Lymphadenopathy laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]Delband Yekta Moazami, M.D.[3] Ogechukwu Hannah Nnabude, MD


CBC with differential is a simple test and basic screening for regional and generalized lymphadenopathy. Bacterial, viral, or fungal pathology may be suggested by the number and differentiation of white blood cells. Furthermore, with many hematological neoplasms causing lymphadenopathy, typical white blood cell (WBC) trends are observed.

Laboratory findings

Laboratory findings consistent with the diagnosis of lymphadenopathy may include:[1][2]

  • Complete Blood Count
  • EBV serology: Epstein-Barr viral mono is present causing regionalized lymphadenopathy.
  • Sedimentation rate: A measure of inflammation though not diagnostic, can contribute to diagnostic reasoning.
  • HIV serology: This serology can be used to diagnose acute HIV syndrome-related lymphadenopathy or to infer the diagnosis of secondary HIV-elated pathologies causing lymphadenopathy.
  • Hepatitis B serology
  • ANA: is a screening test for SLE that can help establish it as a cause for generalized lymphadenopathy


  1. Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A (2014). "Peripheral lymphadenopathy: approach and diagnostic tools". Iran J Med Sci. 39 (2 Suppl): 158–70. PMC 3993046. PMID 24753638.
  2. Freeman AM, Matto P. PMID 30020622. Missing or empty |title= (help)

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