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__NOTOC__
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{{Stress cardiomyopathy}}
{{Stress cardiomyopathy}}
{{CMG}}; {{AE}}{{DN}}
{{CMG}}; {{AE}}{{DN}} {{AKK}}
==Overview==
==Overview==
Stress cardiomyopathy is a relatively new disease, with the first case documented in literature under the name of Takotsobu Cardiomyopathy in Japan in 1991. It is not very well understood, but the disease is thought to arise following intense [[emotional]] or physical [[stress]]. Stress cardiomyopathy mostly affects post-[[menopausal]] women. The clinical presentation, laboratory findings and imaging studies largely mimic that of [[anterior MI]]. However, the absence of significant [[coronary artery stenosis]] supports the diagnosis of stress cardiomyopathy. It is generally a self-limiting disease and the majority of patients have a restored cardiac function within a matter of weeks. Complications and death are relatively rare, but they are mostly related to the development of [[heart failure]] and [[pulmonary edema]].
Stress cardiomyopathy is a relatively new disease, with the first case documented in literature under the name of Takotsobu Cardiomyopathy in Japan in 1991. It is not very well understood, but the disease is thought to arise following intense [[emotional]] or physical [[stress]]. Stress cardiomyopathy mostly affects post-[[menopausal]] women. The clinical presentation, laboratory findings and imaging studies largely mimic that of [[anterior MI]]. However, the absence of significant [[coronary artery stenosis]] supports the diagnosis of stress cardiomyopathy. It is generally a self-limiting disease and the majority of patients have a restored cardiac function within a matter of weeks. Complications and death are relatively rare, but they are mostly related to the development of [[heart failure]] and [[pulmonary edema]].


==Historical Perspective==
==Historical Perspective==
Stress cardiomyopathy is a relatively new disease, with the first case documented in literature in Japan in 1991. However, cases of death upon going through severe [[emotional]] or psychological [[stress]] have been described as early as the biblical times.
Stress cardiomyopathy is a relatively new disease, with the first case documented in literature in Japan in 1991. However, cases of death upon going through severe [[emotional]] or psychological [[stress]] have been described as early as the biblical times.<ref name="pmid21401402">{{cite journal |vauthors=Omerovic E |title=How to think about stress-induced cardiomyopathy?--Think "out of the box"! |journal=Scand. Cardiovasc. J. |volume=45 |issue=2 |pages=67–71 |year=2011 |pmid=21401402 |doi=10.3109/14017431.2011.565794 |url=}}</ref><ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref>
 
==Classification==
==Classification==
There is no classification scheme for stress cardiomyopathy.
Stress cardiomyopathy can be divided into several types, depending on the location of regional wall motion abnormality. The area of motion abnormality (whether [[hypokinesia]], [[dyskinesia]] or [[akinesia]]) can be detected on [[echocardiography]] or [[left ventriculography]]. The most common type is the [[apical]] type, resulting in [[apical ballooning]].<ref name="pmid26332547">{{cite journal |vauthors=Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF |title=Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy |journal=N. Engl. J. Med. |volume=373 |issue=10 |pages=929–38 |year=2015 |pmid=26332547 |doi=10.1056/NEJMoa1406761 |url=}}</ref><ref name="pmid17573507">{{cite journal |vauthors=Kurowski V, Kaiser A, von Hof K, Killermann DP, Mayer B, Hartmann F, Schunkert H, Radke PW |title=Apical and midventricular transient left ventricular dysfunction syndrome (tako-tsubo cardiomyopathy): frequency, mechanisms, and prognosis |journal=Chest |volume=132 |issue=3 |pages=809–16 |year=2007 |pmid=17573507 |doi=10.1378/chest.07-0608 |url=}}</ref><ref name="pmid21771988">{{cite journal |vauthors=Eitel I, von Knobelsdorff-Brenkenhoff F, Bernhardt P, Carbone I, Muellerleile K, Aldrovandi A, Francone M, Desch S, Gutberlet M, Strohm O, Schuler G, Schulz-Menger J, Thiele H, Friedrich MG |title=Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy |journal=JAMA |volume=306 |issue=3 |pages=277–86 |year=2011 |pmid=21771988 |doi=10.1001/jama.2011.992 |url=}}</ref><ref name="pmid21272226">{{cite journal |vauthors=Win CM, Pathak A, Guglin M |title=Not takotsubo: a different form of stress-induced cardiomyopathy--a case series |journal=Congest Heart Fail |volume=17 |issue=1 |pages=38–41 |year=2011 |pmid=21272226 |doi=10.1111/j.1751-7133.2010.00195.x |url=}}</ref>
 
