Lymphadenopathy history and symptoms

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Lymphadenopathy Microchapters


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Historical Perspective




Differentiating Lymphadenopathy from other Diseases

Epidemiology and Demographics

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Natural History, Complications and Prognosis


Diagnostic Criteria

History and Symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2], Raviteja Guddeti, M.B.B.S. [3]Delband Yekta Moazami, M.D.[4] Ogechukwu Hannah Nnabude, MD


Physical examination and history are the basis of time and cost-effective diagnosis of lymphadenopathy. The evident occurrence and associated localized anterior cervical adenopathy of strep pharyngitis need far less clinical brainpower than generalized adenopathy secondary to sarcoidosis or Gaucher disease. The hallmark of lymphadenopathy is swollen lymph node. A positive history of a lump in the neck, red, tender skin over lymph node, and swollen, tender, or hard lymph nodes is suggestive of lymphadenopathy. The most common symptoms of lymphadenopathy include a lump in neck or affected part and constitutional symptoms like fatigue, fever, malaise, flu-like illness, nausea and vomiting, night sweats, weight loss, and cachexia.

History and Symptoms


A directed history should be obtained to ascertain:[1]

Patients with lymphadenopathy may have a positive history of:

Common Symptoms

Common symptoms of lymphadenopathy include:


  1. Freeman AM, Matto P. PMID 30020622. Missing or empty |title= (help)
  2. Bazemore AW, Smucker DR (December 2002). "Lymphadenopathy and malignancy". Am Fam Physician. 66 (11): 2103–10. PMID 12484692.
  3. Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A (2014). "Peripheral lymphadenopathy: approach and diagnostic tools". Iran J Med Sci. 39 (2 Suppl): 158–70. PMC 3993046. PMID 24753638.

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