modulation in humans". J. Neurosci. 24 (48): 10974–9. doi:10.1523/JNEUROSCI.2619-04.2004. PMID 15574747.
  • Su X, Li Q, Shrestha K; et al. (2007). "Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator". J. Biol. Chem. 281 (48): 36960–8. doi:10.1074/jbc.M608002200. PMID 17012229.

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