==Pathophysiology==
==Pathophysiology==
The pathogenesis of stress cardiomyopathy is not completely understood. However, the most accepted theory behind it is thought to be due to [[catecholamine]] surge, which are thought to contribute to [[myocardial necrosis]] and [[Myocardial stunning|stunning]] seen in stress cardiomyopathy.<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid27611570">{{cite journal |vauthors=Goico A, Chandrasekaran M, Herrera CJ |title=Novel developments in stress cardiomyopathy: From pathophysiology to prognosis |journal=Int. J. Cardiol. |volume=223 |issue= |pages=1053–1058 |year=2016 |pmid=27611570 |doi=10.1016/j.ijcard.2016.08.241 |url=}}</ref><ref name="pmid25071891">{{cite journal |vauthors=Testa M, Feola M |title=Usefulness of myocardial positron emission tomography/nuclear imaging in Takotsubo cardiomyopathy |journal=World J Radiol |volume=6 |issue=7 |pages=502–6 |year=2014 |pmid=25071891 |pmc=4109102 |doi=10.4329/wjr.v6.i7.502 |url=}}</ref> On biopsy, findings include an [[inflammatory]] infiltrate, [[fibrosis]] and formation of contraction bands, which may or may not be associated with [[myocardial necrosis]].<ref name="pmid191064002">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref> Stress cardiomyopathy is associated with various [[neurological]] and psychological conditions.
The pathogenesis of stress cardiomyopathy is not completely understood. However, the most accepted theory behind it is thought to be due to [[catecholamine]] surge, which are thought to contribute to [[myocardial necrosis]] and [[Myocardial stunning|stunning]] seen in stress cardiomyopathy.<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid27611570">{{cite journal |vauthors=Goico A, Chandrasekaran M, Herrera CJ |title=Novel developments in stress cardiomyopathy: From pathophysiology to prognosis |journal=Int. J. Cardiol. |volume=223 |issue= |pages=1053–1058 |year=2016 |pmid=27611570 |doi=10.1016/j.ijcard.2016.08.241 |url=}}</ref><ref name="pmid25071891">{{cite journal |vauthors=Testa M, Feola M |title=Usefulness of myocardial positron emission tomography/nuclear imaging in Takotsubo cardiomyopathy |journal=World J Radiol |volume=6 |issue=7 |pages=502–6 |year=2014 |pmid=25071891 |pmc=4109102 |doi=10.4329/wjr.v6.i7.502 |url=}}</ref> On biopsy, findings include an [[inflammatory]] infiltrate, [[fibrosis]] and formation of contraction bands, which may or may not be associated with [[myocardial necrosis]].<ref name="pmid191064002">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref> Stress cardiomyopathy is associated with various [[neurological]] and psychological conditions.
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==Epidemiology and Demographics==
==Epidemiology and Demographics==
The true incidence and prevalence of stress cardiomyopathy is unknown. However, this disease most commonly affects post-[[menopausal]] women, with the mean age of diagnosis ranging between 58-75 years.
The true incidence and prevalence of stress cardiomyopathy is unknown. However, this disease most commonly affects post-[[menopausal]] women, with the mean age of diagnosis ranging between 58-75 years.<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid26332547">{{cite journal |vauthors=Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF |title=Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy |journal=N. Engl. J. Med. |volume=373 |issue=10 |pages=929–38 |year=2015 |pmid=26332547 |doi=10.1056/NEJMoa1406761 |url=}}</ref><ref name="pmid21401402">{{cite journal |vauthors=Omerovic E |title=How to think about stress-induced cardiomyopathy?--Think "out of the box"! |journal=Scand. Cardiovasc. J. |volume=45 |issue=2 |pages=67–71 |year=2011 |pmid=21401402 |doi=10.3109/14017431.2011.565794 |url=}}</ref><ref name="pmid18294473">{{cite journal |vauthors=Prasad A, Lerman A, Rihal CS |title=Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction |journal=Am. Heart J. |volume=155 |issue=3 |pages=408–17 |year=2008 |pmid=18294473 |doi=10.1016/j.ahj.2007.11.008 |url=}}</ref><ref name="pmid15276100">{{cite journal |vauthors=Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS |title=Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome |journal=Am. J. Cardiol. |volume=94 |issue=3 |pages=343–6 |year=2004 |pmid=15276100 |doi=10.1016/j.amjcard.2004.04.030 |url=}}</ref>
 
==Risk Factors==
==Risk Factors==
Stress cardiomyopathy seems to be triggered by intense [[emotional]] or physical [[stress]], mostly the unexpected death of a loved one.
Stress cardiomyopathy seems to be triggered by intense [[emotional]] or physical [[stress]], mostly the unexpected death of a loved one.<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref>
 
==Screening==
==Screening==
There are no screening recommendations for stress cardiomyopathy.
There are no screening recommendations for stress cardiomyopathy.<ref name="USPSTF"> U.S. Preventive Services Task Force https://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=stress+cardiomyopathy. Accessed on Jan 9, 2017.</ref>
 
==Natural History, Complications and Prognosis==
==Natural History, Complications and Prognosis==
The prognosis of stress cardiomyopathy is generally excellent, with most patients making a complete recovery within a matter of weeks. However, death from complications of [[heart failure]] and [[Myocardial rupture|heart rupture]] may occur.<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid18294473">{{cite journal |vauthors=Prasad A, Lerman A, Rihal CS |title=Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction |journal=Am. Heart J. |volume=155 |issue=3 |pages=408–17 |year=2008 |pmid=18294473 |doi=10.1016/j.ahj.2007.11.008 |url=}}</ref><ref name="pmid19726776">{{cite journal |vauthors=Tsai TT, Nallamothu BK, Prasad A, Saint S, Bates ER |title=Clinical problem-solving. A change of heart |journal=N. Engl. J. Med. |volume=361 |issue=10 |pages=1010–6 |year=2009 |pmid=19726776 |doi=10.1056/NEJMcps0903023 |url=}}</ref>
The prognosis of stress cardiomyopathy is generally excellent, with most patients making a complete recovery within a matter of weeks. However, death from complications of [[heart failure]] and [[Myocardial rupture|heart rupture]] may occur.<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid18294473">{{cite journal |vauthors=Prasad A, Lerman A, Rihal CS |title=Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction |journal=Am. Heart J. |volume=155 |issue=3 |pages=408–17 |year=2008 |pmid=18294473 |doi=10.1016/j.ahj.2007.11.008 |url=}}</ref><ref name="pmid19726776">{{cite journal |vauthors=Tsai TT, Nallamothu BK, Prasad A, Saint S, Bates ER |title=Clinical problem-solving. A change of heart |journal=N. Engl. J. Med. |volume=361 |issue=10 |pages=1010–6 |year=2009 |pmid=19726776 |doi=10.1056/NEJMcps0903023 |url=}}</ref>


