Congestive heart failure pathophysiology: Difference between revisions
Jump to navigation
Jump to search
(New page: {{Template:Congestive heart failure}} {{CMG}} '''Associate Editor-In-Chief:''' {{CZ}}; Saleh El Dassouki, M.D [mailto:seldassouki@hotmail.com], Atif Mohammad, MD == Pathophysiology== *[...) |
No edit summary |
||
Line 18: | Line 18: | ||
*Decompensation; most often is non compliance with therapeutic regimens. | *Decompensation; most often is non compliance with therapeutic regimens. | ||
*[[Atrial fibrillation]] is a major target of therapy. It occurs in 20% of patients with [[congestive heart failure]]. | *[[Atrial fibrillation]] is a major target of therapy. It occurs in 20% of patients with [[congestive heart failure]]. | ||
==References== | ==References== |
Revision as of 20:24, 28 June 2011
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Saleh El Dassouki, M.D [3], Atif Mohammad, MD
Pathophysiology
- Cardiac output can be maintained if LV dilation occurs and stroke volume is preserved even though the LVEF is low.
- As LV dilation occurs, functional mitral regurgitation (MR) may develop despite an anatomically normal mitral valve.
- The ejection fraction is usually below 35% in symptomatic patients.
- Rales usually develop if the pulmonary capillary wedge pressure is >25 mm Hg. Rales may not be present in the patient with chronic heart failure. Rales may develop at even lower pressures if LV function deteriorates suddenly.
- Dyspnea and orthopnea occur due to interstitial edema at lower pressures.
- Hypoperfusion at rest is suggested by cool extremities, altered mentation, and declining renal function.
- EKG often shows low voltage. The differential diagnosis of low voltage on the EKG includes amyloid.
- Poor R wave progression in the precordial leads and LBBB are both common with both ischemic and non-ischemic causes.
- Since the LV often dilates in the anteroposterior direction, the cardiac silhouette may appear deceptively normal. Once the heart failure is advanced, the enlarged right ventricle forms the left border of the cardiac silhouette.
- The presence of enlargement of vessels to the upper lobes, per bronchial cuffing, and pulmonary interstitial and alveolar edema are all indicative of pulmonary venous hypertension.
- As part of the diagnostic maneuvers check the serum TSH and iron levels. Check TSH particularly in those e patients treated with amiodarone.
- Decompensation; most often is non compliance with therapeutic regimens.
- Atrial fibrillation is a major target of therapy. It occurs in 20% of patients with congestive heart failure.