Lymphadenopathy other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]Delband Yekta Moazami, M.D.[3]


Other diagnostic studies for lymphadenopathy include lymph node biopsy which is often easy to perform and demonstrates a histological diagnosis and its accuracy depends on technical consistency.

Other Diagnostic Studies

Indications for a lymph node biopsy include:[1][2]

Three types of biopsy methods can be used to diagnose swollen lymph nodes include followings:

  • Fine needle aspiration cytology- a thin needle is used to take samples from the lymph node. Usually used for recurrent cancers. Lacks information about tissue architecture. False positives are common.
  • Core needle biopsy- a specialized needle is used to take a sample of tissue from the lymph node. Provides some detail about architecture. The tissue sample can be used for other special studies.
  • Open biopsy- best diagnostic biopsy method, because the tissue taken is intact and will provide finer details about the presence of abnormal cells and the structure of the lymph node. Performed under local anesthesia.


  1. Barroca H, Marques C (2016). "A Basic Approach to Lymph Node and Flow Cytometry Fine-Needle Cytology". Acta Cytol. 60 (4): 284–301. doi:10.1159/000448679. PMID 27639613.
  2. Brousse N (1996). "[Lymph node biopsy]". Ann Pathol (in French). 16 (3): 219–24. PMID 8766185.

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