==Diagnostic Criteria==
==Diagnostic Criteria==
In 2004, researchers at the Mayo Clinic proposed a criteria for the diagnosis of stress cardiomyopathy. All 4 points of the criteria must be fulfilled, which include ruling out other medical conditions, such as obstructive [[coronary disease]], [[myocarditis]] and [[pheochromocytoma]].
In 2004, researchers at the Mayo Clinic proposed a criteria for the diagnosis of stress cardiomyopathy. All 4 points of the criteria must be fulfilled, which include ruling out other medical conditions, such as obstructive [[coronary disease]], [[myocarditis]] and [[pheochromocytoma]].<ref name="pmid18294473">{{cite journal |vauthors=Prasad A, Lerman A, Rihal CS |title=Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction |journal=Am. Heart J. |volume=155 |issue=3 |pages=408–17 |year=2008 |pmid=18294473 |doi=10.1016/j.ahj.2007.11.008 |url=}}</ref><ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref>
 
==History and Symptoms==
==History and Symptoms==
The most common presenting symptoms of stress cardiomyopathy are [[shortness of breath]] and [[chest pain]].  
The most common presenting symptoms of stress cardiomyopathy are [[shortness of breath]] and [[chest pain]].<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref><ref name="pmid18294473">{{cite journal |vauthors=Prasad A, Lerman A, Rihal CS |title=Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction |journal=Am. Heart J. |volume=155 |issue=3 |pages=408–17 |year=2008 |pmid=18294473 |doi=10.1016/j.ahj.2007.11.008 |url=}}</ref><ref name="pmid15276100">{{cite journal |vauthors=Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS |title=Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome |journal=Am. J. Cardiol. |volume=94 |issue=3 |pages=343–6 |year=2004 |pmid=15276100 |doi=10.1016/j.amjcard.2004.04.030 |url=}}</ref><ref name="pmid26332547">{{cite journal |vauthors=Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF |title=Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy |journal=N. Engl. J. Med. |volume=373 |issue=10 |pages=929–38 |year=2015 |pmid=26332547 |doi=10.1056/NEJMoa1406761 |url=}}</ref><ref name="pmid28041712">{{cite journal |vauthors=Efferth T, Banerjee M, Paul NW |title=Broken heart, tako-tsubo or stress cardiomyopathy? Metaphors, meanings and their medical impact |journal=Int. J. Cardiol. |volume= |issue= |pages= |year=2016 |pmid=28041712 |doi=10.1016/j.ijcard.2016.12.129 |url=}}</ref>
 
==Physical Examination==
==Physical Examination==
Physical examination findings in patients with stress cardiomyopathy are non-specific and non-diagnostic. The diagnosis of stress cardiomyopathy is largely based on [[ECG]], [[echocardiographic]] findings, as well as [[cardiac catheterization]].
Physical examination findings in patients with stress cardiomyopathy are non-specific and non-diagnostic. The diagnosis of stress cardiomyopathy is largely based on [[ECG]], [[echocardiographic]] findings, as well as [[cardiac catheterization]].<ref name="pmid23073280">{{cite journal |vauthors=Y-Hassan S, Yamasaki K |title=History of takotsubo syndrome: is the syndrome really described as a disease entity first in 1990? Some inaccuracies |journal=Int. J. Cardiol. |volume=166 |issue=3 |pages=736–7 |year=2013 |pmid=23073280 |doi=10.1016/j.ijcard.2012.09.183 |url=}}</ref>
 
==Laboratory Findings==
==Laboratory Findings==
Elevated levels of [[catecholamines]], [[cardiac enzymes]] and [[Brain natriuretic peptide|BNP]] may be seen in patients with stress cardiomyopathy.
Elevated levels of [[catecholamines]], [[cardiac enzymes]] and [[Brain natriuretic peptide|BNP]] may be seen in patients with stress cardiomyopathy. However, none of these laboratory findings are specific to stress cardiomyopathy.<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref><ref name="pmid15276100">{{cite journal |vauthors=Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS |title=Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome |journal=Am. J. Cardiol. |volume=94 |issue=3 |pages=343–6 |year=2004 |pmid=15276100 |doi=10.1016/j.amjcard.2004.04.030 |url=}}</ref><ref name="pmid28041712">{{cite journal |vauthors=Efferth T, Banerjee M, Paul NW |title=Broken heart, tako-tsubo or stress cardiomyopathy? Metaphors, meanings and their medical impact |journal=Int. J. Cardiol. |volume= |issue= |pages= |year=2016 |pmid=28041712 |doi=10.1016/j.ijcard.2016.12.129 |url=}}</ref>
 
==ECG==
==ECG==
[[ECG]] findings in stress cardiomyopathy are similar to those seen in [[Anterior myocardial infarction|anterior MI]]. The most common findings include [[ST elevation]] in the [[precordial leads]], [[T wave inversion]] and the formation of a [[Q wave]].
[[ECG]] findings in stress cardiomyopathy are similar to those seen in [[Anterior myocardial infarction|anterior MI]]. The most common findings include [[ST elevation]] in the [[precordial leads]], [[T wave inversion]] and the formation of a [[Q wave]].<ref name=Bybee-2006>{{cite journal | author=Bybee KA, Motiei A, Syed IS, Kara T, Prasad A, Lennon RJ, Murphy JG, Hammill SC, Rihal CS, Wright RS | title=Electrocardiography cannot reliably differentiate transient left ventricular apical ballooning syndrome from anterior ST-segment elevation myocardial infarction | journal=J Electrocardiol | year=2006 | id=PMID 17067626}}</ref><ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref> Findings on [[ECG]] include:<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref><ref name="pmid18294473">{{cite journal |vauthors=Prasad A, Lerman A, Rihal CS |title=Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction |journal=Am. Heart J. |volume=155 |issue=3 |pages=408–17 |year=2008 |pmid=18294473 |doi=10.1016/j.ahj.2007.11.008 |url=}}</ref><ref name="pmid19726776">{{cite journal |vauthors=Tsai TT, Nallamothu BK, Prasad A, Saint S, Bates ER |title=Clinical problem-solving. A change of heart |journal=N. Engl. J. Med. |volume=361 |issue=10 |pages=1010–6 |year=2009 |pmid=19726776 |doi=10.1056/NEJMcps0903023 |url=}}</ref><ref name="pmid15276100">{{cite journal |vauthors=Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS |title=Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome |journal=Am. J. Cardiol. |volume=94 |issue=3 |pages=343–6 |year=2004 |pmid=15276100 |doi=10.1016/j.amjcard.2004.04.030 |url=}}</ref><ref name="pmid26332547">{{cite journal |vauthors=Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF |title=Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy |journal=N. Engl. J. Med. |volume=373 |issue=10 |pages=929–38 |year=2015 |pmid=26332547 |doi=10.1056/NEJMoa1406761 |url=}}</ref><ref name="pmid28041712">{{cite journal |vauthors=Efferth T, Banerjee M, Paul NW |title=Broken heart, tako-tsubo or stress cardiomyopathy? Metaphors, meanings and their medical impact |journal=Int. J. Cardiol. |volume= |issue= |pages= |year=2016 |pmid=28041712 |doi=10.1016/j.ijcard.2016.12.129 |url=}}</ref>
 
==Chest X-Ray==
==Chest X-Ray==
 Typical findings on [[chest x-ray]] include [[apical ballooning]] and narrowing of the neck.
 Typical findings on [[chest x-ray]] include [[apical ballooning]] and narrowing of the neck.


==CT Scan==
==CT Scan==
A [[CT scan]] may be done in patients with stress cardiomyopathy to asses coronary anatomy, as well as detect the presence of regional wall motion abnormalities.
A [[CT scan]] may be done in patients with stress cardiomyopathy to asses [[coronary anatomy]], as well as detect the presence of regional wall motion abnormalities.<ref name="pmid28041712">{{cite journal |vauthors=Efferth T, Banerjee M, Paul NW |title=Broken heart, tako-tsubo or stress cardiomyopathy? Metaphors, meanings and their medical impact |journal=Int. J. Cardiol. |volume= |issue= |pages= |year=2016 |pmid=28041712 |doi=10.1016/j.ijcard.2016.12.129 |url=}}</ref>
 
==MRI==
==MRI==
[[Cardiovascular magnetic resonance imaging (CMR)|Cardiac magnetic resonance (CMR)]] is a useful imaging modality in distinguishing between stress cardiomyopathy and [[myocarditis]] or [[MI]]. The most common findings on [[Cardiovascular magnetic resonance imaging (CMR)|CMR]] in patients with stress cardiomyopathy include absence of [[gadolinium]] hyper-enhancement, as well as [[myocardial edema]].<ref name="pmid18294473">{{cite journal |vauthors=Prasad A, Lerman A, Rihal CS |title=Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction |journal=Am. Heart J. |volume=155 |issue=3 |pages=408–17 |year=2008 |pmid=18294473 |doi=10.1016/j.ahj.2007.11.008 |url=}}</ref><ref name="pmid15687136">{{cite journal |vauthors=Sharkey SW, Lesser JR, Zenovich AG, Maron MS, Lindberg J, Longe TF, Maron BJ |title=Acute and reversible cardiomyopathy provoked by stress in women from the United States |journal=Circulation |volume=111 |issue=4 |pages=472–9 |year=2005 |pmid=15687136 |doi=10.1161/01.CIR.0000153801.51470.EB |url=}}</ref><ref name="pmid17175045">{{cite journal |vauthors=Haghi D, Fluechter S, Suselbeck T, Kaden JJ, Borggrefe M, Papavassiliu T |title=Cardiovascular magnetic resonance findings in typical versus atypical forms of the acute apical ballooning syndrome (Takotsubo cardiomyopathy) |journal=Int. J. Cardiol. |volume=120 |issue=2 |pages=205–11 |year=2007 |pmid=17175045 |doi=10.1016/j.ijcard.2006.09.019 |url=}}</ref><ref name="pmid17631086">{{cite journal |vauthors=Mitchell JH, Hadden TB, Wilson JM, Achari A, Muthupillai R, Flamm SD |title=Clinical features and usefulness of cardiac magnetic resonance imaging in assessing myocardial viability and prognosis in Takotsubo cardiomyopathy (transient left ventricular apical ballooning syndrome) |journal=Am. J. Cardiol. |volume=100 |issue=2 |pages=296–301 |year=2007 |pmid=17631086 |doi=10.1016/j.amjcard.2007.02.091 |url=}}</ref><ref name="pmid16669180">{{cite journal |vauthors=Deetjen AG, Conradi G, Mollmann S, Rad A, Hamm CW, Dill T |title=Value of gadolinium-enhanced magnetic resonance imaging in patients with Tako-Tsubo-like left ventricular dysfunction |journal=J Cardiovasc Magn Reson |volume=8 |issue=2 |pages=367–72 |year=2006 |pmid=16669180 |doi= |url=}}</ref><ref name="pmid12628715">{{cite journal |vauthors=Abe Y, Kondo M, Matsuoka R, Araki M, Dohyama K, Tanio H |title=Assessment of clinical features in transient left ventricular apical ballooning |journal=J. Am. Coll. Cardiol. |volume=41 |issue=5 |pages=737–42 |year=2003 |pmid=12628715 |doi= |url=}}</ref><ref name="pmid15687123">{{cite journal |vauthors=Dec GW |title=Recognition of the apical ballooning syndrome in the United States |journal=Circulation |volume=111 |issue=4 |pages=388–90 |year=2005 |pmid=15687123 |doi=10.1161/01.CIR.0000155234.69439.E4 |url=}}</ref><ref name="pmid19944334">{{cite journal |vauthors=Handy AD, Prasad A, Olson TM |title=Investigating genetic variation of adrenergic receptors in familial stress cardiomyopathy (apical ballooning syndrome) |journal=J Cardiol |volume=54 |issue=3 |pages=516–7 |year=2009 |pmid=19944334 |doi=10.1016/j.jjcc.2009.08.008 |url=}}</ref><ref name="pmid19167638">{{cite journal |vauthors=Sharkey SW, Maron BJ, Nelson P, Parpart M, Maron MS, Bristow MR |title=Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy |journal=J Cardiol |volume=53 |issue=1 |pages=53–7 |year=2009 |pmid=19167638 |doi=10.1016/j.jjcc.2008.08.006 |url=}}</ref><ref name="pmid21771988">{{cite journal |vauthors=Eitel I, von Knobelsdorff-Brenkenhoff F, Bernhardt P, Carbone I, Muellerleile K, Aldrovandi A, Francone M, Desch S, Gutberlet M, Strohm O, Schuler G, Schulz-Menger J, Thiele H, Friedrich MG |title=Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy |journal=JAMA |volume=306 |issue=3 |pages=277–86 |year=2011 |pmid=21771988 |doi=10.1001/jama.2011.992 |url=}}</ref><ref name="pmid18820322">{{cite journal |vauthors=Eitel I, Behrendt F, Schindler K, Kivelitz D, Gutberlet M, Schuler G, Thiele H |title=Differential diagnosis of suspected apical ballooning syndrome using contrast-enhanced magnetic resonance imaging |journal=Eur. Heart J. |volume=29 |issue=21 |pages=2651–9 |year=2008 |pmid=18820322 |doi=10.1093/eurheartj/ehn433 |url=}}</ref>
[[Cardiovascular magnetic resonance imaging (CMR)|Cardiac magnetic resonance (CMR)]] is a useful imaging modality in distinguishing between stress cardiomyopathy and [[myocarditis]] or [[MI]]. The most common findings on [[Cardiovascular magnetic resonance imaging (CMR)|CMR]] in patients with stress cardiomyopathy include absence of [[gadolinium]] hyper-enhancement, as well as [[myocardial edema]].<ref name="pmid18294473">{{cite journal |vauthors=Prasad A, Lerman A, Rihal CS |title=Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction |journal=Am. Heart J. |volume=155 |issue=3 |pages=408–17 |year=2008 |pmid=18294473 |doi=10.1016/j.ahj.2007.11.008 |url=}}</ref><ref name="pmid15687136">{{cite journal |vauthors=Sharkey SW, Lesser JR, Zenovich AG, Maron MS, Lindberg J, Longe TF, Maron BJ |title=Acute and reversible cardiomyopathy provoked by stress in women from the United States |journal=Circulation |volume=111 |issue=4 |pages=472–9 |year=2005 |pmid=15687136 |doi=10.1161/01.CIR.0000153801.51470.EB |url=}}</ref><ref name="pmid17175045">{{cite journal |vauthors=Haghi D, Fluechter S, Suselbeck T, Kaden JJ, Borggrefe M, Papavassiliu T |title=Cardiovascular magnetic resonance findings in typical versus atypical forms of the acute apical ballooning syndrome (Takotsubo cardiomyopathy) |journal=Int. J. Cardiol. |volume=120 |issue=2 |pages=205–11 |year=2007 |pmid=17175045 |doi=10.1016/j.ijcard.2006.09.019 |url=}}</ref><ref name="pmid17631086">{{cite journal |vauthors=Mitchell JH, Hadden TB, Wilson JM, Achari A, Muthupillai R, Flamm SD |title=Clinical features and usefulness of cardiac magnetic resonance imaging in assessing myocardial viability and prognosis in Takotsubo cardiomyopathy (transient left ventricular apical ballooning syndrome) |journal=Am. J. Cardiol. |volume=100 |issue=2 |pages=296–301 |year=2007 |pmid=17631086 |doi=10.1016/j.amjcard.2007.02.091 |url=}}</ref><ref name="pmid16669180">{{cite journal |vauthors=Deetjen AG, Conradi G, Mollmann S, Rad A, Hamm CW, Dill T |title=Value of gadolinium-enhanced magnetic resonance imaging in patients with Tako-Tsubo-like left ventricular dysfunction |journal=J Cardiovasc Magn Reson |volume=8 |issue=2 |pages=367–72 |year=2006 |pmid=16669180 |doi= |url=}}</ref><ref name="pmid12628715">{{cite journal |vauthors=Abe Y, Kondo M, Matsuoka R, Araki M, Dohyama K, Tanio H |title=Assessment of clinical features in transient left ventricular apical ballooning |journal=J. Am. Coll. Cardiol. |volume=41 |issue=5 |pages=737–42 |year=2003 |pmid=12628715 |doi= |url=}}</ref><ref name="pmid15687123">{{cite journal |vauthors=Dec GW |title=Recognition of the apical ballooning syndrome in the United States |journal=Circulation |volume=111 |issue=4 |pages=388–90 |year=2005 |pmid=15687123 |doi=10.1161/01.CIR.0000155234.69439.E4 |url=}}</ref><ref name="pmid19944334">{{cite journal |vauthors=Handy AD, Prasad A, Olson TM |title=Investigating genetic variation of adrenergic receptors in familial stress cardiomyopathy (apical ballooning syndrome) |journal=J Cardiol |volume=54 |issue=3 |pages=516–7 |year=2009 |pmid=19944334 |doi=10.1016/j.jjcc.2009.08.008 |url=}}</ref><ref name="pmid19167638">{{cite journal |vauthors=Sharkey SW, Maron BJ, Nelson P, Parpart M, Maron MS, Bristow MR |title=Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy |journal=J Cardiol |volume=53 |issue=1 |pages=53–7 |year=2009 |pmid=19167638 |doi=10.1016/j.jjcc.2008.08.006 |url=}}</ref><ref name="pmid21771988">{{cite journal |vauthors=Eitel I, von Knobelsdorff-Brenkenhoff F, Bernhardt P, Carbone I, Muellerleile K, Aldrovandi A, Francone M, Desch S, Gutberlet M, Strohm O, Schuler G, Schulz-Menger J, Thiele H, Friedrich MG |title=Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy |journal=JAMA |volume=306 |issue=3 |pages=277–86 |year=2011 |pmid=21771988 |doi=10.1001/jama.2011.992 |url=}}</ref><ref name="pmid18820322">{{cite journal |vauthors=Eitel I, Behrendt F, Schindler K, Kivelitz D, Gutberlet M, Schuler G, Thiele H |title=Differential diagnosis of suspected apical ballooning syndrome using contrast-enhanced magnetic resonance imaging |journal=Eur. Heart J. |volume=29 |issue=21 |pages=2651–9 |year=2008 |pmid=18820322 |doi=10.1093/eurheartj/ehn433 |url=}}</ref>


==Echocardiography==
==Echocardiography==
Echocardiography is done in patients with stress cardiomyopathy to document [[apical ballooning]], [[dyskinesia]]/[[akinesia]] and reduced [[ejection fraction]].
Echocardiography is done in patients with stress cardiomyopathy to document [[apical ballooning]], [[dyskinesia]]/[[akinesia]] and reduced [[ejection fraction]].<ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref><ref name="pmid18294473">{{cite journal |vauthors=Prasad A, Lerman A, Rihal CS |title=Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction |journal=Am. Heart J. |volume=155 |issue=3 |pages=408–17 |year=2008 |pmid=18294473 |doi=10.1016/j.ahj.2007.11.008 |url=}}</ref><ref name="pmid19726776">{{cite journal |vauthors=Tsai TT, Nallamothu BK, Prasad A, Saint S, Bates ER |title=Clinical problem-solving. A change of heart |journal=N. Engl. J. Med. |volume=361 |issue=10 |pages=1010–6 |year=2009 |pmid=19726776 |doi=10.1056/NEJMcps0903023 |url=}}</ref><ref name="pmid28041712">{{cite journal |vauthors=Efferth T, Banerjee M, Paul NW |title=Broken heart, tako-tsubo or stress cardiomyopathy? Metaphors, meanings and their medical impact |journal=Int. J. Cardiol. |volume= |issue= |pages= |year=2016 |pmid=28041712 |doi=10.1016/j.ijcard.2016.12.129 |url=}}</ref>
 
==Other Imaging Findings==
==Other Imaging Findings==
In patients with stress cardiomyopathy, [[coronary angiography]] usually shows normal [[anatomy]] of the [[coronary arteries]] no evidence of [[coronary artery stenosis]].<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid15276100">{{cite journal |vauthors=Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS |title=Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome |journal=Am. J. Cardiol. |volume=94 |issue=3 |pages=343–6 |year=2004 |pmid=15276100 |doi=10.1016/j.amjcard.2004.04.030 |url=}}</ref><ref name="pmid28041712">{{cite journal |vauthors=Efferth T, Banerjee M, Paul NW |title=Broken heart, tako-tsubo or stress cardiomyopathy? Metaphors, meanings and their medical impact |journal=Int. J. Cardiol. |volume= |issue= |pages= |year=2016 |pmid=28041712 |doi=10.1016/j.ijcard.2016.12.129 |url=}}</ref>
In patients with stress cardiomyopathy, [[coronary angiography]] usually shows normal [[anatomy]] of the [[coronary arteries]] no evidence of [[coronary artery stenosis]].<ref name="pmid19106400">{{cite journal |vauthors=Akashi YJ, Goldstein DS, Barbaro G, Ueyama T |title=Takotsubo cardiomyopathy: a new form of acute, reversible heart failure |journal=Circulation |volume=118 |issue=25 |pages=2754–62 |year=2008 |pmid=19106400 |pmc=4893309 |doi=10.1161/CIRCULATIONAHA.108.767012 |url=}}</ref><ref name="pmid15276100">{{cite journal |vauthors=Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS |title=Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome |journal=Am. J. Cardiol. |volume=94 |issue=3 |pages=343–6 |year=2004 |pmid=15276100 |doi=10.1016/j.amjcard.2004.04.030 |url=}}</ref><ref name="pmid28041712">{{cite journal |vauthors=Efferth T, Banerjee M, Paul NW |title=Broken heart, tako-tsubo or stress cardiomyopathy? Metaphors, meanings and their medical impact |journal=Int. J. Cardiol. |volume= |issue= |pages= |year=2016 |pmid=28041712 |doi=10.1016/j.ijcard.2016.12.129 |url=}}</ref>


==Other Diagnostic Studies==
==Other Diagnostic Studies==
[[Coronary angiography]] and [[cardiac catheterization]] are the diagnostic modalities of choice to distinguish between stress cardiomyopathy and acute [[anterior MI]]. Normal [[anatomy]] of the [[coronary arteries]], along with a reduced [[ejection fraction]] supports the diagnosis of stress cardiomyopathy.
[[Coronary angiography]] and [[cardiac catheterization]] are the diagnostic modalities of choice to distinguish between stress cardiomyopathy and acute [[anterior MI]]. Normal [[anatomy]] of the [[coronary arteries]], along with a reduced [[ejection fraction]] supports the diagnosis of stress cardiomyopathy.<ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref><ref name="pmid19726776">{{cite journal |vauthors=Tsai TT, Nallamothu BK, Prasad A, Saint S, Bates ER |title=Clinical problem-solving. A change of heart |journal=N. Engl. J. Med. |volume=361 |issue=10 |pages=1010–6 |year=2009 |pmid=19726776 |doi=10.1056/NEJMcps0903023 |url=}}</ref><ref name="pmid15276100">{{cite journal |vauthors=Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS |title=Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome |journal=Am. J. Cardiol. |volume=94 |issue=3 |pages=343–6 |year=2004 |pmid=15276100 |doi=10.1016/j.amjcard.2004.04.030 |url=}}</ref>
 
==Medical Therapy==
==Medical Therapy==
Medical therapy in stress cardiomyopathy is indicated to treat the complications that may arise. The most common complications related to stress cardiomyopathy include [[heart failure]] and [[pulmonary edema]]. [[Diuretics]] and anti-[[heart failure]] medications are the treatment of choice in these conditions.
Medical therapy in stress cardiomyopathy is indicated to treat the complications that may arise. The most common complications related to stress cardiomyopathy include [[heart failure]] and [[pulmonary edema]]. [[Diuretics]] and anti-[[heart failure]] medications are the treatment of choice in these conditions.<ref name="pmid21401402">{{cite journal |vauthors=Omerovic E |title=How to think about stress-induced cardiomyopathy?--Think "out of the box"! |journal=Scand. Cardiovasc. J. |volume=45 |issue=2 |pages=67–71 |year=2011 |pmid=21401402 |doi=10.3109/14017431.2011.565794 |url=}}</ref><ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref>
 
==Surgery==
==Surgery==
There is no role for surgery in the treatment of stress cardiomyopathy.
Treatment of stress cardiomyopathy is mostly supportive and medications are used to treat complications.<ref name="pmid21401402">{{cite journal |vauthors=Omerovic E |title=How to think about stress-induced cardiomyopathy?--Think "out of the box"! |journal=Scand. Cardiovasc. J. |volume=45 |issue=2 |pages=67–71 |year=2011 |pmid=21401402 |doi=10.3109/14017431.2011.565794 |url=}}</ref><ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref> There is no role for surgery in the treatment of stress cardiomyopathy.


==Primary Prevention==
==Primary Prevention==
Line 60: Line 74:


==Secondary Prevention==
==Secondary Prevention==
Stress cardiomyopathy is a self-limiting disease, which usually resolves within a few weeks. However, medical therapy may be necessary during the acute phase of the illness or when complications arise.
Stress cardiomyopathy is a self-limiting disease, which usually resolves within a few weeks. However, medical therapy may be necessary during the acute phase of the illness or when complications arise.<ref name="pmid21401402">{{cite journal |vauthors=Omerovic E |title=How to think about stress-induced cardiomyopathy?--Think "out of the box"! |journal=Scand. Cardiovasc. J. |volume=45 |issue=2 |pages=67–71 |year=2011 |pmid=21401402 |doi=10.3109/14017431.2011.565794 |url=}}</ref><ref name="pmid18206521">{{cite journal |vauthors=Brenner ZR, Powers J |title=Takotsubo cardiomyopathy |journal=Heart Lung |volume=37 |issue=1 |pages=1–7 |year=2008 |pmid=18206521 |doi=10.1016/j.hrtlng.2006.12.003 |url=}}</ref>


==References==
==References==

Latest revision as of 15:42, 14 December 2017

Stress cardiomyopathy Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2] Arzu Kalayci, M.D. [3]

Overview

Stress cardiomyopathy is a relatively new disease, with the first case documented in literature under the name of Takotsobu Cardiomyopathy in Japan in 1991. It is not very well understood, but the disease is thought to arise following intense emotional or physical stress. Stress cardiomyopathy mostly affects post-menopausal women. The clinical presentation, laboratory findings and imaging studies largely mimic that of anterior MI. However, the absence of significant coronary artery stenosis supports the diagnosis of stress cardiomyopathy. It is generally a self-limiting disease and the majority of patients have a restored cardiac function within a matter of weeks. Complications and death are relatively rare, but they are mostly related to the development of heart failure and pulmonary edema.

Historical Perspective

Stress cardiomyopathy is a relatively new disease, with the first case documented in literature in Japan in 1991. However, cases of death upon going through severe emotional or psychological stress have been described as early as the biblical times.[1][2]

Classification

Stress cardiomyopathy can be divided into several types, depending on the location of regional wall motion abnormality. The area of motion abnormality (whether hypokinesia, dyskinesia or akinesia) can be detected on echocardiography or left ventriculography. The most common type is the apical type, resulting in apical ballooning.[3][4][5][6]

Pathophysiology

The pathogenesis of stress cardiomyopathy is not completely understood. However, the most accepted theory behind it is thought to be due to catecholamine surge, which are thought to contribute to myocardial necrosis and stunning seen in stress cardiomyopathy.[2][7][8] On biopsy, findings include an inflammatory infiltrate, fibrosis and formation of contraction bands, which may or may not be associated with myocardial necrosis.[9][10] Stress cardiomyopathy is associated with various neurological and psychological conditions.

Causes

The cause of stress cardiomyopathy is largely unknown. However, it is usually triggered by emotional and/or physical stress and may be related to certain medical conditions.

Differentiating Stress Cardiomyopathy from Other Diseases

The clinical presentation, laboratory findings and imaging studies of stress cardiomyopathy resembles that of anterior MI and must be differentiated from it. Also, stress cardiomyopathy must be differentiated from other medical conditions, such as pheochromocytoma, dilated cardiomyopathy and hypertrophic cardiomyopathy.[11][12]

Epidemiology and Demographics

The true incidence and prevalence of stress cardiomyopathy is unknown. However, this disease most commonly affects post-menopausal women, with the mean age of diagnosis ranging between 58-75 years.[2][3][1][13][14]

Risk Factors

Stress cardiomyopathy seems to be triggered by intense emotional or physical stress, mostly the unexpected death of a loved one.[2]

Screening

There are no screening recommendations for stress cardiomyopathy.[15]

Natural History, Complications and Prognosis

The prognosis of stress cardiomyopathy is generally excellent, with most patients making a complete recovery within a matter of weeks. However, death from complications of heart failure and heart rupture may occur.[2][13][16]

Diagnostic Criteria

In 2004, researchers at the Mayo Clinic proposed a criteria for the diagnosis of stress cardiomyopathy. All 4 points of the criteria must be fulfilled, which include ruling out other medical conditions, such as obstructive coronary disease, myocarditis and pheochromocytoma.[13][2]

History and Symptoms

The most common presenting symptoms of stress cardiomyopathy are shortness of breath and chest pain.[2][10][13][14][3][17]

Physical Examination

Physical examination findings in patients with stress cardiomyopathy are non-specific and non-diagnostic. The diagnosis of stress cardiomyopathy is largely based on ECG, echocardiographic findings, as well as cardiac catheterization.[18]

Laboratory Findings

Elevated levels of catecholamines, cardiac enzymes and BNP may be seen in patients with stress cardiomyopathy. However, none of these laboratory findings are specific to stress cardiomyopathy.[2][10][14][17]

ECG

ECG findings in stress cardiomyopathy are similar to those seen in anterior MI. The most common findings include ST elevation in the precordial leads, T wave inversion and the formation of a Q wave.[19][2] Findings on ECG include:[2][10][13][16][14][3][17]

Chest X-Ray

 Typical findings on chest x-ray include apical ballooning and narrowing of the neck.

CT Scan

A CT scan may be done in patients with stress cardiomyopathy to asses coronary anatomy, as well as detect the presence of regional wall motion abnormalities.[17]

MRI

Cardiac magnetic resonance (CMR) is a useful imaging modality in distinguishing between stress cardiomyopathy and myocarditis or MI. The most common findings on CMR in patients with stress cardiomyopathy include absence of gadolinium hyper-enhancement, as well as myocardial edema.[13][20][21][22][23][24][25][26][27][5][28]

Echocardiography

Echocardiography is done in patients with stress cardiomyopathy to document apical ballooning, dyskinesia/akinesia and reduced ejection fraction.[10][13][16][17]

Other Imaging Findings

In patients with stress cardiomyopathy, coronary angiography usually shows normal anatomy of the coronary arteries no evidence of coronary artery stenosis.[2][14][17]

Other Diagnostic Studies

Coronary angiography and cardiac catheterization are the diagnostic modalities of choice to distinguish between stress cardiomyopathy and acute anterior MI. Normal anatomy of the coronary arteries, along with a reduced ejection fraction supports the diagnosis of stress cardiomyopathy.[10][16][14]

Medical Therapy

Medical therapy in stress cardiomyopathy is indicated to treat the complications that may arise. The most common complications related to stress cardiomyopathy include heart failure and pulmonary edema. Diuretics and anti-heart failure medications are the treatment of choice in these conditions.[1][10]

Surgery

Treatment of stress cardiomyopathy is mostly supportive and medications are used to treat complications.[1][10] There is no role for surgery in the treatment of stress cardiomyopathy.

Primary Prevention

There are no means of prevention of stress cardiomyopathy.

Secondary Prevention

Stress cardiomyopathy is a self-limiting disease, which usually resolves within a few weeks. However, medical therapy may be necessary during the acute phase of the illness or when complications arise.[1][10]

References

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